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INTRODUCTION
MELACARE CREAM is a combination of Hydroquinone, Tretinoin, Mometasone furoate which belongs to the group of medicines called Depigmenting agents, Retinoids and Corticosteroids respectively. It is used in adults for the treatment of moderate to severe melasma (dark spots on the skin) in association with sun-avoidance measures, like using sunscreens and wearing protective clothing.
Melasma is one of the most frequently acquired hyperpigmentation (excess melanin production) disorders with symptoms such as symmetrical brown patches on sun exposed areas mainly on face.
It is advised to avoid exposure to sun during treatment with MELACARE CREAM for better results. While going out apply sunscreens and wear full covering protective clothes.
Before using MELACARE CREAM inform your doctor if you have any liver, kidney, lung or heart diseases.
Safety and efficacy of MELACARE CREAM is not established in pregnant women and in children below 12 years of age. Ask for your doctor’s advice before using. MELACARE CREAM should be used with caution in breastfeeding women.
The most common side effects of using MELACARE CREAM are mild burning, stinging, redness and dryness. Consult your doctor if any of the symptoms worsen or doesn’t improve.
USES OF MELACARE CREAM
It is used in adults to
- treats moderate to severe melasma (dark spots on the skin)
HOW MELACARE CREAM WORKS
MELACARE CREAM helps in treating melasma where Hydroquinone is a skin bleaching agent that blocks enzyme tyrosinase which is responsible for the production of melanin that cause pigmentation. Thus, it helps for fading of dark spots in skin. Tretinoin helps to recover the damage to the skin caused by sun exposure (photodamage) by thickening skin layer and loss of keratinized cells.it helps to rejuvenate the skin. Mometasone furoate blocks prostaglandin synthesis and reduces redness, swelling and itching caused by tretinoin and other skin infections.
DIRECTIONS FOR USE
Apply MELACARE CREAM as advised by your physician. It is for external use only. Wash your hands before and after applying MELACARE CREAM. Wash your face with a mild soap and dry properly. Apply MELACARE CREAM at night and gently massage it in until it is absorbed. Avoid contact with your eyes, nose, mouth, mucous membrane. Avoid exposure to sunlight while using this medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF MELACARE CREAM
COMMON
- mild burning
- stinging
- redness
- dryness
RARE
Stop using MELACARE CREAM and consult your doctor immediately if you experience any of the following:
- infraorbital and paranasal fissures
HOW TO MANAGE SIDE EFFECTS
Dry skin:
Drink plenty of water, milk, honey and stay hydrated. Apply sunflower oil, coconut oil ,aloe vera or petroleum jelly to moisturize skin. Contact doctor if it doesn’t improve.
Burning sensation:
Apply cool compress or wet cloth over affected area. Avoid hot bath because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin and apply calamine lotion as a coolant. Contact doctor if it is not subsiding.
WARNING & PRECAUTIONS
PREGNANCY
The safety and efficacy of MELACARE CREAM is not being established in pregnant women. Consult with your doctor before using.
BREASTFEEDING
MELACARE CREAM should be used with caution in breast feeding women. Consult with your doctor before using.
ALLERGY
Do not use MELACARE CREAM if you are allergic to Hydroquinone, Tretinoin, Mometasone or any other constituents of this medicine. Consult your doctor before using.
OTHERS
Use in paediatrics:
The safety and efficacy of MELACARE CREAM is not being established in children below 12 years of age. Consult with your child’s doctor before using it for your child.
Use in geriatrics:
There is no information on the use of MELACARE CREAM in elderly patients. Consult your doctor before using MELACARE CREAM.
INTERACTIONS
A. Drug – drug interactions:
Before using MELACARE CREAM, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine.
Overdosage:
If you or anyone else accidentally ingests or apply too much of MELACARE CREAM, consult your doctor immediately.
SYNOPSIS
| Drug | : | Hydroquinone, Tretinoin, Mometasone |
| Pharmacological Category | : | Hypopigmenting agents, Retinoids, Corticosteroids |
| Therapeutic Indication | : | Melasma |
| Dosage Forms | : | Cream, Gel, Ointment, Soap |
MORE INFORMATION
- Keep MELACARE CREAM out of reach of children
- Store MELACARE CREAM at room temperature not exceeding 25°C
FAQs ABOUT MELACARE CREAM
What is MELACARE CREAM used for?
MELACARE CREAM is used in adults for the treatment of moderate to severe melasma (dark spots on the skin) in association with sun-avoidance measures, like using sunscreens and wearing protective clothing. Consult doctor before using.
How to use MELACARE CREAM?
Apply MELACARE CREAM as advised by your physician. It is for external use only. Wash your hands before and after applying MELACARE CREAM. Wash your face with a mild soap and dry properly and gently massage the medicine until it is absorbed. Avoid contact with your eyes, nose, mouth, mucous membrane. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can I use MELACARE CREAM to treat wounds?
MELACARE CREAM is not recommended to use on wounds and ulcerated skin . Consult doctor before using MELACARE CREAM.
Do I need to take any precaution while using MELACARE CREAM?
It is advised to reduce exposure to sun during treatment with MELACARE CREAM for better results. While going out apply sunscreens and wear full covering protective clothes. Exposure to sunlight or ultra-violet light will cause repigmentation of lightened skin. Do not apply MELACARE CREAM to broken skin.
What is the best time to use MELACARE CREAM?
It is advised to use MELACARE CREAM before bedtime. This will reduce the chances of exposure of the treated skin to sun. However, ask for your doctor’s advice before using.
REFERENCES
1. KD Tripathi. Drugs Acting on Skin and Mucous Membranes. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 952, 953, 955.
2. Kiran V Godse. Triple combination of hydroquinone, tretinoin and mometasone furoate with glycolic acid peels in melasma. NIH National Library of Medicine, National Centre for Biotechnology. Pubmed Central. Jan 2009. [Accessed on 15th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800888/
3. Kowichi Jimbow, HirokoObata, Madhu A.Pathak, Thomas B.Fitzpatrick. Mechanism of depigmentation by hydroquinone. Journal of investigative dermatology. Science Direct. January 2016. [Accessed on 15th September 2022] https://www.sciencedirect.com/science/article/pii/S0022202X15442642
4. Torrent Pharmaceuticals Ltd. Aurochem Laboratorie. Lookbrite (Hydroquinone + Tretinoin + Mometasone) [Accessed on 15th September 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2476.pdf
5. Torque pharma. No Scars (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.torquepharma.com/no-scars-cream/
6. Leeford Healthcare. Ultrabrite Cream (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.leeford.in/product/1346/ultrabrite-cream-15-g
7. Leeford Healthcare. Elosone HT Forte (Hydroquinone + Tretinoin + Mometasone). [Accessed on 15th September 2022] https://www.leeford.in/product/1459/elosone-ht-forte
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