Alkem Laboratories Ltd

Gemcal Kit Tablet 1's

Osteoporosis
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    Introduction About GEMCAL KIT TABLET

    GEMCAL KIT TABLET is a combination of Calcitriol, Calcium Carbonate, Elemental Zinc, and Risedronate, which belong to the group of medicines called Vitamin D metabolites, Minerals and Bone Conserving Agents respectively. GEMCAL KIT TABLET is indicated in the management of osteoporosis in postmenopausal women.

    Prior to the management with GEMCAL KIT TABLET, your doctor might ask you to take some diagnostic tests.

    Before taking GEMCAL KIT TABLET, inform your doctor if you have kidney diseases, stomach or digestive problems, problems swallowing, difficulty in movement such as after an operation, low blood calcium, difficulty in absorption, and plan to undergo dental surgery.

    GEMCAL KIT TABLET is not recommended for use in patients with high levels of calcium in the blood, extra deposits of calcium in the body, abnormalities of the esophagus, and an inability to stand or sit upright.

    GEMCAL KIT TABLET should be used with caution in pregnant and breast-feeding women. GEMCAL KIT TABLET is not intended for use by children.

    The most common side effects of taking GEMCAL KIT TABLET are pain, including back and joint pain, stomach pain, and heartburn. Ask for your doctor’s advice if any of these worsen or don’t improve.

    Uses Of GEMCAL KIT TABLET

    • To manage osteoporosis in postmenopausal women

    How GEMCAL KIT TABLET Works

    GEMCAL KIT TABLET is used to manage osteoporosis, where calcitriol enhances the absorption of dietary calcium and phosphate from the gastrointestinal tract and kidneys and helps stimulate the release of calcium stores from the skeletal system, which improves calcium regulation in the blood. Calcium carbonate directly increases calcium stores in the body. Elemental zinc helps in restoring bone health by managing bone resorption. Risedronate is a bisphosphonate that acts on the bone-resorbing cells called osteoclasts and inhibits their activity. It also aids in bone mineralization and regeneration.

    How to use GEMCAL KIT TABLET

    Take GEMCAL KIT TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not lie down for at least 30 minutes after you take GEMCAL KIT TABLET and after you eat your first meal of the day. Your doctor will decide the correct dose and duration of GEMCAL KIT TABLET for you depending upon your age, body weight, and disease condition.

    Side Effects Of GEMCAL KIT TABLET

    Common

    • back and joint pain
    • stomach pain
    • heartburn

    Rare

    • signs of high levels of calcium in your blood such as loss of appetite, weight loss, nausea, vomiting, headache, and feeling sluggish, drowsy, or weak
    • mental problems
    • kidney stones
    • changes in kidney function

    Warning & Precautions

    Pregnancy

    Use with Caution

    GEMCAL KIT TABLET should be used with caution in pregnant women. Consult your doctor before taking it

    Breastfeeding

    Use with Caution

    GEMCAL KIT TABLET should be used with caution in breast-feeding women. Consult your doctor before taking it.

    Driving and Using Machines

    Use with Caution

    GEMCAL KIT TABLET does not impair your ability to drive or use machines.

    Kidney

    Use with Caution

    GEMCAL KIT TABLET should be used with caution in patients with kidney diseases. Consult your doctor before taking.

    Allergy

    Contraindicated

    Do not take GEMCAL KIT TABLET if you are allergic to Calcitriol, Calcium Carbonate, Elemental Zinc or Risedronate.

    Use In Pediatrics

    Contraindicated

    GEMCAL KIT TABLET is not recommended for use in children under 18 years of age. Consult your doctor before taking.

    Use In Geriatrics

    Consult your doctor

    Your doctor will decide the correct dose and duration of the management with GEMCAL KIT TABLET for you depending upon your age, health condition, and body weight. Consult your doctor.

    Others

    GEMCAL KIT TABLET is not recommended for use if you:

    • have increased levels of calcium in the blood (hypercalcemia)
    • have more deposits of calcium in your body
    • have abnormalities of the esophagus causing delayed oesophageal emptying, such as stricture or achalasia
    • are unable to stand or sit upright for at least 30 minutes

    Before taking GEMCAL KIT TABLET, tell your doctor if you:

    • have stomach or digestive problems
    • have problems with swallowing
    • have difficulty in movement, such as after an operation
    • have low blood calcium
    • have difficulty in absorption
    • plan to undergo dental surgery

    Interactions

    A. Drug-Drug Interactions:

    Inform your physician if you are taking any of the following drugs before taking GEMCAL KIT TABLET:

    • other medicines containing Vitamin D
    • diuretics (water tablets) such as bendroflumethiazide, chlortalidone, and indapamide (used to manage high blood pressure) and digoxin (used to manage heart diseases)
    • antacids such as magnesium sulphate (used to manage indigestion)
    • steroids such as hydrocortisone, prednisolone, and dexamethasone (used to manage pain and inflammation)
    • cholestyramine (used in managing high levels of cholesterol)
    • ergocalciferol, cholecalciferol (used in the management of low calcium levels in the blood)

    B. Drug-food interactions:

    • avoid taking any vitamins or food supplements that contain vitamin D
    • avoid eating foods rich in vitamin D

    Overdosage:

    If you or anyone else accidentally takes too much of GEMCAL KIT TABLET, consult your doctor immediately or visit the nearby hospital.

    Synopsis

    Drug :   Calcitriol, Calcium Carbonate, Elemental Zinc, Risedronate
    Pharmacological Category :   Vitamin D metabolites, Minerals, Bisphosphonates
    Therapeutic Indication :   Osteoporosis in Postmenopausal Women        
    Dosage Forms :   Tablet

    More Information

    • Keep GEMCAL KIT TABLET out of reach of children
    • Store GEMCAL KIT TABLET below 25°C

    FAQs About GEMCAL KIT TABLET

    Q: What is GEMCAL KIT TABLET and why is it prescribed?

    A: GEMCAL KIT TABLET is a combination of Calcitriol, Calcium Carbonate, Elemental Zinc and Risedronate which belong to the group of medicines called Vitamin D metabolites, Minerals and Bone Conserving Agents respectively. GEMCAL KIT TABLET is indicated in the management of osteoporosis in postmenopausal women.

    Q: Can GEMCAL KIT TABLET affect oral health?

    A: Patients taking GEMCAL KIT TABLET should take care of their oral hygiene. If, after taking GEMCAL KIT TABLET, they have any symptoms like loosening of teeth, pain in the mouth or jaw, delayed wound healing, or infection after extraction, they should immediately talk to their doctor.

    Q: Is GEMCAL KIT TABLET safe for use in pregnant and breast-feeding women?

    A: GEMCAL KIT TABLET should be used with caution in pregnant and breast-feeding women. Consult your doctor before taking it.

    Q: What are the dietary instructions that need to be followed while taking GEMCAL KIT TABLET?

    A: Avoid the consumption of vitamins or food supplements that contain vitamin D while you are taking GEMCAL KIT TABLET. Avoid eating foods that have vitamin D added. It is very important to keep following the diet that your doctor has given you. If you change the amount of calcium or vitamin D you have in your diet while taking GEMCAL KIT TABLET, this can increase the risk of side effects. Also, drink plenty of water and other fluids to keep yourself hydrated.

    Q: What precautions should I follow while taking GEMCAL KIT TABLET?

    A: Take GEMCAL KIT TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Do not lie down for at least 30 minutes after you take GEMCAL KIT TABLET and after you eat your first meal of the day.

    References

    1. KD. Tripathi. Drugs Affecting Calcium Balance. Essentials of medical pharmacology. Seventh edition. 2013. Page – 336, 341 & 344.

    2. John K Brooks, Allen J Gilson, Arnold J Sindler, Steven G Ashman, Kevin G Schwartz, Nikolaos G Nikitakis. Osteonecrosis of the jaws associated with use of risedronate: report of 2 new cases. NIH. National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2007. [Accessed on 7th February 2024] https://pubmed.ncbi.nlm.nih.gov/17223592/

    3. Sandeep Kalra, Veena Jain. Dental complications and management of patients on bisphosphonate therapy: A review article. NIH. National Library of Medicine, National center for biotechnology information. PubMed.gov. November 2012. [Accessed on 7th February 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942225/

    4. Masayoshi Yamaguchi. Role of nutritional zinc in the prevention of osteoporosis. NIH. National Library of Medicine, National center for biotechnology information. PubMed.gov. May 2010. [Accessed on 7th February 2024] https://pubmed.ncbi.nlm.nih.gov/20035439/

    5. NIH. National Library of Medicine, National center for biotechnology information. PubChem. Risedronate Sodium. [Accessed on 7th February 2024] https://pubchem.ncbi.nlm.nih.gov/compound/Risedronate-sodium

    6. Torrent Pharmaceuticals Ltd. Gemitrol Kit. [Revised in January 2020]. [Accessed on 7th February 2024] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1083.pdf

    7. Drug Bank. Calcitriol. [Accessed on 7th February 2024] https://go.drugbank.com/drugs/DB00136

    8. Drug Bank. Calcium Carbonate. [Accessed on 7th February 2024] https://go.drugbank.com/drugs/DB06724

    Useful Diagnostic Tests

    • Calcium
    • Vitamin D 1,25 Dihydroxy
    • Extended Arthritis Care
    • Comprehensive Arthritis Care
    • Basic Bone Care
    • Advance Bone Care
    • Comprehensive Bone Care
    • Esr Automated
    • Phosphorus-Inorganic, Serum
    • Basic Arthritis Care Plan
    • Bone Strength Package
    • Arthritis Profile-Basic
    • Arthritis Profile-Advanced
    • Pth-Intact Molecule Parathyroid Hormone

    Author Details

    Written By Dr. N. Sai Swaroop - Pharm.D
    Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)
    Last updated on 08 Feb 2024 | 03:51 PM(IST)
    Lab updated