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INTRODUCTION
LOROX P TABLET is a combination of Lornoxicam and Paracetamol which belongs to the group of medicines called Non-steroidal Anti-inflammatory drugs (NSAIDs) and Analgesics and Antipyretics respectively. It is used to treat pain and inflammation in conditions such as rheumatoid arthritis (chronic inflammatory condition of joints), ankylosing spondylitis (chronic inflammatory disease of the spine) and osteoarthritis (degenerative joint disease).
Also, it is used to treat low back pain, post operative pain, acute sciatica (nerve pain from an injury or irritation to the sciatic nerve), muscle and musculoskeletal pain.
LOROX P TABLET is not recommended for use if you have gastrointestinal bleeding, ulceration of the stomach and salicylate sensitivity. Before taking LOROX P TABLET, inform your doctor if you have ulcerative colitis or crohn’s disease (intestinal disease), history of bleeding tendency or having systemic lupus erythematosus (rare immunological disorder).
LOROX P TABLET is not recommended for use in patients with severe liver or kidney impairment and heart problems. [ GBNKEYWORD] is not recommended for use in pregnant and breast-feeding women.
LOROX P TABLET is not recommended for use in children and adolescents (under 18 years of age). It should be used with caution in elderly patients (aged above 65 years and above). Consult your doctor before taking it.
The most common side effects of taking LOROX P TABLET are nausea, vomiting, indigestion, stomach pain and diarrhoea. Consult your doctor if any of the side effect worsens.
USES OF LOROX P TABLET
Treats,
- muscle and musculoskeletal pain
- lower back pain
- postoperative pain
- rheumatoid arthritis and osteoarthritis
- ankylosing spondylitis
- acute sciatica
HOW LOROX P TABLET WORKS
LOROX P TABLET acts as an anti-inflammatory agent as well as painkiller. It works by inhibiting the production of a chemical called prostaglandins in the body which are responsible for causing pain and swelling in the body. As a result, it reduces various pain and swelling in joints.
DIRECTIONS FOR USE
Take LOROX P TABLET as advised by your physician. Swallow LOROX P TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF LOROX P TABLET
COMMON
- nausea, vomiting
- indigestion
- stomach pain
- diarrhoea
RARE
Stop taking LOROX P TABLET and contact your doctor immediately if you experience any of the following side effects:
- shortness of breath, chest pain or swelling of ankle
- severe or continuous stomach pain or your stools become black
- signs of liver problems (such as yellowing of the skin and eyes (jaundice))
- allergic reaction (signs include skin problems such as ulcers or blistering or swelling of the face, lips, tongue or throat which may cause difficulty in breathing)
- stevens-johnson syndrome (signs include fever, blistering eruption or inflammation especially on hands and feet or in the mouth area)
- experience any unusual abdominal symptoms such as abdominal bleeding
- skin reactions (such as skin rash, damage to the internal lining of the nostrils, mouth, eyelids, ears, genitals or anus)
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Consult your doctor if the symptom does not improve.
Nausea And Vomiting
Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedLOROX P TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
BREASTFEEDING
ContraindicatedLOROX P TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionLOROX P TABLET has no influence on the ability to drive or use machinery.
KIDNEY
Consult your doctorLOROX P TABLET is not recommended in patients with severe kidney impairment and it should be used with caution in patients with impaired kidney function. Consult your doctor before taking it.
LIVER
ContraindicatedLOROX P TABLET is not recommended for use in patients with severe liver impairment. Consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take LOROX P TABLET if you are allergic to Lornoxicam and Paracetamol.
LUNGS
Use with CautionLOROX P TABLET should be taken with caution in patients suffering from asthma. Consult your doctor before taking it.
HEART DISEASE
LOROX P TABLET is not recommended for use in patients with severe heart failure. It should be taken with caution in patients having high blood pressure and high blood pressure. Consult your doctor before taking it.
OTHERS
LOROX P TABLET is not recommended for use if you:
- have gastrointestinal bleeding, rupture and bleeding of a blood vessel in the brain or other bleeding disorders
- have stomach ulceration
- have salicylate sensitivity
- have thrombocytopenia (low blood platelet count which increases risk of bleeding or bruising)
Before taking LOROX P TABLET, inform your doctor if you:
- have ulcerative colitis or crohn’s disease (intestinal disease)
- have a history of bleeding tendency
- have systemic lupus erythematosus (rare immunological disease)
Use in paediatrics:
LOROX P TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
LOROX P TABLET should be used with caution in elderly patients (aged above 65 years and above). Consult your doctor before taking it.
INTERACTIONS
A. Drug - Drug interactions:
Before taking LOROX P TABLET, inform your doctor if you are taking any of the following medicines:
- cimetidine (used to treat stomach acidity)
- anti-coagulants (medicines used to prevent clotting of blood) Ex. heparin, warfarin
- sulfonylureas (medicines used to treat increased blood sugar levels) Ex. glimepiride, glyburide
- methotrexate (used to treat cancer)
- diuretics (medicine used to treat water retention in the body) Ex. furosemide
- digoxin (used to treat heart problems)
- ciclosporin (medicine used to prevent organ rejection after transplantation)
- angiotensin-converting-enzyme inhibitors (medicine used to treat blood pressure) Ex. enalapril, captopri
Overdosage:
If you or anyone else accidentally take too much of LOROX P TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of LOROX P TABLET includes nausea, vomiting, dizziness, disturbance in vision and liver damage.
SYNOPSIS
| Drug | : | Lornoxicam, Paracetamol |
| Pharmacological Category | : | Non-steroidal Anti-inflammatory drugs (NSAIDs), Analgesics and Antipyretics |
| Therapeutic Indication | : | Pain and inflammation |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- keep LOROX P TABLET out of reach of children
- Store at room temperature
FAQs ABOUT LOROX P TABLET
Q: How does LOROX P TABLET work?
A: LOROX P TABLET acts as an anti-inflammatory agent as well as painkiller. It works by inhibiting the production of a chemical called prostaglandins in the body which are responsible for causing pain and swelling in the body. As a result, it reduces various pain and swelling in joints.
Q: Can LOROX P TABLET be used in pregnant and breast-feeding women?
A: LOROX P TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant or breast-feeding your child.
Q: Is LOROX P TABLET safe to use in patients with kidney problems?
A: LOROX P TABLET is not recommended in patients with severe kidney impairment and it should be used with caution in patients with impaired kidney function. Consult your doctor before taking it.
Q: Can LOROX P TABLET be used in children?
A: LOROX P TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice to select a suitable alternative therapy for your child to treat the specific condition.
Q: Does LOROX P TABLET cause diarrhoea?
A: Yes, LOROX P TABLET may cause diarrhoea in some individuals. To manage this effect, drink lot of fluids such as water or fruit juices to keep yourself hydrated. Do not take any medicine on your own for treating diarrhoea. Consult your doctor if the symptom does not improve.
REFERENCES
1. KD Tripathi. NSAIDS and Anti-pyretic Analgesics. Essentials of Medical Pharmacology. Seventh Edition 2019. Page – 206 & 207
2. Guzel AI, Kuyumcuoglu U, Celik Y. Comparative effect of lornoxicam and paracetamol in pain relief in endometrial sampling. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Accessed on 31st January 2023] https://pubmed.ncbi.nlm.nih.gov/22545424/
3. Takeda UK Limited Health Products Regulatory Authority (HPRA). [Revised in January 2015] [Accessed on 31st January 2023] https://www.hpra.ie/img/uploaded/swedocuments/2161377.PA1547_005_004.8c107a5e-a8cd-4d47-bfce-2b57776096de.000001Xefo%20Rapid.150421.pdf
4. DM Pharma. Lorax (Lornoxicam and Paracetamol Tablet). [Accessed on 31st January 2023] http://dmpharma.co.in/Lornoxicam%20+Paracetamol.html
5. Leeford Healthcare. Lexicam (Lornoxicam and Paracetamol Tablet). [Accessed on 31st January 2023] https://www.leeford.in/product/719/lexicam
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Liver function test
- Kidney function test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 03 Feb 2023 | 11:03 AM(IST)
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