NACFIL TABLET 10'S


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Drug Information

What is Acetylcysteine used for?

Acetylcysteine is also known as N-acetylcysteine (NAC) or N-acetyl-L-cysteine.

  • Acetylcysteine oral tablets, capsules and respiratory powder for inhalation are used
  • to treat chest infections like bronchitis, pneumonia, cystic fibrosis;
  • in anti-aging treatment;
  • to treat kidney failure (which occurs due to certain dyes used in X-ray procedure).
  • Intravenous Acetylcysteine (injectable) is used to treat
  • symptoms of chest pain (angina);
  • an overdose of Paracetamol.

Acetylcysteine may also be prescribed for other conditions as determined by your doctor.

How does Acetylcysteine work?

  • Acetylcysteine is derived from N-acetyl cysteine, which is formed from the amino acid L-cysteine.
  • Acetylcysteine thins and clears the mucus from the airways in respiratory diseases.
  • Acetylcysteine helps in the formation of glutathione, a powerful antioxidant normally found in the liver, and enhances non-toxic metabolism of Acetaminophen. This protects the liver cells from NAPQI (N-acetyl-p-benzoquinone imine) toxicity, which can lead to acute liver failure.

How to take Acetylcysteine?

  • The dosage of oral tablets, capsules, inhalation powder and intravenous form of Acetylcysteine depends on the age, weight and medical condition of an individual. Take Acetylcysteine as prescribed by your doctor.
  • If you miss a dose of Acetylcysteine formulation, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.
  • On oral administration:
  • Acetylcysteine inhalation solution must be prepared from the powder and inhaled directly from the nebulizer or with a face mask, mouth piece, tent, or intermittent positive pressure breathing (IPPB) machine.
  • Do not discontinue the medication without consulting a doctor.
  • On intravenous Acetylcysteine (injectable) administration:
  • Do not administer yourself. Please take the help of a medical professional.

What should you do when you have taken an overdose of Acetylcysteine?

If you have taken an overdose of Acetylcysteine, please contact your doctor immediately.

Symptoms of overdose may include the following:

  • Running nose
  • Mouth sores
  • Flushing
  • Hypotension
  • Airway obstruction
  • Nausea & vomiting
  • Diarrhoea

What are the drugs that interact with Acetylcysteine?

Drugs that interact with Acetylcysteine:

  • Alprazolam
  • Aspirin
  • Ascorbic acid
  • Bifidobacterium infantis/lactobacillus acidophilus (Probiotic)
  • Budesonide/Formoterol
  • Cetirizine
  • Cholecalciferol
  • Cyanocobalamin
  • Duloxetine
  • Esomeprazole
  • Fish Oil
  • Ginkgo biloba
  • Levocarnitine
  • Montelukast
  • Pyridoxine
  • Tiotropium
  • Ubiquinone

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Acetylcysteine?

Most common side effects of Acetylcysteine are:

  • Diarrhoea, nausea, vomiting, abdominal pain
  • Heartburn, gas
  • Change in taste
  • Skin rash

Please contact your physician immediately if you have

  • On oral administration
  • severe chest pain, tightness and breathing difficulty;
  • severe abdominal pain, black colour stool, coffee ground colour vomit;
  • On intravenous administration:
  • hepatic encephalopathy (occurrence of confusion, altered level of consciousness, and coma due to liver failure); 
  • anaphylactoid hypersensitivity reactions (angioedema, bronchospasm, respiratory distress, tachycardia and hypotension).

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Acetylcysteine?

Seek doctor’s advice before taking any other drug or herbal products while on Acetylcysteine.

You are advised not to take Acetylcysteine if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Acetylcysteine?

Tell your doctor if

  • you are allergic to Acetylcysteine.
  • you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • you have any history of asthma, stomach or intestinal ulcers.
  • you are allergic to food, dyes, and preservatives.
  • you have rare hereditary problems of fructose intolerance.
  • you are sensitive to Carbocysteine, Erdosteine or Mecysteine.
  • you have a genetic condition called phenylketonuria where your body is unable to break down a substance called phenylalanine.
  • you are planning a surgery or any procedure.
  • you are pregnant or trying to conceive or are breastfeeding.

Frequently asked questions about Acetylcysteine

  1. How should Acetylcysteine be stored?
  2. Acetylcysteine must be stored in original package to protect from moisture.

    Acetylcysteine must not be exposed to light and moisture as it becomes less active. Acetylcysteine must be kept out of children’s reach.

  3. Should I follow any special dietary instructions while taking Acetylcysteine?
  4. No, you can have your normal diet unless advised by your doctor.

  5. What are the other formulations of Acetylcysteine available?
  6. Acetylcysteine comes in oral tablets, capsules, inhalation solution, injectable and eye drops formulations.

  7. Can I drive while taking Acetylcysteine?
  8. Acetylcysteine does not affect the driving ability. However, if you are feeling dizzy, it is better to avoid driving.

  9. Can I drink alcohol with Acetylcysteine?
  10. No interference has been found with alcohol while taking Acetylcysteine. However, it is advisable not to consume alcohol while taking Acetylcysteine.

Disclaimer:

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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