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Introduction About NVG TABLET
NVG TABLET is a combination of Doxylamine and Pyridoxine which belongs to the group of medicines called Anti-emetics and Vitamin B Complex respectively. It is used in pregnant women to manage nausea and vomiting (morning sickness) when changes in diet or other non-medical managements does not provide adequate response.
Doxylamine is an antihistamine. It blocks the actions of certain chemicals in the body that causes nausea and vomiting. Pyridoxine is a vitamin B supplement. It supplements our body with necessary vitamins that is required for proper foetal growth and development. Collectively, they both reduce nausea and vomiting during pregnancy while replacing the lost nutrients.
Take NVG TABLET as advised by your physician. NVG TABLET cannot manage vomiting caused due to pregnancy. It can only manage the symptoms for a short period. Therefore, continue to take NVG TABLET as advised by the physician to achieve better results. NVG TABLET can be used in all trimesters of pregnancy.
Before taking NVG TABLET inform your doctor if you have asthma or any stomach problems. You must also inform your doctor if you have any problems in your bladder. Consult your doctor before taking NVG TABLET if you are breastfeeding.
NVG TABLET may make you feel dizzy or drowsy and therefore be cautious while you drive or handle any heavy tools or machines. Other most common side effects of NVG TABLET are headache, stomach pain and trouble sleeping.
Uses Of NVG TABLET
- Manage morning sickness (nausea and vomiting) during pregnancy
How NVG TABLET Works
NVG TABLET manages nausea and vomiting in pregnant women where doxylamine acts by blocking the actions of a certain chemicals (histamine) in the body that causes nausea and vomiting and pyridoxine acts by replacing the lost nutrients in the body. Collectively they reduce morning sickness during pregnancy while replacing the lost nutrients.
How to use NVG TABLET
Take NVG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. NVG TABLET must be taken on an empty stomach. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking NVG TABLET unless your doctor tells you to stop, as it may make the nausea and vomiting to reoccur.
Side Effects Of NVG TABLET
Common
- feeling sleepy, dizzy or tired
- dryness of mouth
Stop taking NVG TABLET and contact your doctor immediately if you experience any of the following side effects such as:
- signs of allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, tongue, or throat causing difficulty in swallowing or breathing)
How To Manage Side Effects
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your condition did not improve.
Warning & Precautions
Pregnancy
SafeNVG TABLET is intended for use in pregnant women. However, consult your doctor before taking.
Breastfeeding
ContraindicatedNVG TABLET is not recommended for use in breast-feeding women as it may pass through breast milk. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or handle any heavy tools or machines if you experience dizziness, drowsiness, or blurred vision after taking NVG TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while undergoing management with NVG TABLET.
Allergy
ContraindicatedDo not take NVG TABLET if you are allergic to pyridoxine, doxylamine or to any other antihistamines (such as diphenhydramine).
Lungs
Use with CautionNVG TABLET should be used with caution in patients who have or ever had asthma. Therefore, consult your doctor before taking it.
Use In Pediatrics
ContraindicatedNVG TABLET is not intended for use in children and adolescents (below18 years). Therefore, consult your doctor before taking it.
Others
Before taking NVG TABLET, inform your doctor if you:
- have or every had glaucoma
- have or every had ulcers in the stomach
- have or every had blockage in the gut, between stomach and small intestine
- have or every had blockage in the urinary bladder
- have hyperemesis gravidarum (a condition which causes severe nausea and vomiting which is uncontrollable)
- are going to have a urine test
Interactions
A. Drug - Drug interactions:
Before taking NVG TABLET, inform your doctor if you are taking any of the following medicines such as:
- linezolid (an antibiotic medicine used to manage bacterial infections)
- medicines used to manage parkinson’s disease (Ex. levodopa)
- methylene blue (used to manage blood disorder)
- medicines used to manage conditions such as disorders in bowel, bladder or
respiratory systems (Ex. solifenacin, scopolamine, ipratropium) - medicines used to manage depression or other mental illness (Ex. sertraline, citalopram, escitalopram, selegiline, rasagiline)
- medicine used to reduce anxiety and to induce sleep (Ex. alprazolam, lorazepam, zolpidem, triazolam)
- medicines used to manage allergies (Ex. cetirizine, montelukast, fexofenadine)
- anaesthetics medicines used before surgeries for sedation (Ex. etomidate, sevoflurane, isoflurane)
- medicines used to relive severe pain (Ex. fentanyl, codeine, paracetamol, ibuprofen)
- cough medicine (Ex. dextromethorphan)
- vitamin B supplements
B. Drug-Food interactions
Avoid taking NVG TABLET with food as it may delay the absorption of NVG TABLET.
Overdosage:
If you or anyone else accidentally took more NVG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include restlessness,
dry mouth, dilated pupils (blurred vision), dizziness, sleepiness, vertigo (spinning sensation), confusion and increased heartbeat, seizures or severe muscle pain or weakness.
Synopsis
| Drug | : | Doxylamine, Pyridoxine |
| Pharmacological Category | : | Anti-emetics, Vitamin B Complex |
| Therapeutic Indication | : | Morning Sickness |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep NVG TABLET out of reach of children
- Store NVG TABLET at room temperature
FAQs About NVG TABLET
Q: Will the use of NVG TABLET affect the growth of foetus?
A: No. NVG TABLET is generally safe and well tolerated. It does not affect the growth of foetus. There is no evidence reported for foetal abnormalities in pregnant women taking NVG TABLET. However, consult your doctor before taking.
Q: Is NVG TABLET addictive?
A: No. NVG TABLET does not cause addiction. However, take NVG TABLET only as advised by your doctor. Continue to take NVG TABLET as instructed by your doctor as premature discontinuation may cause the symptoms to reoccur.
Q: How long will it take for NVG TABLET to stop vomiting?
A: NVG TABLET may reduce vomiting within 5-7 hours of administration. However, it may take around few weeks (2 weeks) for NVG TABLET show improvement in your overall health condition. Therefore, continue to take NVG TABLET regularly as instructed by the doctor. NVG TABLET cannot manage vomiting caused due to pregnancy. It can only manage the symptoms for a short period.
Q: Will taking a higher dose of NVG TABLET be more effective?
A: No. Do not take a high dose of NVG TABLET without consulting your doctor as it may lead to toxicity. If the prescribed dose, does not provide you with adequate results, consult your doctor for advice. Your doctor would evaluate your health condition and suggest a suitable dose for you.
Q: Can I take NVG TABLET to manage nausea without consulting doctor?
A: No. Do not take NVG TABLET to manage nausea without consulting a doctor. Although the use of NVG TABLET is safe, proper evaluation of pre-existing disease conditions such as presence of asthma, stomach problems or glaucoma should be considered prior to the use of NVG TABLET. Therefore, always consult your doctor before taking NVG TABLET.
Q: Can NVG TABLET be used in non-pregnant individuals?
A: NVG TABLET is intended for use only in pregnant women. There is no adequate information about use of NVG TABLET in non-pregnant individuals. If you are not pregnant and wish to stop nausea and vomiting, choose over the counter anti-emetics or consult your doctor for a suitable therapy.
Q: Can I increase the daily dose of NVG TABLET than recommended by the physician?
A: No. Take NVG TABLET only as directed by your physician. Do not increase the number of doses without consulting your doctor, as it may lead to toxicity.
Q: When and how should I take NVG TABLET?
A: Take NVG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. NVG TABLET should be taken on an empty stomach. NVG TABLET works faster when taken 4-6 hours before having food. Do not stop taking NVG TABLET unless your doctor tells you to stop, as it may make the symptoms to reappear.
Q: Can I give NVG TABLET to my child suffering from nausea and vomiting?
A: No. Do not give NVG TABLET to children, as there is no proper information regarding the use of NVG TABLET this medicine in children. Therefore, consult your doctor before taking it.
Q: Can I stop taking NVG TABLET once my symptom subsides?
A: No. Do not stop taking NVG TABLET without consulting your doctor. If you stop taking NVG TABLET suddenly your symptoms may reappear. If you any doubts regarding the use of NVG TABLET kindly consult your doctor immediately.
References
1. K.D. Tripathi, Antiemetic, Prokinetic and digestant drugs. Essentials of pharmacology. Seventh Edition. 2013. Page – 663.
2. Cada, D. J., Demaris, K., Levien, T. L., & Baker, D. E. Doxylamine succinate/pyridoxine hydrochloride. NCBI. PMC US National Library of Medicine, National Institute of Health. October 2013. [Accessed on 6th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857125/
3. Koren G, Clark S, Hankins GD, Caritis SN, Umans JG, Miodovnik M, Mattison DR, Matok I. Maternal safety of the delayed release doxylamine and pyridoxine combination for nausea and vomiting of pregnancy; a randomized placebo-controlled trial. BMC Pregnancy Childbirth. NCBI, PMC US National Library of Medicine, National Institute of Health. March 2015. [Accessed on 6th May 2022] https://pubmed.ncbi.nlm.nih.gov/25884778/
4. Duchesnay USA, Inc U.S. Food & Drug Administration [Revised in November 2016] [Accessed on 6th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/209661lbl.pdf
5. Elara Pharma services Europe Limited. Health Products Regulatory Authority. [Revised in January 2020] [Accessed on 6th May 2022] https://www.hpra.ie/img/uploaded/swedocuments/e1d5eb8d-a06b-4bc9-b0e1-e2f769bf7dd2.pdf
6. Svizera health care. Doxinate OD. Doxylamine/pyridoxine. 2020. [Accessed on 22nd June 2022] https://www.doxinate.com/doxinateod
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