LAFARZE Tablet 10's
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Introduction About LAFARZE TABLET
LAFARZE TABLET contains a combination of Diacerein and Gucosamine sulfate potassium chloride which belongs to the group of medicines called Nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to manage osteoarthritis of the knee.
Osteoarthritis is a type of joint degeneration that occurs when the protective cartilage that cushions the ends of the bones wears down over time and generates symptoms such as stiffness, pain in movement, tenderness, swelling, bone spurs, crackling sound while walking.
Before taking LAFARZE TABLET inform your doctor if you have liver, kidney, heart, intestine, abdominal disease, asthma, or suffer from impaired glucose tolerance, or severe issues with the joints. Avoid consumption of alcohol during this management as it can increase liver damage.
LAFARZE TABLET is not recommended for use in pregnant and breastfeeding women. It is not recommended for use in children and adolescents below 18 years of age. LAFARZE TABLET should be used with caution in the elderly above 65 years of age.
The most common side effects of taking LAFARZE TABLET are diarrhea, abdominal pain, flatulence, headache, and nausea. Consult your doctor if symptoms do not show improvement.
Uses Of LAFARZE TABLET
- Manage osteoarthritis of the knee
How LAFARZE TABLET Works
LAFARZE TABLET works by relieving symptoms of osteoarthritis in which diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of osteoarthritis and glucosamine sulfate potassium chloride delays many inflammation-induced catabolic processes in the cartilage and promotes the formation of cartilage.
How to use LAFARZE TABLET
Take LAFARZE TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will decide the right dose and duration depending on your age, body weight and disease condition.
Side Effects Of LAFARZE TABLET
Common
- soft stools
- abdominal pain
- frequent bowel movements
- flatulence
- skin effects such as rash, itching, eczema
- discoloration of urine
- headache, tiredness
- nausea
- indigestion
- constipation
Uncommon
- flushing
- increase in liver enzymes levels in blood tests
- discoloration of colon mucosa
Rare
Stop taking LAFARZE TABLET and contact your doctor immediately if you experience any of the following side effects:
- abdominal pain, jaundice, changes in the color of the urine (from yellow-orange to red or even brown), pigmentation of the intestinal mucosa, reduced consciousness or itching of the skin occur (signs of liver disease)
- severe diarrhea
- swollen face, tongue and/or pharynx and/or difficulty swallowing or hives together with difficulties breathing (angioedema)
How To Manage Side Effects
Bloating
Eat smaller and more frequent meals, and exercise regularly. If the symptom does not show improvement, consult your doctor.
Constipation
Eat lots of fiber-rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not show improvement, consult your doctor.
Diarrhea
Drink lots of water or fruit juice to keep yourself hydrated. If the symptom does not show improvement, consult your doctor.
Headache
Avoid bright lights, drink more water and take a rest. If the symptom does not show improvement, consult your doctor.
Nausea And Vomiting
Stick to simple meals. Avoid eating oily or spicy food. If the symptom does not show improvement, consult your doctor.
Stomach Pain
Eat and drink slowly. Keep a heating pad on your stomach. If the symptom does not show improvement, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedLAFARZE TABLETis not recommended for use in pregnancy or for women planning to be pregnant. Consult your doctor before taking it.
Breastfeeding
ContraindicatedLAFARZE TABLETis not recommended for use in breastfeeding women. Consult your doctor before taking it.
Driving and Using Machines
Use with CautionThe effect of LAFARZE TABLET on driving and using machines has not been established yet, however, if you feel dizzy or sleepy abstain from driving.
Alcohol
ContraindicatedDo not consume alcohol while taking LAFARZE TABLET as it can make increase your liver problems.
Kidney
Use with CautionLAFARZE TABLETshould be used with caution in patients with kidney disease. Consult your doctor before taking it.
Liver
Consult your doctorLAFARZE TABLETis not recommended for use in patients with liver problems. LAFARZE TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.
Allergy
ContraindicatedDo not take LAFARZE TABLET if you are allergic to Diacerein or Gucosamine sulfate potassium chloride or any other ingredients of this medicine.
Lungs
Use with CautionLAFARZE TABLET should be used with caution in patients with asthma. Consult your doctor before taking it.
Heart Disease
Use with CautionLAFARZE TABLET should be used with caution in patients with heart disease. Consult your doctor before taking it.
Use In Pediatrics
ContraindicatedLAFARZE TABLET is not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking it.
Use In Geriatrics
Use with CautionLAFARZE TABLET should be used with caution in the elderly above 65 years of age as they are more vulnerable to diarrheal problems and other side effects. Consult your doctor before taking it.
Others
LAFARZE TABLET is not recommended for use if you:
- are allergic to shellfish, peanuts, soya
Before taking LAFARZE TABLET, inform your doctor if you:
- suffer from impaired glucose tolerance
- have joint swelling, warmth and redness, painfulness, persistent joint stiffness, pain at rest, pain in more than one joint, increased body temperature and decrease in body weight (can be symptoms of rheumatoid arthritis, systemic lupus, gout, tumors)
- suffer ulcerative colitis or Crohn’s disease
- suffer from intestinal obstruction or pseudo-obstruction.
- have abdominal disorders
- intolerant to certain sugars
Interactions
A. Drug-Drug interactions:
Before taking LAFARZE TABLET, inform your doctor if you are taking any of the following medicine:
- warfarin (a medicine used to thin the blood)
- medicines for diabetes (Ex. metformin, glipizide)
- tetracycline (an antibiotic against bacterial infections)
- antacids (medicines for managing stomach acidity)
- a diuretic or cardiac glycosides (Ex. digitoxin, digoxin)
- laxatives (Ex. bisacodyl)
Overdosage:
If you or anyone else accidentally take too much of LAFARZE TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are intense diarrhea, dizziness, headache, nausea, vomiting, constipation, and joint pain.
Synopsis
| Drug | : | Diacerein, Gucosamine |
| Pharmacological Category | : | Anthraquinone, Anti inflammatory |
| Therapeutic Indication | : | Osteoarthritis |
| Dosage Forms | : | Tablet |
More Information
- Keep LAFARZE TABLET out of reach from children
- Store at room temperature
FAQs About LAFARZE TABLET
Q: What is LAFARZE TABLET used for?
A: LAFARZE TABLET is used to manage osteoarthritis of the knee. Osteoarthritis is a type of joint degeneration that occurs when the protective cartilage that cushions the ends of the bones wears down over time and generates symptoms such as stiffness, and pain in movement.
Q: How does LAFARZE TABLET work?
A: LAFARZE TABLET works by relieving symptoms of osteoarthritis in which diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that plays a role in the development of symptoms of osteoarthritis and glucosamine sulfate potassium chloride delays many inflammation-induced catabolic processes in the cartilage and promotes the formation of cartilage.
Q: What if I accidentally take more of LAFARZE TABLET?
A: If you or anyone else accidentally take too much of LAFARZE TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are intense diarrhea, dizziness, headache, nausea, vomiting, constipation, and joint pain.
Q: Can LAFARZE TABLET be used in elderly patients?
A: LAFARZE TABLETshould be used with caution in the elderly above 65 years of age as they are more vulnerable to diarrheal problems and other side effects. Consult your doctor before taking.
Q: Can LAFARZE TABLET be used in children?
A: LAFARZE TABLETis not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking this medicine.
References
1. KD Tripathi. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. Eighth Edition. 2019. Page –220-224.
2. Jörg Jerosch. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. [Accessed on 5th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150191/
3. Johanne Martel-Pelletier. Effects of Diacerein at the Molecular Level in the Osteoarthritis Disease Process. [Accessed on 5th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383474/
4. Chanelle Medical. Health Products Regulatory Authority (HPRA). [Revised in May 2016] [Accessed on 5th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/2171814.PA1521_003_003.1a94fbbc-f593-4a32-a58c-5f8f8bb39b75.000001PIL%201500mg.160824.pdf
5. Chanelle Medical. Health Products Regulatory Authority (HPRA). [Revised in May 2016] [Accessed on 5th August 2022] https://www.hpra.ie/img/uploaded/swedocuments/2171814.PA1521_003_002.cb4ba0a2-1887-4c40-afe6-e19cea656342.000001750mg%20PIL%20.160824.pdf
6. TRB PHARMA S.A. Diacerein [Revised in April 2019] [Accessed on 5th August 2022] https://myhealthbox.eu/en/view/3364878/1066595e9806313ef81279755226ab79/leaflet
7. Trima Israel Pharmaceutical Products Maabarot Ltd. Diacerein. [Revised in November 2015] [Accessed on 5th August 2022] https://myhealthbox.eu/en/view/3529427/469334cbb76f29e848cd1e9f1a64d1ac/leaflet
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