Mirazep 15mg Tablet 10'S
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Introduction About MIRAZEP
MIRAZEP contains Mirtazapine which belongs to the group of medicines called Antidepressants. It is used in adults to manage depression. Depression is a mood disorder characterized by persistent feeling of sadness, loss of interest, feeling guilty or worthless, attention impairment, lack of energy, suicidal thoughts and slow or abnormal physical movements.
MIRAZEP can be taken with or without meals. It may take around 1-2 weeks for MIRAZEP to start working and you may notice improvement in your condition only after 2-4 weeks of therapy. Therefore, take MIRAZEP for the duration recommended by your doctor to achieve better results.
Before taking MIRAZEP inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have jaundice, diabetes, glaucoma, low blood pressure, previous history of fits, suicidal thoughts or other mental illnesses (such as manic depression or schizophrenia) as a precaution.
Avoid concomitant use of MIRAZEP with other antidepressants (MAO inhibitor) without consulting your doctor. Consult your doctor before taking MIRAZEP if you are pregnant or breastfeeding.
The most common side effects of taking MIRAZEP are dizziness, drowsiness, weight gain, headache, constipation, dry mouth, problems in sleeping, tremors, anxiety, confusion, joint pain and muscle pain. Contact your doctor if any of these side effect worsens.
You must also inform your doctor immediately if your depression worsens or if you experience any suicidal thoughts after taking MIRAZEP.
Uses Of MIRAZEP
- Manage depression in adults
How MIRAZEP Works
MIRAZEP is an antidepressant medication. It acts by increasing the levels of certain chemical messengers (such as serotonin and norepinephrine) in the brain that can stabilize mood and mental health. As a result, it improves your mood and energy and reduce the signs of depression.
How to use MIRAZEP
Take MIRAZEP as advised by your physician. It can be taken with or without food.
For Tablets: Swallow the medicine with a glass of water. Do not chew or crush the medicine.
For Dispersible Tablets: Disperse the medicine in the required amount of water as mentioned in the product label. Consume the mixture immediately after dispersion.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Do not stop taking MIRAZEP without consulting your doctor as it may make your symptoms re-appear once again or can cause withdrawal symptoms such as vomiting, dizziness, agitation, anxiety or headaches.
Side Effects Of MIRAZEP
Common
- increased hunger, weight gain
- drowsiness or sleepiness
- headache, dizziness
- feeling dizzy while standing up
- feeling tired
- dry mouth
- shakiness or tremor
- nausea, vomiting, diarrhea, constipation
- skin rash or eruptions
- joint pain, muscle pain or back pain
- swelling of ankles and feet
- abnormal dreams, problems in sleeping
- confusion, anxiety
- increased blood fat levels
Uncommon
- burning, stinging, tickling sensation in the skin
- restless legs (urge to move the legs)
- numbness in the mouth
- low blood pressure
- nightmares
- agitation, hallucination
Rare
- muscle twitching
Stop taking MIRAZEP and contact your doctor immediately if you experience any of the following side effects such as:
- worsening of depression, suicidal thoughts or behavior
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane, skin lesions with a pink/red ring and a pale center which may be itchy, scaly or filled with fluid accompanied with fever and tiredness)
- severe, frequent paranoid thoughts
- alternative episodes of happiness/pleasure and sadness (manic depression)
- signs of infection (such as unexplainable high fever, sore throat and mouth ulcers)
- memory problems
- inflammation of the liver (causing yellowing of skin and whites of the eye)
- inflammation of the pancreas (causing severe stomach pain with nausea and vomiting)
- fits (epilepsy)
- signs of serotonin syndrome (such as high fever, sweating, fast heart rate, diarrhea, muscle contractions, shivering, overactive reflexes, restlessness, mood changes, unconsciousness and increased salivation)
- signs of rhabdomyolysis (such as muscle pain, stiffness and/or weakness and darkening of the urine)
How To Manage Side Effects
Nausea and Vomiting:
Take MIRAZEP with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Try to eat more fiber rich foods such as fresh fruit, vegetables and cereals. Drink plenty of water and exercise regularly. If this does not help, consult your doctor for advice.
Warning & Precautions
Pregnancy
MIRAZEP should be used with caution in pregnant women and in women who think that they might be pregnant or planning to have a baby. Therefore, consult your doctor before taking it.
Breastfeeding
MIRAZEP should be used with caution in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Do not drive or operate any heavy tools or machines if you experience dizziness or tiredness after taking MIRAZEP.
Alcohol
Avoid consumption of alcohol while taking MIRAZEP as it may make you feel dizzier.
Kidney
MIRAZEP should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
MIRAZEP should be used with caution in patients with liver problems (such as jaundice). Therefore, consult your doctor before taking it.
Allergy
Do not take MIRAZEP if you are allergic to Mirtazapine.
Heart Disease
MIRAZEP should be used with caution in patients with heart problems (such as changes in heart rhythm, a recent heart attack or heart failure). Therefore, consult your doctor before taking it.
Others
Before taking MIRAZEP, inform your doctor if you:
- have suicidal thoughts
- are aged less than 25 years
- have or ever had fits in the past
- have low blood pressure
- have schizophrenia (mental illness affecting thinking abilities)
- have manic depression (alternative episodes of happiness/pleasure and sadness)
- have diabetes
- have glaucoma (increased pressure in the eye)
- have difficulty in passing urine due to prostate enlargement
Use in Pediatrics:
MIRAZEP is generally not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. However, your doctor may prescribe MIRAZEP to your child if considered necessary. Proper dose adjustments and careful monitoring are required in such patients.
Use in Geriatrics:
MIRAZEP should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug Interactions:
Before taking MIRAZEP, inform your doctor, if you are taking any of the following medicines such as:
- other medicines used to manage depression such as MAO inhibitors (Ex. moclobemide, tranylcypromine, selegiline), SSRI (venlafaxine, duloxetine)
- medicines used to manage control abnormal heart rhythm (such as digoxin, amiodarone)
- medicines used to manage migraine headaches (such as L-tryptophan, sumatriptan, zolmitriptan)
- tramadol, morphine (medicine used for pain relief)
- linezolid (an antibiotic used to manage bacterial infection)
- lithium, St. John’s Wort, nefazodone (medicines used to manage depression)
- methylene blue (a medicine used to manage high levels of methaemoglobin in the blood)
- medicines used to reduce anxiety and to induce sleep (such as alprazolam, midazolam, diazepam, clonazepam)
- medicines used to manage schizophrenia (such as olanzapine)
- medicines used to manage allergic conditions (as cetirizine)
- medicines used to manage bacterial infections (Ex. erythromycin)
- medicines used to manage fungal infections (such as ketoconazole)
- medicines used to manage HIV infection (such as ritonavir, atazanavir, nelfinavir)
- medicines used to manage stomach ulcers (such as cimetidine)
- medicines used to manage epilepsy (such as carbamazepine and phenytoin)
- rifampicin (a medicines used to manage tuberculosis)
- medicines used to manage blood clotting (such as warfarin)
Overdosage:
If you or anyone else accidentally took more MIRAZEP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include severe drowsiness, fast or rapid heart rate, fainting or disorientation.
Synopsis
| Drug | : |
Mirtazapine |
| Pharmacological Category | : |
Atypical Antidepressants |
| Therapeutic Indication | : |
Depression |
| Dosage Forms | : |
Tablet, Dispersible Tablet |
More Information
- Keep MIRAZEP out of reach of children
- Store MIRAZEP at room temperature
FAQs About MIRAZEP
What is the use of MIRAZEP?
MIRAZEP is used in adults to manage depression.
How MIRAZEP works?
MIRAZEP is an antidepressant medication. It acts by increasing the levels of certain chemical messengers (such as serotonin and norepinephrine) in the brain that can stabilize mood and mental health. As a result, it improves your mood and energy and reduce the signs of depression.
How to take MIRAZEP?
Take MIRAZEP as advised by your physician. It can be taken with or without food. Your doctor may advice you to take MIRAZEP once or twice daily based on your age and health condition. If you are taking mirtazapine as tablets, swallow the medicine with a glass of water. Do not chew or crush the medicine. If you are taking mirtazapine as dispersible tablets, disperse the medicine in the required amount of water as mentioned in the product label.
Can I stop taking MIRAZEP once I started feeling better?
No. Do not stop taking MIRAZEP without consulting your doctor as it may make your symptoms re-appear once again or can cause withdrawal symptoms such as vomiting, dizziness, agitation, anxiety or headaches. Take MIRAZEP as advised by your doctor for the stipulated duration.
What is the best time to take MIRAZEP?
MIRAZEP can be taken with or without food. It is best to take MIRAZEP as a single dose before going to bed. However, your doctor may suggest you to split your doses once in the morning and once at night before bed time.
Can I take MIRAZEP daily?
Take MIRAZEP as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take MIRAZEP every day or not.
Will taking a higher dose of MIRAZEP be more effective?
No, taking a higher dose of MIRAZEP will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
What to do if I forgot to take a dose of MIRAZEP?
If you forgot to take a dose of MIRAZEP, take it as soon as you remember. However, if it is time for the next dose of MIRAZEP, skip the missed dose and take the next one regularly. Do not take a double dose of MIRAZEP to compensate the missed ones. Consult your doctor for advice.
How long will it take for MIRAZEP to reduce my symptoms?
MIRAZEP starts working after 1-2 weeks of the therapy. However, you may notice a difference in your condition only after 2-4 weeks of the therapy. It may take around 4-6 months for MIRAZEP to completely reduce the symptoms of depression. Therefore, take MIRAZEP consistently as advised by your physician to achieve better results.
Can the use of MIRAZEP make me feel ill?
MIRAZEP rarely causes signs of illness (such as unexplainable fever with sore throat or mouth ulcers). This is due to decrease in immune cells produced by the bone marrow. If you experience any signs of illness, particularly during 4-6 weeks of the therapy, consult your doctor immediately.
What are the side effects of MIRAZEP?
The most common side effects of taking MIRAZEP are dizziness, drowsiness, weight gain, headache, constipation, dry mouth, problems in sleeping, tremors, anxiety, confusion, joint pain and muscle pain. Contact your doctor if any of these side effect worsens. You must also inform your doctor immediately if you depression worsens or experience any suicidal thoughts after taking MIRAZEP.
Is MIRAZEP safe to use in children?
MIRAZEP is generally not recommended for use in children and adolescents (aged below 18 years). However, consult your doctor before taking it.
Can MIRAZEP cause constipation?
Yes. Constipation is a common side effect of taking MIRAZEP. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Can MIRAZEP cause dry mouth?
MIRAZEP may cause dryness of mouth. Contact your doctor if this side effect bothers you.
Is MIRAZEP safe?
MIRAZEP is safe at doses prescribed by the doctor. Do not alter the dosage of MIRAZEP without consulting your doctor.
References
1. KD. Tripathi. Antidepressants and anti-anxiety drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 462.
2. Prithpal S Matreja, Dinesh K Badyal, Randhir S Deswal, Arvind Sharma. Efficacy and safety of add on low-dose mirtazapine in depression. Indian Journal of Pharmacology. 2012. [Accessed on 7th November 2022] https://www.ijp-online.com/article.asp?issn=0253-7613;year=2012;volume=44;issue=2;spage=173;epage=177;aulast=Matreja
3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2022] [Accessed on 7th November 2022] https://www.medicines.org.uk/emc/files/pil.8717.pdf
4. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 7th November 2022] https://www.medicines.org.uk/emc/files/pil.531.pdf
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