MESACOL Suppository 5's

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Drug Information

What is Mesalamine used for?

Mesalamine is used for the treatment of ulcerative colitis. It is also recommended to treat mild to moderate Crohn’s disease.

Mesalamine may also be prescribed for other conditions as determined by the doctor.

How does Mesalamine work?

Mesalamine belongs to the class of drugs called anti-inflammatory agents. This drug acts by increasing the mucosal production and diminishing the inflammation by inhibiting the synthesis of prostaglandins and blocking the action of cyclooxygenase enzymes. Inhibition of prostaglandins reduces the inflammation in the colon and other symptoms associated with ulcerative colitis.

How to use Mesalamine?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Use Mesalamine as prescribed by your doctor.

  • Mix the required amount of Mesalamine powder in a glass of cold water and drink it immediately.
  • Swallow the whole tablet. Do not crush or chew the tablet. Take the drug with or without food. However, taking the drug with food prevents stomach upset.
  • Use Mesalamine enema as suggested by the doctor.

If you miss a dose of Mesalamine, please use it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for the missed dose.

The overdose symptoms of Mesalamine may include:

  • Ringing in the ears
  • Confusion
  • Rapid breath
  • Seizures

What are the drugs that interact with Mesalamine?

Drugs that interact with Mesalamine include the following:

  • Cidofovir
  • Diatrizoate
  • Iodipamide
  • Iopamidol
  • Lopinavir
  • Tacrolimus

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Mesalamine?

The following are the most common side effects of Mesalamine:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Itching
  • Dyspepsia

The following are the severe side effects, and you may require immediate medical attention:

  • Hair loss
  • Pancreatitis
  • Tremor
  • Gout
  • Shortness of breath
  • Chest pain

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while using Mesalamine?

  • Avoid using the medicine if you are allergic to Mesalamine or similar drugs.
  • Avoid consumption of alcohol as it may alter the absorption of Mesalamine.
  • Monitor your uric acid levels on a regular basis while using Mesalamine.
  • Avoid Mesalamine during pregnancy or breastfeeding because the safe use of the drug is not yet established.
  • Do not stop using the medication abruptly unless instructed by the doctor.
  • Do not exceed the dose more than prescribed.

What should you tell your doctor before using Mesalamine?

  • Tell your doctor if you have any history of heart, liver, kidney or respiratory diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Inform the doctor if you are pregnant or breastfeeding.

Frequently asked questions about Mesalamine

  1. Does Mesalamine enema affect male fertility?
  2. Yes. Mesalamine enema may alter the sperm count and affects the male fertility. Consult your doctor for further information.

  3. Can I use mesalamine tablet and enema at the same time?
  4. Yes. You can use Mesalamine tablet and enema at the same time, only when recommended by the doctor.

  5. Is it safe to use Mesalamine in anaemic patients?
  6. No. It is not safe to use Mesalamine in patients with anaemia.

  7. Do I need to be monitored for any laboratory parameters while using Mesalamine?
  8. Blood tests and Kidney function tests must be regularly monitored while using Mesalamine.

  9. What are the other formulations of Mesalamine available?
  10. Mesalamine is available as granules, foam enemas, rectal suppositories, and capsules.



The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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