INTRODUCTION

PERISET SYRUP contains Ondansetron which belongs to a group of medicines called Anti-emetics. PERISET SYRUP is used to prevent nausea and vomiting in children caused by cancer chemotherapy, radiation therapy, and surgery.

Before giving PERISET SYRUP, to your child, inform your doctor if your child have or had severe constipation, heart problems, liver, kidney problems, imbalance with the levels of salts in your blood, (potassium, sodium, and magnesium) or have been scheduled for any surgery. During the therapy, your doctor would regularly monitor your child’s health to avoid the risk of side effects.

Your doctor will prescribe the right dose and duration depends on the child’s age, body weight and health condition, so stick to the dose, time, and duration prescribed by the doctor.  Minor and temporary side effects may be experienced after the intake of this medicine. These includes headache, flushing and constipation.

Generally, these effects subside once the child’s body adapts to the medicine. However, in case of prolonged or bothersome events, consult your doctor immediately without any delay. Inform your doctor about your child’s complete medical history including any previous episodes of allergies.

USES OF PERISET SYRUP

• Used to prevent nausea and vomiting in children caused by cancer chemotherapy, radiation therapy and surgery

HOW PERISET SYRUP WORKS

PERISET SYRUP is a serotonin 5-HT3 receptor antagonist (specific chemical receptor), and it works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

DIRECTIONS FOR USE

Always give this PERISET SYRUP to your child as instructed by your doctor. Shake well before use. It is for pediatric use. Your doctor will prescribe the right dose depends on your child’s age body weight and disease condition.

SIDE EFFECTS OF PERISET SYRUP

HOW TO MANAGE SIDE EFFECTS

Headache:

Give plenty of water and apply a wet or cold cloth on child’s forehead. Apply pain balm to head to ease off the pain. If there is no improvement in the symptom, contact your doctor.

Constipation:

Give more fiber-rich foods like green leafy vegetables and fruits. Give lots of water. If there is no improvement in the symptom, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before using PERISET SYRUP, inform your doctor if your child is taking any of the following medicine:

• medicines used to treat fits/epilepsy (ex. phenytoin, carbamazepine)
• medicines used to treat lung infections (ex. rifampicin)
• tramadol (used to treat severe pain)
• medicines used to treat heart problems such as abnormal heart beats (anti-arrhythmic   ex. amiodarone)  
• cancer medicines (ex. doxorubicin, daunorubicin and monoclonal, trastuzumab) 
• medicines used to treat infections (erythromycin, ketoconazole)

Overdosage:

If your child accidentally takes too much of PERISET SYRUP, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach in children
• Store PERISET SYRUP at room temperature

FAQs ABOUT PERISET SYRUP

What PERISET SYRUP is used for?

PERISET SYRUP is generally given before any major surgery or before chemotherapy and radiotherapy sessions. In case your child is about to undergo any of the above procedures, the doctor may ask you to give PERISET SYRUP to your child to prevent vomiting post-procedure.

What if my child takes too much PERISET SYRUP?

PERISET SYRUP is unlikely to cause harm if you give an extra dose by mistake. However, you must still tell your child’s doctor immediately.

Can other medicines be given at the same time as PERISET SYRUP?

PERISET SYRUP may interact with other medicines or substances. Tell your doctor about any other medicines your child is taking before starting PERISET SYRUP. Also, check with your child’s doctor before giving any medicine to your child.

For how long should I give PERISET SYRUP?

Your doctor might advise you on how long your child should continue to take PERISET SYRUP. You will need to consult your doctor from time to time to review the child’s treatment and assess the symptoms.

What are the side effects are seen with PERISET SYRUP?

The most common side effects include PERISET SYRUP are headache, flushing (feeling of warmth), constipation. Consult your doctor if the above side effects persist for a long time.

REFERENCES

1. KD. Tripathi. Section 11, Gastrointestinal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 661.

2. Alexandria Griddine, Jeffery S. Bush. Ondansetron Book from Stat Pearls Publishing, Treasure Island (FL), 16 May 2018 PMID: 29763014. [Updated September 2021] [Accessed on 21st June 2022] https://europepmc.org/article/nbk/nbk499839

3. Apollo Pharma Ltd, Unit 1, Irwell Works, Lower Woodhill Road, Bury, BL8 1AA, UK, PL 14308/0015 [ revised in June 20] [Accessed on 21st June 20221] https://www.medicines.org.uk/emc/files/pil.6049.pdf

4. Leeford. [Accessed on 21st June 20221] https://www.leeford.in/product/145/vomishield-drops