PIMPLEX Gel 20gm
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Introduction About PIMPLEX GEL
PIMPLEX GEL is a combination of Clindamycin and Nicotinamide which belongs to a group of medicines called Lincomycin antibiotics and Vitamin B3 complex, respectively. PIMPLEX GEL is used to manage mild to moderate acne which is a skin condition that occurs when hair follicles become plugged with oil and dead skin cells which may occur due to variety of causes such as genetics, fluctuating hormone levels, stress, high humidity or using oily or greasy personal care products which may affect people of all ages.
It is characterized by symptoms such as open or closed plugged pores, small red & tender bumps, pimples, large, solid or painful lumps under the skin and painful & pus-filled lumps under the skin.
Before using PIMPLEX GEL inform your doctor if you have liver, kidney, lung or heart diseases. Avoid applying PIMPLEX GEL to a cut, scrapped, sunburnt or eczema affected skin.
PIMPLEX GEL should be used with caution in pregnant and in breastfeeding women. PIMPLEX GEL is not recommended for use in children and adolescents (below 12 years). Consult your doctor before applying.
The most common side effects of using PIMPLEX GEL are skin inflammation, contact dermatitis (red, itchy rash), inflammation of hair follicles, itchy skin, dry skin and peeling of skin. Consult your doctor if any of these symptoms worsen.
Uses Of PIMPLEX GEL
- Manage mild to moderate acne
How PIMPLEX GEL Works
PIMPLEX GEL helps to manage acne, where Clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes), a bacteria found in sebaceous glands and follicles and Nicotinamide exerts anti-inflammatory effect in acne and interrupts sebum production.
How to use PIMPLEX GEL
Apply PIMPLEX GEL as advised by your physician. It is for external use only. Before applying the medicine normally wash and dry the affected area and apply a thin layer of this medicine on the affected area. Managed areas on the face need not be covered with a plaster or bandage. Do not apply this medicine beyond the recommended duration. Avoid applying PIMPLEX GEL around your eyes, including eyelids. Rinse it off with water if you accidentally get it in these areas.
Side Effects Of PIMPLEX GEL
Common
- contact dermatitis (red, itchy rash)
- inflammation of hair follicles
- itchy skin
- dry skin
- peeling of skin
How To Manage Side Effects
Skin rash/Itchy skin:
Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin and apply calamine lotion as a coolant. Discuss with your doctor if the symptom worsens.
Warning & Precautions
Pregnancy
PIMPLEX GEL should be used with caution in pregnant women. Consult your doctor before applying.
Breastfeeding
PIMPLEX GEL should be used with caution in breastfeeding women. Consult your doctor before applying.
Allergy
PIMPLEX GEL is not recommended for use if you are allergic to Clindamycin, Nicotinamide or any other ingredients of this medicine.
Others
PIMPLEX GEL is not recommended for use if you have:
- eczema (skin inflammation)
- cut, scrapped, sunburnt skin
Use in Pediatrics:
PIMPLEX GEL is not recommended for use in children and adolescents (below 12 years). Consult your doctor before using it for your child.
Use in Geriatrics:
There is no information on the use of PIMPLEX GEL in elderly patients. Consult with your doctor before using.
Interactions
A. Drug - Drug interactions:
Before using PIMPLEX GEL, inform your doctor if you are taking any of the following medicines:
- acepromazine (used a sedative/tranquilizer)
- acetaminophen (used to manage pain and inflammation)
Overdosage:
If you or anyone else accidentally ingests or applies too much of PIMPLEX GEL, consult your doctor immediately or visit the nearby hospital.
Synopsis
| Drug | : | Clindamycin, Nicotinamide |
| Pharmacological Category | : | Lincomycin antibiotics, Vitamin B3 complex |
| Therapeutic Indication | : | Mild to moderate acne |
| Dosage Forms | : | Gel, Cream, Ointment |
More Information
- Keep PIMPLEX GEL out of reach of children
- Store PIMPLEX GEL at a temperature below 25°C
FAQs About PIMPLEX GEL
What special precautions should I follow while using PIMPLEX GEL?
Before using PIMPLEX GEL inform your doctor if you have liver, kidney, lung or heart diseases. Avoid applying PIMPLEX GEL to a cut, scrapped, sunburnt or eczema affected skin. This medicine is not for oral, ophthalmic or intravaginal use.
What is PIMPLEX GEL used for?
PIMPLEX GEL is indicated for the management of mild to moderate acne in patients above 12 years of age. Do not use it for any other condition other than that prescribed by your doctor.
How should I use PIMPLEX GEL?
Always apply PIMPLEX GEL, as directed by your physician. It is for external use only. On the affected area, apply a thin layer of this medicine. Managed areas on the face need not be covered with a plaster or bandage. Do not apply this medicine on your face beyond 5 days. Avoid applying PIMPLEX GEL around your eyes, including eyelids.
Is PIMPLEX GEL safe to use in pregnant and breastfeeding women?
PIMPLEX GEL should be used with caution during pregnancy, women planning for pregnancy and in breastfeeding women. Consult your doctor before applying.
Can PIMPLEX GEL cause skin irritation or itchy skin?
PIMPLEX GEL may cause skin irritation or itchy skin. Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin and apply calamine lotion as a coolant. Discuss with your doctor if the symptom worsens.
References
1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide & Other Antibacterial Antibiotics; Urinary Antiseptics and Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 756 & 914.
2. Pooja Bains, Manpreet Kaur, Jasleen Kaur, Saurabh Sharma. Nicotinamide: Mechanism of action and indications in dermatology. Indian Journal of Dermatology, Venereology and Leprology. 2018. [Accessed on 7th June 2022] https://ijdvl.com/nicotinamide-mechanism-of-action-and-indications-in-dermatology/
3. A R Shalita, J G Smith, L C Parish, M S Sofman, D K Chalker. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 1995. [Accessed on 7th June 2022] https://pubmed.ncbi.nlm.nih.gov/7657446/
4. Curatio. Clinmiskin Gel. [Accessed on 7th June 2022] https://curatiohealthcare.com/product/clinmiskin-gel/
5. Bionova. Clindis N Acne Gel (Clindamycin + Nicotinamide). [Accessed on 7th June 2022] https://www.bionova.co.in/clindis-anti-acne-gel.html
6. Leeford Healthcare. Clinsol Gel (Clindamycin + Nicotinamide). [Accessed on 7th June 2022] https://www.leeford.in/product/1164/clinsol-gel
7. Aliana Pharma. Clindasoft Gel (Clindamycin + Nicotinamide). [Accessed on 7th June 2022] https://alainapharma.com/Clindamycin%20and%20Nicotinamide%20Gel.html
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