Nextril 50mg Tablet 10'S

Anxiety Rx required

Best Price* ₹ 146.80 MRP ₹ 183.50
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Torrent Pharmaceuticals Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

NEXTRIL contains Tofisopam which belongs to the group of medicines called as Benzodiazepine derivatives. It is used in the treatment of anxiety and depression. Anxiety is an intense, excessive, persistent worry and fear about everyday situations which is characterized by symptoms such as fast heart rate, rapid breathing, sweating and tiredness. Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest that affects the way you feel, think, and behave which can lead to variety of emotional and physical problems such as back pain or headache.

Tofisopam works by increasing the action of a chemical messenger in the brain known as GABA (gamma-amino-butyric-acid), which suppresses the excessive and abnormal activity of nerve cells in the brain that results in reducing depression and anxiety.

NEXTRIL is not recommended for use in patients having decompensated respiratory insufficiency (shortness of breath and wheezing), history of coma and sleep apnoea, increased pressure in the eye, chronic psychosis, and obsessive-compulsive phobic disorders. Before taking NEXTRIL, inform your doctor if you have mental illness, personality disorders, atherosclerosis, epilepsy, liver, and kidney disease.

NEXTRIL is not recommended for use in first trimester during pregnancy and in breast-feeding women. It should be used with caution in children and adolescents (below 18 years). The most common side effects of taking NEXTRIL are loss of appetite, vomiting, nausea, constipation, flatulence, dry mouth, and rash. Consult your doctor if any of the symptoms worsen.

USES OF NEXTRIL

  • To treat anxiety and depression

HOW NEXTRIL WORKS

NEXTRIL works by increasing the action of a chemical messenger in the brain known as GABA (gamma-amino-butyric-acid), which suppresses the excessive and abnormal activity of nerve cells in the brain that results in reducing depression and anxiety.

DIRECTIONS FOR USE

Take NEXTRIL as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of NEXTRIL for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF NEXTRIL

COMMON

  • loss of appetite
  • respiratory depression
  • vomiting
  • nausea
  • constipation
  • flatulence
  • dry mouth
  • rash
  • scarlatiniform rash
  • itching
  • muscle tension
  • muscle aches

HOW TO MANAGE SIDE EFFECTS

Constipation:

Try to eat high-fiber foods such as vegetables, cereals, fresh fruits, and drink plenty of water. Involve in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor for receiving alternate treatments for constipation.

Nausea and vomiting:

Try to take NEXTRIL with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.

Flatulence:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If it does not improve, contact your doctor.

Loss of appetite:

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

NEXTRIL is not recommended for use in pregnant women in the first trimester. It should be used with caution after first three months of pregnancy only if it is clearly necessary. Consult your doctor before taking it.

BREASTFEEDING

NEXTRIL is not recommended for use in breastfeeding women as it passes through breast milk. Consult your doctor before taking it.

DRIVING AND USING MACHINES

NEXTRIL might cause hyperactivity and aggressiveness at high doses which might affect your ability to drive and using machines. Consult your doctor before taking NEXTRIL.

ALCOHOL

Avoid the use of alcohol with NEXTRIL as it may reduce therapeutic efficacy.

KIDNEY

[GBNKEYWORD should be used with caution in patients having kidney disease. Consult your doctor before taking NEXTRIL.

LIVER

NEXTRIL should be used with caution in patients having liver disease. Consult your doctor before taking NEXTRIL.

ALLERGY

Do not take NEXTRIL if you are allergic to Tofisopam.

LUNGS

NEXTRIL is not recommended for use in patients having lung diseases such as decompensated respiratory insufficiency (shortness of breath and wheezing). Consult your doctor before taking NEXTRIL.

OTHERS

NEXTRIL is not recommended for use if you:

  • have history of coma
  • have history of sleep apnoea (serious sleep disorder)
  • have increased pressure in the eye (narrow-angle glaucoma)
  • have chronic psychosis
  • have obsessive compulsive phobic disorders (excessive thoughts and repetitive behaviours)

Before taking NEXTRIL inform your doctor if you:

  • have mental illness
  • have organic disorders (mental disorder) of brain such as atherosclerosis (disorder of brain)
  • have seizures
  • have personality disorders such as antisocial personality disorder, dependent personality disorder

Use in Pediatrics:

NEXTRIL should be used with caution in children and adolescents (below 18 years). Consult child’s doctor for advice.

Use in Geriatrics:

NEXTRIL should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking [GBNKEYORD].

INTERACTIONS

A. Drug – Drug Interactions:

Before taking NEXTRIL inform your doctor if you are taking any of the following medicines:

  • medicines used to suppress graft rejection (Ex. tacrolimus, sirolimus, ciclosporin)
  • analgesics (medicines used to reduce fever and relive pain) Ex. paracetamol
  • total anaesthetics (medicines used to prevent pain during surgery and other procedures) Ex. propofol
  • antidepressants (medicines used to help relieve symptoms of depression) Ex. citalopram
  • sedative and hypnotics (medicines used to induce sleep and or maintain sleep) Ex. zolpidem
  • neuroleptics (medicines used to treat psychosis) Ex. haloperidol
  • H1-antihistaminics (medicine used to treat allergic rhinitis) Ex. levocetirizine
  • antifungals (medicines used to treat fungal infections) Ex. ketoconazole, itraconazole
  • antihypertensives (medicines used to treat high blood pressure) Ex. clonidine, verapamil
  • medicines used to treat heart problems (Ex. digoxin)
  • anticoagulants (medicines used to prevent blood clot) (Ex. warfarin)
  • medicines used to treat chronic alcoholism (Ex. disulfiram)
  • antacids (medicines used to relieve indigestion and heartburn) (Ex. calcium carbonate)
  • oral contraceptives (medicines used to prevent pregnancy) (Ex. estradiol)

Overdosage:

If you or anyone else accidentally take too much of NEXTRIL, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of NEXTRIL include vomiting, confusion, coma, respiratory depression, and seizures.

SYNOPSIS

Drug :  

Tofisopam

Pharmacological Category :  

Benzodiazepine derivative

Therapeutic Indication :  

Anxiety, Depression

Dosage Forms :   Tablet

MORE INFORMATION

  • Keep NEXTRIL out of reach of children
  • Store below 30°C

FAQs ABOUT NEXTRIL

What is NEXTRIL and why is it prescribed?

NEXTRIL contains Tofisopam which belongs to the group of medicines called as Benzodiazepine derivatives which is used in the treatment of anxiety and depression. Consult your doctor for advice before taking NEXTRIL.

Is NEXTRIL safe in pregnant and breast-feeding women?

NEXTRIL is not recommended for use in pregnant women in the first trimester. It should be used with caution after first three months of pregnancy. NEXTRIL is not recommended for use in breastfeeding women as it is passed in the breast milk. Consult your doctor before taking NEXTRIL.

Can NEXTRIL affect the ability to drive?

NEXTRIL might cause hyperactivity and aggressiveness at high doses which might affect your ability to drive and using machines. Consult your doctor before taking NEXTRIL.

What if someone takes more NEXTRIL than recommended dose?

If you or anyone else accidentally take too much of NEXTRIL, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are vomiting, confusion, coma, respiratory depression, and seizures.

Can NEXTRIL be given to children?

 NEXTRIL should be used with caution in children and adolescents (below 18 years of age) since safety and efficacy not established. Consult child’s doctor for advice before giving NEXTRIL to your children.

REFERENCES

1. Ashton Acton. Therapies and Treatments. Nephropathy: New Insights for the Healthcare Professional. Edition 2013. Page – 111-114.

2. Tofisopam. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 13th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Tofisopam

3. Mai Yamamoto, Ken Inada, Minori Enomoto, Mitsunari Habukawa, Takahisa Hirose, Yuichi Inoue, Jun Ishigooka, Yuichi Kamei, Tsuyoshi Kitajima, Masayuki Miyamoto, Hideto Shinno, Katsuji Nishimura, Motohiro Ozone, Masahiro Takeshima, Mayumi Suzuki, Hidehisa Yamashita, and Kazuo Mishima. Current state of hypnotic use disorders: Results of a survey using the Japanese version of Benzodiazepine Dependence Self-Report Questionnaire. NIH National Library of Medicine, National Center for Biotechnology Information. PMC PubMed Central. March 2021 [Accessed on 13th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182966/

4. Torrent Pharmaceuticals. Nextril 50 (Tofisopam Tablets 50mg). [Revised in June 2015] [Accessed on 13th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2735.pdf

5. Torrent Pharmaceuticals. Nextril 100. (Tofisopam Tablets 100mg). [Revised in June 2015] [Accessed on 13th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2736.pdf

USEFUL DIAGNOSTIC TESTS

  • Dexamethasone suppression test (DST)

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    17.5 g
    Ingredient
    Tofisopam 50 mg
    Hsn Code
    30049089
ALTERNATE BRANDS
Toficalm 50mg Tablet 10'S
Prescription Anxiety Rx required
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Nextril 50mg Tablet 10'S

Nextril 50mg Tablet 10'S Mkt: Torrent Pharmaceuticals Ltd

M.R.P.: Rs.183.50
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