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INTRODUCTION

NADOXIN PLUS CREAM is a combination of Mometasone, Nadifloxacin and Terbinafine, which belong to a group of medicines known as Corticosteroids, Fluoroquinolone antibiotics and Antifungal agents. It is used to treat mixed bacterial and fungal infections of the skin. NADOXIN PLUS CREAM is also used to treat redness, itching and rash formation in the affected area. It also aids in treating the pus-containing eruptions that occur as a result of inflammation.

Along with the treatment, your doctor may ask you to practise good hand and self-hygiene practices to lessen the chances of re-infection. NADOXIN PLUS CREAM is not recommended for use in patients who are diagnosed or suspected with rosacea, characterised by reddening and flushing of the face along with visibility of underlying blood vessels, have redness and an itchy rash around the mouth (perioral dermatitis) or anus and genital region or have bacterial, viral or parasitic infections like tuberculosis, syphilis, impetigo or chicken pox.

NADOXIN PLUS CREAM is not recommended for use in children under the age of 14, pregnant or planning to become pregnant women or nursing mothers. The common side effects of using NADOXIN PLUS CREAM are damage and loss of the uppermost layer of the skin (skin peeling) and itching.

USES OF NADOXIN PLUS CREAM

  • Treats mixed bacterial and fungal infections of the skin
  • Treats itching and redness sensation of the skin in conditions like eczema and psoriasis
  • Relieves inflammation of the skin conditions

HOW NADOXIN PLUS CREAM WORKS

NADOXIN PLUS CREAM contains Mometasone, Nadifloxacin and Terbinafine. Mometasone works by preventing the release of mediators that causes swelling, redness, itching sensation etc. of the skin. Nadifloxacin works by preventing the multiplication of bacteria by blocking the production of bacterial enzymes. Terbinafine works by blocking the production of sterol components in the fungi, which helps to build its cell wall.

DIRECTIONS FOR USE

Always apply NADOXIN PLUS CREAM as directed by your physician. It is meant only for external use. Apply a thin layer of NADOXIN PLUS CREAM on the affected area and ensure not to cover the area with a plaster or bandage. Avoid applying NADOXIN PLUS CREAM near your breast, around your eyes and on your eyelids. Wash your hands thoroughly after using NADOXIN PLUS CREAM. The doctor will determine the amount and frequency of application based on your age, body weight and disease condition. 

SIDE EFFECTS OF NADOXIN PLUS CREAM

COMMON

  • damage and loss of the uppermost layer of the skin (skin peeling)
  • itch (pruritis)

UNCOMMON

  • lesions on the skin
  • scab formation
  • alteration in skin color
  • redness of skin (erythema)
  • burning sensation in the skin
  • pain associated with skin
  • irritation on the skin at the site of application

RARE

  • irritation of/near the eyes
  • worsening of the existing symptoms
  • rash or allergy associated with touching/ coming in contact with any substance (contact dermatitis)
  • rash or allergy of the skin characterized by redness, extreme itching and swelling usually occurring in the skin folds (eczema)
  • puffy face
  • feeling of weakness and tiredness
  • feeling dizzy while standing up or sitting down

Stop taking NADOXIN PLUS CREAM and consult your doctor immediately if you experience any of the following:

  • swollen lips, tongue and face
  • swelling in the throat causing difficulty in swallowing
  • skin reactions like hives along with difficulty and trouble breathing
  • dry, irritated and itchy skin
  • formation of pustules and blisters
  • burning sensation on the skin
  • decolorized skin
  • disturbances in vision such as blurred vision

HOW TO MANAGE SIDE EFFECTS

Skin Peeling:

Wash the skin’s peeling surface using a cleanser to avoid dirt and bacterial build-up. Do not rub the area with a cloth. Let the area dry and apply moisturizer. You may also use an air humidifier to prevent dryness of the skin. Drink a sufficient amount of water to stay hydrated. Consult your doctor if your symptoms get worse or persist.

Itching:

Avoid scratching the itchy area, as it may lead to further damage. Use a gentle cleanser to wash the skin to avoid dirt and bacterial build-up. Consult your doctor if your symptoms get worse or persist.

Burning sensation of skin:

Applying ice packs may provide relief from the burning sensation of the skin. Attempt to keep your body. Do not sweat a lot, as it may further irritate the skin. Use a gentle cleanser to wash the skin to avoid dirt and bacterial build-up. Do not rub the area roughly with a harsh cloth, as it may cause more damage. Instead, let the area air-dry. Cover with a generous layer of moisturizer. Also, stay hydrated. Consult your doctor if your symptoms get worse or persist.

WARNING & PRECAUTIONS

PREGNANCY

NADOXIN PLUS CREAM is generally not recommended for use in pregnant women unless considered necessary. Consult your doctor before using it.

BREASTFEEDING

NADOXIN PLUS CREAM is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before using it.

DRIVING AND USING MACHINES

NADOXIN PLUS CREAM does not affect your ability to drive or use machinery.

ALLERGY

Do not take NADOXIN PLUS CREAM if you are allergic to Mometasone and/or Nadifloxacin and/or Terbinafine and/or any other constituent of NADOXIN PLUS CREAM.

LUNGS

NADOXIN PLUS CREAM is not recommended in patients having bacterial infections of the lungs like Tuberculosis. Consult your doctor before using it.

OTHERS

NADOXIN PLUS CREAM is not recommended for use if you:

  • are diagnosed or suspected of having rosacea, characterized by reddening and flushing of the face along with visibility of underlying blood vessels
  • have acne
  • have thinning of the skin (skin atrophy)
  • have redness and itchy rash around the mouth (perioral dermatitis)
  • itching of the area around the anus and genital region
  • have bacterial infections like tuberculosis, syphilis and impetigo
  • have viral infections like shingles, chickenpox
  • recently had/ are reacting to vaccination
  • had a non-healing, wet wound (ulcerated wound)
  • have cold sores
  • have infections caused by parasites 
  • rash occurring in babies due to constant use of diapers 

Use in Pediatrics:

NADOXIN PLUS CREAM is not recommended for children below the age of 14. It should be used with caution in children above 14 years of age. Consult your doctor before applying NADOXIN PLUS CREAM.

Use in Geriatrics:

NADOXIN PLUS CREAM should be used with caution by the elderly. Consult your doctor before using NADOXIN PLUS CREAM.

INTERACTIONS

A. Drug-Drug Interactions:

Before using NADOXIN PLUS CREAM, inform your doctor if you are taking any of the following medicine:

  • medicines used to treat acne by peeling the skin (Ex. aromatic agents, alcohol)

Overdosage:

If you or anyone else accidentally applied or consumed too much of NADOXIN PLUS CREAM, consult your doctor immediately or visit the nearby hospital if the symptoms get worse or persist.

SYNOPSIS

Drug :   Mometasone, Nadifloxacin, Terbinafine
Pharmacological Category :   Topical corticosteroid, Antibiotic, Anti-fungal
Therapeutic Indication :   Treats mixed bacterial and fungal infection of the skin, treats itching and redness sensation of the skin and reduces skin inflammation
Dosage Forms :   Cream

MORE INFORMATION

  • Keep NADOXIN PLUS CREAM out of reach from children
  • Keep NADOXIN PLUS CREAM away from light and humidity
  • Store NADOXIN PLUS CREAM at room temperature

FAQs ABOUT NADOXIN PLUS CREAM

What is NADOXIN PLUS CREAM used for? 

NADOXIN PLUS CREAM is used to treat various infections caused by bacteria and fungi, which lead to redness, itching and rash formation in the area. In a few cases, swelling and fluid discharge may also occur. NADOXIN PLUS CREAM is used to treat bacterial and fungal infections of the skin and genital area. It is also used to treat inflammatory acne. However, consult your doctor before using it.

What happens if I suddenly stop taking NADOXIN PLUS CREAM?

NADOXIN PLUS CREAM should not be stopped suddenly, as it may result in redness and a stinging and burning sensation. It should always be brought to the attention of the doctor if you want to stop using it, so that he may gradually taper off the dosage and frequency of NADOXIN PLUS CREAM to avoid unwanted effects.

Can NADOXIN PLUS CREAM be applied by kids? 

NADOXIN PLUS CREAM should not be used by children under the age of 14. However, for children of age 14 or above, NADOXIN PLUS CREAM can be applied only after a doctor’s recommendation. The amount and frequency of application should strictly be according to the doctor’s advice. Excessive application of NADOXIN PLUS CREAM can lead to hormonal imbalance and may affect their growth and development.

Can NADOXIN PLUS CREAM be applied by elderly people?

Yes, NADOXIN PLUS CREAM can be applied to the elderly, but only if recommended by the doctor. Always make sure to consult the doctor before using NADOXIN PLUS CREAM.

Is it safe to apply NADOXIN PLUS CREAM during pregnancy? 

No, NADOXIN PLUS CREAM is generally not recommended to be used during pregnancy. However, if you get pregnant during the treatment, make sure to inform the doctor. Always make sure to consult the doctor before using NADOXIN PLUS CREAM.

How can I store NADOXIN PLUS CREAM?

NADOXIN PLUS CREAM should be stored at room temperature. It should not be kept in the freezer. Also, care must be taken to keep it safe and away from children.

Can I use NADOXIN PLUS CREAM if I have viral infections?

No, NADOXIN PLUS CREAM is strictly contraindicated for various viral infections like shingles and chickenpox. Also, if you were or are suffering from any bacterial disease like tuberculosis, syphilis, impetigo or an infection from parasites, NADOXIN PLUS CREAM is not recommended and relevant medical history must be brought to the attention of a doctor.

Can I drive after applying NADOXIN PLUS CREAM? 

NADOXIN PLUS CREAM does not affect your ability to drive or use machinery. You can drive after applying NADOXIN PLUS CREAM. No instance of dizziness has yet been reported after the application of medicine.

REFERENCES

1. KD. Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of Medical Pharmacology. 7th edition Page- 886.

2. KD. Tripathi. Antifungal Drugs. Essentials of Medical Pharmacology. 7th edition Page- 787.

3. Karadkhele, A., Puppalwar, G., Pandya, M.R. and Jain, R., 2020. Knowledge, awareness, approach and management of vulvovaginal infections with topical combination preparations: A cross-sectional, questionnaire-based gynaecologists survey. Indian Journal of Obstetrics and Gynecology Research [Revised on 15th June 2020] [Accessed on 26th July 2022] https://www.semanticscholar.org/paper/Knowledge%2C-awareness%2C-approach-and-management-of-A-Karadkhele-Puppalwar/2b694ac79aa8492b5f419dcd7791fdf7ee571763?p2df

4. Gerard Laboratories Electronic Medicines Compendium (EMC). [Revised in April 2019] [Accessed on 26th July 2022] https://www.medicines.org.uk/emc/files/pil.12831.pdf

5. Glenmark Pharmaceuticals. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 26th July 2022]  https://www.medicines.org.uk/emc/files/pil.9994.pdf

6. Cipla Med Nadifloxacin 1%. [Revised in August 2015] [Accessed on 26th July 2022] https://www.ciplamed.com/content/nadibact-creamgel

7. SP Schering Corporation. U.S. Food & Drug Administration. [Revised in July 2002] [Accessed on 26th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/19625s12s13lbl.pdf

8. Tiofarma B.V. [Revised in August 2021] [Accessed on 26th July 2022] https://www.medicines.org.uk/emc/files/pil.5042.pdf

9. Berko Ilaç ve Kimya Sanayi A.S. [ Revised on 4th January 2016] [Accessed on 26th July 2022] http://berkoilac.com.tr/wp-content/uploads/2018/08/aknefloks-cream-PIL-revH.pdf

USEFUL DIAGNOSTIC TESTS

  • ACTH stimulation test
  • A.M. plasma cortisol test
  • Urinary-free cortisol test

PRODUCT DETAILS

    Net Qty
    1 N
    Ingredient
    MOMETASONE 0.1 %+NADIFLOXACIN 1 %+TERBINAFINE 1 %
    Hsn Code
    30049087
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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