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INTRODUCTION
LIVRITE TABLET is a combination of Acetylcysteine, Alpha Lipoic Acid, Selenomethionine and Silymarin which belongs to the group of medicines called Amino acids, Antioxidant, Amino acids, Flavonolignans respectively. It is used to treat jaundice (yellowish discolouration of skin or whites of the eye), alcoholic liver disorder, and viral hepatitis (infection of the liver causing inflammation or liver damage due to hepatitis A, B, C, D, E viruses).
It also treats alcoholic hepatitis (inflammation of the liver due to excessive alcohol consumption), non-alcoholic fatty liver disease (build-up of fat in the liver due to obesity) and to minimize the hepatotoxic effects of anti-TB chemotherapy.
Avoid consumption of alcohol while taking this medicine. LIVRITE TABLET is not recommended in patients with biliary obstruction. LIVRITE TABLET should be used with caution in patients with liver and kidney disease or on dialysis, high blood pressure, congestive heart failure, stomach ulcer, bleeding problems, undergoing any surgeries, diabetes, thyroid problems, anaemia, cancer, vitamin-B1 (thiamine deficiency).
LIVRITE TABLET is not recommended for use in pregnant and breastfeeding women unless it is considered clearly necessary. The most common side effects of taking LIVRITE TABLET are nausea, vomiting, stomach pain, fever, or skin rashes. Consult your physician if you experience any side effects.
USES OF LIVRITE TABLET
It is used to treat:
- jaundice
- alcoholic liver disorder
- viral hepatitis, alcoholic hepatitis
- non-alcoholic fatty liver disease
- minimize the hepatotoxic effects of anti-TB chemotherapy
HOW LIVRITE TABLET WORKS
LIVRITE TABLET helps to prevent liver damage, where Acetylcysteine, alpha lipoic acids and silymarin acts as an antioxidant and helps to neutralise the free radicals (responsible for liver damage) and selenomethionine acts by stabilizing liver cell membranes, thereby reducing their entry to certain toxic substances. Together they treat liver disease effectively.
DIRECTIONS FOR USE
Take LIVRITE TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Depending on your age, body weight, disease condition, your doctor will fix the correct dose and duration for you.
SIDE EFFECTS OF LIVRITE TABLET
COMMON
- anaphylactoid reactions (such as urticaria, flushing (facial flushing), rash, itching)
- nausea, vomiting, stomach pain
- fever
RARE
Stop taking LIVRITE TABLET and contact your physician immediately if you experience any of the following side effects:
- serious allergic reaction (angioedema) such as skin rash, hives, itching, fever, swelling of the face, tongue, and throat causing difficulty in breathing, chest tightness, wheezing, severe cough, blue colour skin, seizure, low blood pressure, fast heartbeat, or shock
- symptoms of low blood sugar such as headache, hunger, dizziness, tremor, rapid heartbeat, confusion, irritability, nervousness, or sweating
HOW TO MANAGE SIDE EFFECTS
Nausea And Vomiting
Stick to simple meals. Avoid eating oily or spicy food. If the nausea and vomiting does not improve, consult your doctor.
Skin Rash Or Itching
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Contact your doctor if symptoms worsens.
Stomach Pain
Try to rest and relax. Eat small meals but take them frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain did not improve.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredLIVRITE TABLET is not recommended for use in pregnancy or women planning to have a baby unless it is considered clearly necessary. Contact your doctor before taking LIVRITE TABLET.
BREASTFEEDING
Monitoring requiredLIVRITE TABLET is not recommended for use in breastfeeding women unless it is considered clearly necessary. Contact your doctor before taking LIVRITE TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking LIVRITE TABLET.
KIDNEY
Use with CautionLIVRITE TABLET should be used with caution in patients with kidney disease or on dialysis. Contact your doctor before taking LIVRITE TABLET.
LIVER
ContraindicatedLIVRITE TABLET is not recommended in patients with biliary obstruction. Contact your doctor before taking LIVRITE TABLET.
ALLERGY
ContraindicatedDo not take LIVRITE TABLET if you are allergic to Acetylcysteine or Alpha Lipoic Acid or Selenomethionine or Silymarin or to other ingredients of this medicine.
LUNGS
Use with CautionLIVRITE TABLET should be used with caution in asthmatic patients. Contact your doctor before taking LIVRITE TABLET.
HEART DISEASE
Use with CautionLIVRITE TABLET should be used with caution in patients with high blood pressure, or congestive heart failure. Contact your doctor before taking LIVRITE TABLET.
OTHERS
Before taking LIVRITE TABLET, inform your doctor if you have:
- stomach ulcer
- bleeding problems
- any surgeries
- diabetes
- thyroid problems
- anaemia
- cancer
- vitamin-B1 (thiamine deficiency
- are on a low salt diet
INTERACTIONS
A. Drug - Drug interactions:
Before taking LIVRITE TABLET inform your doctor if you are taking any of the following medicines:
- nitroglycerin (medicine used to prevent angina)
- activated charcoal (used to treat poisoning)
- chloroquine (medicine used to treat malaria)
- medications used for antihypertensive drugs (high blood pressure) such as captopril, enalapril, lisinopril, ramipril, losartan, valsartan, diltiazem, amlodipine, hydrochlorothiazide, furosemide etc.
- medications used to prevent blood clotting (anticoagulant / antiplatelet drugs) such as aspirin, clopidogrel, dalteparin, enoxaparin, heparin, warfarin, etc.
- diclofenac, ibuprofen, naproxen (medicines used to reduce pain)
- medicines such as insulin or oral diabetes (used to treat diabetes)
- levothyroxine (medicine to treat underactive thyroid)
- medicines used to treat cancer (Ex. busulfan)
Overdosage:
If you or anyone else accidentally takes too much of LIVRITE TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Acetylcysteine, Alpha Lipoic Acid, Selenomethionine, Silymarin |
| Pharmacological Category | : | Amino acids, Antioxidant, Amino acids, flavonolignans |
| Therapeutic Indication | : | Liver disease |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep LIVRITE TABLET out of reach of children.
- Store LIVRITE TABLET below 30°C
FAQs ABOUT LIVRITE TABLET
Q: What is LIVRITE TABLET used for?
A: LIVRITE TABLET is used to treat jaundice, alcoholic liver disorder, viral hepatitis,
alcoholic hepatitis, non-alcoholic fatty liver disease. It can also be used to minimize the hepatotoxic effects of anti-TB chemotherapy. Consult your doctor before taking LIVRITE TABLET.
Q: Can I use LIVRITE TABLET in pregnancy?
A: LIVRITE TABLET is not recommended for use in pregnancy or women planning to have a baby unless it is considered clearly necessary. Contact your doctor before taking LIVRITE TABLET.
Q: How does LIVRITE TABLET work?
A: LIVRITE TABLET helps to prevent liver damage, where Acetylcysteine, alpha lipoic acids and silymarin acts as an antioxidant and helps to neutralise the free radicals (responsible for liver damage) and selenomethionine acts by stabilizing liver cell membranes, thereby reducing their entry to certain toxic substances. Together they treat liver disease effectively.
Q: What are the side effects of taking LIVRITE TABLET?
A: The most common side effects of taking LIVRITE TABLET are nausea, vomiting, stomach pain, or fever. Consult your physician if you experience any side effects.
Q: Who should not take LIVRITE TABLET?
A: LIVRITE TABLET is not recommended in patients with biliary obstruction or allergic history to Acetylcysteine or Alpha Lipoic Acid or Selenomethionine or Silymarin. Contact your doctor before taking LIVRITE TABLET.
REFERENCES
1. Padmaja Udayakumar. Enzymes in Therapy, Antioxidants, Vitamins and Minerals. Pharmacology for Pharmacy Students. 2019. Page: 688.
2. Cathi E. Dennehy, Candy Tsourounis. Dietary Supplements & Herbal Medications. Basic & Clinical Pharmacology. Fourteenth Edition. 2017. Page – 1138.
3. Arif A. Faruqui, Shashikant Pawar, Sanjoy Dasgupta. Efficacy And Tolerability of Fixed Dose Combination of Silymarin, Alpha Lipoic Acid, N-Acetyl Cysteine and Selenium in the Management of Some Liver Disorders. Pacific Journal of Medical Sciences, January 2016. [Accessed on 20th September 2022] https://www.researchgate.net/publication/317162939_Beneficial_Role_of_Silymarin_Alpha_Lipoic_Acid_N-Acetyl_Cysteine_and_Selenium_in_the_Management_of_Liver_Disorders_An_Observational_Post-Marketing_Study_from_India
4. Li S, Tan HY, Wang N, Zhang ZJ, Lao L, Wong CW, Feng Y. The Role of Oxidative Stress and Antioxidants in Liver Diseases. International Journal of Molecular Sciences. NIH, National library of medicine, National center for biotechnology informtatioon. Pubmed Central. November 2015. [Accessed on 20th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661801/
5. Karimi G, Vahabzadeh M, Lari P, Rashedinia M, Moshiri M. "Silymarin", a promising pharmacological agent for treatment of diseases. Iranian Journal of Basic Medical Sciences. NIH, National library of medicine, National center for biotechnology informtatioon. Pubmed Central. July 2011. [Accessed on 20th September 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/
6. Ershad M, Naji A, Vearrier D. N Acetylcysteine. National Institute of Health. NLM. National centre for biotechnology information. StatPearls. June 2022. [Accessed on 20th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK537183/
7. Nguyen H, Gupta V. Alpha-Lipoic Acid. National Institute of Health. NLM. National centre for biotechnology information. StatPearls. November 2021 Accessed on 20th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK564301/
8. Achufusi TGO, Patel RK. Milk Thistle. National Institute of Health. NLM. National centre for biotechnology information. StatPearls. September 2021 Accessed on 20th September 2022] https://www.ncbi.nlm.nih.gov/books/NBK541075/
9. Acetylcysteine, Alpha Lipoic Acid, Selenomethionine and Silymarin. Medley Pharmaceuticals Ltd. [Accessed on 20th September 2022] https://www.medleylab.com/product/suprakare/hepatoprotective.html
10. Acetylcysteine. Rxlist.com [Revised in June 20211] [Accessed on 20th September 2022] https://www.rxlist.com/n-acetyl_cysteine/supplements.htm
11. Acetylcysteine. Drugs.com[Revised in December 2022] [Accessed on 20th September 2022] https://www.drugs.com/mtm/acetylcysteine.html
12. Alpha Lipoic Acid. Drugs.com [Revised in June 2022] [Accessed on 20th September 2022] https://www.drugs.com/mtm/alpha-lipoic-acid.html
13. Alpha Lipoic Acid. Drugs.com [Revised in September 2022] [Accessed on 20th September 2022] https://www.drugs.com/npc/alpha-lipoic-acid.html
14. Selenium. Drugs.com [Revised in June 2022] [Accessed on 20th September 2022] https://www.drugs.com/mtm/selenium.html
USEFUL DIAGNOSTIC TESTS
- Liver Function Test
AUTHOR DETAILS
Written By Dr. Shruthi M R, BDS
Last updated on 11 Feb 2023 | 01:07 PM(IST)
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