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INTRODUCTION
OLMAX H 40MG TABLET is a combination of Hydrochlorothiazide and Olmesartan which belongs to the group of medicines called Anti-hypertensives. It is indicated for the treatment of essential hypertension. Essential hypertension (also known as primary hypertension) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high and as a result it may lead to severe damage to the blood vessels of several organs, thus causing heart attack, heart or kidney failure, stroke or even blindness.
Along with the treatment, follow a low-sodium diet and drink plenty of fluids as advised by your physician. During the treatment, your doctor might regularly check your blood pressure, blood cholesterol levels, kidney function and electrolyte balance to avoid the risk of unwanted side effects.
Before taking OLMAX H 40MG TABLET, inform your doctor if you have any problems related to kidney, liver, lungs or heart. Treatment with OLMAX H 40MG TABLET particularly for a longer period can increase the risk of certain types of skin and lip cancer, and so protect your skin from sun exposure or UV rays while taking this medicine.
OLMAX H 40MG TABLET is strictly not recommended for use in patients with diabetes-related kidney disease and in pregnant or breast-feeding women. Consult your doctor for alternative therapy.
The most common side effects of taking OLMAX H 40MG TABLET are dizziness, headache, weakness, tiredness, nausea and vomiting. Consult your doctor if any of the side effects worsen.
USES OF OLMAX H 40MG TABLET
- To treat essential hypertension
HOW OLMAX H 40MG TABLET WORKS
OLMAX H 40MG TABLET effectively reduces elevated blood pressure, where Olmesartan acts by inhibiting the action of Angiotensin – II (a peptide hormone that causes narrowing of blood vessels and increase in blood pressure) by blocking the angiotensin-II receptors and hydrochlorothiazide acts by inhibiting the reabsorption of sodium, chloride and fluids from the kidneys, thus leading to a marked decrease in blood volume which in turn reduces blood pressure.
DIRECTIONS FOR USE
Take OLMAX H 40MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF OLMAX H 40MG TABLET
COMMON
- dizziness and headache
- weakness, tiredness
- chest pain
- swelling of hands, arms, ankles, feet or legs
- bronchitis (inflammation of the bronchus)
- cough, runny nose, sore throat or flu-like symptoms
- nausea, vomiting, diarrhea, stomach pain, indigestion, bloating, constipation
- back pain, joint pain or bone
- urinary tract infection or blood in urine
- confusion
UNCOMMON
- fluttering of the heartbeat
- rash, eczema
- vertigo
- muscle cramps and muscular pain
- erection difficulties in men
- feeling unwell, allergic skin rash
- itching, exanthema (skin eruption), skin lumps
- decreased or loss of appetite
- severe difficulty breathing
- worsening of pre-existing myopia
- erythema, skin reactions to light
- swelling of the face
- angina (chest pain)
- purplish spots or patches on the skin due to small haemorrhages (purpura)
RARE
- disturbances in consciousness
- acute kidney failure, impaired kidney function
- lack of energy
- swollen and sore salivary glands
- restlessness, feeling-un interested (apathy)
- blurred vision, dry eyes
- irregular heartbeat
- inflammation of the blood vessels
- blood clots (thrombosis or embolism)
- inflammation of the lung, fluid accumulation in the lungs
- inflammation of the pancreas
- jaundice (yellowing of the skin or white of the eyes)
- infection in the gall bladder
- symptoms of lupus erythematosus such as rash, joint pains and cold hands and fingers
- peeling and blistering of the skin
- non-infectious inflammation of the kidney (interstitial nephritis), fever, muscle weakness (sometimes causing impaired movement)
- feeling depressed
- tingling and numbness, fits
Stop taking OLMAX H 40MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, mouth and/or throat)
- hypotension (fainting or lightheadedness)
- yellowing of the whites of the eyes, dark urine and itching of the skin
- severe persistent diarrhea with a substantial weight loss
- painful eyes or decrease in vision
- signs of electrolyte depletion (nausea, vomiting, thirst, dry mouth, hypotension, feeling weak, tired, sluggish, sleepy, or restless, muscle pain, less need to pass urine or a rapid heart rate)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Try to take this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.
Diarrhea:
Drink lots of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Constipation:
Eat fiber rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.
WARNING & PRECAUTIONS
PREGNANCY
OLMAX H 40MG TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing baby. Consult your doctor before taking OLMAX H 40MG TABLET.
BREASTFEEDING
OLMAX H 40MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking OLMAX H 40MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any tools or machines if you feel dizzy or sleepy after taking this medicine.
ALCOHOL
Avoid consumption of alcohol while taking this medicine, as it may cause orthostatic hypotension (low blood pressure when standing up from sitting or lying position).
KIDNEY
OLMAX H 40MG TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with mild to moderate kidney problems or if you recently had a kidney transplant. Consult your doctor before taking OLMAX H 40MG TABLET.
LIVER
OLMAX H 40MG TABLET is not recommended for use in patients with severe liver disease such as jaundice (yellowing of skin and eyes with fever) or biliary obstruction (problems in drainage of bile from gallbladder), severely impaired liver function. It should be used with caution in patients with mild to moderate liver impairment. Consult your doctor before taking OLMAX H 40MG TABLET.
ALLERGY
Do not take OLMAX H 40MG TABLET if you are allergic to Hydrochlorothiazide, Olmesartan or substances similar to hydrochlorothiazide (Ex. sulfonamides).
LUNGS
OLMAX H 40MG TABLET should be used with caution in patients with bronchial asthma due to increased risk of hypersensitivity reactions.
HEART DISEASE
OLMAX H 40MG TABLET should be taken with caution in patients with heart diseases (such as heart failure or problems with your heart valves or heart muscles). Consult your doctor before taking OLMAX H 40MG TABLET.
OTHERS
OLMAX H 40MG TABLET is not recommended for use if you:
- have diabetes and treated with a blood pressure lowering medicine containing aliskiren
- have low levels of potassium or sodium in the blood
- have hypercalcemia (high calcium levels in blood) or high uric acid levels in the blood (with symptoms of gout or kidney stones)
Before taking OLMAX H 40MG TABLET, inform your doctor if you:
- have severe vomiting or diarrhea
- have problems in adrenal glands (Ex. primary aldosteronism)
- have lupus erythematosus (an autoimmune disease)
- other allergic disorders
- have had a skin cancer
- are due to have tests for parathyroid function
- are due to have anti-dope test (used in sports persons)
Use in pediatrics:
OLMAX H 40MG TABLET is not suitable for use in children and adolescents (aged less than 18 years). Consult your child’s doctor for advice.
Use in geriatrics:
OLMAX H 40MG TABLET should be taken with caution in elderly patients (aged 65 years or above). Proper dose adjustments and careful monitoring are required in such patients. Consult your doctor before taking OLMAX H 40MG TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking OLMAX H 40MG TABLET inform to your doctor, if you are taking any of these medicines:
- other medicines used to treat high blood pressure (Ex. aliskiren, methyldopa, captopril, enalapril, valsartan, propranolol, atenolol)
- other diuretics (used to increase urine output) Ex. chlorothiazide, furosemide
- medicines which can alter the levels of potassium in the blood (such as potassium supplements
- heparin (used to prevent or treat blood clots)
- adrenocorticotrophic hormone (used to stimulate the production of cortisol)
- carbenoxolone (used to treat mouth and stomach ulcers)
- laxatives (used to relieve constipation) Ex. liquid paraffin, ispaghula
- corticosteroids (used to treat pain or inflammation Ex. prednisolone, dexamethasone
- medicines used to induce sleep (Ex. phenobarbitone, pentobarbital, diazepam, lorazepam, clonazepam)
- medicines used to treat depression (Ex. fluoxetine, sertraline, imipramine, amitriptyline)
- medicines used to treat psychiatric disorders (Ex. chlorpromazine, trifluoperazine, levomepromazine, cyamemazine, sulpiride, amisulpride, pimozide, thioridazine, sultopride, tiapride, droperidol or haloperidol)
- medicines used to treat heart problems (Ex. digitalis, quinidine, hydroquinidine, disopyramide, amiodarone, dofetilide, ibutilide or sotalol)
- mizolastine, terfenadine (used to treat allergic reactions)
- pentamidine (used to treat pneumonia)
- medicines used to control blood sugar levels (Ex. metformin, insulin or diazoxide)
- medicines used to increase blood pressure and slow heart rate (Ex. noradrenaline)
- medicines used to treat gout (Ex. probenecid, sulfinpyrazone and allopurinol)
- skeletal muscle relaxants (used to treat muscle cramps) Ex. baclofen and tubocurarine
- medicines use to treat cancer (Ex. amifostine, methotrexate or cyclophosphamide)
- medicines used to control blood cholesterol levels (Ex. cholestyramine, colestipol, colesevelam)
- non-steroidal anti-inflammatory drugs (used to treat pain, swelling or inflammation) Ex. ibuprofen, diclofenac, aspirin
- anticholinergic agents (used to decrease muscle movements or secretions) such as atropine and biperiden
- lithium (used to treat mental illness)
- diphemanil (used to treat a slow heartbeat or reduce sweating)
- calcium supplements
- amantadine (used to treat viral infections)
- ciclosporin (used to prevent graft rejection)
- certain antibiotics (used to treat bacterial infections) such as tetracyclines, erythromycin injection, penicillin G or sparfloxacin
- amphotericin (a medicine used to treat fungal infections)
- antacids (used to neutralize stomach acid) such as aluminium hydroxide, magnesium hydroxide
- cisapride (used to increase gastrointestinal movements)
- halofantrine (a medicine used to treat malaria)
Overdosage:
If you or anyone else accidentally take too much of OLMAX H 40MG TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage might include low blood pressure, slow or fast heart rate, parasympathetic (vagal) stimulation, electrolyte depletion, dehydration and increased urination.
SYNOPSIS
| Drug | : | Hydrochlorothiazide, Olmesartan |
| Pharmacological Category | : | Thiazide diuretics, Angiotensin-II receptor blockers |
| Therapeutic Indication | : | Essential Hypertension |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep OLMAX H 40MG TABLET out of reach of children
- Store at room temperature
FAQs ABOUT OLMAX H 40MG TABLET
Can OLMAX H 40MG TABLET cause leg swelling?
Yes, OLMAX H 40MG TABLET may cause swelling of hands, arms, feet, ankles or legs in some individuals. Try to keep your legs elevated for some time. Follow a calorie-restricted diet as advised by your doctor. If the condition did not improve or become worse consult your doctor.
Can OLMAX H 40MG TABLET be taken during pregnancy?
No, OLMAX H 40MG TABLET is strictly not recommended for use during pregnancy since it may cause serious harm to the growing baby. Consult your doctor before taking this medicine. Women of childbearing potential should follow suitable contraceptive method to avoid pregnancy and should discontinue using OLMAX H 40MG TABLET if became pregnant as early as possible.
Can I take my diabetic medicines along with OLMAX H 40MG TABLET?
Avoid concomitant use of anti-diabetic medicines (such as metformin, insulin, diazoxide or others) with OLMAX H 40MG TABLET without consulting your doctor. Your doctor may adjust the dose or frequently monitor your blood sugar levels to safely use these medicines together.
Can OLMAX H 40MG TABLET cause dehydration?
Yes, OLMAX H 40MG TABLET may cause severe dehydration in some individuals. If you experience severe persistent diarrhea or vomiting, consult your doctor immediately to avoid the risk of electrolyte imbalance.
Can OLMAX H 40MG TABLET cause low sodium levels?
Yes, OLMAX H 40MG TABLET can cause hyponatremia (low sodium levels in blood) in some individuals. To avoid this, your doctor will regularly check electrolyte balance in your body and adjust your dose accordingly. However, if you experience any symptoms of hyponatremia such as fainting, dizziness, thirst, dry mouth, contact your doctor immediately.
What to do if I forget to take a dose of OLMAX H 40MG TABLET?
You should take OLMAX H 40MG TABLET immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
REFERENCES
1. KD. Tripathi. Diuretics and Drugs Affecting ReninAngiotensin System and Plasma Kinins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 582-586 & 505-508.
2. Randa Hilal-Dandan. Renin and angiotensin. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 738-739.
3. Thomas Michel and Brian B. Hoffman. Treatment of Myocardial ischemia and hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 769-770.
4. Gerald G. Briggs and Roger K. Freeman. H & O. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1869 & 2852-2853.
5. Luis M Ruilope. Clinical efficacy and safety of olmesartan/hydrochlorothiazide combination therapy in patients with essential hypertension. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2008. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663442/
6. Xiaoshen Zhang, Han Zhang, Yuxia Ma, Wenliang Che, and Michael R. Hamblin. Management of Hypertension Using Olmesartan Alone or in Combination. NCBI; PMC US National Library of Medicine, National Institute of Health. [Revised in June 2017]. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446820/
7. Mark Greathouse. Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2006. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994014/
8. Daiichi Sankyo Europe GmbH. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.8529.pdf
9. Mylan Pharmaceuticals, Inc. U.S. Food & Drug Administration. [Revised in May 2011] [Accessed on 21st October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/040735s004,040770s003lbl.pdf
10. Torrent Pharmaceuticals Ltd. Olsar – H. Torrentian.com. November 2017. [Accessed on 21st October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2979.pdf
11. Torrent Pharmaceuticals Ltd. Olmetor-H. Torrentian.com. [Revised in March 2019. [Accessed on 21st October 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1773.pdf
12. Cipla Ltd. Olmecip H Tablets (Olmesartan medoxomil + Hydrochlorothiazide). Ciplamed.com. [Revised in September 2015]. [Accessed on 21st October 2022] https://www.ciplamed.com/content/olmecip-h-tablets
USEFUL DIAGNOSTIC TESTS
- Kidney function test
VIDEOS
Hydrochlorothiazide+Olmesartan TABLET - Drug Information
Hydrochlorothiazide+Olmesartan TABLET : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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