PREMARIN 0.625mg Tablet 28's

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Drug Information for PREMARIN 0.625mg Tablet 28's

What is Conjugated Estrogen used for?

Conjugated Estrogen tablet is used for the treatment of symptoms of menopause. It is also used to treat the symptoms of breast and prostate cancer.

Conjugated Estrogen cream is used for the treatment of vaginal dryness, itching and burning. 

Conjugated Estrogen may also be prescribed for other conditions as determined by the doctor.

How does Conjugated Estrogen work?

Conjugated Estrogen belongs to the class of drugs called hormones. The drug acts by binding to the oestrogen receptors and mimics the action of oestrogen, thereby reducing the menopausal symptoms.

How to use Conjugated Estrogen?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Use Conjugated Estrogen cream/tablet as prescribed by your doctor.

  • Swallow the tablet Do not crush or chew the tablet. Take the drug with or without food. However, taking the drug with food prevents stomach upset.
  • Wash and dry the affected area. Apply a thin layer of Conjugated Estrogen cream to the affected area and rub gently.

If you miss a dose of Conjugated Estrogen, please use it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for the missed dose.

The overdose symptoms of Conjugated Estrogen include the following:

  • Severe nausea and vomiting
  • Unusual vaginal bleeding

You must seek immediate medical care if you experience any of the above symptoms.

What are the drugs that interact with Conjugated Estrogen?

Drugs that interact with Conjugated Estrogen include the following:

  • Acetaminophen
  • Anastrozole
  • Atorvastatin
  • Atropine
  • Cimetidine
  • Dexamethasone
  • Fulvestrant
  • Glimepiride
  • Hydrocortisone
  • Metformin
  • Methylprednisolone
  • Pioglitazone
  • Raloxifene
  • Tamoxifen

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Conjugated Estrogen?

The following are the most common side effects of Conjugated Estrogen:

  • Nausea
  • Vomiting
  • Stomach upset
  • Headache
  • Bloating
  • Breast tenderness
  • Dizziness
  • Hives
  • Itching
  • Skin rash

The following are the severe side effects and you may require immediate medical attention:

  • Chest tightness
  • Tingling of the hands or feet
  • Vaginal bleeding
  • Weight changes
  • Slurred speech

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while using Conjugated Estrogen?

  • Avoid using the medicine if you are allergic to Conjugated Estrogen or similar drugs.
  • Avoid consumption of alcohol as it may alter the absorption of Conjugated Estrogen.
  • Do not drive or operate heavy machinery if Conjugated Estrogen causes dizziness or blurred vision.
  • Avoid Conjugated Estrogen during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not stop using the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Do not exceed the dose prescribed by the doctor.

You are advised not to use Conjugated Estrogen if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before using Conjugated Estrogen?

  • Tell your doctor if you have any history of heart, liver or kidney diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.

Frequently Asked Questions about Conjugated Estrogen

  1. Can Conjugated Estrogen be used in the treatment of osteoporosis?
  2. Yes. Conjugated Estrogen can be used in the treatment of osteoporosis when recommended by the doctor.

  3. Can I undergo metyrapone test while using Conjugated Estrogen?
  4. No. It is advisable not to use Conjugated Estrogen as it alters the test result. However, please consult your doctor.

  5. Is it safe to use Conjugated Estrogen in patients having a history of deep vein thrombosis?
  6. No. It is unsafe to use Conjugated Estrogen in patients having a history of deep vein thrombosis, as it increases the risk of blood clot.

  7. What precautions do I need to take while using Conjugated Estrogen?
  8. Conjugated Estrogen causes blotchy and dark areas on the skin, so avoid excessive exposure to the sun. Use sunscreen and wear protective clothing while using Conjugated Estrogen.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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