Availability & Expiry
INTRODUCTION
PACIMOL PLUS TABLET is a combination of Nimesulide and Paracetamol which belongs to the group of medicines called Non-steroidal Anti-inflammatory drugs. PACIMOL PLUS TABLET is used to provide relief from inflammation and pain in conditions such as headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and/or painful menses in affected individuals.
PACIMOL PLUS TABLET is not recommended for use in patients allergic to nimesulide, paracetamol and/or other NSAIDS. It is also not recommended for use in patients with peptic ulcer, gastrointestinal bleeding, severe liver disease and/or severe kidney disease.
Before taking PACIMOL PLUS TABLET, inform your doctor if you are alcohol dependent and/or have other kidney problems and/or heart problems such as heart failure.
PACIMOL PLUS TABLET is not recommended for use during pregnancy and in breastfeeding women. It is also not recommended for use in children (aged below 12 years). PACIMOL PLUS TABLET should be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of PACIMOL PLUS TABLET are dizziness, excess sleepiness, stomach upset, nausea, abdominal discomfort, diarrhoea and/or peripheral oedema (swelling in legs/arms). Consult your doctor if any of the symptoms worsen.
USES OF PACIMOL PLUS TABLET
- Provides relief from inflammation and pain in conditions (such as headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and/or painful menses) in affected individuals.
HOW PACIMOL PLUS TABLET WORKS
PACIMOL PLUS TABLET provides relief from pain and inflammation, where nimesulide and paracetamol act by blocking the action of prostaglandin (chemical messengers responsible for pain and inflammation) resulting in reduced inflammation and providing relief from pain in affected individuals.
DIRECTIONS FOR USE
Take PACIMOL PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF PACIMOL PLUS TABLET
COMMON
- Dizziness, excess sleepiness
- Stomach upset, nausea, abdominal discomfort, diarrhoea
- Peripheral oedema (swelling in legs/arms)
- Signs of hypersensitivity reactions such as skin rash, red itchy welts, itching, shortness of breath
RARE
Stop taking PACIMOL PLUS TABLET and contact your doctor immediately if you experience any of the following side effects:
- Signs of severe allergic reactions such as skin rash, itching, swelling of the mouth/face and/or shortness of breath
- Skin rash/peeling, mouth ulcers
- Breathing problems, unexplained bruising/bleeding
- Signs of impaired liver function such as nausea, sudden weight loss, loss of appetite and yellowing of the eyes and skin
HOW TO MANAGE SIDE EFFECTS
Diarrhea:
Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Nausea/vomiting:
Try to take PACIMOL PLUS TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.
WARNING & PRECAUTIONS
PREGNANCY
PACIMOL PLUS TABLET is not recommended for use during pregnancy. Consult your doctor before taking PACIMOL PLUS TABLET.
BREASTFEEDING
PACIMOL PLUS TABLET is not recommended for use in breast feeding women. Consult your doctor before taking PACIMOL PLUS TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizzy, drowsy and/or sleepy after taking PACIMOL PLUS TABLET.
ALCOHOL
Avoid consumption of alcohol while taking PACIMOL PLUS TABLET because it might cause liver damage.
KIDNEY
PACIMOL PLUS TABLETis not recommended for use in patients with severe kidney disease and/or analgesic nephropathy. It should be used with caution in patients with other kidney problems. Consult your doctor before taking PACIMOL PLUS TABLET.
LIVER
PACIMOL PLUS TABLET is not recommended in patients with liver disease. Consult your doctor before taking PACIMOL PLUS TABLET.
ALLERGY
Do not take PACIMOL PLUS TABLET if you are allergic to Nimesulide, Paracetamol, other NSAIDS and/or other ingredients of this medicine.
HEART DISEASE
PACIMOL PLUS TABLET should be used with caution in patients with heart failure. Consult your doctor before taking PACIMOL PLUS TABLET.
OTHERS
PACIMOL PLUS TABLET is not recommended for use if you:
- Have peptic ulcer and/or gastrointestinal bleeding
Before taking PACIMOL PLUS TABLET, inform your doctor if you:
- Are alcohol dependent
Use in Paediatrics:
PACIMOL PLUS TABLET is not recommended for use in children (aged below 12 years). Consult your doctor before administering the medicine to the child.
Use in Geriatrics:
PACIMOL PLUS TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking PACIMOL PLUS TABLET.
INTERACTIONS
A. Drug - Drug interactions:
Before taking PACIMOL PLUS TABLET, inform your doctor if you are taking any of the following medicine:
- Anticoagulants (medicines used to prevent blood clotting) Ex. warfarin
- Cholestyramine (medicine used to lower high cholesterol levels)
- Metoclopramide, domperidone (medicines used to treat nausea and vomiting)
B. Drug - Food interaction:
Avoid consumption of foods containing caffeine and/or drinks such as tea, chocolate, coffee since it leads to excessive dizziness and sleepiness.
Overdosage:
If you or anyone else accidentally took more of PACIMOL PLUS TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Nimesulide, Paracetamol |
| Pharmacological Category | : | Non-steroidal Anti-inflammatory drugs |
| Therapeutic Indication | : | Osteoarthritic pain, Fever, Dismenorrhea |
| Dosage Forms | : | Tablet, Capsule, Suspension |
MORE INFORMATION
- Keep PACIMOL PLUS TABLET out of reach of children
- Store PACIMOL PLUS TABLET in a cool, dry place
FAQs ABOUT PACIMOL PLUS TABLET
What is PACIMOL PLUS TABLET used for?
PACIMOL PLUS TABLET is used to provide relief from inflammation and pain in conditions such as headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis and/or painful menses in affected individuals.
How PACIMOL PLUS TABLET works?
PACIMOL PLUS TABLET provides relief from pain and inflammation, where nimesulide and paracetamol act by blocking the action of prostaglandin (chemical messengers responsible for pain and inflammation) resulting in reduced inflammation and providing relief from pain in affected individuals.
What are the most common side effects of receiving PACIMOL PLUS TABLET?
The most common side effects of PACIMOL PLUS TABLET are dizziness, excess sleepiness, stomach upset, nausea, abdominal discomfort, diarrhoea and/or peripheral oedema (swelling in legs/arms). Consult your doctor if any of the symptoms worsen.
Can PACIMOL PLUS TABLET be used in pregnant and breast-feeding women?
No, PACIMOL PLUS TABLET is not recommended for use during pregnancy and in breast feeding since it may affect the foetus and nursing child. Consult your doctor before taking the medicine.
How PACIMOL PLUS TABLET is taken?
Take PACIMOL PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
REFERENCES
1. KD Tripathi. Nonsteroidal Antiinflammatory Drugs and Antipyretic analgesics. Essentials of Medical Pharmacology. Seventh Edition. 2013. Page – 203,206.
2. Cristina Monteiro, Beatriz Dias and Maria Vaz-Patto. Headache as an Adverse Reaction to the Use of Medication in the Elderly: A Pharmacovigilance Study. NIH National Library of Medicine. National centre of biotechnology. PMC PubMed Central. March 2021. [Accessed on 22nd June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7967518/
3. Crescent Pharma Limited. Electronic Medicines Compendium (EMC) [Revised in October 2021] [Accessed 22nd June 2022] https://www.medicines.org.uk/emc/files/pil.14044.pdf
4. Leeford Healthcare Limited. Nedolide-P. [Accessed on 22nd June 2022] https://www.leeford.in/product/1046/nedolide-p
5. Orlife Healthcare Pvt Ltd. Orflam-P. [Accessed on 22nd June 2022] https://www.orlifehealthcare.com/product/orflam-p/
6. P&B Pharmaceuticals Ltd. Algiril tablet. [Accessed on 22nd June 2022] http://www.pbpharma.co.in/algiril_tab.html
7. Pharmatech Healthcare. DIPLONIM-P Tab. [Accessed on 22nd June 2022] http://www.pharmatechworld.com/product_division.php?page=2&id=2
8. Medlock Healthcare NICLOC-P. [Accessed on 22nd June 2022] https://www.medlockhealthcare.in/product/nimesulide-100mg-paracetamol-325mg-
9. Nilrise Pharmaceuticals Pvt.Ltd. Zoynim-P Tablet. [Accessed on 22nd June 2022] https://www.nilrisepharma.com/product/zoynim-p-tablet
10. PCD Pharma Franchise Company. Apikos Pharma. ORNIMOL-N. [Accessed on 22nd June 2022] https://www.apikospharma.com/product/nimesulide-100-mg-paracetamol-325-mg/
USEFUL DIAGNOSTIC TESTS
- Erythrocyte sedimentation rate (ESR)
- C-reactive protein (CRP)
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