NEPTAZ 100 Tablet 14's

Heart Failure Rx required

Best Price* ₹ 944.80 MRP ₹ 1,181.00
(Inclusive of all taxes) *14 Tablet(s) in a Strip * Mkt: Mankind Pharma Pvt Ltd * Country of Origin: Italy * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

NEPTAZ 100 is a combination of Sacubitril and Valsartan which belongs to a group of medicines called Angiotensin receptor neprilysin inhibitors. NEPTAZ 100 is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction. Heart failure occurs when the heart is weak and cannot pump enough blood to the lungs and to the rest of the body and it is characterized by symptoms such as breathlessness, fatigue, tiredness, and ankle swelling.

Sacubitril is a neprilysin inhibitors which works by relaxing and widening the blood vessels and makes it easier for the heart to pump blood throughout the body. Valsartan is an angiotensin-II receptor blocker works by relaxing the blood vessels by blocking a substance called angiotensin-II (causing blood vessels to tighten) which is produced in the body and thus lowers the blood pressure.

Before taking NEPTAZ 100 inform your doctor if you have liver, kidney, or heart problems. NEPTAZ 100 is not recommended for use in pregnant and breast-feeding women. It is not suitable for use in children and adolescents under 18 years of age and it should be used with caution in elderly patients (65 years of age and above). Before taking NEPTAZ 100 inform your doctor about previous allergy and medication history to prevent serious effect. The most common side effects of taking NEPTAZ 100 are dizziness, cough headache, tiredness, nausea, and weakness. Contact your doctor if any of the symptoms worsen.

USES OF NEPTAZ 100

  • Treats long-term heart failure in adults

HOW NEPTAZ 100 WORKS

NEPTAZ 100 helps to treat long-term heart failure, where sacubitril works by relaxing and widening the blood vessels and makes it easier for the heart to pump blood throughout the body and valsartan works by relaxing the blood vessels by blocking a substance called angiotensin-II (causing blood vessels to tighten) which is produced in the body and thus lowers the blood pressure.

DIRECTIONS FOR USE

Take NEPTAZ 100 as advised by your physician. Swallow NEPTAZ 100 with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF NEPTAZ 100

COMMON

  • dizziness, light-headedness (low blood pressure)
  • signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness)
  • decrease in renal function
  • cough
  • diarrhoea
  • signs of low red blood cells (anemia)
  • tiredness
  • headache
  • fainting or spinning sensation
  • weakness
  • nausea
  • inflammation of lining of the stomach (stomach pain, nausea)
  • signs of low sugar levels in the blood (fast heartbeat, sweating, nervousness, or anxiety)

UNCOMMON

  • allergic reaction with rash and itching
  • dizziness when switching from sitting to standing position

RARE

  • hallucinations
  • changes in sleeping pattern

Stop taking NEPTAZ 100 and contact your doctor immediately if you experience any of the following side effects:

  • severe allergic reactions (swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing (angioedema))

HOW TO MANAGE SIDE EFFECTS

Tiredness:

Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if your symptom did not improve.

Nausea:

Stick to simple meals. Avoid eating oily, fried, and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Headache:

Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

PREGNANCY

NEPTAZ 100 is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking NEPTAZ 100 if you think you may be pregnant.

BREASTFEEDING

NEPTAZ 100 is not recommended for use in breastfeeding women. Consult your doctor before taking NEPTAZ 100 if you are breast-feeding or about to start breast-feeding.

DRIVING AND USING MACHINES

Avoid driving or handle any machines while taking NEPTAZ 100 because it may cause dizziness or tiredness.

KIDNEY

NEPTAZ 100 should be used with caution in patients with severe kidney disease and with narrowed kidney artery. Consult your doctor before taking NEPTAZ 100.

LIVER

NEPTAZ 100 is not recommended in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking NEPTAZ 100.

ALLERGY

Do not take NEPTAZ 100 if you are allergic (hypersensitive) to Sacubitril and Valsartan.

OTHERS

NEPTAZ 100 is not recommended for use, if you have:

  • diabetes or impaired kidney function (and being treated with aliskiren (blood pressure lowering medicine))
  • personal or family history of angioedema (when taking angiotensin receptor blockers (ARB) such as valsartan, telmisartan)

Before taking NEPTAZ 100 inform your doctor if you have:

  • history of angioedema
  • low blood pressure
  • vomiting or diarrhea
  • dehydration
  • hallucinations, paranoia, or changes in sleeping pattern

Use in pediatrics:

NEPTAZ 100 is generally not recommended for use in children and adolescents (under 18 years of age). Consult child’s doctor for advice.

Use in geriatrics:

NEPTAZ 100 should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking NEPTAZ 100.

INTERACTIONS

A. Drug-Drug interactions:

Before taking NEPTAZ 100 inform to your doctor, if you are taking any of these medicines: 

  • enalapril, lisinopril or ramipril (treats high blood pressure)
  • aliskiren and angiotensin receptor blockers such as telmisartan, losartan (treats heart failure)
  • atorvastatin (lowers high cholesterol levels)
  • sildenafil (treats erectile dysfunction or lung hypertension)
  • potassium supplements, salt substitutes containing potassium, potassium-sparing medicines such as spironolactone (used to increase potassium levels in blood)
  • heparin, warfarin (treats blood clot)
  • non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen, indomethacin, or selective cyclooxygenase-2 (Cox-2) inhibitors such as celecoxib (treats pain and inflammation)
  • lithium (used to treat psychiatric illness)
  • furosemide (used to increase the amount of urine)
  • nitroglycerine (treats angina pectoris)
  • rifamycin (treats infections)
  • ciclosporin (used to prevent rejection of transplanted organs)
  • ritonavir (used to treat HIV/AIDS)
  • metformin (treats diabetes)

Overdosage:

If you or anyone else take too much of NEPTAZ 100, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of NEPTAZ 100 includes severe dizziness and fainting.

SYNOPSIS

Drug :   Sacubitril and Valsartan
Pharmacological Category :   Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Indication :   Heart failure
Dosage Forms :   Tablet

MORE INFORMATION

  • Keep out of reach of children
  • Do not store above 30°C

FAQs ABOUT NEPTAZ 100

What is NEPTAZ 100 used for?

NEPTAZ 100 is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction.

What are the common side effects of taking NEPTAZ 100?

The most common side effects of taking NEPTAZ 100 are dizziness, light-headedness (low blood pressure), signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness), decrease in renal function, cough, diarrhea, signs of low red blood cells (anemia), tiredness, headache, fainting or spinning sensation. Consult your doctor immediately if any of the symptoms worsen.

Can NEPTAZ 100 be used in pregnant women?

No, NEPTAZ 100 is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking NEPTAZ 100 if you think you may be pregnant.

Is NEPTAZ 100 safe to use in liver disease patients?

NEPTAZ 100 is not recommended in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking NEPTAZ 100.

What to do If I forget to take NEPTAZ 100?

You should take NEPTAZ 100 immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.

REFERENCES

1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page – 508.

2. Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. NCBI; PMC. Pubmed Central. National Library of Medicine, National Institute of Health. September 2018. [Accessed on 1st July 2021] ncbi.nlm.nih.gov/pmc/articles/PMC4636283/

3.  Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 1st July 2021] https://pubmed.ncbi.nlm.nih.gov/29532764/

4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2021] [Accessed on 1st July 2021] https://www.medicines.org.uk/emc/files/pil.7751.pdf

5. Cipla Ltd. Azmarda Tablets (Sacubitril/Valsartan). Ciplamed. [Revised in March 2017] [Accessed on 1st July 2021] https://www.ciplamed.com/content/azmarda-tablets

USEFUL DIAGNOSTIC TESTS

  • Electrolyte panel

PRODUCT DETAILS

    Country Of Origin
    Italy
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

NEPTAZ 100 Tablet 14's

NEPTAZ 100 Tablet 14's Mkt: Mankind Pharma Pvt Ltd

M.R.P.: Rs.1,181.00
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