INTRODUCTION

IBUVENT PLUS TABLET is a combination of Ibuprofen and Paracetamol, which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAIDs) and Analgesics respectively. It is used to treat minor aches and pains such as headaches, toothaches, muscular aches, backaches, pain due to inflammation and for reduction of fever due to any of the above conditions in adults and children aged 12 years and above. Analgesics help to reduce fever.

Before taking this medicine, inform your doctor if you are allergic (hypersensitive) to ibuprofen, paracetamol, or any other NSAIDs such as aspirin.

Also tell the doctor if you have, liver, kidney, or heart problems. Pregnant and breastfeeding women should consult their doctors before taking the medicine.

The most common side effects are diarrhoea, nausea, vomiting, stomach pain, and dizziness. Consult your doctor for advice if any of the above side effects worsen or persist for a longer duration.

USES OF IBUVENT PLUS TABLET

• It is used to treat minor aches and pains such as headaches, toothaches, muscular aches, backaches and pain due to inflammation and for reduction of fever due to any of the above conditions

HOW IBUVENT PLUS TABLET WORKS

IBUVENT PLUS TABLET collectively works as non-steroidal anti-inflammatory (NSAIDs) and analgesic agent which works by inhibiting the effect of a chemical messenger called prostaglandins that are responsible for producing pain and inflammation. This blocks the Cox-enzyme (a natural substance produced in our body) thereby, restricting its action, which reduces the inflammation and pain at the site.

DIRECTIONS FOR USE

Take IBUVENT PLUS TABLET as advised by your physician. It can be taken with or without food.

For Tablet, Capsule: Swallow IBUVENT PLUS TABLET with a glass of water. Do not crush or chew the medicine.

For Dispersible Tablet: Disperse the medicine in the specified quantity of water as mentioned in the label. Consume the medicine immediately after reconstitution.

Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of the infection.

SIDE EFFECTS OF IBUVENT PLUS TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take this medicine with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food.

Diarrhoea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking IBUVENT PLUS TABLET, inform your doctor if you are taking any of the following medicine:

• other NSAIDs (Ex. naproxen, diclofenac)
• anti-hypertensives to reduce hypertension (Ex. atenolol, propranolol)
• diuretics promotes diuresis (Ex. hydrochlorothiazide, furosemide)
• cardiac glycosides to treat heart failure (Ex. digoxin, digitoxin)
• lithium to treat depression or anxiety
• methotrexate to treat cancer
• ciclosporin to treat rheumatoid arthritis
• mifepristone is used for abortion
• corticosteroids treat inflammation and allergy (Ex. prednisone, dexamethasone)
• anti-coagulants prevent blood clots (Ex. warfarin)
• quinolone antibiotics are used to treat bacterial infections (Ex. ciprofloxacin, levofloxacin)
• anti-platelet agents and selective serotonin reuptake inhibitors to treat depression (Ex. citalopram, fluoxetine)
• immunosuppressant (Ex. tacrolimus)
• zidovudine to treat human immunodeficiency (HIV infection)
• cholestyramine to treat high cholesterol levels
• metoclopramide and domperidone to treat nausea and vomiting
• chloramphenicol to treat serious bacterial infections
• promethazine used to treat stomach ulcers

Overdosage:

If you or anyone else accidentally took too much of IBUVENT PLUS TABLET, consult your doctor immediately. Symptoms includes nausea, upset stomach, vomiting and gastric irritation, feel light-headed, dizzy, or drowsy, excitability, convulsions, blood in urine.

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at room temperature

FAQs ABOUT IBUVENT PLUS TABLET

Does IBUVENT PLUS TABLET cause nausea?

Yes, IBUVENT PLUS TABLET may cause nausea or vomiting in some people. In order to avoid the same, you can take IBUVENT PLUS TABLET immediately after food or with food. In case you are still experiencing excessive nausea while consuming IBUVENT PLUS TABLET, speak with your doctor right away.

For what conditions IBUVENT PLUS TABLET is prescribed?

IBUVENT PLUS TABLET is given to treat acute painful conditions in adults and relief of
musculoskeletal pain associated with spasms.

Does IBUVENT PLUS TABLET cure rheumatoid arthritis? 

No, IBUVENT PLUS TABLET does not cure rheumatoid arthritis but instead, it helps in reducing the pain and inflammation caused due to the condition.

Is [GNKEYWORD] safe for pregnant women?

It is not recommended for pregnant women as the study shows effects of the medicine in new born. Consult your doctor for advice.

Can I take IBUVENT PLUS TABLET with antibiotics?

IBUVENT PLUS TABLET may interact with antibiotics and can produce an altered response. Consult your doctor before taking any medicine.

REFERENCES

1. Joseph. T. Dipiro. Pharmacotherapy. A Pathophysiologic Approach. Eighth edition. Page No: 1067-1068.

2. Derry, Christopher J et al. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Jun. 2013. [Accessed on 19th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485825/

3. Reckitt Benckiser Healthcare. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 19th April 2022] https://www.medicines.org.uk/emc/files/pil.4967.pdf

4. Alpha pharm Ptd. Limited. [Accessed on 19th April 2022] https://www.news-medical.net/drugs/Ibupane.aspx

5. European Medicines Agency. [Revised in August 2017] [Accessed on 19th April 2022] https://www.ema.europa.eu/en/documents/referral/paracetamol/ibuprofen-500mg/150mg-article-294-referral-questions-answers-paracetamol/ibuprofen-500mg/150mg-film-coated-tablets-associated-names-tablets-containing-500-mg-paracetamol-150-mg-ibuprofen_en.pdf

6. Motrin. U.S. Food and Drug Administration. [Revised in January 2007] [Accessed on 19th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017463s105lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Renal function test
• Liver function test
• Blood count