Availability & Expiry
INTRODUCTION
GRILINCTUS DX SYRUP is a combination of Chlorpheniramine and Dextromethorphan which belongs to the group of medicines called Antihistamines and Antitussives respectively. It is used to relieve cough due to throat or bronchial irritation, sneezing, and running nose caused by cold, dry cough, allergic cough, post-operative cough, smokers cough and night-time cough. It is also used to treat hay fever or upper respiratory allergies such as sneezing, runny nose, itchy, watery eyes, itching of the nose and throat.
Avoid consumption of alcohol while taking this medicine as this may lead to unwanted effects. GRILINCTUS DX SYRUP is not recommended for use in patients with or at risk of developing, respiratory failure (Ex. chronic obstructive airways disease or pneumonia, or an exacerbation of asthma).
GRILINCTUS DX SYRUP should be used with caution in patients with lung disease, severe kidney or heart diseases. GRILINCTUS DX SYRUP is not recommended for use in pregnant or breastfeeding women. Contact your doctor before taking. GRILINCTUS DX SYRUP is not recommended for use in children under 2 years of age. Contact your doctor before taking. GRILINCTUS DX SYRUP should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking. The most common side effects of this medicine are sedation, somnolence, disturbance in attention, abnormal coordination, dizziness, drowsiness, headache, blurred vision, nausea, vomiting, dry mouth, abdominal discomfort, fatigue. Contact your physician if any of the symptoms worsen.
USES OF GRILINCTUS DX SYRUP
- Used to treat cough (allergy, post-operative cough, smokers cough and night-time cough, throat irritation, sneezing and running nose)
HOW GRILINCTUS DX SYRUP WORKS
GRILINCTUS DX SYRUP helps to treat cough, where Chlorpheniramine is an antihistamine works by blocking the histamine H1 receptor and prevents the release of histamine (which normally produces symptoms of sneezing, itching, watery eyes, and runny nose) and Dextromethorphan is a cough suppressant which relieves cough by acting on the cough centre in the brain. Together relives cough effectively.
DIRECTIONS FOR USE
Take GRILINCTUS DX SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF GRILINCTUS DX SYRUP
COMMON
- sedation, somnolence
- disturbance in attention, abnormal coordination
- dizziness, drowsiness, headache
- blurred vision
- nausea, vomiting
- dry mouth
- abdominal discomfort
- fatigue
RARE
Stop taking GRILINCTUS DX SYRUP and contact your physician immediately if you experience any of the following side effects:
- severe allergic reactions such as itching, rash, hives, redness, swelling of the face, lips, mouth, tongue or throat causing difficulty in breathing or sudden drop in blood pressure causing collapse
HOW TO MANAGE SIDE EFFECTS
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if dizziness persists.
Nausea And Vomiting
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if nausea or vomiting bothers you.
Stomach Pain
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the stomach pain worsens.
Headache
Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if your headache did not improve.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedGRILINCTUS DX SYRUP is generally not recommended for use in pregnancy. Contact your doctor before taking.
BREASTFEEDING
ContraindicatedGRILINCTUS DX SYRUP is not recommended for use in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel drowsiness, dizziness, blurred vision and psychomotor impairment after taking GRILINCTUS DX SYRUP.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking GRILINCTUS DX SYRUP as it may lead to unwanted effects.
KIDNEY
Use with CautionGRILINCTUS DX SYRUP should be used with caution in patients with severe kidney disease. Contact your doctor before taking.
LIVER
Use with CautionGRILINCTUS DX SYRUP should be used with caution in patients with severe liver disease. Contact your doctor before taking.
ALLERGY
ContraindicatedDo not take GRILINCTUS DX SYRUP if you are allergic to Chlorpheniramine, Dextromethorphan or to other ingredients of this medicine.
LUNGS
Consult your doctorGRILINCTUS DX SYRUP is not recommended for use in patients with or at risk of developing, respiratory failure (Ex. chronic obstructive airways disease or pneumonia or an exacerbation of asthma) and should be used with caution in patients with asthma, bronchitis, bronchiectasis, emphysema. Contact your doctor before taking.
HEART DISEASE
Use with CautionGRILINCTUS DX SYRUP should be used with caution in patients with severe heart diseases and severe hypertension. Contact your doctor before taking.
USE IN PEDIATRICS
Consult your doctorYour doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Contact your doctor before taking GRILINCTUS DX SYRUP.
USE IN GERIATRICS
Use with CautionGRILINCTUS DX SYRUP should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.
OTHERS
GRILINCTUS DX SYRUP is not recommended for use if you have:
- confusion
- rare hereditary problems like fructose intolerance, glucose-galactose malabsorption and sucrase-isomaltase insufficiency
Before taking GRILINCTUS DX SYRUP, inform your doctor if you have:
- epilepsy
- glaucoma
- urinary retention
- prostatic enlargement
- pyloroduodenal obstruction
- thyrotoxicosis
- diabetes
INTERACTIONS
A. Drug-Drug interactions:
Inform your physician, if you are taking:
- hypnotics or anxiolytics Ex. alprazolam, diazepam, lorazepam (medicines that induces sleep and to treat anxiety)
- sedatives Ex. phenobarbital, pentobarbital (medicines used to reduce excitement)
- opioid analgesics like tramadol, morphine, codeine, methadone (medicines used for severe pain)
- fluphenazine, thioridazine, haloperidol, perphenazine (medicines used to treat psychoses)
- antimuscarinic drugs Ex. dicyclomine (medicines used to relax stomach and intestine)
- fluoxetine, paroxetine, sertraline, amitriptyline, imipramine, selegiline, rasagiline, bupropion (medicines used for depression)
- cough and cold medicines
- phenytoin (medicines used to treat fits)
- quinidine, amiodarone, propafenone and flecainide (medicines used to treat heart rhythm disorders)
- cinacalcet (medicine used to treat hyperparathyroidism)
- terbinafine (medicines used to treat fungal infections)
- antihistamines (drugs used to treat the symptoms of allergic reactions) Ex. dimenhydrinate
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdosage are drowsiness, lethargy, nystagmus, ataxia, depression, nausea, vomiting and hyperactivity, excitation, mental confusion, tremors, psychosis, hallucinations, high fever and convulsions, restlessness, nervousness and irritability, stupor, dystonia and respiratory depression.
SYNOPSIS
| Drug | : | Chlorpheniramine, Dextromethorphan |
| Pharmacological Category | : | Antihistamines, Antitussives |
| Therapeutic Indication | : | Treats Cough |
| Dosage Forms | : | Syrup, Suspension, Tablet |
MORE INFORMATION
- Keep out of reach of children
- Store GRILINCTUS DX SYRUP below 30°C
FAQs ABOUT GRILINCTUS DX SYRUP
Q: For what conditions GRILINCTUS DX SYRUP is used?
A: GRILINCTUS DX SYRUP is used to relieve cough due to throat or bronchial irritation, sneezing and running nose caused by cold, dry cough, allergic cough, post-operative cough, smokers cough and night-time cough. It is also used to treat hay fever or upper respiratory allergies such as sneezing, runny nose, itchy, watery eyes, itching of the nose and throat. Contact your doctor before taking.
Q: How GRILINCTUS DX SYRUP work?
A: GRILINCTUS DX SYRUP helps to treat cough, where Chlorpheniramine is an antihistamine works by blocking the histamine H1 receptor and prevents the release of histamine (which normally produces symptoms of sneezing, itching, watery eyes and runny nose) and Dextromethorphan is a cough suppressant which relieves cough by acting on the cough centre in the brain. Together relives cough effectively.
Q: What are the possible side effects of taking GRILINCTUS DX SYRUP?
A: The most common side effects of this medicine are sedation, somnolence, disturbance in attention, abnormal coordination, dizziness, drowsiness, headache, blurred vision, nausea, vomiting, dry mouth, abdominal discomfort, fatigue. Contact your physician if any of the symptoms worsen.
Q: How to take GRILINCTUS DX SYRUP?
A: Take GRILINCTUS DX SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Q: Does GRILINCTUS DX SYRUP cause sleepiness?
A: Yes. GRILINCTUS DX SYRUP cause sleepiness. Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling sleepy. Do not consume alcohol, as it can aggravate your sleepiness. Contact your doctor if sleepiness did not improve.
REFERENCES
1. K.D. Tripathi. Drugs for cough and bronchial asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 220.
2. Bethesda (MD). Chlorpheniramine. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 21st June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Chlorpheniramine
3. Bethesda (MD). Dextromethorphan. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 21st June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/5360696
4. GlaxoSmithKline Consumer Healthcare (UK). Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 21st June 2022] https://www.medicines.org.uk/emc/files/pil.3928.pdf
5. Delpharm Orleans. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed on 21st June 2022] https://www.medicines.org.uk/emc/files/pil.1523.pdf
6. GlaxoSmithKline Pharmaceuticals Limited. Chlorpheniramine and Dextromethorphan. [Revised in November 2019] [Accessed on 21st June 2022] https://india-pharma.gsk.com/media/6399/piriton-cs.pdf
7. Accudial Pharmaceutical, Inc. Chlorpheniramine and Dextromethorphan. [Revised in November 2011] [Accessed on 21st June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=03401433-923e-4577-ba58-9087515c8053
8. Cheston CS Syrup (Chlorpheniramine and Dextromethorphan). Cipla Ltd. [Revised in November 2013] [Accessed on 21st June 2022] https://www.ciplamed.com/content/cheston-cs-syrup
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