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INTRODUCTION
OLET 1.25 TABLET contains Olanzapine which belongs to the group of medicines called Antipsychotics. It is used in the treatment of schizophrenia (hearing, seeing or sensing things which are not there, mistaken beliefs, unusual suspiciousness, may also feel depressed, anxious), moderate to severe manic episodes (symptoms of excitement or euphoria) and to prevent recurrence of these symptoms in patients with bipolar disorder. Bipolar disorder (also called manic depression) is a mental disorder characterized by alternative episodes of mania (sudden unusual and extreme sense of happiness) and depression.
Along with this treatment, your doctor might ask you to make certain lifestyle changes, such as eating a healthy diet, regular exercise and quitting alcohol. Prior to the treatment, your doctor may want you to take several blood tests to understand your existing condition. Avoid consumption of alcohol during treatment with OLET 1.25 TABLET as it can make you feel drowsy.
OLET 1.25 TABLET is not recommended for use in patients previously diagnosed with eye problems like glaucoma or dementia in the elderly. Before taking OLET 1.25 TABLET, inform your doctor if you have history of blood clotting, stroke, Parkinson’s disease, prostate, intestine, heart, liver or kidney disease, diabetes, and seizures.
OLET 1.25 TABLET should be used with caution among women who are pregnant. Consult your doctor before taking it. OLET 1.25 TABLET is not recommended for use in breastfeeding women and in children less than 18 years of age. OLET 1.25 TABLET should be used with caution in elderly patients with dementia as it can cause death. The most common side effects of taking OLET 1.25 TABLET are changes in the levels of some blood cells, weight gain, sleepiness and feeling dizzy.
USES OF OLET 1.25 TABLET
- Treats schizophrenia and manic episodes
HOW OLET 1.25 TABLET WORKS
OLET 1.25 TABLET exerts its action primarily on certain chemical messengers in the nervous system (dopamine and serotonin). It blocks the action of dopamine allowing for normal dopamine neurotransmission which leads to a decrease in positive symptoms in patients like hallucinations, delusions, and disorganized speech, thought, and behavior. It also blocks the action of serotonin, helping in the decrease of negative symptoms like poor speech, being unable to express emotions, low motivation, and poor attention.
DIRECTIONS FOR USE
For Tablet: Take OLET 1.25 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
For Orally disintegrating tablet: Place OLET 1.25 TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Continue to take OLET 1.25 TABLET for the stipulated duration prescribed by your doctor to achieve better results.
SIDE EFFECTS OF OLET 1.25 TABLET
COMMON
- weight gain
- sleepiness
- increases in levels of prolactin in the blood, changes in the levels of some blood cells, circulating fats and liver enzymes
- feel dizzy (with a slow heart rate), especially while getting up from a lying or sitting position
- increases in the level of sugars in the blood and urine and of uric acid and creatine phosphokinase in the blood
- restlessness, tremor, unusual movements (dyskinesias)
- constipation, dry mouth
- rashes
- loss of strength, extreme tiredness, feeling more hungry
- water retention leading to swelling of the hands, ankles, or feet
- fever, joint pain
- sexual dysfunctions (decreased libido in males and females or erectile dysfunction in males)
UNCOMMON
- hypersensitivity (swelling in the mouth and throat, itching, rash)
- worsening of diabetes, at times associated with ketoacidosis (ketones in the blood, urine) or coma
- seizures, muscle stiffness (even eye movements)
- syndrome of restless legs, problems with speech (stuttering)
- slow heart rate
- sensitivity to sunlight
- bleeding from the nose
- abdominal distension
- drooling
- memory loss or forgetfulness
- lack of ability to urinate
- hair loss
- absence or decrease in menstrual periods
- changes in breasts in males and females like an abnormal production of breast milk or abnormal growth
RARE
- lowering of normal body temperature
- abnormal rhythms of the heart
- sudden unexplained death
- inflammation of the pancreas with severe stomach pain and fever
- liver disease(jaundice)
- muscle disease presenting as aches and pains and painful erection
- elderly patients with dementia may suffer from stroke, pneumonia, urinary incontinence, tiredness, visual hallucinations, rise in body temperature, redness of the skin and trouble walking. Some fatal cases have been reported in elderly
Stop taking OLET 1.25 TABLET and contact your doctor immediately if you experience any of the following side effects:
- unusual movement of face or tongue
- blood clots in the veins especially in the legs (swelling, pain, and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing
- a combination of fever, faster breathing, sweating, muscle stiffness and drowsiness
HOW TO MANAGE SIDE EFFECTS
Dizziness:
Lie down until dizziness is resolved, then get up slowly. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if your symptom gets worse or persist.
Dry mouth:
Sip water regularly and other sugar free liquids. Do not use alcohol-containing mouthwashes because they can make your mouth dry, use the one that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if your symptom gets worse or persist.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. Consult your doctor if your symptom gets worse or persist.
Stomach pain:
Try to rest and relax. Try to have smaller and more frequent meals and have them slowly. Keep a heat pad on your stomach. Consult your doctor if your symptom gets worse or persist.
WARNING & PRECAUTIONS
PREGNANCY
OLET 1.25 TABLET should be used with caution in pregnant women. Consult your doctor before taking it.
BREASTFEEDING
OLET 1.25 TABLET is not recommended for use in breastfeeding women as it can pass through breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive and use machines while taking OLET 1.25 TABLET as it can make you feel drowsy.
ALCOHOL
Do not drink alcohol while taking OLET 1.25 TABLET as it can make you feel drowsy.
KIDNEY
OLET 1.25 TABLET should be used with caution in patients with kidney disease. Consult your doctor before taking OLET 1.25 TABLET.
LIVER
OLET 1.25 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking OLET 1.25 TABLET.
ALLERGY
Do not take OLET 1.25 TABLET if you are allergic to Olanzapine.
HEART DISEASE
OLET 1.25 TABLET should be used with caution in patients with heart disease. Consult your doctor before taking OLET 1.25 TABLET.
OTHERS
OLET 1.25 TABLET is not recommended for use if you:
- have been previously diagnosed with eye problems such as certain kinds of glaucoma (increased pressure in eye)
- have dementia (especially elderly patients)
Before taking OLET 1.25 TABLET, inform your doctor if you:
- you or your family has a history of blood clots or blood disorders
- stroke or mini stroke (temporary symptoms of stroke)
- Parkinson’s disease
- prostate problems, blocked intestine (paralytic ileus)
- diabetes
- seizures
- may have salt depletion because of prolonged severe diarrhea and vomiting
- intolerant to some sugars
- have phenylketonuria (increase phenylalanine in blood)
Use in pediatrics:
OLET 1.25 TABLETis not recommended for children under 18 years of age. Consult your doctor before taking OLET 1.25 TABLET.
Use in geriatrics:
OLET 1.25 TABLET should be used with caution in elderly patients. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Consult your doctor before taking OLET 1.25 TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking OLET 1.25 TABLET, inform your doctor if you are taking any of the following medicine:
- diuretics (water tablets)
- antidepressants or medicines for anxiety or to help you sleep (tranquillizers)
- medicines for Parkinson’s disease (Ex. carbamazepine, fluvoxamine, or ciprofloxacin)
Overdosage:
If you or anyone else accidentally take too much of OLET 1.25 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are rapid beating of the heart, agitation, problems with speech, unusual movements (especially of the face or tongue), reduced level of consciousness, acute confusion, seizures, and coma.
SYNOPSIS
| Drug | : | Olanzapine |
| Pharmacological Category | : | Antipsychotics |
| Therapeutic Indication | : | Schizophrenia, manic episodes, bipolar disorder |
| Dosage Forms | : | Orally disintegrating tablet |
MORE INFORMATION
- Keep OLET 1.25 TABLET out of reach from children
- Do not store above 30°C
FAQs ABOUT OLET 1.25 TABLET
Is it safe to drink alcohol while taking OLET 1.25 TABLET?
Yes, one should avoid alcohol while taking OLET 1.25 TABLET since it may cause more drowsiness.
Can I stop taking OLET 1.25 TABLET?
Do not stop taking OLET 1.25 TABLET just because you feel better. It is important that you carry on the treatment for as long as your doctor tells you. If you suddenly stop taking OLET 1.25 TABLET symptoms such as sweating, unable to sleep, tremor, anxiety or nausea and vomiting might occur.
Is OLET 1.25 TABLET a sleeping pill?
No, OLET 1.25 TABLET is an antipsychotic used to treat schizophrenia and bipolar disorder (manic depressive disorder). It causes episodes of depression, mania, and other abnormal moods.
Can OLET 1.25 TABLET be taken during pregnancy?
OLET 1.25 TABLET should be avoided during pregnancy and should only be given if benefits outweigh the risk. Using it in last 3 months of pregnancy may cause unwanted symptoms in the unborn baby like shaking, muscle stiffness and/or weakness, sleepiness, agitation, breathing problems, and difficulty in feeding.
REFERENCES
1. K D Tripathi. Drugs Used in Mental Illness: Antipsychotic and Antimanic Drugs. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –469.
2. Kristina Thomas; Abdolreza Saadabadi. Olanzapine. [Revised on May 2022] [Accessed on 19th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK532903/
3. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in March 2020] [Accessed on 19th May 2022] https://www.medicines.org.uk/emc/files/pil.3071.pdf
4. Sun Pharmaceutical Industries Europe. Electronic Medicines Compendium (EMC). [Revised in May 2020] [Accessed on 19th May 2022] https://www.medicines.org.uk/emc/files/pil.9717.pdf
5. Olanzapine. Mayoclinic. [Revised in January 2020] [Accessed on 19th May 2022] https://www.mayoclinic.org/diseases-conditions/schizophrenia/diagnosis-treatment/drc-20354449
USEFUL DIAGNOSTIC TESTS
- MRI & CT scan
- Blood tests
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 07 Oct 2022 | 12:41 PM(IST)
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