INTRODUCTION

MYOMIX TABLET contains a combination of Metformin and Myo Inositol, which belong to groups of medicines called antidiabetic agents and nutritional supplements, respectively. It is used in the treatment of polycystic ovarian syndrome (PCOS) in women. Polycystic ovarian syndrome is a hormonal disorder among women of reproductive age that causes the ovaries to enlarge, which prevents the release of eggs at regular intervals. The symptoms may include menstrual irregularity, excess hair growth, acne, weight gain etc.

While taking MYOMIX TABLET, your doctor will monitor your blood sugar level and kidney functions at regular intervals. During the course of treatment with MYOMIX TABLET, your doctor may advise regular monitoring of blood sugar levels and kidney function. Before taking MYOMIX TABLET, inform your doctor if you have liver, kidney, lung or heart problems or should undergo any surgery. Do not consume alcohol while taking MYOMIX TABLET as it can worsen the side effects.

Inform your doctor if you are pregnant or breastfeeding before taking this medicine. MYOMIX TABLET is not recommended for use by children. The most common side effects of taking MYOMIX TABLET are nausea, changes in taste, diarrhoea, dizziness, stomach pain and loss of appetite.

USES OF MYOMIX TABLET

• Treats polycystic ovarian syndrome (PCOS) in women

HOW MYOMIX TABLET WORKS

MYOMIX TABLET is a drug that combines metformin and myo-inositol. Metformin enhances the body's sensitivity to insulin by decreasing the level of circulating insulin and producing a positive effect on the accumulated adipose (fat) tissue. Myo-inositol works by reducing insulin resistance and regulating hormonal imbalances. These types of actions aid in the control of polycystic ovarian syndrome symptoms and the regulation of the menstrual cycle.

DIRECTIONS FOR USE

Take MYOMIX TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.

SIDE EFFECTS OF MYOMIX TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea :

Stick to simple meals. Avoid eating oily or spicy foods. If your symptoms do not improve, consult your doctor.

Diarrhea:

Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Consult your doctor if your symptoms don’t improve.

Stomach pain:

Try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.

Loss of appetite:

Eat when you are hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your symptoms do not improve, see your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking MYOMIX TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used to treat high blood pressure (Ex. propranolol, metoprolol)
• Medicines used in depression treatment (Ex. fluoxetine, amitriptyline)
• cholesterol-lowering agents (Ex. cholestyramine)
• fluorouracil (used in cancer treatment)
• sulfasalazine (used to treat stomach or duodenum ulcers)
• medicines used to relieve pain and inflammation (Ex. ibuprofen, celecoxib)
• medicine used to treat heart conditions (Ex. digoxin, digitalis)
• medicines used to provide relief from inflammation (Ex. prednisone, hydrocortisone)

Overdosage:

If you or anyone else accidentally take too much of MYOMIX TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are lactic acidosis (vomiting, stomachache, muscle cramps, tiredness, difficulty breathing, reduced body temperature and heartbeat) as this condition may lead to coma.

SYNOPSIS

MORE INFORMATION

• Keep MYOMIX TABLET out of reach from children
• Store below 25°C

FAQs ABOUT MYOMIX TABLET

What is MYOMIX TABLET used for?

MYOMIX TABLET is used to treat polycystic ovarian syndrome (PCOS) in women. Polycystic ovary syndrome (PCOS) is a hormonal disorder in women where the ovaries may develop numerous small collections of fluid (follicles) and fail to regularly release eggs.

Can MYOMIX TABLET be used in patients with kidney disease?

No, MYOMIX TABLET is not recommended for use in patients with severe kidney disease. Patients with mild to moderate disease should take this medicine with caution and regular monitoring of kidney function is needed, especially in the elderly.

How does MYOMIX TABLET work?

MYOMIX TABLET helps your body to utilise insulin and regulate menstrual cycles. Metformin decreases glucose production in the liver and improves insulin sensitivity. Myo-inositol increases insulin sensitivity (body cells utilise insulin effectively to produce glucose) and decreases hyperandrogenism (levels of the male hormone androgen are reduced).

What if I take more of MYOMIX TABLET?

If you or anyone else takes more MYOMIX TABLET, consult your doctor right away because you could develop lactic acidosis (vomiting, stomachache, muscle cramps, tiredness, difficulty breathing, reduced body temperature and decreased heartbeat) and end up in a coma.

Can I consume alcohol or drive while taking MYOMIX TABLET?

No, do not consume alcohol while taking MYOMIX TABLET as it can increase the side effects and do not drive or use machines as it can make you feel dizzy or sleepy, which affects your ability to drive.

REFERENCES

1. KD Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of medical pharmacology. Eighth Edition. 2019. Page –299-300.

2. Philippe Merviel, Pandora James, Sarah Bouée, Mathilde Le Guillou, Camille Rince, Charlotte Nachtergaele & Véronique Kerlan. Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies [Revised in January 2021] [Accessed on 21st June 2022] https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-021-01073-3

3. R Dumitrescu, C Mehedintu, I Briceag, VL Purcarea and D Hudita. Metformin-Clinical Pharmacology in PCOs. [Accessed on 21st June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392089/

4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 21st June 2022] https://www.medicines.org.uk/emc/files/pil.594.pdf

5. Myo inositol. Drugs.com. [Accessed on 27th June 2022] https://www.drugs.com/ingredient/inositol.html

USEFUL DIAGNOSTIC TESTS

• Blood tests
• Kidney function test