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Introduction About MAXVOID PLUS 8/0.5MG TABLET
MAXVOID PLUS 8/0.5MG TABLET is a combination of Silodosin + Dutasteride formulated to provide effective relief from urinary symptoms caused by an enlarged prostate (Benign Prostatic Hyperplasia). It helps alleviate signs like frequent urination, especially at night (nocturia), a weak or interrupted urine flow, difficulty starting urination, and a feeling of incomplete bladder emptying.
Take MAXVOID PLUS 8/0.5MG TABLET at the same time every day, swallowing it whole without breaking, chewing, or crushing it. Your doctor will determine the appropriate dosage for you. To maximize its effectiveness, take it consistently and avoid missing doses, even if you feel better. It may take up to 4 weeks to notice significant symptom relief. If your symptoms do not improve or worsen, inform your doctor.
This medication is not suitable for women or children. Before taking MAXVOID PLUS 8/0.5MG TABLET, inform your doctor if you have low blood pressure, or liver or kidney conditions, as it may not be appropriate for you. Additionally, it can interact with other medications, so ensure your doctor is aware of all medicines you are taking.
You may be advised to use condoms during sexual activity and to monitor your blood pressure regularly. Speak with your healthcare provider if you consume alcohol, as it could affect how this medicine works.
Men taking MAXVOID PLUS 8/0.5MG TABLET should not donate blood for at least 6 months after their last dose, in order to manage the exposure of the medicine to pregnant women via blood transfusion. Avoid consumption of alcohol while taking MAXVOID PLUS 8/0.5MG TABLET, as it may lower your blood pressure.
The most common side effects of this medicine include reduced libido, difficulty achieving an erection (impotence), breast tenderness, and breast enlargement.
Dizziness and drowsiness may also occur, especially when starting the treatment. If these side effects persist or bother you, consult your doctor for guidance. Remember, the benefits of this medicine are considered to outweigh the risks of potential side effects.
Uses Of MAXVOID PLUS 8/0.5MG TABLET
Urinary symptoms of benign prostatic hyperplasia such as:
- Frequent urination
- Weak Urine Flow
- Difficulty Starting Urination
- Incomplete Bladder Emptying
- Urgency to Urinate
- Dribbling After Urination
- Straining During Urination
- Urinary Retention
Benefits of MAXVOID PLUS 8/0.5MG TABLET in BPH:
- Relieves difficulty in urination
- Improves urine flow and bladder control
- Reduces frequent nighttime urination (nocturia)
- Helps shrink the enlarged prostate gland over time
How MAXVOID PLUS 8/0.5MG TABLET Works
MAXVOID PLUS 8/0.5MG TABLET is a combination of two active ingredients, Silodosin and Dutasteride, that work together to manage the symptoms of an enlarged prostate (Benign Prostatic Hyperplasia or BPH):
- Silodosin: This is an alpha-blocker that relaxes the muscles in the prostate gland and bladder neck. By improving muscle relaxation, it helps enhance urine flow and reduces urinary symptoms such as frequent urination, difficulty starting urination, and incomplete bladder emptying.
- Dutasteride: This is a 5-alpha reductase inhibitor that reduces the production of dihydrotestosterone (DHT), a hormone responsible for prostate growth. Over time, this helps shrink the prostate gland, alleviating pressure on the bladder and urethra.
By combining these actions, MAXVOID PLUS 8/0.5MG TABLET effectively manages urinary symptoms of BPH, improving quality of life and reducing the risk of complications like urinary retention. For best results, it should be taken as prescribed by your doctor.
How to use MAXVOID PLUS 8/0.5MG TABLET
- Take MAXVOID PLUS 8/0.5MG TABLET once daily, preferably after a meal to reduce the risk of stomach upset.
- Swallow the medicine with a glass of water. Do not crush or chew.
- Consistency is key for best results, take at the same time every day.
Dosage and Administration:
- Initial Dosage: One dose per day, as directed by your physician.
- Adjustments: Dosage adjustments should only be made under a doctor's supervision based on your condition and response to treatment.
- Duration: Follow your healthcare provider’s recommendation for how long you should take MAXVOID PLUS 8/0.5MG TABLET.
Missed Dosage Instructions for MAXVOID PLUS 8/0.5MG TABLET:
- If you forgot a dose of MAXVOID PLUS 8/0.5MG TABLET, take it as soon as you remember, unless it is almost time for the next dose.
- Do not take two doses at once to make up for a missed dose.
Overdosage instructions for MAXVOID PLUS 8/0.5MG TABLET:
- In case of an overdose, contact your doctor or seek emergency medical attention immediately.
- Symptoms of overdose may include dizziness, fainting, and abnormal heartbeats.
- Treatment of overdose may involve supportive care depending on the severity of the symptoms.
Misuse, Drug Abuse, and Dependence:
- MAXVOID PLUS 8/0.5MG TABLET is not intended for misuse or abuse. It is a prescription medication that should only be used as directed by your healthcare provider.
- There is no known risk of physical dependence or addiction with MAXVOID PLUS 8/0.5MG TABLET, but misuse can lead to ineffective results or side effects.
Side Effects Of MAXVOID PLUS 8/0.5MG TABLET
Like all medicines MAXVOID PLUS 8/0.5MG TABLET may cause certain side effects, although not everybody gets them.
Common side effects of MAXVOID PLUS 8/0.5MG TABLET are
- Dizziness, Headache
- Ejaculation Problems
- Fatigue
- Decreased Libido
- Breast Tenderness, breast enlargement or pain
- Nausea, abdominal discomfort, or diarrhea
- trouble getting or keeping an erection (impotence)
- nasal congestion
- low blood pressure while standing up from sitting or lying position
When to Consult your doctor?
Stop taking MAXVOID PLUS 8/0.5MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- Allergic Reactions: Severe allergic reactions like rash, itching, or swelling of the face or throat may occur, though rare. If any of these signs occur, immediate medical attention is necessary.
- Breast Changes: Rarely, users may experience more noticeable breast enlargement or tenderness.
- Prolonged Erection (Priapism): A rare but serious side effect that requires immediate medical attention if an erection lasts more than 4 hours.
How To Manage Side Effects
Dizziness Or Drowsiness
- Rise Slowly: Avoid sudden movements. When standing up from a sitting or lying position, do so slowly to help prevent dizziness caused by a drop in blood pressure.
- Stay Hydrated: Drink plenty of fluids throughout the day to help prevent dehydration, which can worsen dizziness.
- Rest in a Comfortable Position: If you feel dizzy, sit or lie down in a comfortable position until the sensation passes. Avoid walking or performing any tasks that require balance when you're feeling dizzy.
- Avoid Alcohol: Alcohol can exacerbate dizziness and interact with Silofast D Capsule, so it's best to avoid it while on the medication.
- Avoid Overexertion: Rest and avoid strenuous physical activities that could trigger or worsen dizziness.
- Monitor Your Blood Pressure: Dizziness can be a sign of low blood pressure, which may occur with Tamsulosin. Keep track of your blood pressure regularly, and consult your doctor if it becomes too low.
- Consult Your Doctor: If dizziness persists or becomes bothersome, contact your healthcare provider. They may adjust your dosage or recommend an alternative treatment.
These measures can help alleviate mild dizziness at home, but if symptoms worsen or don't improve, it's important to seek medical advice.
Warning & Precautions
Pregnancy
ContraindicatedMAXVOID PLUS 8/0.5MG TABLET is not recommended for use during pregnancy, particularly due to the presence of Dutasteride. Dutasteride can harm a developing fetus, especially male fetuses, as it may affect the development of the male reproductive organs. If you are pregnant or planning to become pregnant, consult your doctor before using this medication.
Breastfeeding
ContraindicatedIt is not known whether MAXVOID PLUS 8/0.5MG TABLET passes into breast milk. Due to potential risks to the infant, this medicine is generally not recommended for use while breastfeeding. Always discuss with your healthcare provider before taking this medication if you are breastfeeding.
Driving and Using Machines
Use with CautionDo not drive or handle any machines if you experience low blood pressure when standing up from sitting or lying position (with or without symptoms such as dizziness). Consult your doctor before taking MAXVOID PLUS 8/0.5MG TABLET.
Alcohol
ContraindicatedConsumption of alcohol is not recommended while taking MAXVOID PLUS 8/0.5MG TABLET, as it may lower your blood pressure.
Kidney
Consult your doctorMAXVOID PLUS 8/0.5MG TABLET is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients with moderate kidney impairment. In such patients, treatment should be started at low doses and gradually increased with close medical monitoring. Therefore, inform your doctor as a precaution.
Liver
Consult your doctorMAXVOID PLUS 8/0.5MG TABLET is not recommended for use in patients with severe liver impairment. It should be used with caution in patients with liver problems. Therefore, inform your doctor as a precaution.
Allergy
ContraindicatedDo not take MAXVOID PLUS 8/0.5MG TABLET if you are allergic (hypersensitive) to Silodosin or Dutasteride or other 5 alpha-reductase inhibitors such as finasteride.
Use In Pediatrics
ContraindicatedMAXVOID PLUS 8/0.5MG TABLET is not recommended for use in children and adolescents (below 18 years of age) due to lack of safety and efficacy information.
Use In Geriatrics
Use with CautionMAXVOID PLUS 8/0.5MG TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking MAXVOID PLUS 8/0.5MG TABLET.
Others
Before taking MAXVOID PLUS 8/0.5MG TABLET, inform your physician if you:
- have low blood pressure
- planned for cataract surgery or other procedures involving the eyes
Safety Advice
Expert Advice to Maximize the Effects of MAXVOID PLUS 8/0.5MG TABLET:
- Follow Your Doctor’s Instructions: Take MAXVOID PLUS 8/0.5MG TABLET exactly as prescribed. Do not change your dose or stop the medication without consulting your doctor, even if you feel better, to ensure consistent results and prevent symptom recurrence.
- Establish a Routine: Take the medicine at the same time every day to maintain consistency. Skipping doses can reduce effectiveness and delay symptom improvement.
- Take with a Light Meal: For better absorption, take MAXVOID PLUS 8/0.5MG TABLET with a light meal. Avoid high-fat meals as they may increase drug levels and the risk of side effects.
- Monitor Blood Pressure: Silodosin may cause dizziness or low blood pressure, especially at the start of treatment. Regularly check your blood pressure, particularly if you take antihypertensive medications. Consult your doctor if you feel faint or dizzy.
- Stay Hydrated: Drink plenty of water to help prevent urinary discomfort and manage BPH symptoms.
- Limit Alcohol: Alcohol can increase the risk of side effects like dizziness and drowsiness when combined with MAXVOID PLUS 8/0.5MG TABLET. Limit or avoid alcohol during treatment.
- Avoid Grapefruit: Grapefruit and its juice can interfere with the medication's metabolism, increasing the risk of side effects. Avoid grapefruit while taking MAXVOID PLUS 8/0.5MG TABLET.
- Regular Check-ups: Keep regular appointments with your doctor to track progress and adjust treatment as needed. It may take several weeks to see significant symptom relief.
- Inform Your Doctor About Other Medications: Always inform your doctor about any other medications, including over-the-counter drugs and supplements, to avoid drug interactions that may affect the effectiveness or increase the risk of side effects.
Interactions
Drug-Drug interactions:
- Alpha-blockers: When MAXVOID PLUS 8/0.5MG TABLET is taken with other alpha-blockers (e.g., Tamsulosin), the risk of low blood pressure (hypotension), dizziness, and fainting increases. Combining these medications may lead to a stronger reduction in blood pressure.
- CYP3A4 Inhibitors: Drugs such as Ketoconazole, Itraconazole, and certain antifungal medications can increase Silodosin levels in the body, potentially leading to an increased risk of side effects like dizziness, drowsiness, and low blood pressure.
- CYP3A4 Inducers: Drugs like Rifampin, Carbamazepine, and certain anticonvulsants can reduce the effectiveness of Silodosin by increasing its metabolism, decreasing its therapeutic effects.
- Prostate Cancer Medications: Combining MAXVOID PLUS 8/0.5MG TABLET with other medications used to treat prostate cancer, such as Finasteride, may cause an overlap in their effects, leading to increased risks of side effects or complications related to prostate gland activity.
- Antihypertensives: Combining MAXVOID PLUS 8/0.5MG TABLET with blood pressure-lowering medications (e.g., ACE inhibitors, Beta-blockers) may lead to an excessive drop in blood pressure, resulting in dizziness, lightheadedness, and fainting, particularly when standing up.
Drug-Food Interactions
- Grapefruit: Grapefruit and grapefruit juice can affect the metabolism of Silodosin, increasing its levels in the bloodstream. This can heighten the risk of side effects like dizziness, fatigue, and hypotension. It’s best to avoid grapefruit products while taking MAXVOID PLUS 8/0.5MG TABLET.
- Fatty Foods: Consuming high-fat meals with MAXVOID PLUS 8/0.5MG TABLET may increase the absorption of Silodosin, leading to higher levels of the drug in the body and a greater likelihood of side effects. It’s advisable to take this medication with a light meal.
- Alcohol: Alcohol can increase the risk of side effects like dizziness, drowsiness, and low blood pressure when combined with MAXVOID PLUS 8/0.5MG TABLET. It’s recommended to limit alcohol intake while on this medication.
Synopsis
| Drug | : | Silodosin and Dutasteride |
| Pharmacological Category | : | Alpha-blockers and 5-alpha-reductase inhibitor |
| Therapeutic Indication | : | Benign prostatic hyperplasia |
| Dosage Forms | : | Tablet, Capsule |
More Information
Lifestyle Changes to Complement MAXVOID PLUS 8/0.5MG TABLET for BPH:
- Stay Active: Engage in regular physical activity, such as walking or swimming, to improve urinary function and overall health.
- Maintain a Healthy Weight: Losing excess weight can reduce pressure on the prostate and improve urinary symptoms.
- Limit Caffeine and Alcohol: These can irritate the bladder and worsen urinary symptoms. Consider reducing or eliminating them from your diet.
- Practice Bladder Training: Try to extend the time between urinations gradually to improve bladder control.
- Stay Hydrated: Drink plenty of water throughout the day, but reduce fluid intake before bed to avoid frequent nighttime urination (nocturia).
- Manage Stress: Practice relaxation techniques such as deep breathing, meditation, or yoga to reduce stress, which can negatively impact urinary health.
- Avoid Heavy Lifting: Straining can worsen BPH symptoms. Practice good posture and avoid heavy lifting that can put pressure on the pelvic area.
- Eat a Balanced Diet: A diet rich in fruits, vegetables, and healthy fats can support prostate health and overall well-being.
- Quit Smoking: Smoking can worsen urinary symptoms and impact circulation. Quitting may improve overall health and symptoms of BPH.
FAQs About MAXVOID PLUS 8/0.5MG TABLET
Q: What is MAXVOID PLUS 8/0.5MG TABLET used for?
A: MAXVOID PLUS 8/0.5MG TABLET is primarily used for managing benign prostatic hyperplasia (BPH), a condition characterized by an enlarged prostate. It combines silodosin (an alpha-blocker) and Dutasteride (a 5-alpha reductase inhibitor) to reduce prostate size and improve urinary flow, alleviating BPH symptoms like frequent urination and difficulty in urination.
Q: What are MAXVOID PLUS 8/0.5MG TABLET benefits for prostate enlargement?
A: MAXVOID PLUS 8/0.5MG TABLET helps reduce the size of an enlarged prostate, improving urinary symptoms associated with benign prostatic hyperplasia (BPH). It works by relaxing the muscles around the prostate and bladder and inhibiting the hormone responsible for prostate growth. This results in better urine flow, reduced urgency, and fewer nighttime bathroom visits.
Q: How does MAXVOID PLUS 8/0.5MG TABLET work for BPH?
A: MAXVOID PLUS 8/0.5MG TABLET works by combining two active ingredients: Dutasteride+Silodosin. Silodosin relaxes the muscles in the prostate and bladder, making it easier to urinate, while Dutasteride inhibits the enzyme that converts testosterone into dihydrotestosterone, the hormone responsible for prostate growth. Together, these actions relieve BPH symptoms and reduce the size of the prostate.
Q: What are the side effects of MAXVOID PLUS 8/0.5MG TABLET?
A: Common side effects of MAXVOID PLUS 8/0.5MG TABLET include dizziness, especially when standing up quickly, fatigue, headaches, decreased libido, and sexual side effects like difficulty with ejaculation. Some men may also experience breast tenderness or enlargement due to Dutasteride. Serious side effects like allergic reactions or priapism (prolonged erection) are rare but require immediate medical attention.
Q: Is MAXVOID PLUS 8/0.5MG TABLET effective for BPH symptoms?
A: Yes. MAXVOID PLUS 8/0.5MG TABLET is highly effective in manging BPH symptoms. It reduces prostate size and improves urinary flow, helping with common symptoms like frequent urination, urgency, and difficulty starting urination. The combination of Tamsulosin and Dutasteride offers a dual-action approach for managing benign prostatic hyperplasia (BPH).
Q: Can MAXVOID PLUS 8/0.5MG TABLET cause sexual side effects and libido?
A: MAXVOID PLUS 8/0.5MG TABLET may cause sexual side effects, including a reduction in libido (sexual desire) and changes in ejaculation, such as reduced semen volume. These side effects are primarily associated with Dutasteride, but they tend to improve over time or upon discontinuation of the medication.
Q: What happens if you forgot a dose of MAXVOID PLUS 8/0.5MG TABLET?
A: If you forget a dose of MAXVOID PLUS 8/0.5MG TABLET, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose, as this can increase the risk of side effects.
Q: Can MAXVOID PLUS 8/0.5MG TABLET cause dizziness or fatigue?
A: Yes, MAXVOID PLUS 8/0.5MG TABLET may cause dizziness and fatigue, especially when standing up quickly due to the effects of silodosin on blood pressure. To minimize dizziness, it is advised to rise slowly from a sitting or lying position. If fatigue or dizziness persists, consult your healthcare provider for adjustments.
Q: Can MAXVOID PLUS 8/0.5MG TABLET be used for long-term?
A: MAXVOID PLUS 8/0.5MG TABLET is generally considered safe for long-term use, especially for managing benign prostatic hyperplasia (BPH). However, it is important to have regular check-ups with your healthcare provider to monitor your response to the medication and adjust the dosage if necessary.
Q: Is MAXVOID PLUS 8/0.5MG TABLET safe for older adults?
A: MAXVOID PLUS 8/0.5MG TABLET can be used by older adults, but they may be more sensitive to the effects of the medication, particularly dizziness or fatigue. It is essential for older patients to start with the lowest effective dose and regularly monitor for any side effects. Always consult with a healthcare provider for appropriate adjustments.
Q: MAXVOID PLUS 8/0.5MG TABLET vs Finasteride: Which is better for BPH?
A: Both MAXVOID PLUS 8/0.5MG TABLET and Finasteride are used for managing BPH, but MAXVOID PLUS 8/0.5MG TABLET combines two medications: silodosin (for muscle relaxation) and Dutasteride (for inhibiting prostate growth). Finasteride is a single-drug therapy that also targets DHT. MAXVOID PLUS 8/0.5MG TABLET may provide faster symptom relief by combining both mechanisms. Your healthcare provider can recommend the best treatment based on individual needs.
Q: Can MAXVOID PLUS 8/0.5MG TABLET help with prostate cancer prevention?
A: MAXVOID PLUS 8/0.5MG TABLET is not intended for prostate cancer prevention. While Dutasteride may reduce the risk of developing prostate cancer by lowering DHT levels, MAXVOID PLUS 8/0.5MG TABLET is primarily used to manage benign prostatic hyperplasia. Always consult your healthcare provider about cancer prevention strategies and treatments.
Q: Can MAXVOID PLUS 8/0.5MG TABLET cause infertility?
A: MAXVOID PLUS 8/0.5MG TABLET can cause sexual impotence, decreased sex drive, or difficulty in ejaculation in men because it reduces the sperm count, semen volume, and sperm movement. Consult your doctor if this bothers you.
References
- KD. Tripathi. Antiadrenergic Drugs and Drugs for Glaucoma & Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 142-144 & 303
- Iram Kahkashan, Shabnam Chawdhary, Vishal R. Tandon, Rahul Gupta. To compare the efficacy and safety of silodosin and dutasteride combination with alfuzosin and dutasteride combination in patients of benign prostatic hyperplasia: a randomized, open label study. International journal of basic & clinical pharmacology (IJBCP). 2019. [Accessed on 25th August 2021] click here
- Cipla House. Swiss Garnier Genexiaa Sciences Pvt. Ltd. [Revised in February 2021] [Accessed on 25th August 2021] click here
- APL Swift Services (Malta) Limited or Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in August 2019] [Accessed on 25th August 2021] click here
- Recordati S.p.A. European Medicines Agency (EMA). [Accessed on 25th August 2021] click here
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