Best Price* ₹ 130.00 MRP ₹ 162.50
(Inclusive of all taxes) *10 Capsule(s) in a Strip * Mkt: Rapross Pharmaceuticals (P) Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

MECOBAL PLUS CAPSULE is a combination of Alpha lipoic acid, Methylcobalamin, Folic acid, Pregabalin and Pyridoxine which belongs to the group of medicines called Antioxidants, Cyclic GABA analogues and Vitamin B complex respectively. It is used in adults to treat painful diabetic neuropathy (nerve damage occurring over time because of high sugar and fat levels in the blood due to diabetes).

The symptoms depend on the type of neuropathy, such as pain and numbness in your feet or problems with organ functions like those of your heart and bladder. Avoid consuming alcohol during treatment with GBNKEYWORD.

MECOBAL PLUS CAPSULE is not recommended for use in children and adolescents (younger than 18 years), so consult your doctor before taking it. Before taking MECOBAL PLUS CAPSULE, inform your doctor if you have any kidney, liver, heart, respiratory or nervous system problems; diabetes; or a history of alcoholism or any drug abuse or dependence.

MECOBAL PLUS CAPSULE should not be used in pregnant or breastfeeding women unless necessary. The most common side effects of taking MECOBAL PLUS CAPSULE are dizziness, drowsiness, headache, increased appetite, blurred vision, weight gain etc. Contact your doctor if any of the symptoms get worse.

USES OF MECOBAL PLUS CAPSULE

  • Treats painful diabetic neuropathy in adults

HOW MECOBAL PLUS CAPSULE WORKS

MECOBAL PLUS CAPSULE relieves nerve pain where alpha-lipoic acid reduces oxidative stress, which is considered a main pathophysiology of diabetic neuropathy development, folic acid (Vitamin B9) is found to improve the functional recovery of nerves, speed of nerve conduction and cell multiplication and methylcobalamin takes part in the production of myelin (a compound which covers and protects nerve fibres), thus restoring the damaged nerve cell. Pregabalin binds with high affinity to certain sites in the tissues of the central nervous system and acts as a growth factor for nerve cells, helping to regenerate the damaged nerve tissue and pyridoxine acts as a coenzyme in a wide range of metabolic functions affecting protein, carbohydrate and lipid utilization, like the breakdown of glycogen to glucose-1-phosphate and the synthesis of gamma-aminobutyric acid (GABA).

DIRECTIONS FOR USE

Take MECOBAL PLUS CAPSULE as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of MECOBAL PLUS CAPSULE for you based on your age, body weight and disease condition. Do not stop taking MECOBAL PLUS CAPSULE unless your doctor advises you to stop.

SIDE EFFECTS OF MECOBAL PLUS CAPSULE

COMMON

  • dizziness, drowsiness, headache
  • feeling elated, confused or disorientated
  • decreased sexual interest, irritability
  • disturbed attention, clumsiness, memory impairment or loss, shaking, trouble speaking, tingling feeling, numbness, sedation, lethargy, lack of sleep, fatigue, feeling weird
  • double vision
  • spinning sensation, problems with balance, fall
  • increased appetite, dry mouth, constipation, vomiting, gas, diarrhoea, nausea, swollen abdomen
  • difficulties with erection
  • swollen body including extremities
  • feeling drunk, abnormal walking style
  • weight gain
  • muscle cramp, joint, back or limb pain
  • sore throat

UNCOMMON

  • loss of appetite and weight
  • low or high blood sugar
  • change in self-perception, agitation, mood swings, restlessness, depression, difficulty finding words
  • seeing things that are not there, unusual dreams, panic attacks, lack of interest, aggression, elevated mood
  • mental impairment, trouble thinking, increased sexual interest, sexual problems including inability to achieve a sexual climax, delayed ejaculation
  • changes in eyesight, unusual eye movement, tunnel vision, flashes of light
  • jerky movements, reduced reflexes, increased activity, dizziness on standing, skin sensitivity
  • taste loss, burning sensation, shaking on movement, low or loss of consciousness, increased noise sensitivity, feeling unwell
  • eye swelling, pain, weakness, watering, irritation or dryness
  • heart rhythm changes, increased heart rate, low or high blood pressure, changes in heartbeat, heart failure
  • flushing, hot flushes
  • nasal dryness or congestion
  • increased salivation, heartburn, numbness around the mouth
  • sweating, rash, chills, fever
  • muscle twitching, swollen joints, stiff muscle, muscle or neck pain
  • breast pain
  • troubled or painful urination, incontinence
  • weakness, thirst, chest tightness
  • changes in blood and liver test results (high blood creatinine phosphokinase, alanine aminotransferase, aspartate aminotransferase, blood creatinine and low platelet count, neutrophils and blood potassium)
  • hypersensitivity, swollen face, itchiness, hives, cough, snoring, runny nose, nosebleed
  • painful menstrual periods
  • cold hands and feet

RARE

  • abnormal sense of smell, swinging vision, changed the perception of depth, visual brightness, vision loss
  • dilated pupils, cross eyes
  • cold sweat, throat tightness
  • pancreatic inflammation
  • trouble swallowing
  • slow or decreased body movement
  • trouble writing properly
  • increased abdominal fluid
  • fluid in the lungs
  • muscle damage
  • breast discharge, unusual breast growth, breast enlargement in men
  • interrupted menstrual periods
  • decreased white blood cell count
  • inappropriate behaviour
  • allergic reactions (trouble breathing, eye inflammation, a serious skin reaction characterized by rash, blisters, peeling skin and pain)
  • jaundice (yellow skin and eyes)

Stop taking MECOBAL PLUS CAPSULE and contact your doctor immediately if you experience any of the following side effects:

  • swollen face
  • skin turning red and starting to blister or peel
  • allergic reaction (swelling of the face, lips, tongue and throat, diffuse skin rash)
  • blurring or loss of eyesight or other changes in vision
  • kidney failure, reduced urine volume
  • thoughts of harming or killing self
  • constipation
  • fits
  • trouble breathing or shallow breaths

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take MECOBAL PLUS CAPSULE with or just after, meals. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, contact your doctor.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don't have to eat or avoid any specific foods. If vomiting does not improve, contact your doctor.

Constipation:

Eat plenty of fibre-rich foods like fresh fruits and vegetables and cereals and drink plenty of water. Exercise more regularly. If you still feel constipated, contact your doctor.

Diarrhea:

Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Ask your doctor before taking any medicine for diarrhea. If diarrhoea does not improve, contact your doctor.

Gas:

Eat smaller and more frequent meals. Eat and drink slowly and exercise regularly. If flatulence does not improve, contact your doctor.

Headache:

Drink plenty of water and get adequate rest. Try to be relaxed and stress-free. Check with your doctor before taking any medicine for a headache. If your headache does not improve, consult your doctor.

Dizziness:

Lie down until the dizziness is resolved, then get up slowly. Do not hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. If dizziness does not improve, consult your doctor.

WARNING & PRECAUTIONS

PREGNANCY

MECOBAL PLUS CAPSULE is not recommended for use in pregnant women unless considered necessary. Females of child-bearing capability must use effective contraception. Consult your doctor before taking it.

BREASTFEEDING

MECOBAL PLUS CAPSULE is not recommended for use in breastfeeding women unless considered necessary. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience dizziness, sleepiness or decreased concentration after taking MECOBAL PLUS CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking MECOBAL PLUS CAPSULE. Let your doctor know if you have a history of alcoholism.

KIDNEY

MECOBAL PLUS CAPSULE should be taken with caution in patients with kidney disease or impairment. Consult your doctor before taking it.

LIVER

MECOBAL PLUS CAPSULE should be taken with caution in patients with liver disease. Consult your doctor before taking it.

ALLERGY

Do not take MECOBAL PLUS CAPSULE if you are allergic to Alpha lipoic acid, Methylcobalamin, Folic acid, Pregabalin, Pyridoxine or any of the other ingredients of MECOBAL PLUS CAPSULE.

LUNGS

MECOBAL PLUS CAPSULE should be taken with caution in patients with respiratory disorders. Consult your doctor before taking it.

HEART DISEASE

MECOBAL PLUS CAPSULE should be taken with caution in patients with a history of heart disease or who received a coronary stent (a tube inserted in the artery that leads to the heart, to prevent blockages). Consult your doctor before taking it.

OTHERS

Before taking MECOBAL PLUS CAPSULE, inform your doctor if you:

  • have diabetes (high blood sugar)
  • are prone to constipation
  • have a history of any drug abuse or dependence
  • have nervous system disorders
  • have a folate-dependent tumour

Use in Pediatrics:

MECOBAL PLUS CAPSULE is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.

Use in Geriatrics:

MECOBAL PLUS CAPSULE should be used with caution in elderly patients (aged above 75 years) with kidney problems and the elderly in general as it causes dizziness and sleepiness which could increase the occurrence of accidental injury (fall) in them. Consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking MECOBAL PLUS CAPSULE, inform your doctor if you are taking any of the following medicines:

  • oxycodone (used to treat severe pain)
  • lorazepam (used to treat anxiety)
  • medicines containing alcohol

Overdosage:

If you or anyone else accidentally took too much of MECOBAL PLUS CAPSULE, contact your doctor immediately. Symptoms of MECOBAL PLUS CAPSULE overdose are sleepiness, confusion, agitation, restlessness or fits.

SYNOPSIS

Drug :   Alpha Lipoic Acid, Methylcobalamin, Folic Acid, Pyridoxine, Pregabalin
Pharmacological Category :   Antioxidants, Vitamins, Cyclic GABA analogues
Therapeutic Indication :   Painful diabetic neuropathy
Dosage Forms :   Tablet, Capsule

MORE INFORMATION

  • Keep MECOBAL PLUS CAPSULE out of reach from children
  • Store MECOBAL PLUS CAPSULE below 25°C

FAQs ABOUT MECOBAL PLUS CAPSULE

Q: Can I take MECOBAL PLUS CAPSULE if I have diabetes?

A: Before taking MECOBAL PLUS CAPSULE, inform your doctor if you have diabetes and about the medicines you are taking for it, as according to current clinical practice, some diabetic patients who gain weight on MECOBAL PLUS CAPSULE treatment may need to adjust the doses of their anti-diabetic medicines.

Q: Can MECOBAL PLUS CAPSULE make me feel suicidal?

A: Thoughts of harming or killing oneself are seen in a small number of patients being treated with MECOBAL PLUS CAPSULE. If at any time you have such thoughts, immediately contact your doctor or go to the nearest hospital.

Q: Can MECOBAL PLUS CAPSULE be taken during pregnancy?

A: MECOBAL PLUS CAPSULE should not be used in pregnant women unless necessary. Females who are of childbearing age must use effective contraception. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking MECOBAL PLUS CAPSULE. Inform your doctor immediately if you become pregnant during treatment with MECOBAL PLUS CAPSULE.

Q: Can MECOBAL PLUS CAPSULE cause constipation?

A: MECOBAL PLUS CAPSULE may cause constipation and other gastrointestinal problems like blocked or paralysed intestines when taken with other medicines (like some types of pain medicines). In such cases, eat plenty of fibre-rich foods, such as fresh fruits, vegetables and cereals and drink plenty of water. Inform your doctor if you feel constipated, especially if you are prone to this problem.

Q: Can I drink alcohol during treatment with MECOBAL PLUS CAPSULE?

A: Avoid drinking alcohol during treatment with MECOBAL PLUS CAPSULE and inform your doctor if you have a history of alcoholism.

Q: Can MECOBAL PLUS CAPSULE be given to children?

A: No. MECOBAL PLUS CAPSULE is used for adults and not recommended for children and adolescents below 18 years of age, as the safety and efficacy of MECOBAL PLUS CAPSULE in this age group have not been established. Your doctor will select a suitable alternative treatment for your child.

Q: Can I take MECOBAL PLUS CAPSULE on an empty stomach?

A: Take MECOBAL PLUS CAPSULE as advised by your physician. You take it with or without food. However, if you feel nauseous, take MECOBAL PLUS CAPSULE with meals or just after meals.

Q: What if I forget to take a dose of MECOBAL PLUS CAPSULE?

A: If you forget to take a dose of MECOBAL PLUS CAPSULE, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take MECOBAL PLUS CAPSULE twice to make up for the missed dose.

Q: Can I stop taking MECOBAL PLUS CAPSULE on my own?

A: Continue taking MECOBAL PLUS CAPSULE until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition or any new symptoms. In such a case, contact your doctor. Your doctor will advise you to stop taking MECOBAL PLUS CAPSULE gradually over a period of at least one week.

Q: Can MECOBAL PLUS CAPSULE discontinuation cause withdrawal symptoms?

A: After stopping MECOBAL PLUS CAPSULE treatment, you may experience certain side effects like trouble sleeping, headache, nausea, anxiety, diarrhoea, flu-like symptoms, fits, nervousness, depression, pain, sweating and dizziness. There are more chances of getting these symptoms if you have been taking this medicine for a longer period. If you have any further doubts regarding the use of MECOBAL PLUS CAPSULE, ask your doctor.

Q: How should MECOBAL PLUS CAPSULE be taken? Can it be crushed?

A: No. Do not break, crush or chew MECOBAL PLUS CAPSULE. Take it as advised by your physician. Swallow it with a glass of water. Your doctor will determine the correct dose and duration for you based on your age, body weight and disease condition.

REFERENCES

1. KD Tripathi. Antiepileptic Drugs. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 420, 608.

2. Serhiyenko V, Serhiyenko L, Suslik G et al. Alpha-lipoic acid: mechanisms of action and beneficial effects in the prevention and treatment of diabetic complications. MOJ Public Health. MedCrave. July 2018. [Accessed on 2nd August 2022] https://medcraveonline.com/MOJPH/alpha-lipoic-acid-mechanisms-of-action-and-beneficial-effects-in-the-prevention-and-treatment-of-diabetic-complications.html

3. Kang WB, Chen YJ, Lu DY, Yan JZ. Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration and secretion of nerve growth factor. NIH National Library of Medicine, National centre for biotechnology information. PubMed Central. January 2019. [Accessed on 2nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263007/

4. Vasudevan D, Naik MM, Mukaddam QI. Efficacy and safety of methylcobalamin, alpha lipoic acid and pregabalin combination versus pregabalin monotherapy in improving pain and nerve conduction velocity in type 2 diabetes associated impaired peripheral neuropathic condition. [MAINTAIN]: Results of a pilot study. NIH National Library of Medicine, National canter for biotechnology information. PubMed Central. January 2014. [Accessed on 2nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992764/

5. Innova Captab Ltd. Alpha Lipoic Acid + Methylcobalamin + Folic Acid + Pregabalin + Pyridoxine. [Revised in May 2021] [Accessed on 2nd August 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2732.pdf

6. Micro Labs Ltd. Alpha Lipoic Acid + Methylcobalamin + Folic Acid + Pregabalin + Pyridoxine. [Accessed on 2nd August 2022] https://www.microlabsltd.com/elibrary/node/1891

USEFUL DIAGNOSTIC TESTS

  • Nerve conduction testing
  • Electromyography

PRODUCT DETAILS

    Country Of Origin
    India
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

MECOBAL PLUS Capsule 10's

MECOBAL PLUS Capsule 10's Mkt: Rapross Pharmaceuticals (P) Ltd

M.R.P.: Rs.162.50
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