Ovunal HP 5000IU Injection 1'S

INTRODUCTION

OVUNAL HP 5000IU INJECTION contains Chorionic Gonadotropin which belongs to the group of medicines called Gonadotropins. It is used to treat hypogonadism (deficiency of sex hormones) in men. It also helps in the release of matured ovum (eggs) from the ovaries (ovulation) among infertile women after undergoing pretreatment with suitable hormonal medicines (such as menotropins or FSH).

It also helps in sustaining pregnancy during the early stages among women who experience habitual abortions. It can also be used in the treatment of prepubertal cryptorchidism (failure of testis to descend into the scrotum) caused due to hormone deficiency in young male children (aged between 4-9 years).

During treatment with OVUNAL HP 5000IU INJECTION, your doctor would monitor your health condition through several blood test and ultrasound to avoid the risk of side effects like fluid accumulation, abnormally enlarged ovarian follicles or multiple pregnancies (pregnant with more than one child), especially if you are undergoing assisted reproductive techniques.

Before receiving OVUNAL HP 5000IU INJECTION inform your doctor if you have any forms of cancer in the ovaries, uterus, breasts or prostate. You must also inform your doctor if you have any damage in the fallopian tubes, as treatment with OVUNAL HP 5000IU INJECTION may cause ectopic pregnancy (pregnancy outside of the womb) in such cases.

OVUNAL HP 5000IU INJECTION may cause false positive pregnant result in women who take pregnancy test using their blood or urine. This effect may last up to 10 days even after discontinuing treatment with OVUNAL HP 5000IU INJECTION.

OVUNAL HP 5000IU INJECTION may be used to sustain pregnancy during the initial stages (luteal phase). However, it should not be used on the later stages of pregnancy. Therefore, consult your doctor for advice. It is also not recommended for use in breastfeeding women.

The most common side effects of OVUNAL HP 5000IU INJECTION are reaching puberty at an early age, pain at the injection site, headache and irritability. Consult your doctor if they worsen.

USES OF OVUNAL HP 5000IU INJECTION

• Treats prepubertal cryptorchidism (failure of testis to descend into the scrotum due to sex hormone deficiency) in male children (aged between 4-9 years)
• Treats male hypogonadism (failure of testis to produce male sex hormones)
• Induces ovulation among infertile women
• Supports pregnancy among women who experience habitual abortions

HOW OVUNAL HP 5000IU INJECTION WORKS

OVUNAL HP 5000IU INJECTION is a gonadotrophic hormone which stimulates the production of sex hormones in both men and women. In men, it acts by stimulating the release of androgens which are responsible for the development of secondary sexual characteristics and for regulating the onset of puberty. It also helps to move down the testicles into the scrotum in children having undescended testis.

In women, it triggers the release of matured egg from the ovaries and helps to sustain pregnancy by supplementing enough female sex hormones (estrogen and progesterone) which are required for maintaining a successful conception.

DIRECTIONS FOR USE

OVUNAL HP 5000IU INJECTION will be given to you only by a doctor or a nurse into the muscle (intramuscularly) or under the skin (subcutaneously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.

SIDE EFFECTS OF OVUNAL HP 5000IU INJECTION

HOW TO MANAGE SIDE EFFECTS

Headache:  

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom worsens.

Pain at Injection site:

Apply an ice pack on the affected area. Do not move or shake the affected site frequently. Do not inject the medicine at the same site each time. Instead, alter the site. Consult your doctor if the symptom worsens.

WARNING & PRECAUTIONS

PREGNANCY

OVUNAL HP 5000IU INJECTION may be used to sustain pregnancy during the initial stages (luteal phase). However, it should not be used on the later stages of pregnancy. Therefore, consult your doctor for advice.

BREASTFEEDING

OVUNAL HP 5000IU INJECTION is not recommended for use in breastfeeding women. Therefore, consult your doctor before receiving it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if your ability is affected by OVUNAL HP 5000IU INJECTION.

ALCOHOL

Avoid consumption of alcohol while receiving OVUNAL HP 5000IU INJECTION.

KIDNEY

OVUNAL HP 5000IU INJECTION should be used with caution in patients having or ever had any kidney diseases. Therefore, consult your doctor before receiving it.

ALLERGY

Do not receive OVUNAL HP 5000IU INJECTION of you are allergic to Chorionic Gonadotropin.

LUNGS

OVUNAL HP 5000IU INJECTION should be used with caution in patients having or ever had asthma. Therefore, consult your doctor before receiving it.

HEART DISEASE

OVUNAL HP 5000IU INJECTION should be used with caution in patients having or ever had heart diseases (such as high blood pressure). Therefore, consult your doctor before receiving it.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving OVUNAL HP 5000IU INJECTION, inform your doctor if you are taking:

• other medicines used to treat stimulate ovulation (Ex. menotropin, clomiphene citrate)

Overdosage:

OVUNAL HP 5000IU INJECTION will be given to you only by a doctor or nurse, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms like lower stomach pain, swollen stomach, rapid weight gain, nausea, vomiting, breast pain, difficulty in breathing, fluid accumulation in the chest or difficulty in passing urine, consult your doctor immediately as it could be signs of ovarian hyperstimulation syndrome.

SYNOPSIS

MORE INFORMATION

• Keep OVUNAL HP 5000IU INJECTION out of reach of children
• Store OVUNAL HP 5000IU INJECTION in a refrigerator (at 2-8°C)

FAQs ABOUT OVUNAL HP 5000IU INJECTION

Can OVUNAL HP 5000IU INJECTION help me lose weight?

OVUNAL HP 5000IU INJECTION has no effect on fat metabolism, fat distribution or appetite. There is no substantial evidence to prove that OVUNAL HP 5000IU INJECTION can reduce body weight or has its effects on therapy of obesity. Consult your doctor before receiving OVUNAL HP 5000IU INJECTION if you are wishing to use it for losing weight.

Can OVUNAL HP 5000IU INJECTION be used in men?

Yes. OVUNAL HP 5000IU INJECTION can be used to treat hypogonadism and its related complications in men. It helps in the development of secondary sexual characteristics in males who experience delayed onset of puberty and moves down testis into the scrotum among patients having undescended testis. It can also be used in male children aged between 4-9 years. Your doctor will prescribe a suitable dose for you depending upon your condition.

Can OVUNAL HP 5000IU INJECTION help in getting pregnant?

Yes. OVUNAL HP 5000IU INJECTION stimulates the release of eggs from the ovaries among infertile women. It also helps to sustain pregnancy among women experiencing habitual abortions by supplementing enough female sex hormones (estrogen and progesterone) which are required for maintaining a successful conception. However, consult your doctor before receiving it.

Can OVUNAL HP 5000IU INJECTION cause children to puberty at the early age?

Yes. OVUNAL HP 5000IU INJECTION can cause prepubertal precocity (reaching puberty in early age) and sexual precocity (development of sexual characters) in very young children due to increased production of sex hormones. Proper dose adjustments and careful monitoring during treatment with OVUNAL HP 5000IU INJECTION can overcome this. However, if your child shows any such changes consult your doctor immediately. Your doctor might reduce the dose or suggest an alternative therapy.

Can pregnant women use OVUNAL HP 5000IU INJECTION?

Although, OVUNAL HP 5000IU INJECTION helps to sustain pregnancy at the early stages (preferably from luteal phase to first 2 months), it is not recommended for use during the later stages. However, consult your doctor for advice.

Can OVUNAL HP 5000IU INJECTION be used to improve sexual performance?

No. OVUNAL HP 5000IU INJECTION generally does not improve sexual performance. It only stimulates the release of sex hormones in men and women which ultimately resolves infertility issues and supports better health.

Can OVUNAL HP 5000IU INJECTION be self-administered?

No. OVUNAL HP 5000IU INJECTION is generally administered by a doctor or nurse into the muscle (intramuscularly) or under the skin (subcutaneously). Do not self-administer OVUNAL HP 5000IU INJECTION without consulting your doctor. In case of subcutaneous administration, your doctor may teach you how, when and where GBNKEYWORD] should be administered. Kindly follow the instructions advised by the doctor if requested for self-administration. Consult your doctor if you have any doubts regarding the administration of OVUNAL HP 5000IU INJECTION.

Can OVUNAL HP 5000IU INJECTION be used to treat PCOD?

Before receiving OVUNAL HP 5000IU INJECTION inform your doctor if you have polycystic ovarian disease (PCOD). Your doctor will decide whether you can use OVUNAL HP 5000IU INJECTION or not based on your disease condition.

Can treatment with OVUNAL HP 5000IU INJECTION cause twin pregnancy?

Yes. Usage of OVUNAL HP 5000IU INJECTION has a higher risk of being pregnant with more than one child at the same time (twin pregnancy or multiple pregnancy) than if conceived naturally. This risk further increases if treatment with OVUNAL HP 5000IU INJECTION is combined with assisted reproductive techniques. To avoid this, your doctor will carefully monitor you through several blood tests (for estradiol levels) and ultrasounds.

Will the use of OVUNAL HP 5000IU INJECTION cause breast pain or tenderness?

OVUNAL HP 5000IU INJECTION may cause breast pain or tenderness in some individuals. It is caused due to overstimulation of ovaries. If the symptom worsens, consult your doctor immediately.

Why I’m experiencing positive result in pregnancy kit after taking OVUNAL HP 5000IU INJECTION even though I’m not pregnant?

It is because, OVUNAL HP 5000IU INJECTION contains a medicine which is similar to the endogenous HCG secreted by placenta of pregnant women. Because pregnancy kits are designed in such a way to capture the levels of naturally produced HCG hormone from the urine of pregnant women, they tend to show a false positive result after receiving OVUNAL HP 5000IU INJECTION, even if you are not pregnant.

What precautions need to be followed while taking OVUNAL HP 5000IU INJECTION?

Before receiving OVUNAL HP 5000IU INJECTION inform your doctor if you have any other problems in reproductive organs like a tumor or cancers, unexplained vaginal bleeding, PCOD, or damage in fallopian tubes. Regularly monitor your health condition through blood tests and ultrasounds as instructed by your doctor. Regularly receive OVUNAL HP 5000IU INJECTION as instructed by your physician. If you become pregnant while undergoing treatment with OVUNAL HP 5000IU INJECTION inform your doctor immediately.

Can OVUNAL HP 5000IU INJECTION be used to induce periods?

OVUNAL HP 5000IU INJECTION is a hormone which is primarily used to improve the chances of getting pregnant in infertile women. Only failure in fertilization or over stimulation of ovaries during therapy can cause miscarriage or menstruation. OVUNAL HP 5000IU INJECTION is not a first line medicine to induce periods among patients who have amenorrhea (lack of periods). Consult your doctor for some alternative therapy.

REFERENCES

1. KD. Tripathi. Anterior Pituitary Hormones. Hormones and Related Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 241

2. Keith L. Parker and Bernard P. Schimmer. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1123-1124

3. Rina Balducci, V. Toscano, Daniela Casilli, Marella Maroder, F. Sciarra, B. Boscherini. Testicular Responsiveness Following Chronic Administration of hCG (1500 IU Every Six Days) in Untreated Hypogonadotropic Hypogonadism. Thieme. Hormone and Metabolic Research. 1987. [Accessed on 21st September 2022] https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-1011782

4. Swashti Agarwal, Doung D. Tu and Paul F. Austin. Testosterone versus hCG in Hypogonadotropic Hypogonadism – Comparing Clinical Effects and Evaluating Current Practice. Global Pediatric Health. SAGE journals. September 2020. [Accessed on 21st September 2022] https://journals.sagepub.com/doi/full/10.1177/2333794X20958980

5. Piotr Kucharski and Jerzy Niedzielski. Neoadjuvant human Chorionic Gonadotropin (hCG) therapy may improve the position of undescended testis: a preliminary report. NIH. National Library of Medicine, National Center for Biotechnology Information. PubMed Central. August 2013. [Accessed on 21st September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936151/

6. Ilkka Y Järvelä,1 Juha S Tapanainen, and Hannu Martikainen. Improved pregnancy rate with administration of hCG after intrauterine insemination: a pilot study. NIH. National Library of Medicine, National Center for Biotechnology Information. PubMed Central. February 2010. [Accessed on 21st September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838901/

7. Fresenius Kabi Canada Ltd. Chorionic Gonadotropin for Injection, USP. September 2016. [Accessed on 21st September 2022] https://www.ferring.ca/media/1020/hcg-pi-eng-v21c.pdf

8. Ferring Pharmaceuticals Inc. NOVAREL- gonadotrophin, chorionic. Dailymed. [Revised in May 2018]. [Accessed on 21st September 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ac6918ff-9dc3-40d9-8619-54b26e4bdfc8&type=display

9. Sanzyme Ltd. Pubergen. 2018. [Accessed on 21st September 2022]. https://www.sanzyme.com/therapy-presence/infertility-hormones/#human-chorionic-gonadotropin-hcg-

10. Bharat Serums and Vaccines Ltd. HUCOG. Highly Purified Chorionic Gonadotrophin Injection. [Accessed on 21st September 2022] https://www.bharatserums.com/assets/pdf/products/Hucog-HP.pdf

11. Cipla Ltd. IVF-C Injection (Human Chorionic Gonadotropin (hCG). Ciplamed.com. [Accessed on 21st September 2022] https://www.ciplamed.com/content/ivf-c-injection

12. Bharat Serums and Vaccines Ltd. Ovipure HP. Highly Purified Chorionic Gonadotrophin Injection. [Accessed on 21st September 2022] https://www.bharatserums.com/assets/pdf/products/Ovipure-HP.pdf

13. NV Organon. Health Products Regulatory Authority (HPRA). [Revised in April 2018] [Accessed on 21st September 2022] https://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA0964-005-002_13062018152057.pdf

USEFUL DIAGNOSTIC TESTS

• Anti-Mullerian Hormone
• Follicle Stimulating Hormone
• Glycosylated Hemoglobin
• Testosterone Free
• Testosterone Total
• Thyroid Stimulating Hormone

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 26 Sep 2022 | 05:32 PM(IST)