INTRODUCTION

MYOSPAZ TABLET is a combination of Chlorzoxazone and Paracetamol which belongs to the group of medicines called Muscle relaxants and Analgesics respectively. It is used to treat muscular pains and spasms. It can also be used to provide relief from joint pain (Ex. osteoarthritis, rheumatoid arthritis), back pain (Ex. ankylosing spondylitis) and neck pain.

Take MYOSPAZ TABLET preferably with meals to avoid gut irritation. Avoid consumption of alcohol as it could aggravate the risk of stomach problems. Do not take MYOSPAZ TABLET if you have any ulcers, bleeding or perforations in the gut.

Before taking MYOSPAZ TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have asthma, alcoholism, any eating disorder or any disease that causes loss of skeletal muscles and fats (such as cachexia) as a precaution.

Consult your doctor before taking MYOSPAZ TABLET if you are pregnant or breastfeeding. The common side effects of taking MYOSPAZ TABLET are stomach upset and orangish urine. Consult your doctor if any of these side effect worsens.

USES OF MYOSPAZ TABLET

It is used to treat:

• Muscle pain and spasms
• Joint pain, back pain, neck pain

HOW MYOSPAZ TABLET WORKS

MYOSPAZ TABLET contains two medicines namely Chlorzoxazone and paracetamol. Chlorzoxazone is a muscle relaxant. It acts by increasing the effects of certain chemical messengers (such as GABA) in the brain and in spinal cord that induces muscle relaxation. As a result, it prevents muscle twitching, relieves pain caused due to muscle spasms and improves muscle movement.

Paracetamol is a pain-relieving agent. It provides pain relief by blocking the release of certain chemicals (such as prostaglandins) in the body that causes pain, inflammation and swelling. Collectively, these action helps in reducing muscle spasms, joint pain and inflammation.

DIRECTIONS FOR USE

Take MYOSPAZ TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It is preferably taken with meals to avoid gastric irritation.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF MYOSPAZ TABLET

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if your skin rash worsens.

WARNING & PRECAUTIONS

PREGNANCY

MYOSPAZ TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

BREASTFEEDING

MYOSPAZ TABLET should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness or vision problems after taking MYOSPAZ TABLET.

ALCOHOL

Avoid consumption of alcohol while taking MYOSPAZ TABLET as it may increase the risk of side effects.

KIDNEY

MYOSPAZ TABLET is not recommended for use in patients with moderate to severe kidney diseases. It should be used with caution in patients with mild kidney problems. Therefore, consult your doctor before taking it.

LIVER

MYOSPAZ TABLET is not recommended in patients with severe liver problems (such as liver failure). It should be used with caution in patients with mild liver problems. Therefore, consult your doctor before taking it.

ALLERGY

Do not take MYOSPAZ TABLET if you are allergic to Chlorzoxazone or Paracetamol.

LUNGS

MYOSPAZ TABLET is not recommended for use in patients who previous experienced asthma attack or breathing difficulties after taking any pain-relieving medicine.

INTERACTIONS

A. Drug-Drug Interactions:

Before taking MYOSPAZ TABLET, inform your doctor if you are taking any of the following medicines such as:

• medicines used to stop blood clotting (Ex. warfarin, heparin, clopidogrel)
• cholestyramine (a medicine used to control blood cholesterol levels)
• medicines used to treat nausea and vomiting (Ex. domperidone, metoclopramide)
• medicines that can induce sleep (Ex. alprazolam, midazolam, clonazepam, nitrazepam)
• rifampicin, isoniazid (medicines used to treat tuberculosis)
• disulfiram (a medicine used to quit alcoholism)
• medicines used to treat epilepsy (such as carbamazepine, phenobarbitone, phenytoin)
• primidone (a medicine used to treat mental illnesses)
• St. John's Wort (an herbal medicine used to treat depression)

Overdosage:

If you or anyone else accidentally took more MYOSPAZ TABLET, visit the nearby hospital or consult your doctor immediately. Symptoms of overdosage might include paleness, nausea, vomiting, loss of appetite, stomach pain, liver damage, low blood sugar levels, edema, bloody urine, loss of protein in urine, dizziness, drowsiness, headache and tiredness.

SYNOPSIS

MORE INFORMATION

• Keep MYOSPAZ TABLET out of reach of children
• Store MYOSPAZ TABLET below 25°C

FAQs ABOUT MYOSPAZ TABLET

What is the use of MYOSPAZ TABLET?

MYOSPAZ TABLET is used to treat muscular pains and spasms. It can also be used to provide relief from joint pain (Ex. osteoarthritis, rheumatoid arthritis), back pain (Ex. ankylosing spondylitis) and neck pain.

How MYOSPAZ TABLET works?

MYOSPAZ TABLET works by reducing pain and inflammation in the muscles and bones. It increases the effects of certain chemical messengers (such as GABA) in the brain and in spinal cord that induces muscle relaxation and blocks the release of certain chemicals (such as prostaglandins) in the body that causes pain, inflammation and swelling. Collectively, these action helps in reducing muscle spasms, joint pain and inflammation.

How to take MYOSPAZ TABLET?

Take MYOSPAZ TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not chew or crush the medicine. It is preferably taken with meals to avoid gastric irritation.

What is the best time to take MYOSPAZ TABLET?

MYOSPAZ TABLET can be taken at any time of the day. However, your doctor will decide the best time to take MYOSPAZ TABLET.

Can I stop taking MYOSPAZ TABLET once I started feeling better?

No. Do not stop taking MYOSPAZ TABLET without consulting your doctor as it may make your symptoms re-appear once again. If you feel better during the midway of therapy, consult your doctor for advice.

Can I take MYOSPAZ TABLET daily?

Take MYOSPAZ TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take MYOSPAZ TABLET every day or not.

Will taking a higher dose of MYOSPAZ TABLET be more effective?

No. Taking a higher dose of MYOSPAZ TABLET will not be effective rather it would be making you drowsier. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.

What to do if I forgot to take a dose of MYOSPAZ TABLET?

If you forgot to take a dose of MYOSPAZ TABLET, take it as soon as you remember. However, if it is time for the next dose of MYOSPAZ TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of MYOSPAZ TABLET to compensate the missed ones. Consult your doctor for advice.

What are the side effects of MYOSPAZ TABLET?

The common side effects of taking MYOSPAZ TABLET are stomach upset and orangish urine. Consult your doctor if any of these side effect worsens.

Can I consume alcohol while taking MYOSPAZ TABLET?

Avoid consumption of alcohol while taking MYOSPAZ TABLET as it might make you feel dizzier and drowsier.

Can MYOSPAZ TABLET be taken during pregnancy?

MYOSPAZ TABLET should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.

Can the use of MYOSPAZ TABLET affect the liver?

Yes. MYOSPAZ TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is not recommended for use in patients with liver failure. It should be used with caution in patients with other mild liver problems. Consult your doctor before taking it.

REFERENCES

1. KD. Tripathi. Nonsteroidal Anti-Inflammatory Drugs and Antipyretic-Analgesics. Skeletal Muscle Relaxants. Seventh edition. Page – 206 & 357.

2. Himanshu D. Patel, R. B. Uppin, A. Ramakrishnam Naidu, Y. Ratnakar Rao, Suhas Khandarkar, and Amit Garg. Efficacy and Safety of Combination of NSAIDs and Muscle Relaxants in the Management of Acute Low Back Pain. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. January 2019. [Accessed on 24th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513919/

3. GlaxoSmithKline. PARACETAMOL/CHLORZOXAZONE. [Accessed on 24th December 2022] https://gskpro.com/content/dam/global/hcpportal/en_TZ/PI/MYOLGIN-NCDS-v-03.pdf

4. Solubiomix, LLC. Chlorzoxazone 250 mg. Dailymed.com. [Revised in October 2022]. [Accessed on 24th December 2022] https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=c3d40a90-6df8-4b44-bc61-d7655c52bacb&type=pdf

5. Reliable 1 Laboratories LLC. Acetaminophen 325mg – Acetaminophen tablet. Dailymed.com. [Revised in October 2021]. [Accessed on 24th December 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=25626b46-78f8-7226-e054-00144ff8d46c

6. Accord. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 24th November 2022] https://www.medicines.org.uk/emc/files/pil.5916.pdf

AUTHOR DETAILS

Written By Srilekha. R, B.Pharm
Last updated on 24 Dec 2022 | 04:44 PM(IST)