ISTAMET 50/1000mg Tablet 15's

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Drug Information for ISTAMET 50/1000mg Tablet 15's

What is Metformin + Sitagliptin combination used for?

Metformin + Sitagliptin combination is used for the treatment of type 2 diabetes. It is used in conjunction with diet and exercise for effective glycaemic control.

Metformin + Sitagliptin combination may also be prescribed for other conditions as determined by the doctor.

How does Metformin + Sitagliptin combination work?

In Metformin + Sitagliptin combination, Metformin belongs to the class of drugs called anti-diabetic drugs.  This drug acts by inhibiting hepatic glucose production, which reduces blood sugar levels.

Sitagliptin belongs to the class of drugs called anti-diabetic drugs. This drug acts by regulating the levels of glucose produced by the body after consuming food.

How to take Metformin + Sitagliptin combination?

The dosage and the drug form depend on the age, weight and medical condition of an individual. Take Metformin + Sitagliptin combination as prescribed by your doctor.

Swallow the tablet whole. Do not crush or chew the tablet. Take the drug with or without food. However, taking the drug with food prevents stomach upset.

If you miss a dose of Metformin + Sitagliptin combination, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

The overdose symptoms of Metformin + Sitagliptin combination may include

  • Extreme weakness
  • Blurred vision
  • Sweating
  • Trouble speaking
  • Tremors
  • Stomach pain
  • Confusion
  • Seizure

What are the drugs that interact with Metformin + Sitagliptin combination?

Drugs that interact with Metformin + Sitagliptin combination include the following:

  • Acetaminophen
  • Cetirizine
  • Diatrizoate
  • Gatifloxacin
  • Iohexol
  • Iopamidol
  • Iopromide
  • Iothalamate
  • Loratadine
  • Nifedipine
  • Phenylephrine

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Metformin + Sitagliptin combination?

The following are the most common side effects of Metformin + Sitagliptin:

  • Indigestion
  • Muscle pain
  • Sore throat
  • Vomiting
  • Lack of strength

The following are the severe side effects and you may require immediate medical attention:

  • Anxiety
  • Blurred vision
  • Chills
  • Seizures
  • Confusion
  • Slurred speech
  • Depression

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Metformin + Sitagliptin combination?

  • Avoid using the medicine if you are allergic to Metformin + Sitagliptin combination or similar drugs.
  • Do not stop using the medication abruptly unless instructed by the doctor. Stopping the medication suddenly may cause the illness to return.
  • Do not exceed the dose more than what is prescribed.
  • Keep the medication out of reach of children.
  • Consult the doctor immediately if you experience muscle pain, numbness in your arms and legs, trouble breathing, nausea with vomiting or dizziness.

You are advised not to take Metformin + Sitagliptin combination if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Metformin + Sitagliptin combination?

  • Tell your doctor if you have any history of diabetes, kidney and liver diseases.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Notify the doctor if you are pregnant or breastfeeding.

Frequently asked questions about Metformin + Sitagliptin combination

  1. Can I drive after taking Metformin + Sitagliptin combination?
  2. You must avoid driving if you experience drowsiness after taking Metformin + Sitagliptin.

  3. How long should I take Metformin + Sitagliptin combination?
  4. Metformin + Sitagliptin combination must be taken as per doctor’s recommendations.

  5. Can I alter the dose of Metformin + Sitagliptin combination?
  6. Do not alter the dose of Metformin + Sitagliptin combination without medical consultation.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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