ISTAVEL D 100/10 Tablet 15's
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Introduction About ISTAVEL D 100/10 TABLET
ISTAVEL D 100/10 Tablet contains Dapagliflozin and Sitagliptin, supporting healthy blood sugar levels in adults with type II diabetes mellitus.
ISTAVEL D 100/10 TABLET is not recommended for use in patients having severe kidney problems or those on dialysis. Before taking the medicine, inform your doctor if you have inflammation of the pancreas, gallstones, alcohol dependence, or very high levels of triglycerides in the blood or any heart, kidney or liver problems.
It should be used in pregnant women only if considered clearly necessary. It should be used with caution in breastfeeding women. Safety and effectiveness of ISTAVEL D 100/10 TABLET in children and adolescents (under 18 years of age) have not been established.
It is important to stay on the diet and exercise recommended by your doctor while taking ISTAVEL D 100/10 TABLET as it can help the body use its blood sugar better. Common side effects are headache, flatulence and constipation. Consult your doctor if any of the side effects worsen or persists.
Uses Of ISTAVEL D 100/10 TABLET
- Manages type II diabetes mellitus (which is inadequately controlled on metformin monotherapy)
Benefits of ISTAVEL D 100/10 TABLET
- Supports better blood sugar level management, especially when metformin alone is insufficient.
- Combines Dapagliflozin and Sitagliptin to enhance glucose control by promoting glucose excretion through urine and improving insulin synthesis.
- Helps maintain stable blood glucose, reducing the risks associated with prolonged high sugar levels.
- Contributes to lowering the chances of diabetes-related complications such as kidney damage, nerve problems, and cardiovascular risks.
- Offers once-daily dosing that fits well with lifestyle and routine to support ongoing diabetes management.
- Helps improve overall metabolic health and may support long-term well-being in adults managing type 2 diabetes mellitus.
How ISTAVEL D 100/10 TABLET Works
- Dapagliflozin inhibits the sodium-glucose co-transporter 2 (SGLT2) protein in the kidneys, which reduces glucose reabsorption and promotes the excretion of excess glucose through urine. This action lowers blood sugar by avoiding the kidneys from reclaiming glucose back into the bloodstream.
- Sitagliptin acts as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones. These hormones enhance insulin release after meals and reduce the amount of glucose produced by the liver, helping maintain balanced blood sugar levels.
Combined, these ingredients improve glycemic control by reducing blood sugar through both increased insulin activity and enhanced glucose elimination, making the tablet an effective adjunct for type 2 diabetes management alongside diet and exercise.
How to use ISTAVEL D 100/10 TABLET
- Take the tablet orally once daily, with or without food.
- Swallow the tablet whole with a glass of water; do not crush or chew.
- Maintain consistent timing every day to support effective blood sugar management.
- Follow the exact instructions provided by your prescribing doctor.
Recommended Dosage and Timing
- Dosage is individualized by your doctor based on your health status and blood sugar control.
- Usually taken once daily in the morning.
- Do not exceed the prescribed dose or alter the timing without medical advice.
Dosage for Adults and Special Populations
- Intended primarily for adults with type 2 diabetes needing additional blood sugar support beyond diet and exercise.
- No dose adjustment typically required for elderly patients but consult your doctor for personalized advice.
Administration Instructions and Precautions
- Take at the same time each day to maintain consistent blood levels.
- Stay hydrated to help avoid dehydration side effects.
Important Considerations Before Use
- Inform your doctor about any history of pancreatitis, gallstones, high triglyceride levels, or heart/kidney/liver problems.
- Inform about all other medications or supplements you are taking to avoid interactions.
- Regular blood sugar monitoring is essential during therapy.
- Do not discontinue the medication without healthcare provider approval, as it may worsen your condition.
What if I forgot to take ISTAVEL D 100/10 TABLET
- If you miss a dose, take it as soon as you remember on the same day.
- If it is nearly time for your next dose, skip the missed one—do not double dose to catch up.
- Consult your doctor if you have any questions or concerns about missed doses.
Side Effects Of ISTAVEL D 100/10 TABLET
Common Side Effects of ISTAVEL D 100/10 TABLET:
- flatulence, constipation, stomach pain, diarrhea
- swelling of hands or legs
- headache, dizziness
- stuffy or runny nose, sore throat
- passing urine more often
- dry mouth
When to consult your doctor?
- inflamed pancreas (severe and persistent stomach pain that might reach through the back with or without nausea and vomiting)
- serious allergic reaction (rash, hives, blisters on the skin or peeling skin and swelling of the lips, tongue, face and throat that may cause difficulty in breathing or swallowing)
- diabetic ketoacidosis (increased levels of ketone bodies in urine or blood, nausea or vomiting, stomach ache, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breathe, a sweet or metallic taste in the mouth or a different odor in urine or sweat, rapid weight loss)
- urinary tract infection
- low blood sugar levels
Warning & Precautions
Pregnancy
Consult your doctorIf you are pregnant or think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Breastfeeding
Consult your doctorIt is not known if this medicine passes into breast milk. You should not take this medicine if you are breast-feeding or plan to breast-feed.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if you feel dizzy or sleepy after taking ISTAVEL D 100/10 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking ISTAVEL D 100/10 TABLET as it may increase the chance of diabetic ketoacidosis.
Kidney
Use with CautionISTAVEL D 100/10 TABLET can be used with caution in patients who had or have any kidney problems.
Liver
Use with CautionISTAVEL D 100/10 TABLET can be used with caution in patients with severe liver impairment.
Allergy
ContraindicatedDo not take ISTAVEL D 100/10 TABLET if you are allergic to Dapagliflozin, Sitagliptin or any other ingredients of this medicine.
Heart Disease
Use with CautionISTAVEL D 100/10 TABLET can be used with caution in patients who have heart failure.
Use In Pediatrics
Consult your doctorSafety and effectiveness of ISTAVEL D 100/10 TABLET in children and adolescents (under 18 years of age) have not been established.
Use In Geriatrics
Consult your doctorNo dose adjustment is required for elderly patients.
Other Warnings for ISTAVEL D 100/10 TABLET
Before taking ISTAVEL D 100/10 TABLET inform your doctor if you:
- have inflammation of the pancreas
- have gallstones
- have very high levels of triglycerides in the blood
- are fasting
- are dehydrated
Who should not take ISTAVEL D 100/10 TABLET
ISTAVEL D 100/10 TABLET is not recommended for use if you have:
- type I diabetes mellitus
- diabetic ketoacidosis
Safety Advice
- Stay well-hydrated to reduce the risk of dehydration and related side effects.
- Maintain good hygiene to avoid genital fungal and urinary tract infections, which are potential side effects.
- Regularly monitor your blood sugar levels to ensure effective and safe glucose management.
- Do not stop the medication abruptly without consulting your healthcare provider, as this may worsen blood sugar control.
- Carry sugary food or juice to manage potential symptoms of low blood sugar (hypoglycemia), like sweating or trembling.
- Inform your doctor if you experience unexplained tiredness, frequent urination, or signs of dehydration
Drug - Drug interaction
- Caution with Heart Failure Medicines: Medicines like digoxin may interact and require monitoring.
- Diuretics: Concurrent use with diuretics such as furosemide, hydrochlorothiazide, or amiloride can increase the risk of dehydration and low blood pressure.
- Anti-Fungal Agents: Drugs like ketoconazole and itraconazole may affect ISTAVEL D metabolism or efficacy.
- Antibiotics: Clarithromycin and similar antibiotics may interact, requiring dose or monitoring adjustments.
- Anti-Viral Agents: Ritonavir and other HIV medications could interfere with ISTAVEL D’s metabolism.
- Immunosuppressants: Medicines like ciclosporin need caution due to potential interactions.
- Other Anti-Diabetics: Concurrent use with insulin or sulfonylureas increases hypoglycemia risk; dose adjustments and blood sugar monitoring are essential.
Synopsis
| Drug | : | Dapagliflozin, Sitagliptin |
| Pharmacological Category | : | Sodium-Glucose Cotransporter 2 (SGLT2) inhibitor, Dipeptidyl Peptidase 4 (DPP-4) inhibitor |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
More Information
Did you know?
- Dapagliflozin works by avoiding the kidneys from reabsorbing excess glucose, leading to its removal through urine, which helps lower blood sugar levels.
- Sitagliptin enhances the body's natural insulin release by inhibiting the enzyme DPP-4, which increases incretin hormone levels aiding in better blood sugar control, especially after meals.
- This combination not only helps maintain balanced blood glucose but also supports overall metabolic health and reduces risks of diabetes-related complications.
- Alongside medication, continuing a healthy diet, regular exercise, and proper blood sugar monitoring are essential components for optimal diabetes management with ISTAVEL D.
- Being aware of side effects like urinary tract infections or fungal infections and staying hydrated can improve safety.
FAQs About ISTAVEL D 100/10 TABLET
Q: What is ISTAVEL D 100/10 Tablet prescribed for?
A: It is used to help manage blood sugar levels in adults with type 2 diabetes mellitus when diet, exercise, and metformin alone are not enough.
Q: How does ISTAVEL D 100/10 Tablet work?
A: It combines dapagliflozin, which helps remove excess sugar through urine, and sitagliptin, which increases insulin release and reduces sugar production by the liver.
Q: How should I take this tablet?
A: Take it once daily orally with or without food, preferably at the same time each day. Swallow the tablet whole with water.
Q: What should I do if I miss a dose?
A: Take the missed dose as soon as you remember on the same day. Skip it if it is nearly time for the next dose. Do not double up doses.
Q: Are there any common side effects?
A: Some people may experience headache, urinary tract infections, nasal congestion, or mild nausea. Report any severe or persistent symptoms to your doctor.
Q: Can I take ISTAVEL D 100/10 Tablet if I am pregnant or breastfeeding?
A: Consult your healthcare provider before use during pregnancy or breastfeeding. It is generally used only if clearly necessary.
Q: Can I drink alcohol while using this medicine?
A: Avoid excessive alcohol intake as it can increase the risk of side effects and affect blood sugar control.
Q: Are there any special precautions?
A: Inform your doctor about any kidney, liver, or heart problems, or if you are taking other medications including diuretics or insulin.
Q: How do I store ISTAVEL D 100/10 Tablet?
A: Store in a cool, dry place away from direct sunlight and keep out of reach of children.
Q: Can children use this tablet?
A: This medication is not recommended for children or adolescents under 18 years of age.
References
1. KD. Tripathi. Insulin, Oral Antidiabetic Drugs and Glucagon. Essentials of Medical Pharmacology. Eighth edition. 2019. Page – 297 & 301.
2. Serge A. Jabbour; Elise Hardy; Jennifer Sugg; Shamik Parikh. Dapagliflozin Is Effective as Add-on Therapy to Sitagliptin With or Without Metformin: A 24-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study. Journal of Diabetes care. American Diabetes Association. February 2014. [Accessed on 27th November 2025] 
3. Annaswamy Raji, Zhi Jin Xu, Raymond L. H. Lam, Edward A.O’Neill, Keith D. Kaufman, Samuel S. Engel. Efficacy and Safety of Sitagliptin Compared with Dapagliflozin in People ≥65 Years Old with Type 2 Diabetes and Mild Renal Insufficiency. SpringerLink. August 2020. [Accessed on 27th November 2025] 
4. Torrent Pharmaceuticals Ltd. Sitaxa D/ Sitalix D/Glucreta S (Dapagliflozin + Sitagliptin). [Revised in July 2022] [Accessed on 27th November 2025]
5. Cipla Ltd. Exemed Pharmaceuticals. Darasach S (Dapagliflozin + Sitagliptin). Ciplamed. [Revised in September 2022] [Accessed on 27th November 2025]
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