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Introduction About JONCLAV 625MG TABLET
JONCLAV 625MG TABLET is a combination of Amoxicillin and Clavulanic acid, which belongs to the group of medicines called Antibiotics. It is used to manage bacterial infections, including middle ear and sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin and soft tissue infections such as dental infections, bone and joint infections, septic abortion, and abdominal infections. The symptoms of bacterial infection include fever, difficulty breathing, pus formation, and pain.
JONCLAV 625MG TABLET is not recommended for use if you have liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. Before taking this medicine, inform your doctor if you are suffering from a hepatic impairment, liver disease, renal impairment, kidney disease, glandular fever, or are unable to pass water properly.
JONCLAV 625MG TABLET should be used with caution in pregnant and breastfeeding women only if it is considered necessary. It should be used with caution in children (aged below 12 years) and elderly patients (above 50 years). Consult your doctor before taking JONCLAV 625MG TABLET.
The common side effects associated with the use of JONCLAV 625MG TABLET are diarrhea, thrush (fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.
Uses Of JONCLAV 625MG TABLET
- Manage bacterial infection
How JONCLAV 625MG TABLET Works
JONCLAV 625MG TABLET helps in managing bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of the integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby managing the inactivation of amoxicillin.
How to use JONCLAV 625MG TABLET
For Tablet, Capsule:
Take JONCLAV 625MG TABLET as advised by your physician. Swallow the tablet with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse JONCLAV 625MG TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.
Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Side Effects Of JONCLAV 625MG TABLET
Common
- diarrhoea
- thrush (fungal infection in the vagina, skin folds, or mouth)
- nausea
- vomiting
Uncommon
- skin rash
- itching
- raised itchy rash (hives)
- indigestion
- dizziness
- headache
Rare
- erythema multiforme (a skin rash that looks like small targets)
- reversible leucopoenia, including neutropenia (deficiency of white blood cells)
- reversible thrombocytopenia (deficiency of blood platelets)
Stop taking JONCLAV 625MG TABLET and contact your doctor if you experience any of the following side effects:
- signs of allergic reactions on the skin, such as skin rash
- signs of vasculitis (inflammation of blood vessels) such as raised red or purple spots on the skin
- signs of allergic reactions such as fever, joint pain, or swollen glands in the neck, armpit, or groin
- signs of angioedema, such as swelling on the face or mouth resulting in difficulty breathing or collapse
- inflammation of the liver (hepatitis)
- jaundice
- inflammation of kidney tubes
- prolongation of blood clotting time
- convulsions
- black tongue with a hairy look
- staining of teeth
How To Manage Side Effects
Diarrhea
Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine on your own to manage diarrhea and consult your doctor if the diarrhea gets worse.
Nausea And Vomiting
Try to take JONCLAV 625MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the nausea and vomiting do not improve.
Warning & Precautions
Pregnancy
Monitoring requiredJONCLAV 625MG TABLET should be used with caution in pregnant women only if it is considered clearly necessary. Consult your doctor before taking JONCLAV 625MG TABLET.
Breastfeeding
Use with CautionJONCLAV 625MG TABLET should be used with caution in breastfeeding women. Consult your doctor before taking JONCLAV 625MG TABLET.
Driving and Using Machines
Use with CautionDo not drive or operate machines while taking if you feel unwell.
Kidney
Use with CautionJONCLAV 625MG TABLET should be used with caution in patients with renal impairment or kidney problems. Consult your doctor before taking JONCLAV 625MG TABLET.
Liver
Consult your doctorJONCLAV 625MG TABLET is not recommended for use if you have ever had liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. It should be used with caution in patients with hepatic impairment or liver problems. Consult your doctor before taking JONCLAV 625MG TABLET.
Allergy
ContraindicatedDo not take JONCLAV 625MG TABLET if you are allergic to amoxicillin, clavulanic acid, penicillin, any antibiotic, or any other ingredients of this medicine. Consult your doctor before taking JONCLAV 625MG TABLET.
Use In Pediatrics
Use with CautionJONCLAV 625MG TABLET should be used with caution in children (below 12 years). Consult your doctor before taking JONCLAV 625MG TABLET.
Use In Geriatrics
Use with CautionJONCLAV 625MG TABLET should be used with caution in elderly patients (above 50 years). Consult your doctor before taking JONCLAV 625MG TABLET.
Others
Before taking JONCLAV 625MG TABLET, inform your doctor if you:
- have glandular fever
- are unable to pass water properly
Interactions
A. Drug-Drug Interactions
Before taking JONCLAV 625MG TABLET, inform your doctor if you are taking any of the following medicines:
- allopurinol, probenecid (medicine used to manage gout)
- warfarin (medicine used to inhibit blood clotting)
- methotrexate (medicine used to manage rheumatic diseases or certain cancers)
- mycophenolate mofetil (a medicine used to manage the organ rejection after organ transplant)
- contraceptives (medicines used to manage conception)
Overdosage:
If you or anyone else accidentally takes too much of JONCLAV 625MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation).
Synopsis
| Drug | : | Amoxicillin, Clavulanic Acid |
| Pharmacological Category | : | Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet, Dispersible Tablet, Capsule, Sachet |
More Information
Storage
- Keep the medicine out of reach of children
- Store JONCLAV 625MG TABLET below 30°C
FAQs About JONCLAV 625MG TABLET
Q: What JONCLAV 625MG TABLET is used for?
A: JONCLAV 625MG TABLET is used for managing bacterial infections including middle ear & sinus infections, respiratory tract infections, genital tract infections, urinary tract infections, skin & soft tissue infections such as dental infections, bone & joint infections, septic abortion (any abortion complicated by uterine infection), and abdominal infections.
Q: What happens if you take more JONCLAV 625MG TABLET than your required dose?
A: If you or anyone else accidentally takes too much of JONCLAV 625MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are gastrointestinal symptoms (including heartburn, indigestion, bloating, and constipation).
Q: What side effects are seen with JONCLAV 625MG TABLET?
A: The common side effects associated with the use of JONCLAV 625MG TABLET are diarrhea, thrush (fungal infection in the vagina, skin folds, or mouth), nausea, and vomiting. Contact your doctor immediately if any of the symptoms worsen.
Q: Who should avoid taking JONCLAV 625MG TABLET?
A: Do not take JONCLAV 625MG TABLET if you are allergic to amoxicillin, clavulanic acid, penicillin, or any antibiotic. It is not recommended for use if you have liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate.
Q: Is JONCLAV 625MG TABLET safe to use in children?
A: JONCLAV 625MG TABLET should be used with caution in children (below 12 years). Children (aged 6 years or below) should be managed with oral suspension or sachets containing amoxicillin and clavulanic acid. Consult your doctor before taking JONCLAV 625MG TABLET.
Q: How does JONCLAV 625MG TABLET work?
A: JONCLAV 625MG TABLET helps in managing bacterial infection where amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of an integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby managing the inactivation of amoxicillin.
Q: Is JONCLAV 625MG TABLET safe for kidneys?
A: JONCLAV 625MG TABLET should be used with caution in patients with renal impairment or kidney problems. Consult your doctor before taking it.
Q: How should I take JONCLAV 625MG TABLET?
A: For Tablet, Capsule:
Take JONCLAV 625MG TABLET as advised by your physician. Swallow the tablet with a glass of water. Do not crush or chew the medicine.
For Dispersible Tablet: Disperse JONCLAV 625MG TABLET in the specified quantity of water as mentioned in the label. Consume the mixture immediately after reconstitution.
Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Q: What if I forget to take JONCLAV 625MG TABLET dose?
A: If you forgot to take JONCLAV 625MG TABLET dose, take it as early as possible. Avoid taking the next dose too soon. Wait for about 4 hours before taking the scheduled next dose. Consult your doctor before taking JONCLAV 625MG TABLET.
Q: When to stop taking JONCLAV 625MG TABLET?
A: Do not stop taking JONCLAV 625MG TABLET without thoroughly discussing it with your doctor until the management course is completed, even if you start feeling better. This is because if some bacteria survive due to incomplete medication, they may relapse into the infection.
Q: Is JONCLAV 625MG TABLET safe to use in liver patients?
A: JONCLAV 625MG TABLET is not recommended for use if you have liver problems or jaundice upon taking an antibiotic or amoxicillin-clavulanate. It should be used with caution in patients with hepatic impairment or liver problems. Consult your doctor before taking JONCLAV 625MG TABLET.
References
1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 723.
2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. NIH National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. December 2021. [Assessed on 12th August 2024] https://www.ncbi.nlm.nih.gov/books/NBK538164/
3. Lek Pharmaceuticals d.d., Health Products Regulatory Authority (HPRA). [Revised in December 2014] [Assessed on 12th August 2024] https://www.hpra.ie/img/uploaded/swedocuments/pl-clean-2157753-09062015140435-635694554758986250.pdf
4. GSK group of companies. Augmentin. [Revised in December 2017] [Assessed on 12th August 2024] https://gskpro.com/content/dam/global/hcpportal/en_MU/PI/Clavulin-228.5mg5ml-Susp-GDS-24.pdf
5. Macleods Pharmaceuticals Ltd. Polyclav DS Tab. [Assessed on 12th August 2024] https://www.macleodspharma.com/products/
6. Amoxicillin and Clavulanic acid. Micro Labs Ltd. [Assessed on 12th August 2024] https://www.microlabsusa.com/products/amoxicillin-and-clavulanate-potassium-tablets-usp/
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Kidney Function Test (KFT)
- Liver Function Test (LFT)
- Serum Electrolytes/ Electrolytes Profile
- Urine Routine & Microscopy
- Healthy Midlife Checkup
- Men Health Checkup – Advanced
- Complete Women Checkup
- Full Body Checkup – Gold
- Full Body Checkup – Silver
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