Pioz MF 15mg Tablet 10'S

Introduction About PIOZ MF 15MG TABLET

Pioz MF 15mg Tablet is a combination of Pioglitazone and Metformin. Pioz MF 15mg Tablet is an oral antidiabetic medicine used to support healthy blood sugar levels in adults with Type 2 diabetes mellitus, when diet and exercise alone are insufficient.

Before and during therapy with PIOZ MF 15MG TABLET, your doctor might recommend you take several blood tests to check your liver functions and monitor your body weight to rule out unwanted side effects.

Stop taking PIOZ MF 15MG TABLET and inform your doctor if you did not notice any improvements even after using this medicine for 3-6 months.

PIOZ MF 15MG TABLET is strictly not recommended for use in pregnant or breastfeeding women or in patients with active bladder cancer or hematuria (blood in urine). Consult your doctor before taking PIOZ MF 15MG TABLET.

PIOZ MF 15MG TABLET is not recommended for use in children and adolescents (aged under 18 years) due to a lack of safety data and an increased risk of serious side effects. It should be used with extreme caution in elderly patients due to the risk of bladder cancer, heart failure, or bone fracture.

Common side effects of taking PIOZ MF 15MG TABLET are upper respiratory tract infections, headache, weight gain, changes in taste, nausea, vomiting, diarrhea, or stomach pain. Consult your doctor if any of the side effects worsen.

Key Composition

• Pioglitazone 15 mg – improves insulin sensitivity in cells
• Metformin 500 mg – reduces glucose production by the liver and increases its uptake by muscles

Uses Of PIOZ MF 15MG TABLET

• Manages type II diabetes mellitus (as a second line of therapy)

Benefits of PIOZ MF 15MG TABLET

• Helps maintain balanced blood sugar levels in adults with type 2 diabetes.
• Improves body's response to insulin, enhancing glucose uptake by cells.
• Supports reduction of glucose production in the liver, aiding overall glucose control.
• Helps reduce risk of diabetes complications such as kidney, eye, and nerve damage.
• When combined with lifestyle modifications, can lead to better long-term diabetes management and quality of life.

How PIOZ MF 15MG TABLET Works

• Pioglitazone is a thiazolidinedione class drug that selectively activates peroxisome proliferator-activated receptor gamma (PPAR-γ) located mainly in adipose tissue, skeletal muscle, and liver.
• Activation of PPAR-γ alters the transcription of genes regulating glucose and lipid metabolism, enhancing insulin sensitivity in peripheral tissues.
• This activation leads to increased glucose uptake in muscle and fat cells and decreased glucose production by the liver (reduced gluconeogenesis), helping to lower blood glucose levels without raising insulin secretion by pancreatic beta cells.
• Pioglitazone also influences lipid metabolism, reducing free fatty acids and favorably modifying cholesterol levels.
• The drug improves peripheral insulin sensitivity and may have secondary benefits on β-cell function and cardiovascular risk factors.

How to use PIOZ MF 15MG TABLET

How to Take Pioz MF 15mg Tablet

Take Pioz MF 15mg Tablet exactly as prescribed by your healthcare provider—typically once or twice daily depending on your doctor's advice. Swallow the tablet whole with a glass of water; do not crush, chew, or break it. It is generally advised to take the tablet with food, which helps improve absorption and may reduce stomach discomfort. Taking it at the same time each day helps maintain stable blood sugar levels.

Pioz MF 15mg Dosage Guidelines

Your dose will be individualized by your doctor based on your current blood sugar control, age, kidney function, and how you respond to the medicine. Never exceed the prescribed dose and do not change the schedule or stop medication without medical advice.

Step-by-Step Administration Advice

1. Take Pioz MF 15mg Tablet as a whole; do not split, crush, or chew the tablet.
2. Use a full glass of water to aid swallowing.
3. Preferably take it with or after food to minimize stomach upset.
4. Stay consistent with the timing and schedule.
5. If you have difficulty swallowing tablets, talk to your doctor about alternatives.

Dosage Titration and Monitoring Frequency

Dosage may be adjusted by your doctor at regular intervals, typically every few weeks, based on your blood glucose readings and tolerance. Your doctor will monitor kidney and liver function, and may advise regular blood sugar checks to fine-tune the dose.

Oral Tablet Intake and Administration

• Always take Pioz MF 15mg Tablet orally.
• Take with or without food as advised, though with food is preferred if stomach upset occurs.
• Use clean, dry hands to remove tablets from packaging.

What if I forgot to take PIOZ MF 15MG TABLET

If you miss a dose, take it as soon as you remember. If it's almost time for your next scheduled dose, skip the missed one and resume your routine. Do not double the dose to make up for a missed tablet—this can increase the risk of low blood sugar (hypoglycemia).

Overdose

If you or anyone else accidentally takes too much of PIOZ MF 15MG TABLET, contact your doctor immediately or go to the nearest hospital right away, as it could lead to severe hypoglycemia or lactic acidosis. Symptoms of lactic acidosis might include nausea, vomiting, stomach pain with muscle cramps, decreased heartbeat, general weakness with severe tiredness, difficulty breathing, or reduced body temperature.

Side Effects Of PIOZ MF 15MG TABLET

Common

• signs of upper respiratory tract infection (cough, sore throat, chest tightness, or wheezing)
• anemia
• hypoaesthesia (diminished sense of touch)
• headache
• visual disturbance
• arthralgia (joint pain)
• erectile dysfunction
• blood in urine (hematuria)
• weight gain
• nausea, vomiting, diarrhea, abdominal pain, and loss of appetite
• taste disturbance
• numbness

When to consult doctor?

• serious allergic reaction (such as skin rash, itching, swelling of the face, lips, mouth, tongue, or throat, difficulty in swelling or breathing)
• symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, general weakness with severe tiredness, or reduced body temperature)
• signs of liver inflammation (such as tiredness, loss of appetite, weight loss, with or without yellowing of the skin or whites of the eyes)
• signs of heart failure (such as unusual shortness of breath, a rapid increase in body weight, or localized swelling)
• signs of kidney problems (such as hematuria or bladder cancer)
• hypoglycemia (decreased blood glucose level)
• bone fracture
• blurred vision due to swelling at the back of the eye

How To Manage Side Effects

Diarrhea

Drink a lot of fluids, such as water or fruit juices, to keep yourself hydrated. Avoid taking any medicine on your own to manage diarrhea. Consult your doctor if the symptom does not improve.

Headache

Rest and relax. Drink plenty of fluids, such as water. Apply a pain-relieving balm to your forehead if required. Do not consume too much alcohol. Consult your doctor if the symptom does not improve.

Stomach Pain

Rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heat pad on your stomach. Do not self-manage on your own and consult your doctor if the symptom does not improve on its own.

Warning & Precautions

Pregnancy

Contraindicated

PIOZ MF 15MG TABLET is not recommended for use by pregnant women. Consult your doctor before taking PIOZ MF 15MG TABLET

Breastfeeding

Contraindicated

PIOZ MF 15MG TABLET is not recommended for use during breastfeeding as it is not known whether it may be present in the breast milk. Consult your doctor before taking PIOZ MF 15MG TABLET

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if your ability is affected after taking PIOZ MF 15MG TABLET , and you should be alerted about the risk of low blood sugar levels before performing activities that require mental attention.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking PIOZ MF 15MG TABLET due to the increased risk of lactic acidosis.

Kidney

Contraindicated

PIOZ MF 15MG TABLET is strictly not recommended for use in patients with kidney diseases (such as kidney failure, kidney dysfunction, hematuria (blood in urine), bladder cancer, or a history of bladder cancer). Consult your doctor before taking PIOZ MF 15MG TABLET.

Liver

Contraindicated

PIOZ MF 15MG TABLET is not recommended for use in patients with active liver disease. 

Allergy

Contraindicated

Do not take PIOZ MF 15MG TABLET if you are allergic to metformin or pioglitazone.

Lungs

Contraindicated

PIOZ MF 15MG TABLET is not recommended for use in patients with infections affecting the lungs or bronchial system. Consult your doctor before taking PIOZ MF 15MG TABLET.

Heart Disease

Contraindicated

PIOZ MF 15MG TABLET is not recommended for use in patients with severe heart disease (such as grade III-IV heart failure, recent myocardial infarction, edema, or circulatory failure). 

Use In Pediatrics

Contraindicated

PIOZ MF 15MG TABLET is not recommended for use in children and adolescents (aged under 18 years) due to a lack of safety data and an increased risk of serious side effects. Consult your child’s doctor for advice.

Use In Geriatrics

Use with Caution

PIOZ MF 15MG TABLET should be used with extreme caution in elderly patients (aged 65 years or older) due to the risk of bladder cancer, heart failure, and bone fracture. Proper dose adjustments and careful monitoring are required for such patients.

Other Warnings for PIOZ MF 15MG TABLET

Before taking PIOZ MF 15MG TABLET, inform your doctor if you:

• have or had a previous history of smoking
• had previous irradiation of the pelvic region
• are receiving chemotherapy or radiotherapy
• have macular oedema (swelling of the back of the eye with worsening of the vision)
• have polycystic ovary syndrome (the presence of cysts on your ovaries)
• are fasting or malnourished

Who should not take PIOZ MF 15MG TABLET

PIOZ MF 15MG TABLET is not recommended for use if you:

• have acute alcohol intoxication (abnormal behavior during or after alcohol consumption) or alcoholism
• have diabetic pre-coma
• have diabetic ketoacidosis (a diabetic complication causing nausea, vomiting, stomach pain, and rapid weight loss)
• have severe dehydration (either due to vomiting, diarrhea, or shock)
• have a severe infection
• are scheduled for an X-ray or scan using iodination contrast agents
• have an upcoming major surgery

Diet and Lifestyle Advice

Balanced Diet:

• Emphasize a healthy diet rich in vegetables, fruits, whole grains, and lean proteins.
• Limit intake of refined sugars, sugary drinks, and high-fat foods to support blood sugar control.
• Control portion sizes and maintain consistent meal timings to avoid blood sugar spikes.

Regular Physical Activity:

• Engage in at least 30 minutes of moderate exercise most days, such as brisk walking, cycling, or swimming.
• Exercise improves insulin sensitivity and helps maintain overall cardiovascular health.

Weight Management:

• Achieving and maintaining a healthy weight aids in better glucose regulation and reduces medication load.

Hydration & Avoidance of Alcohol:

• Drink plenty of water throughout the day.
• Avoid excessive alcohol consumption as it can impair blood sugar control and increase side effect risks.

Blood Sugar Monitoring:

• Regularly monitor your blood glucose levels as advised by your healthcare provider to track treatment effectiveness.

Stress Management:

• Practice relaxation techniques, such as yoga, meditation, or deep breathing exercises, as stress can affect glucose levels.

Avoid Smoking:

• Smoking cessation is recommended to reduce cardiovascular risks associated with diabetes.

Medication Adherence & Follow-Up:

• Take Pioz MF 15mg Tablet exactly as prescribed.
• Keep regular appointments with your healthcare provider for ongoing assessment and medication adjustment.

Drug - Drug interaction

Before taking PIOZ MF 15MG TABLET, inform your doctor if you are taking any of these medicines:

• Other Antidiabetic Drugs: Combining with insulin, sulfonylureas (e.g., glipizide, glyburide), or other diabetes medicines may increase the risk of low blood sugar (hypoglycemia).
• Immunosuppressants and Chemotherapy Drugs: Cyclophosphamide and corticosteroids (e.g., dexamethasone, prednisolone) may affect blood sugar control and interact with Pioz MF.
• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Drugs like ibuprofen, celecoxib, and etoricoxib can impact kidney function and alter the effectiveness or side effect profile of Pioz MF.
• Cholesterol-Lowering Agents: Gemfibrozil may interact with Pioz MF, requiring monitoring.
• Blood Pressure Medications: ACE inhibitors (captopril, perindopril), angiotensin II receptor blockers (losartan, azilsartan), diuretics (furosemide, hydrochlorothiazide), and beta-2 agonists (salbutamol, terbutaline) may influence blood sugar and potassium levels when combined.
• Thyroid Hormones and Antacids: Thyroxine and cimetidine may affect absorption/metabolism.
• Other Medicines: Rifampicin, dolutegravir, ranolazine, trimethoprim, isavuconazole, crizotinib, and olaparib have reported interactions that warrant medical supervision.
• Radiographic Contrast Agents: Iodinated contrast dyes used in certain X-ray procedures can increase risk of lactic acidosis; Pioz MF should be temporarily discontinued before such procedures.
• Alcohol: Excessive alcohol intake greatly increases the risk of lactic acidosis and hypoglycemia; it is strongly advised to avoid alcohol during treatment.

Synopsis

More Information

Did you know

• Did you know that controlling blood sugar with Pioz MF 15mg Tablet can help reduce the risk of serious complications of diabetes such as kidney damage, nerve problems, and vision loss?
• Did you know that consistent intake of this medication along with a balanced diet and regular exercise significantly enhances its effectiveness in maintaining healthy blood glucose levels?
• Did you know that Pioz MF 15mg Tablet supports better insulin utilization in muscles and fat tissues, helping to lower blood sugar without excessive insulin release?
• Did you know that taking Pioz MF at the same time every day with meals can reduce side effects like stomach upset and improve medication absorption?

FAQs About PIOZ MF 15MG TABLET

Q: What is Pioz MF 15mg Tablet used for?

A: Pioz MF 15mg Tablet is used to help manage blood sugar levels in adults with type 2 diabetes mellitus, especially when diet and exercise alone do not provide adequate control.

Q: How should I take Pioz MF 15mg Tablet?

A: Take the tablet exactly as prescribed by your doctor, usually with food to reduce stomach upset. Swallow the tablet whole with water, preferably at the same time every day.

Q: What should I do if I miss a dose?

A: Take the missed dose as soon as you remember unless it is nearly time for your next dose. Do not take a double dose to make up for the missed one.

Q: Are there any side effects?

A: Common side effects include nausea, diarrhea, stomach pain, headache, and swelling. If you experience severe or persistent side effects, contact your doctor promptly.

Q: Can I consume alcohol while taking Pioz MF?

A: It is advisable to avoid alcohol as it may increase the risk of side effects like lactic acidosis and negatively impact blood sugar control.

Q: Can pregnant or breastfeeding women take Pioz MF?

A: Consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

Q: Are there any precautions?

A: Inform your healthcare provider if you have kidney, liver, or heart problems. Regular medical checkups and blood tests are recommended to monitor your condition during treatment.

Q: How does Pioz MF 15mg Tablet work?

A: It combines pioglitazone, which improves insulin sensitivity, with metformin, which reduces glucose production and absorption, helping to lower blood sugar levels.

Q: Can Pioz MF 15mg Tablet be used in children?

A: This medication is generally not recommended for children and adolescents under 18 years due to lack of safety data.

References

1. KD. Tripathi. Insulin, Oral Hypoglycemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275-277.

2. Gerald G. Briggs and Roger K. Freeman. P and M. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 3514-3515 & 2451-2456.

3. Takeda. Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in July 2011] [Accessed on 23rd October 2025] 

4. Antonio Ceriello, Don Johns, Mario Widel, David J Eckland, Kathryn J Gilmore, Meng H Tan. Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2005. [Accessed on 23rd October 2025] 

5. Kohei Kaku. Efficacy and safety of therapy with metformin plus pioglitazone in the treatment of patients with type 2 diabetes: a double-blind, placebo-controlled, clinical trial. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. May 2009. [Accessed on 23rd October 2025] 

6. Torrent Pharmaceuticals Ltd. Piopod MF Pioglitazone and Metformin Hydrochloride (Extended Release) Tablets. [Revised in January 2016] [Accessed on 23rd October 2025] 

7. Gerard Laboratories. Electronic Medicines Compendium (EMC). [Revised in August 2016] [Accessed on 23rd October 2025] 

8. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 23rd October 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 24 Oct 2025 | 04:57 PM(IST)