MEDISTAT Nasal Spray 5ml

Introduction About MEDISTAT NASAL SPRAY

MEDISTAT NASAL SPRAY contains Midazolam, which belongs to the group of medicines called benzodiazepines (sedatives). MEDISTAT NASAL SPRAY is used to manage sudden repetitive attacks of fits (epilepsy). Epilepsy (fits) is a central nervous system (neurological) disorder which affects the brain creating a disturbance in nerve cells and electrical activity leading to sudden, uncontrolled body movements. Epilepsy can be triggered by sleep deprivation, stress, missing medications, illness with fever or using alcohol and other nonmedical drugs.

Before using MEDISTAT NASAL SPRAY, inform your doctor if you have chronic respiratory problems, myasthenia gravis (muscle weakness), a history of drug abuse or depression, narrow-angle glaucoma, sleep apnoea syndrome (sleep disorder in which breathing stops and starts repeatedly), kidney, heart, liver problems.

MEDISTAT NASAL SPRAY is generally not recommended during pregnancy especially in the last trimester and breastfeeding, unless deemed necessary. MEDISTAT NASAL SPRAY should be used with caution in elderly patients and children. MEDISTAT NASAL SPRAY has a few side effects like nausea, vomiting, headache, drowsiness, runny nose, throat irritation, nasal discomfort and dizziness in some cases. If any of these symptoms worsen, contact your doctor for advice.

Uses Of MEDISTAT NASAL SPRAY

MEDISTAT NASAL SPRAY nasal spray is used for emergencies to stop cluster seizures (episodes of increased seizure activity) in adults and children 12 years of age and older who are taking other medications to manage epilepsy (seizures).

How MEDISTAT NASAL SPRAY Works

MEDISTAT NASAL SPRAY contains midazolam which works by increasing a particular chemical messenger in the brain that acts as a natural nerve-calming agent (GABA) resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant and muscle relaxant properties. Hence MEDISTAT NASAL SPRAY helps manage fits by stabilizing the altered, electrical activity of nerve cells in the brain.

How to use MEDISTAT NASAL SPRAY

Use MEDISTAT NASAL SPRAY as advised by your physician. MEDISTAT NASAL SPRAY is for nasal use only. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Side Effects Of MEDISTAT NASAL SPRAY

How To Manage Side Effects

Nasal discomfort:

Try to take steam inhalation. Do not take any other medication without consulting your doctor.

Nausea:

Try to relax and rest. Eat and drink slowly or try to have smaller and more frequent meals. If symptoms do not improve, contact your doctor.

Headache:

Try a cold pack or use a heating pad or hot compress. Ease pressure on your scalp or head. Dim the lights. Hydrate yourself and practice relaxation.

Warning & Precautions

Pregnancy

MEDISTAT NASAL SPRAY is generally not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before using it.

Breastfeeding

MEDISTAT NASAL SPRAY is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before using it.

Driving and Using Machines

Do not drive or operate any machines if you feel dizzy after using MEDISTAT NASAL SPRAY.

Alcohol

Do not drink alcohol if you are using MEDISTAT NASAL SPRAY. This is because alcohol may make you feel very sleepy and cause problems with your breathing.

Kidney

MEDISTAT NASAL SPRAY should be used with caution in patients with kidney diseases. Consult your doctor before using MEDISTAT NASAL SPRAY.

Liver

MEDISTAT NASAL SPRAY should be used with caution in patients with liver diseases. Consult your doctor before using MEDISTAT NASAL SPRAY.

Allergy

Do not use MEDISTAT NASAL SPRAY if you are allergic to midazolam. Allergic reactions to MEDISTAT NASAL SPRAY are rare but may show as an itchy rash. Very rarely, a severe allergic reaction may occur causing a sudden onset of swelling of the face and neck, and shortness of breath.

Lungs

MEDISTAT NASAL SPRAY should be used with caution in patients with respiratory diseases. Consult your doctor before using MEDISTAT NASAL SPRAY.

Heart Disease

MEDISTAT NASAL SPRAY should be used with caution in patients with heart diseases. Consult your doctor before using MEDISTAT NASAL SPRAY.

Interactions

A. Drug-Drug interactions:

Before using MEDISTAT NASAL SPRAY, inform your doctor if you are taking any of the following medicine:

• medicines for depression (Ex. citalopram)
• hypnotic medicines, to make you sleep (Ex. zopiclone)
• sedatives to make you feel calm or sleepy (Ex. barbiturates, benzodiazepines)
• tranquilliser medicines for anxiety or to help you sleep (Ex. pentobarbital)
• carbamazepine or phenytoin (these may be used for fits or seizures)
• rifampicin to manage tuberculosis
• medicines for HIV called protease inhibitors (Ex. saquinavir)
• antibiotics to manage infection (Ex. erythromycin or clarithromycin)
• medicines to manage fungal infections (Ex. ketoconazole, voriconazole, fluconazole, itraconazole,)
• strong pain killers (Ex. ketorolac)
• antihistamines to manage allergic reactions (Ex. cetirizine)
• any kind of herbal medicine for depression
• medicines for high blood pressure (Ex. diltiazem)

Overdosage:

If you or anyone else accidentally used too much of MEDISTAT NASAL SPRAY, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include feeling sick (nausea), vomiting, dizziness, slowing of breathing, drowsiness or coma, slurred speech, loss of balance, and slow reactions.

Synopsis

More Information

• Keep MEDISTAT NASAL SPRAY out of reach from children
• Store at room temperature

FAQs About MEDISTAT NASAL SPRAY

What are the uses of MEDISTAT NASAL SPRAY?

MEDISTAT NASAL SPRAY contains Midazolam which belongs to the group of medicines called benzodiazepines (sedatives). MEDISTAT NASAL SPRAY is used to manage sudden repetitive attacks of fits (epilepsy). Epilepsy (fits) is a central nervous system (neurological) disorder which affects the brain creating a disturbance in nerve cells and electrical activity leading to sudden, uncontrolled body movements. Epilepsy can be triggered by sleep deprivation, stress, missing medications, illness with fever, or using alcohol or other nonmedical drugs.

How to use MEDISTAT NASAL SPRAY?

Use MEDISTAT NASAL SPRAY as advised by your physician. MEDISTAT NASAL SPRAY is for nasal use only. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

Does MEDISTAT NASAL SPRAY has any side effects?

MEDISTAT NASAL SPRAY has few side effects like any other medicine. The symptoms include nausea, vomiting, headache, drowsiness, runny nose, throat irritation, and nasal discomfort. If any of these symptoms become worsen, contact your doctor for advice.

Can we use MEDISTAT NASAL SPRAY for pregnant women?

If you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before using MEDISTAT NASAL SPRAY. It is generally not recommended during pregnancy and breastfeeding. Consult your doctor for advice.

How does MEDISTAT NASAL SPRAY work?

MEDISTAT NASAL SPRAY contains midazolam which works by increasing a particular chemical messenger in the brain that acts as a natural nerve-calming agent (GABA) resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. Hence MEDISTAT NASAL SPRAY helps manage fits by stabilizing the altered, electrical activity of nerve cells in the brain.

References

1. KD Tripathi. Sedative-Hypnotics Essentials of medical pharmacology. seventh edition. 2017. Page – 397-411.

2. Dundee, J.W., Halliday, N.J., Harper, K.W. et al. Midazolam. Drugs. [Revised in Oct 2012] [Accessed in August 2022] https://doi.org/10.2165/00003495-198428060-00002

3. Proximagen, LLC. U.S. Food and Drug Administration. [Revised in May 2019] [Accessed in August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/211321s000lbl.pdf

4. NAYZILAM. Patient Leaflet. [Accessed in August 2022] https://www.nayzilam.com/patient-brochure.pdf

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Sankara Babu Gorle - MBBS, MD (Pharmacology)

Last updated on 19 Nov 2022 | 04:40 PM(IST)