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INTRODUCTION
KUTUB 30 X is a combination of Dapoxetine and Sildenafil which belongs to the group of medicines called Selective serotonin reuptake inhibitors and Phosphodiesterase type 5 (PDE5) inhibitors respectively. It is used to treat premature ejaculation and erectile dysfunction in adult men.
Premature ejaculation is a common sexual dysfunction that occurs when a man ejaculates sperms very early with less sexual stimulation or before he wants to. Erectile dysfunction (also known as impotence) is a sexual condition where a man cannot sustain a hard erected penis which is required for a normal sexual activity.
Dapoxetine is a selective serotonin reuptake inhibitor. It delays ejaculation (release of semen) by increasing the activity of a particular chemical called serotonin in the brain. This promotes control over ejaculation and helps your body to hold sperms for a longer period. Sildenafil is a PDE5 inhibitor. It improves penile functions by relaxing the blood vessels supplying the penis. Collectively they delay sperm release, improve control over ejaculation and penile erections.
KUTUB 30 X is also not suitable for use in healthy men who do not have sexual problems. Take KUTUB 30 X at least one hour before planning to have sex. Avoid taking KUTUB 30 X with heavy meals or with grapefruit juice.
Before taking KUTUB 30 X inform your doctor if you have any previous history of fainting or dizziness due to low blood pressure. You must also inform your doctor if you have epilepsy, lung problems, mental health problems, or bleeding disorders before taking KUTUB 30 X as a precaution. KUTUB 30 X is not recommended for use in patients with liver or heart problems.
The most common side effects of taking KUTUB 30 X are flushing, headache, dizziness, blurred vision, muscle pain, nausea, tiredness, increased sweating, restlessness and decrease in sex drive. Consult your doctor if any of these side effect troubles you.
Also, inform your doctor immediately if you experience any prolonged painful penile erections without sexual stimulation (priapism) or experience dizziness upon standing up suddenly or if you have sudden mood changes or suicidal thoughts after taking KUTUB 30 X.
USES OF KUTUB 30 X
It is used in adult men to treat:
- Premature ejaculation
- Erectile dysfunction
HOW KUTUB 30 X WORKS
KUTUB 30 X effectively improves penile functions and delays sperms release in patients with sexual problems. It contains two medicines called as dapoxetine and sildenafil. Dapoxetine delays ejaculation by blocking the reuptake of a chemical messenger called serotonin between the nerve cells. This increases the activity of serotonin within the brain which therefore increase the time taken to release the semen (ejaculate) during sexual intercourse.
Sildenafil improves penile erections by improving the blood supply to the penis. It works by blocking the effects of certain enzymes (PDE5) in the body that limits blood flow to the penis. As a result, it relaxes the blood vessels supplying the penis, improves penile function and makes it stay erected throughout the process of sexual intercourse.
DIRECTIONS FOR USE
Take KUTUB 30 X as advised by your physician. Swallow KUTUB 30 X with a glass of water. Do not chew or crush the medicine. Take KUTUB 30 X preferably before meals and at least 30 minutes to 1 hour before planning to have sexual intercourse. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
SIDE EFFECTS OF KUTUB 30 X
COMMON
- dizziness, headache
- nausea, vomiting
- feeling irritable, anxious, agitated, or restless
- sensation of numbness, tingling or prickling
- increased sweating
- hot flushes
- diarrhea, constipation, wind, stomach pain
- problems in sleeping or strange dreams, difficulty in concentration
- tiredness or sleepiness
- blocked nose
- a rise in blood pressure
- decrease in sex drive
- ringing in the ears
- blurred vision, color tinge to vision, visual disturbance
- dry mouth
UNCOMMON
- fainting
- change in mood, feeling overly excited or feelings of paranoia (feeling threatened)
- feeling confused, disoriented, or unable to think clearly
- abnormal heartbeat (slow or fast heart rate)
- feeling depressed or nervous
- feeling hot, jittery, abnormal, or drunk
- eye problems (eye irritation, pain or redenss, watery eyes, double vision, abnormal sensation in the eye, seeing light flashes)
- low blood pressure
- feeling itchy or cold sweats
- spinning sensation
- abnormal taste
- skin rash
- muscle pain
- reduced sense of touch
- signs of inflammation of the lining of the nose such as runny nose, sneezing
- upper abdominal pain
- signs of gastro-esophageal reflux disease such as heartburn
- presence of blood in urine or semen
- pain in the arms or legs
- nosebleed
RARE
- penile bleeding
- dry nose
- throat tightness, numbness of mouth
- temporary decrease in blood flow to brain
- sudden decrease or loss of hearing
- sudden onset of sleep (Ex. narcolepsy)
- urge to empty bowel
Stop taking KUTUB 30 X and contact your doctor if you experience any of the following side effects:
- severe allergic reaction (such as wheeziness, difficulty in breathing or dizziness, swelling of the face, lips, eyelids, or throat)
- prolonged or painful erection (priapism)
- chest pain especially during or after sexual intercourse
- severe skin reactions (blistering of skin around the mouth, genitals or eyes, severe peeling and swelling of skin along with fever)
- sudden decline or loss of vision
- fits or seizures
- fainting or light headedness while standing
- mood changes, suicidal thoughts, or a tendency for self-harming
HOW TO MANAGE SIDE EFFECTS
Nausea or Vomiting:
Take KUTUB 30 X with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your vomiting worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens or if you feel dizzy upon standing up suddenly.
Diarrhea:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
WARNING & PRECAUTIONS
PREGNANCY
KUTUB 30 X is not intended for use in women.
BREASTFEEDING
KUTUB 30 X is not intended for use in women.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience dizziness or blurred vision after taking KUTUB 30 X.
ALCOHOL
Avoid consumption of alcohol while taking KUTUB 30 X as it may cause dizziness, or sleepiness.
KIDNEY
KUTUB 30 X should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
LIVER
KUTUB 30 X is not recommended for use in patients with moderate or severe liver diseases. Therefore, consult your doctor before taking it.
ALLERGY
Do not take KUTUB 30 X if you are allergic to Dapoxetine or Sildenafil.
LUNGS
KUTUB 30 X should be used with caution in patients with pulmonary arterial hypertension. Therefore, consult your doctor before taking it.
HEART DISEASE
KUTUB 30 X is not recommended for use in patients with heart problems (such as heart failure, low blood pressure, problems with the heart rhythm). Therefore, consult your doctor before taking it.
OTHERS
KUTUB 30 X is not recommended for use if you:
- have a history of fainting
- have or ever had signs of mania such as feeling overexcited, irritable, or not being able to think clearly
- have severe depression
- have recently had a stroke
- have low blood pressure
- have signs of retinitis pigmentosa (rare inherited eye disease) such as decreased vision at night or in low light and loss of side vision
Before taking KUTUB 30 X, inform your doctor if you:
- have a history of feeling dizzy due to low blood pressure
- have schizophrenia (a psychiatric disease)
- have epilepsy
- have a history of bleeding or blood clotting problems
- have or at risk of developing glaucoma
- have sickle cell anemia (an abnormality of red blood cells)
- have leukemia (cancer of blood cells)
- have multiple myeloma (cancer of bone marrow)
- have a deformity of your penis
- have Peyronie’s disease (development of fibrous scar tissue in the penis that causes painful erection)
- currently have a stomach ulcer
- have bleeding problems such as hemophilia
- are alcoholic
Use in pediatrics:
KUTUB 30 X is not recommended for use in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.
Use in geriatrics:
KUTUB 30 X is not recommended for use in elderly patients (aged 65 years or above). Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug Interaction:
Before taking KUTUB 30 X, inform your doctor, if you are taking any of the following:
- nitrates or amyl nitrites (used for reliving chest pain) Ex. nitroglycerin, isosorbide dinitrite
- other medicines used to treat prostate problems or blood pressure such as alpha blockers (Ex. silodosin, doxazosin)
- riociguat (a medicine used to treat increased pressure in the lungs)
- medicines used to treat depression (Ex. fluoxetine, sertraline, citalopram, escitalopram, amitriptyline, isocarboxazid, selegiline, nefazodone and St. john’s wort)
- thioridazine (a medicine used to treat a mental disorder called schizophrenia)
- lithium (a medicine used to treat bipolar disorder)
- tryptophan (a medicine used to induce sleep)
- medicines used to treat migraines (Ex. almotriptan, sumatriptan)
- non-steroidal anti-inflammatory drugs (used to treat pain and inflammation) Ex. ibuprofen and aspirin
- tramadol (a medicine used to relieve pain)
- antibiotics (used to treat bacterial infections) Ex. telithromycin, linezolid, erythromycin, and clarithromycin
- medicines used to treat HIV infection (Ex. ritonavir, saquinavir, nelfinavir, atazanavir amprenavir and fosamprenavir)
- medicines used to treat fungal infections (such as ketoconazole, itraconazole and fluconazole)
- warfarin (a medicine used to prevent blood clotting)
- other medicines used to treat erectile dysfunction (such as tadalafil or vardenafil)
- medicines used to treat high blood pressure or chest pain (such as verapamil and diltiazem)
- aprepitant (a medicine which is used to treat nausea)
- medicines used to reduce anxiety and alter mental stability (Ex. morphine, pethidine, alprazolam, midazolam, clonazepam, MDMA (ecstasy) or lysergic acid diethylamide)
B. Drug-Food Interactions:
Avoid drinking grapefruit juice within 24 hours prior taking KUTUB 30 X as it may increase the level of KUTUB 30 X in the body. Also, taking KUTUB 30 X with a heavy meal may delay its onset of action.
Overdosage:
If you or anyone else accidentally took more KUTUB 30 X, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, and vomiting.
SYNOPSIS
| Drug | : | Dapoxetine, Sildenafil |
| Pharmacological Category | : | Selective serotonin reuptake inhibitors (SSRI), Phosphodiesterase type 5 inhibitors |
| Therapeutic Indication | : | Premature Ejaculation, Erectile Dysfunction |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep KUTUB 30 X out of reach of children
- Store KUTUB 30 X at room temperature
FAQs ABOUT KUTUB 30 X
What KUTUB 30 X is used for?
KUTUB 30 X is used to treat premature ejaculation and erectile dysfunction in adult men.
How to take KUTUB 30 X?
Take KUTUB 30 X at least 30 minutes to 1 hour before sexual intercourse. It should be taken preferably before meals for faster onset of action. Avoid taking KUTUB 30 X with heavy meals. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.
Can I take KUTUB 30 X daily?
KUTUB 30 X is generally prescribed as one dose per day. However, your doctor will decide whether you can take this medicine daily or not, depending upon your health condition. Do not take KUTUB 30 X more than once a day without consulting your doctor.
How long does it take for KUTUB 30 X to start working?
It may take around 30 minutes to 1 hour for KUTUB 30 X to start working, therefore take this medicine at least one hour before planning to have sex. This time may vary from person to person depending upon their health condition. Avoid taking heavy meals while taking KUTUB 30 X, as it could further delay the onset of action.
Who can take KUTUB 30 X?
KUTUB 30 X can be used in adult men with sexual problems. It is not suitable for use in healthy men who does not have any sexual problems or in men who are not sexually stimulated. It is also not advisable for use in children or adolescents (aged below 18 years).
Is KUTUB 30 X effective?
Yes. KUTUB 30 X effectively improves penile erection (make penis firm) and delays sperm release during sexual intercourse in patients with sexual problems.
Can healthy men consume KUTUB 30 X to improve sexual performance?
KUTUB 30 X is not an aphrodisiac (sex-stimulating agent). It does not induce sexual thoughts or can improve sexual performance/pleasure in healthy men. It would help you to get an erection only if you are sexually stimulated.
What happens if I consume a high dose of KUTUB 30 X than prescribed by my doctor?
Do not consume a higher dose of KUTUB 30 X than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose, does not help you, contact your doctor.
Can men taking KUTUB 30 X father a child?
There is no confirmed proof that KUTUB 30 X could affect fertility in men. However, it is better to consult your doctor before taking KUTUB 30 X if you are planning to father a child.
Is KUTUB 30 X safe?
Yes. KUTUB 30 X is safe to use. But inform your doctor immediately if you experience painful prolonged erection or chest pain after taking KUTUB 30 X. It can also cause headache dizziness, flushing or muscle pain in some individuals. Contact your doctor if they bother you.
Can I consume alcohol while taking KUTUB 30 X?
Avoid consumption of alcohol while taking KUTUB 30 X as it could reduce the effectiveness of KUTUB 30 X.
How long does the effects of KUTUB 30 X would last long?
The effects of KUTUB 30 X would normally last long for 4 hours. However, this time may vary from person to person depending upon their age and health condition. Consult your doctor if the effects of KUTUB 30 X does not last long until sexual intercourse.
Can KUTUB 30 X make you last longer?
Yes. KUTUB 30 X delays the release of sperms (ejaculation) in patients suffering from premature ejaculation.
Will taking KUTUB 30 X affect my sexual life?
Long term use of KUTUB 30 X may negatively impact your sex life. It may cause sexual problems such as decrease in sex drive. Talk to your doctor if you are facing any sexual problems while taking KUTUB 30 X.
How KUTUB 30 X works?
KUTUB 30 X delays the ejaculation (release of semen) by increasing the activity of a particular chemical called serotonin in the brain. This promotes the control over ejaculation and helps your body to hold sperms for a longer period. It also improves penile functions by improving blood supply to the penis.
Can I stop taking KUTUB 30 X by my own without consulting doctor?
Do not stop taking KUTUB 30 X without consulting your physician, as sudden discontinuation of KUTUB 30 X may cause withdrawal symptoms like sleeping problems or dizziness.
Can KUTUB 30 X cause bipolar disorder?
KUTUB 30 X may cause mood changes in some individuals. Inform your doctor immediately if you experience any sudden changes in mood. Also, it is important to inform you doctor if you already have bipolar disorder as a precaution before starting treatment with KUTUB 30 X.
REFERENCES
1. KD. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs & Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page – 303 & 464.
2. Murat Tukan, Mehmet Gokhan Culha and Ege Can Serefoglu. Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction—DAP-SPEED Study. ResearchGate. March 2019. [Accessed on 7th July 2022] https://www.researchgate.net/publication/330766365_Efficacy_and_safety_of_dapoxetinesildenafil_combination_tablets_in_the_treatment_of_men_with_premature_ejaculation_and_concomitant_erectile_dysfunction-DAP-SPEED_Study
3. Menarini - Von Heyden GmbH. Electronic medicines compendium (EMC). [Revised in June 2021] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.1269.pdf
4. Pharmadox Healthcare Ltd. Electronic medicines compendium (EMC). [Revised in December 2021] [Accessed on 3rd June 2022] https://www.medicines.org.uk/emc/files/pil.13551.pdf
5. DA SUTRA 30X TABLET. Hetero Healthcare. Limited. [Accessed on 3rd June 2022] https://www.heterohealthcare.com/da-sutra-30x-tablet
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