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INTRODUCTION
MONTAIR LC KID is a combination of Levocetirizine and Montelukast which belongs to the group of medicines called H1 receptor antagonists and Leukotriene receptor antagonists respectively. MONTAIR LC KID is indicated for the treatment and prevention of allergic rhinitis, chronic idiopathic urticaria (allergic skin reaction with red raised itchy bumps on skin) and bronchial asthma in adults and in adolescents (aged 15 years or above).
Allergic rhinitis (also known as hay fever) is a heterogeneous disorder characterized by inflammation of the inner lining of nose accompanied by nasal decongestion, repeated sneezing, wheezing, or a red, watery, and itchy eyes. It is usually caused by allergens such as pollens, dusts, mould, or flakes of skin from certain animals and can occur seasonally or year-round. Bronchial asthma is a long-term medical condition in which the path of the airways becomes inflamed, narrow, and swollen. Symptoms include coughing, wheezing, and chest tightness.
Levocetirizine is a H1 receptor antagonist that antagonizes the effects of histamine (a substance that cause allergic reaction) on the surface of the cells and montelukast is a leukotriene receptor antagonist that blocks the actions of leukotrienes responsible for causing narrowing and inflammation of the airways, thus leading to relaxation of smooth muscles in the lungs and reduction in swelling and/or inflammation of the airways.
MONTAIR LC KID is not recommended for use in patients having severe kidney impairment. Consult your doctor before taking. Avoid consumption of alcohol while taking MONTAIR LC KID as it may reduce your alertness and cause impaired performance in activities requiring mental concentration. MONTAIR LC KID may cause certain unpleasant neuropsychiatric events (such as anxiety, depression, nightmares, hallucinations, or even suicidal thoughts) in some individuals. Contact your doctor immediately if you or anyone else experience such events.
MONTAIR LC KID should be taken during pregnancy only if clearly advised by your doctor and not recommended for use in breast-feeding women. MONTAIR LC KID should be used with caution in elderly patients (above 65 years of age) and not recommended for use in children and adolescents (less than 15 years of age). The most common side effects of taking MONTAIR LC KID are upper respiratory tract infection, fever, cough, inflammation of the pharynx, dryness of mouth, headache, and somnolence. Consult your doctor if any of the symptoms worsen.
USES OF MONTAIR LC KID
- To treat and prevent allergic rhinitis, chronic idiopathic urticaria and bronchial asthma in adults and in adolescents (aged 15 years or above)
HOW MONTAIR LC KID WORKS
MONTAIR LC KID provides relief from the symptoms of allergic rhinitis, asthma and urticaria where levocetirizine acts by blocking the actions of histamines (a substance that cause allergic reaction), at the H1 receptors present on the surface of cells and montelukast acts by blocking the action of leukotrienes D4 (an inflammatory molecule causing narrowing and swelling of the airways) in the lungs, thus causing relaxation of smooth muscle, reduction in swelling and/or inflammation of the airways and a marked decrease in the onset of allergic reactions.
DIRECTIONS FOR USE
Take MONTAIR LC KID as advised by your physician. Swallow MONTAIR LC KID with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF MONTAIR LC KID
COMMON
- upper respiratory tract infection
- cough, cold, fever or flu-like symptoms
- headache and tiredness
- sleepiness
- nausea, vomiting, dry mouth, thirst, stomach pain, diarrhea
- otitis media (inflammation or infection of the ears)
- skin rash
UNCOMMON
- changes in behavior and mood (anxiety, nightmares, irritability, sleepwalking)
- dizziness, tingling and prickling sensation or numbness in the body
- indigestion
- bleeding in the nose
- itching, bruising
- joint or muscle pain
- muscle cramps, weakness
- urinary incontinence in children
- swelling
RARE
- attention disturbance, memory impairment, uncontrolled muscle movements
Stop taking MONTAIR LC KID and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as swelling of the face, lips, tongue and/or throat, difficulty in breathing or swallowing, mood changes, agitation, aggressive behavior or hostility, depression, seizure)
- increased bleeding tendency, tremor (shaking), palpitations (fast heartrate)
- flu-like symptoms, numbness of arms and legs, worsening of pulmonary symptoms and/or rash (Churg-Strauss Syndrome)
- decreased blood platelet count
- neuropsychiatric changes (such as disorientation, hallucinations)
- thoughts of harming or killing yourself (suicidal ideation)
- inflammation (swelling) of the lungs
- erythema multiforme (a severe skin reactions)
- hepatitis (inflammation of the liver)
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Try to take MONTAIR LC KID with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom did not improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
MONTAIR LC KID should be used during pregnancy only if considered clearly necessary. Consult your doctor before taking MONTAIR LC KID.
BREASTFEEDING
MONTAIR LC KID is not recommended for use in breastfeeding women. Consult your doctor before taking MONTAIR LC KID.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience drowsiness, tiredness, or sleepiness. Consult your doctor before taking MONTAIR LC KID.
ALCOHOL
Avoid consumption of alcohol while taking MONTAIR LC KID as it may reduce alertness and impairment of performance. Consult your doctor before taking MONTAIR LC KID.
KIDNEY
MONTAIR LC KID is not recommended for use in patients with severe kidney impairment. It should be taken with extreme caution in patients with mild to moderate kidney disease. Consult your doctor for before taking MONTAIR LC KID.
LIVER
MONTAIR LC KID should be taken with caution in patients with liver disease. Consult your doctor before taking MONTAIR LC KID.
ALLERGY
Do not take MONTAIR LC KID if you are allergic to Montelukast or Levocetirizine or Cetirizine.
OTHERS
MONTAIR LC KID is not recommended for use if you:
- have galactose intolerance (inherited condition in which the body cannot convert galactose to glucose)
- have Lapp lactase deficiency (deficiency of the enzyme lactase in the body)
- have glucose-galactose malabsorption
- have phenylketonuria (release of phenylalanine in urine)
- have acute asthma attacks
Before taking MONTAIR LC KID, inform your physician if you:
- have or at risk of having epilepsy
- have sensitivity to aspirin or other NSAIDs
- have any predisposing factors of urinary retention (Ex. spinal cord lesion, prostatic hyperplasia)
- are scheduled for allergy testing
Use in pediatrics:
MONTAIR LC KID is strictly not recommended for use in children aged below 15 years. Consult your doctor before taking MONTAIR LC KID.
Use in geriatrics:
MONTAIR LC KID should be used with caution in elderly patients (aged 65 years or above). Proper dose titrations and careful monitoring of kidney functions are required in such patients. Consult your doctor before taking MONTAIR LC KID.
INTERACTIONS
A. Drug-Drug interactions:
Before taking MONTAIR LC KID inform to your doctor, if you are taking any of these medicines:
- gemfibrozil (used to control high blood cholesterol levels)
- other CNS depressants such as phenobarbital or phenytoin (used to treat epilepsy)
- rifampicin (used to treat tuberculosis)
- ritonavir (used to treat viral infections)
- theophylline (used to treat asthma)
Overdosage:
If you or anyone else take too much of MONTAIR LC KID, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of MONTAIR LC KID include stomach pain, thirst, sleepiness, drowsiness, headache, vomiting, psychomotor hyperactivity, agitation, and restlessness.
SYNOPSIS
| Drug | : | Levocetirizine, Montelukast |
| Pharmacological Category | : | H1 receptor antagonist, Leukotriene receptor antagonist |
| Therapeutic Indication | : | Allergic rhinitis, Bronchial asthma, Chronic idiopathic urticaria |
| Dosage Forms | : | Tablet, Capsule, Dispersible tablet, Syrup, Suspension |
MORE INFORMATION
- Keep MONTAIR LC KID out of reach of children
- Store MONTAIR LC KID at room temperature
FAQs ABOUT MONTAIR LC KID
How long does it take for MONTAIR LC KID to provide relief from symptoms?
Following oral administration of MONTAIR LC KID, it is believed to provide relief from the symptoms of allergy and asthma within 30 minutes to an hour. Please note that the onset of action varies from product to product and consult your doctor if you have any queries.
Can MONTAIR LC KID be used to treat acute asthma attacks?
No. MONTAIR LC KID is used only to prevent asthma attack. It should not be used on an asthma attack that has been started already. Contact your doctor or go to the nearby hospital to avoid exacerbation of the attack.
Can MONTAIR LC KID be used in infants?
No. MONTAIR LC KID is only meant to be used in adults and in adolescents (aged 15 years or above). MONTAIR LC KID is strictly not recommended for use in children aged between 6 months to 11 years of age without consulting your doctor.
Can MONTAIR LC KID make you feel sleepy?
Yes. MONTAIR LC KID may make you feel sleepy or drowsy. Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling sleepy. Avoid alcohol intake, as it could aggravate your existing condition. Consult your doctor if the symptom did not improve.
Can I drink alcohol while taking MONTAIR LC KID?
Avoid consumption of alcohol while taking MONTAIR LC KID as it may reduce your alertness and cause impaired performance in activities requiring mental concentration. Consult your doctor before taking MONTAIR LC KID if you are alcoholic.
What to do If I forget to take MONTAIR LC KID?
You should take MONTAIR LC KID immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose of MONTAIR LC KID to match up your missed dose.
REFERENCES
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3. Gerald G. Briggs and Roger K. Freeman. L & M. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2219-2220 & 2629-2632.
4. Sheila Jacobs. Montelukast Plus Levocetirizine vs Monotherapy in Asthma, Allergic Rhinitis. Pulmonology adviser. [Revised in October 2018]. [Accessed on 13th October 2021] https://www.pulmonologyadvisor.com/home/meetings/chest-2018/montelukast-plus-levocetirizine-vs-monotherapy-in-asthma-allergic-rhinitis/#:~:text=Perennial%20Allergic%20Rhinitis-,Montelukast%20plus%20levocetirizine%20was%20well%20tolerated%2C%20with%20a%20safety%20profile,perennial%20allergic%20rhinitis%20and%20asthma.
5. S M Adsule, D Misra. Long term treatment with montelukast and levocetirizine combination in persistent allergic rhinitis: review of recent evidence. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Revised in June 2010] [Accessed on13th October 2021] https://pubmed.ncbi.nlm.nih.gov/21121394/
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- Absolute Eosinophil Count
- Complete Blood Count
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