GLIMIBRIT M 0.5 Tablet 15's

INTRODUCTION

GLIMIBRIT M 0.5 TABLET is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. GLIMIBRIT M 0.5 TABLET is used to treat type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control.

Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue and blurred vision.

Along treatment with GLIMIBRIT M 0.5 TABLET follow regular exercise and diet plan as advised by your doctor to achieve better results.

Before taking GLIMIBRIT M 0.5 TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding. It is not suitable for use in children and adolescents under 18 years of age.

Avoid consumption of alcohol during treatment with GLIMIBRIT M 0.5 TABLET as it may increase or decrease the blood sugar lowering action of GLIMIBRIT M 0.5 TABLET and increases the risk of lactic acidosis.

The most common side effects of taking GLIMIBRIT M 0.5 TABLET are taste disturbance, nausea, diarrhea, stomachache and vomiting. Contact your doctor if any of the side effects worsen.

USES OF GLIMIBRIT M 0.5 TABLET

• Treats type 2 diabetes mellitus (when diet, exercise and the single agent does not result in adequate glycemic control)

HOW GLIMIBRIT M 0.5 TABLET WORKS

GLIMIBRIT M 0.5 TABLET controls blood glucose levels, where glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestine and increasing the body's sensitivity to insulin.

DIRECTIONS FOR USE

Take GLIMIBRIT M 0.5 TABLET as advised by your physician. Swallow GLIMIBRIT M 0.5 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking GLIMIBRIT M 0.5 TABLET without informing your doctor.   

SIDE EFFECTS OF GLIMIBRIT M 0.5 TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.

Loss Of Appetite

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Consult your doctor if the symptom did not improve.

Nausea And Vomiting

Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.

Stomach Pain

Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

GLIMIBRIT M 0.5 TABLET should not be taken during pregnancy. Consult your doctor before taking GLIMIBRIT M 0.5 TABLET if you are planning to become pregnant. 

BREASTFEEDING

Contraindicated

GLIMIBRIT M 0.5 TABLET should not be taken during breastfeeding as it may pass through breast milk. Consult your doctor for advice before taking GLIMIBRIT M 0.5 TABLET.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels.

ALCOHOL

Consult your doctor

Avoid consumption of alcohol during treatment with GLIMIBRIT M 0.5 TABLET as it may increase or decrease the blood sugar lowering action of GLIMIBRIT M 0.5 TABLET and increases the risk of lactic acidosis. Consult your doctor for advice before taking GLIMIBRIT M 0.5 TABLET.

KIDNEY

Consult your doctor

GLIMIBRIT M 0.5 TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Consult your doctor before taking GLIMIBRIT M 0.5 TABLET.

LIVER

Consult your doctor

GLIMIBRIT M 0.5 TABLET is not recommended if you have severe liver disease and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function. Consult your doctor before taking GLIMIBRIT M 0.5 TABLET. 

ALLERGY

Contraindicated

Do not take GLIMIBRIT M 0.5 TABLET if you are allergic (hypersensitive) to Glimepiride or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or sulfonamides (such as sulfamethoxazole).

HEART DISEASE

Contraindicated

GLIMIBRIT M 0.5 TABLET is not recommended for use in patients with acute heart problems or recently had a heart attack or have severe circulatory problems or breathing difficulties (signs of heart failure). Consult your doctor before taking GLIMIBRIT M 0.5 TABLET.

USE IN PEDIATRICS

Contraindicated

GLIMIBRIT M 0.5 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.

USE IN GERIATRICS

Use with Caution

GLIMIBRIT M 0.5 TABLET is not recommended for use in elderly patients (aged 75 years and above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during treatment with GLIMIBRIT M 0.5 TABLET. Consult your doctor before taking GLIMIBRIT M 0.5 TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking GLIMIBRIT M 0.5 TABLET inform to your doctor, if you are taking any of these medicines:

• other sulphonylureas such as glibenclamide, insulin (used to lower blood sugar levels)
• anabolics (supports muscle build up)
• warfarin (treats blood clot)
• fenfluramine (used to reduce weight)
• phenylbutazone, azopropazone, oxyphenbutazone (treats pain and inflammation)
• disopyramide (treats heart problems)
• fibrates such as fenofibrate, nicotinic acid, colesevelam (lowers high cholesterol level)
• angiotensin-converting enzyme (ACE) inhibitors such as captopril, lisinopril, diuretics such as furosemide, chlorthalidone, hydrochlorothiazide or diazoxide (treats blood pressure)
• fluoxetine, monoamine oxidase inhibitors such as isocarboxazid, selegiline and chlorpromazine (used to treat mental disorders)
• allopurinol, probenecid, sulfinpyrazone (treats gout)
• cyclophosphamide, ifosfamide, trofosfamide (treats cancer)
• tetracyclines (Ex. minocycline, doxycycline), chloramphenicol, fluconazole, miconazole, quinolones (Ex. moxifloxacin, ciprofloxacin), clarithromycin, rifampicin (treats bacterial and fungal infections)
• tritoqualine, glucocorticoids (Ex. beclomethasone, hydrocortisone) (treats nasal allergies)
• pentoxifylline in high doses of intravenous infusion (used to improve blood flow)
• sulfonamides such as sulfamethoxazole (treats urinary infections)
• medicines used for male sex hormone replacement therapy (Ex. testosterone) and medicines containing female sex hormones (Ex. oestrogens, progestogens)
• sympatholytics such as clonidine, methyldopa (treats high blood pressure, heart failure or prostate symptoms)
• levothyroxine (used to stimulate thyroid gland)
• adrenaline and sympathomimetics such as phenylephrine, norepinephrine (treats life-threatening cardiac arrest and low blood pressure)
• laxatives such as bisacodyl (treats constipation)
• phenytoin (treats fits)
• glucagon (used to treat severely low blood sugar)
• barbiturates such as pentobarbital, amobarbital (treats nervousness and sleep problems)
• acetazolamide (treats increased pressure in the eye)

Overdosage:

If you or anyone else accidentally takes too much of GLIMIBRIT M 0.5 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of GLIMIBRIT M 0.5 TABLET includes risk of low blood sugar levels (in severe cases it may lead to loss of consciousness and coma) and it may cause life-threatening lactic acidosis. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat and difficulty in breathing.

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach of children
• Store at temperature below 25°C

FAQs ABOUT GLIMIBRIT M 0.5 TABLET

Q: What is GLIMIBRIT M 0.5 TABLET used for?

A: GLIMIBRIT M 0.5 TABLET is used to treat type 2 diabetes mellitus when diet, exercise and the single agent alone does not result in adequate glycemic control. Along treatment with GLIMIBRIT M 0.5 TABLET follow regular exercise and diet plan as advised by your doctor to achieve better results.

Q: Can I drive or handle machines after taking GLIMIBRIT M 0.5 TABLET?

A: Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels. Consult your doctor before taking GLIMIBRIT M 0.5 TABLET.

Q: Can I consume alcohol while taking GLIMIBRIT M 0.5 TABLET?

A: Avoid consumption of alcohol during treatment with GLIMIBRIT M 0.5 TABLET as it may increase or decrease the blood sugar lowering action of GLIMIBRIT M 0.5 TABLET and increases the risk of lactic acidosis. Consult your doctor for advice before taking GLIMIBRIT M 0.5 TABLET. 

Q: Is GLIMIBRIT M 0.5 TABLET safe to use in patients with kidney problems?

A: GLIMIBRIT M 0.5 TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Consult your doctor before taking GLIMIBRIT M 0.5 TABLET. 

Q: What are the common side effects of GBNKEYWORD]?

A: The most common side effects of taking GLIMIBRIT M 0.5 TABLET are taste disturbance, nausea, vomiting, diarrhea, loss of appetite and stomach pain. Contact your doctor if any of the symptoms worsen.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020 [Accessed on 24th  December 2022] https://www.cureus.com/articles/37779-glimepiride-and-metformin-combinations-in-diabetes-comorbidities-and-complications-real-world-evidence

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on 24th December 2022] https://clinicaltrials.gov/ct2/show/NCT01459809

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on 24th December 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2642.pdf

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on 24th December 2022] http://pharm.cals.am/pharm/data/drug_124396/1470300364248.pdf

USEFUL DIAGNOSTIC TESTS

• Glucose-Fasting Blood
• Glucose-Postprandial Blood
• Glycosylated Hemoglobin

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 06 Mar 2023 | 09:49 AM(IST)