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MEGACHOLIN PLUS Tablet 10's
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INTRODUCTION
MEGACHOLIN PLUS TABLET is a combination of Citicoline and Piracetam which belongs to the group of medicines called Cerebroactive drugs. It is used as an adjunct for the treatment of acute stroke.
Acute stroke can be defined as a brain injury caused due to sudden loss in blood flow, nutrients and oxygen supply to the brain. It is usually characterized by paralysis of one side of the body, loss of sensation, double vision, difficulty in sleeping, facial droop, loss of balance, vertigo, nausea, vomiting, headache and/or blurred vision.
MEGACHOLIN PLUS TABLET can also be used to treat memory problems caused due to brain injury and other age-related brain problems.
Before taking MEGACHOLIN PLUS TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have any bleeding problems, history of bleeding in the brain or parkinsonism.
MEGACHOLIN PLUS TABLET is not recommended for use in patients with Huntington Disease, intracranial hemorrhage (bleeding within the skull) or a previous history of depression. It is also not suitable for use in pregnant or breastfeeding women unless considered necessary by the physician.
Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with MEGACHOLIN PLUS TABLET.
The most common side effects of taking MEGACHOLIN PLUS TABLET are headache, constipation, diarrhea, difficulty in falling asleep, nervousness, dizziness and weight gain. Consult your doctor if any of these side effects bother you.
USES OF MEGACHOLIN PLUS TABLET
It is used to treat:
- Acute stroke
- Memory loss associated with aging or brain injury
HOW MEGACHOLIN PLUS TABLET WORKS
MEGACHOLIN PLUS TABLET contains two medicines namely citicoline and piracetam. Citicoline is a neuroprotectant. It protects the nerve cells by blocking the release of certain chemicals (such as glutamate and other free radicals) within the brain and nervous system that damages the nerve cells.
Piracetam is a GABA analogue. It improves oxygen supply to the brain and nervous system and protects it from further injury. Collectively, MEGACHOLIN PLUS TABLET repairs the brain cells and regulates proper nerve signal transmissions across the brain and the nervous system.
DIRECTIONS FOR USE
Take MEGACHOLIN PLUS TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking MEGACHOLIN PLUS TABLET unless your doctor advice you to stop.
SIDE EFFECTS OF MEGACHOLIN PLUS TABLET
COMMON
- weight gain
- headache
- feeling nervous
- muscle spasms
- anxiety or agitation
- numbness, tingling sensation
- constipation, diarrhea, stomach upset
- dizziness
- difficulty in falling asleep
- nausea, vomiting
- skin rash
- back pain, shoulder pain, joint pain
UNCOMMON
- feeling sad or depressed
- tiredness, weakness
RARE
Stop taking MEGACHOLIN PLUS TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reaction (such as skin rash, swelling of the face, eyelids, lips, tongue or throat which causes difficulty in breathing or swallowing)
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take MEGACHOLIN PLUS TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
WARNING & PRECAUTIONS
PREGNANCY
MEGACHOLIN PLUS TABLET should be used in pregnancy only if it is considered necessary by the physician. Your doctor will evaluate the risks and benefits of the therapy and prescribes it to you accordingly. Therefore, inform your doctor before taking MEGACHOLIN PLUS TABLET if you are pregnant, think you may be pregnant or planning to have a baby. Women of childbearing age must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with MEGACHOLIN PLUS TABLET.
BREASTFEEDING
MEGACHOLIN PLUS TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any heavy tools or machines if you experience drowsiness or shakiness after taking MEGACHOLIN PLUS TABLET.
ALCOHOL
Consumption of alcohol is not recommended during treatment with MEGACHOLIN PLUS TABLET.
KIDNEY
MEGACHOLIN PLUS TABLET is not recommended for use in patients who have or ever had any severe kidney problems. It should be used with caution in patients with other kidney problems. Therefore, consult your doctor before taking it.
LIVER
MEGACHOLIN PLUS TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other liver problems. Therefore, consult your doctor before taking it.
ALLERGY
Do not take MEGACHOLIN PLUS TABLET if you are allergic to Citicoline or Piracetam.
OTHERS
MEGACHOLIN PLUS TABLET is not recommended for use if you:
- have a previous history of bleeding in the brain
- have Huntington Disease (a rare genetic disease that causes degeneration of nerve cells)
- have prolonged bleeding within the skull (intracranial hemorrhage)
- have trimethylaminuria (fishy odor in the urine)
- have Parkinson’s disease
- have a previous history of depression
Before taking MEGACHOLIN PLUS TABLET inform your doctor if you:
- have any bleeding problems
Use in Pediatrics:
MEGACHOLIN PLUS TABLET should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice.
Use in Geriatrics:
MEGACHOLIN PLUS TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug Interactions
Before taking MEGACHOLIN PLUS TABLET inform to your doctor if you are taking any of the following medicines such as:
- medicines used to treat thyroid problems (Ex. thyroxine, thyroid extract)
- medicines used for blood thinning (Ex. warfarin)
- aspirin (a medicine used for pain relief)
- levodopa (a medicine used for parkinsonism)
- meclofenoxate (a dietary supplement used to improve memory)
Overdosage:
If you or anyone else accidentally took more MEGACHOLIN PLUS TABLET, consult your doctor immediately or visit the nearby hospital straight away. Symptoms of overdosage might include severe headache or severe stomach pain with bloody diarrhea.
SYNOPSIS
| Drug | : | Citicoline, Piracetam |
| Pharmacological Category | : | Pyrimidine Ribonucleoside diphosphates, GABA analogs |
| Therapeutic Indication | : | Stroke |
| Dosage Forms | : | Tablet, Capsule, Syrup |
MORE INFORMATION
- Keep MEGACHOLIN PLUS TABLET out of reach of children
- Store MEGACHOLIN PLUS TABLET at room temperature
FAQs ABOUT MEGACHOLIN PLUS TABLET
What are the uses of MEGACHOLIN PLUS TABLET?
MEGACHOLIN PLUS TABLET is used as an adjunct for the treatment of acute stroke.
How MEGACHOLIN PLUS TABLET works?
MEGACHOLIN PLUS TABLET improves blood flow and oxygen supply to the brain and nervous system and protects it from further injury. It also repairs the brain cells and regulates proper nerve signal transmissions across the brain and the nervous system.
What is the best time to take MEGACHOLIN PLUS TABLET?
Take MEGACHOLIN PLUS TABLET as advised by your physician. Your doctor will decide the best time for you to take MEGACHOLIN PLUS TABLET. Therefore, consult your doctor for advice.
What are the side effects of taking MEGACHOLIN PLUS TABLET?
The most common side effects of taking MEGACHOLIN PLUS TABLET are headache, constipation, diarrhea, difficulty in falling asleep, nervousness, dizziness and weight gain. Consult your doctor if any of these side effects bother you.
Can I consume alcohol along with MEGACHOLIN PLUS TABLET?
It is advisable to avoid alcohol consumption while taking MEGACHOLIN PLUS TABLET to achieve maximum benefits.
Who should not take MEGACHOLIN PLUS TABLET?
MEGACHOLIN PLUS TABLET is not recommended for use in patients with severe liver or kidney problems. It is also not suitable for use in patients with Huntington Disease, parkinsonism, prolonged bleeding within the skull (intracranial hemorrhage), trimethylaminuria (fishy odor in the urine) or a previous history of cerebral bleeding or depression. Do not take MEGACHOLIN PLUS TABLET if you are pregnant or breastfeeding without consulting your doctor.
What should I do if I forget to take a dose of MEGACHOLIN PLUS TABLET?
If you forget to take a dose of MEGACHOLIN PLUS TABLET, take it as soon as you remember. However, if it is time to take the next dose of MEGACHOLIN PLUS TABLET, skip the missed dose and take the next one at regular times. Do not take a double dose of MEGACHOLIN PLUS TABLET to compensate the missed dose, as it could lead to toxicity.
Can I stop taking MEGACHOLIN PLUS TABLET once my symptom subsides?
Do not stop taking MEGACHOLIN PLUS TABLET unless your doctor advice you to stop, as sudden withdrawal of the therapy may cause unpleasant withdrawal symptoms such as muscle twitching or jerky movements. If you feel better after using MEGACHOLIN PLUS TABLET, consult your doctor for advice. Your doctor will gradually reduce the dose before complete cessation of the therapy.
Can MEGACHOLIN PLUS TABLET be used during pregnancy?
MEGACHOLIN PLUS TABLET should be used in pregnancy only if it is considered necessary by the physician. Your doctor will evaluate the risks and benefits of the therapy and prescribes it to you accordingly.
How to take MEGACHOLIN PLUS TABLET?
You must take MEGACHOLIN PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
REFERENCES
1. KD. Tripathi. CNS stimulants and cognition enhancers. Essentials of Medical Pharmacology. Seventh Edition. May 2013. Page – 490 & 491.
2. José Álvarez-Sabín and Gustavo C. Román. The Role of Citicoline in Neuroprotection and Neurorepair in Ischemic Stroke. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2013. [Accessed on 17th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061873/
3. P.P. De Deyn, J D Reuck, W Deberdt, R Vlietinck, J M Orgogozo. Treatment of acute ischemic stroke with piracetam. Members of the Piracetam in Acute Stroke Study (PASS) Group. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 1997. [Accessed on 17th October 2022] https://pubmed.ncbi.nlm.nih.gov/9412612/
4. Cipla Ltd. Cognolin P Tablet. [Revised in September 2020] [Accessed on 17th October 2022]. https://www.ciplamed.com/content/cognolin-p-tablets
5. Torrent Pharmaceuticals Ltd. Strolin-P (Citicoline+Piracetam Tablets). [Accessed on 17th October 2022]. https://www.torrentian.com/pisheet/Upload/PI_Sheet/2267.pdf
6. Leeford Healthcare Ltd. Nurocot P. Citicoline+Piracetam Tablets. [Accessed on 19th October 2022] https://www.leeford.in/product/763/nurocot-p
7. BioBrick Pharma. Biocoline-P. Citicoline+Piracetam Tablets. [Accessed on 19th October 2022]. https://www.biobrickpharma.com/product/citicoline-sodium-piracetam-tablets-2/
8. Central Drug Standard Control Organization. Citicholine 500mg + Piracetam 400mg Tablets [Revised in October 2010]. [Accessed on 19th October 2022]. https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalNewDrugs/dciApprovedfdc.pdf
USEFUL DIAGNOSTIC TESTS
- Activated Partial Thromboplastin Time
- Complete Blood Count
- Prothrombin Time
VIDEOS
Citicoline+Piracetam Tablet - Drug Information
Citicoline+Piracetam Tablet : Therapeutic Uses, Warning and Precautions, Interactions, Directions for Use, Side Effects and Storage
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