INTRODUCTION

MARZON contains Sultamicillin which belongs to a group of medicines called beta-lactamase inhibitors. It is indicated to treat upper respiratory tract infections including sinusitis, otitis media and tonsillitis, lower respiratory tract infections including bacterial pneumonias and bronchitis, urinary tract infections, pyelonephritis, skin and soft tissue infections and gonococcal infections. It may also be indicated in patients requiring sulbactam/ampicillin therapy following initial treatment with sulbactam/ampicillin IM/IV.

Sultamicillin is a codrug of ampicillin and sulbactam. After oral administration, it is absorbed and hydrolytically cleaved to ampicillin and sulbactam by enzymes in the gut wall. It is a semi-synthetic orally active broad-spectrum penicillin antibiotic, exerts antibacterial activity against sensitive organisms by inhibiting biosynthesis of cell wall mucopeptide. Sulbactam is a beta-lactamase inhibitor, irreversibly inhibits many beta-lactamases which occur in resistant bacteria strains.

Always take MARZON exactly as directed by your doctor. Tell your physician if you have liver, kidney or heart problems, pregnant women and breastfeeding mothers. Your physician will give the right dose depends on your child’s age and body weight. The common side effects are vomiting, headache, nausea and diarrhoea.

USES OF MARZON

• Treats upper respiratory tract infections including sinusitis, otitis media and tonsillitis, lower respiratory tract infections including bacterial pneumonias and bronchitis, urinary tract infections, pyelonephritis, skin and soft tissue infections and gonococcal infections

HOW MARZON WORKS

MARZON works by killing the bacteria by preventing them from forming the bacterial protective covering which has enhanced activity against bacteria and less antibiotic resistance.

DIRECTIONS FOR USE

Always take MARZON exactly as your doctor has told you. Swallow as whole, with a glass of water. Do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF MARZON

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Ask your doctor to recommend a painkiller.

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Diarrhoea:

Drink more fluids to avoid dehydration. ORS should be used to prevent dehydration.

Vomiting:

Drink clear or ice-cold drinks and take light, bland foods and avoid fried and sweet foods.

Abdominal pain:

Place a warm water bottle on abdomen or soak in a warm bath. Drink plenty of clear fluids and water.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking,

• allopurinol
• anticoagulants
• chloramphenicol, erythromycin, sulfonamides and tetracyclines
• estrogen-containing oral contraceptives
• methotrexate
• probenecid

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT MARZON

What if I forget to take a dose of MARZON?

If you forget a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose.

Can the use of MARZON cause diarrhea?

Yes, it may cause diarrhea in some individuals consult your doctor for advice.

Can I stop taking MARZON when I feel better?

No, do not stop taking this medicine without talking to your doctor even if you feel better.

REFERENCES

1. KD Tripathi MD. Beta-lactam antibiotics. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 725.

2. H A Friedel 1, D M Campoli-Richards, K L Goa. Sultamicillin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. April 1989; [Accessed on May 10, 2021] https://pubmed.ncbi.nlm.nih.gov/2661196/

3. Pfizer Global Supply Japan Inc. [Revised on Nov, 2019] [Accessed on May 10, 2021] http://labeling.pfizer.com/ShowLabeling.aspx?id=12271

4. Pfizer Global Supply Japan Inc. [Revised on June, 2017] [Accessed on May 10, 2021] https://www.pfizerpro.com.my/sites/default/files/lpd_sultamicillin_sultamicillin_tosilate_-_unasyn_oral_-_mys_-_english_3.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count
• Peripheral Smear Examination