Introduction About DOMSTAL 10MG TABLET

Domstal 10mg contains Domperidone commonly used to manage in post-operative vomiting, drug-induced nausea and vomiting, vomiting due to radiation and anticancer drugs and in acute vomiting due to a variety of causes such as fever, gastritis, pancreatitis, uremia and hepatitis.

Domstal 10mg is also indicated in various types of dyspepsia such as postprandial, that associated with peptic ulcer and also in reflux oesophagitis as well as gastritis. It works by blocking dopamine receptors and improving digestion.

Domstal 10mg helps in relieving nausea and vomiting, improves digestion by enhancing stomach movement and also may help with bloating and discomfort.

Take Domstal 10mg as directed by your doctor. Usually taken before meals. Do not exceed the prescribed dose.

Avoid using Domstal Tablet if you have liver disease or a history of heart issues. Consult a doctor if pregnant or breastfeeding.

The possible side effects of Domstal 10mg are dry mouth, dizziness and abdominal cramps. Consult your doctor if any of the above side effects worsen or persists for a longer duration.

Uses Of DOMSTAL 10MG TABLET

It is used to manage:

post-operative vomiting
drug-induced nausea and vomiting
vomiting due to radiation and anticancer drugs
acute vomiting due to a variety of causes such as fever, gastritis, pancreatitis, uremia and hepatitis
various types of dyspepsia such as postprandial, that associated with peptic ulcer and also in reflux oesophagitis as well as gastritis

Benefits of DOMSTAL 10MG TABLET

1. Relieves nausea and vomiting:

Effectively helps manage nausea and vomiting caused by indigestion, gastritis, motion sickness, and certain medications
Works by blocking dopamine receptors in the brain, reducing the urge to vomit

2. Improves digestion by enhancing stomach movement:

Stimulates gastric motility, helping food move smoothly through the stomach and intestines
Beneficial for individuals suffering from acid reflux, delayed digestion, and sluggish bowel movements

3. May help with bloating and discomfort:

Helps relieve gas, bloating, and feelings of fullness after meals
Supports smooth digestion and stomach emptying, managing discomfort from indigestion

How DOMSTAL 10MG TABLET Works

1. How quickly does Domstal 10mg work?

Domstal 10mg typically starts working within 30 to 60 minutes after ingestion
It provides rapid relief from nausea, vomiting, and bloating by improving stomach movement and reducing discomfort

2. How effective is Domstal 10mg for nausea and vomiting?

Domstal 10mg is clinically proven to be effective in managing nausea and vomiting caused by indigestion and acid reflux, gastritis and food poisoning, motion sickness and certain medications (e.g., chemotherapy, painkillers)

How to use DOMSTAL 10MG TABLET

Domstal 10mg Tablet is a prescription medicine which needs to be taken under medical supervision. Always consult your doctor or pharmacist if you have any questions or concerns about taking this medication.

Domstal 10mg dosage instructions:

Take Domstal 10mg as directed by your doctor. Usually taken before meals
Children (weighing more than 35 kg): As prescribed by a doctor
Maximum Dose: Do not exceed 30 mg per day unless advised by a healthcare provider

How to take Domstal 10mg Tablet:

Take 15 to 30 minutes before meals for better absorption
Swallow the tablet whole with a glass of water, do not crush or chew

Can Domstal 10mg be taken on an empty stomach?

Domstal 10mg is best taken on an empty stomach, preferably 15 to 30 minutes before meals
Better absorption - Taking it before meals allows the medication to work faster and more effectively
Enhances stomach movement - Helps food pass through the digestive tract smoothly, reducing nausea and bloating
Manages Vomiting - Taking it in advance helps control nausea before eating

How to take Domstal 10mg Tablet for best results?

Take it on an empty stomach - consume 15 to 30 minutes before meals for better absorption and faster relief
Follow the prescribed dosage - usually one tablet (10mg), up to three times a day, or as directed by your doctor
Swallow whole with water - do not crush or chew the tablet, as this may affect its effectiveness
Avoid alcohol and certain medications - alcohol and some drugs (like antifungals, antibiotics, or acid reducers) may interfere with its action
Stay consistent - For chronic conditions like acid reflux or bloating, take it at the same time daily for optimal results

What if I forgot to take DOMSTAL 10MG TABLET

Take the missed dose as soon as you remember
If it is almost time for the next dose, skip the missed dose, do not double dose for the missed dose

Overdose

Symptoms of Domstal 10mg Overdose:

drowsiness or confusion
irregular heartbeat (arrhythmia or palpitations)
dizziness or fainting
severe restlessness or agitation
uncontrolled muscle movements (twitching or tremors)

What to do in case of an overdose?

Seek immediate medical attention – Call your doctor or visit the nearest hospital
Do not induce vomiting unless instructed by a healthcare provider
Monitor for serious symptoms like difficulty breathing or chest pain
Take the medicine packaging with you to the hospital for reference

Side Effects Of DOMSTAL 10MG TABLET

Common:

dry mouth
dizziness
abdominal cramps

When to consult a doctor?

swelling of the hands, feet, ankle, face, lips and throat which may cause difficulty in swallowing or breathing
itchy lumpy rash (hives), nettle rash (urticaria)
uncontrolled movements, which include irregular movements of eyes, an unusual move of the tongue, abnormal posture (Ex. twisted neck, trembling and muscle stiffness)
have a fast unusual heartbeat
seizures

How To Manage Side Effects

Dizziness Or Drowsiness

Take adequate sleep. Do not involve in rigorous activities
Do not interfere with your sleep cycle

Dry Mouth

Dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva
Sip water at regular intervals of time
Do not use mouthwashes that contain alcohol because they can be drying

Stomach Pain

Apply Heat: Use a warm compress or heating pad on your stomach to relax muscles
Drink Herbal Teas: Ginger, peppermint, or chamomile tea can soothe digestion
Gentle Massage: Lightly rub your abdomen in a circular motion to relieve tightness

Warning & Precautions

Pregnancy

Monitoring required

Pregnant women should use Domstal 10mg only if necessary under medical supervision. It crosses the placenta, and while no major birth defects have been reported, studies on its safety in pregnancy are limited. Doctors may prescribe it only if the benefits outweigh the risks, particularly in cases of severe nausea and vomiting (morning sickness or hyperemesis gravidarum).

Breastfeeding

Monitoring required

Breastfeeding mothers should discuss the risks with their doctor. If prescribed while breastfeeding, monitor the baby for any unusual symptoms and seek pediatric advice if needed. Domstal 10mg passes into breast milk in small amounts, so caution is advised. It is sometimes prescribed to increase breast milk production (off-label use), but its safety for this purpose is debated. Potential risks for the baby may cause drowsiness, irritability, or digestive issues in infants, long-term effects on breastfed babies are not well studied.

Driving and Using Machines

Use with Caution

Domstal 10mg does not affect the ability to drive or use machines. Yet do not drive or operate any machines if you feel dizzy after taking the medicine.

Kidney

Use with Caution

Domstal 10mg should be taken with caution in patients with kidney problems such as kidney impairment or kidney failure.

Liver

Use with Caution

Domstal 10mg may be used with dose adjustments, as advised by a doctor in patients with mild to moderate liver disease. Domstal 10mg is metabolized in the liver, and impaired liver function can lead to higher drug accumulation, increasing the risk of side effects in patients with severe liver disease (cirrhosis, hepatic impairment).

Allergy

Contraindicated

Do not take Domstal 10mg if you are allergic to Domperidone or any other ingredients of this medicine.

Heart Disease

Contraindicated

Domstal 10mg is not recommended in patients suffering from heart problems such as prolonged QT corrected interval or heart failure.

Use In Pediatrics

Consult your doctor

Domstal 10mg is not recommended for use in children and adolescents below 12 years of age or weighing less than 35 kgs. Consult with your child’s doctor before giving this medicine to your child.

Use In Geriatrics

Use with Caution

Domstal 10mg should be used with caution for use over 60 years of age, as this medicine may associated with an increased risk of heart rhythm disorder and cardiac arrest.

Who should not take [GBNKEYWORD

Domstal 10mg is not recommended for use if you have:

tumor in the pituitary gland (prolactinoma)
history of blockage or tear in the intestine
hypokalemia (low level of potassium)
hyperkalemia (high level of potassium in the blood)
hypomagnesemia (low level of magnesium in the blood)
signs and symptoms of bleeding in the stomach or intestine (black tarry bowel motions or blood in your bowel motions)

Diet and Lifestyle Advice

Natural Remedies vs Domstal 10mg - what works faster?

Speed of action: Which is faster?

Domstal 10mg starts working within 30 to 60 minutes after ingestion. It blocks dopamine receptors in the brain, helping relieve nausea and vomiting quickly
Natural remedies may take longer to show effects as they work by soothing the digestive system gradually. However, some remedies like ginger or peppermint may provide mild relief within 30 to 60 minutes

Remedy	Time to Work	Best for
Domstal 10mg	30-60 minutes	Nausea, vomiting, bloating
Ginger	30-60 minutes	Mild nausea, morning sickness
Peppermint tea	30-90 minutes	Bloating, indigestion
Fennel seeds	1-2 hours	Gas, bloating
Hydration (warm water, electrolyte drinks)	30 minutes	Dehydration-related nausea

Foods to eat when taking Domstal 10mg:

Rice, oatmeal, toast, boiled potatoes
Lean meats, eggs, tofu, lentils
Ginger & herbal teas
Bananas & apples
Yogurt & probiotics

Foods to avoid when taking Domstal 10mg:

Spicy & oily foods
Caffeinated drinks (coffee, tea, energy drinks)
Carbonated beverages
High-fat & processed foods
Dairy (if lactose intolerant)

Lifestyle changes for better digestion:

Chew food slowly to improve digestion and prevent bloating
Avoid overeating - opt for small, frequent meals instead of large portions
Take a short walk after meals (10-15 minutes) to aid digestion
Drink warm water throughout the day to support digestion
Sleep on your left side to reduce acid reflux
Avoid lying down immediately after meals and wait for at least 2-3 hours

Natural ways to reduce nausea - Do they work?

Effective Natural Remedies for Nausea - For mild nausea, these remedies can be effective

Ginger
Peppermint
Lemon & citrus scents
Acupressure (P6 Pressure Point)
Stay hydrated

Drug - Drug interaction

Medications to Avoid: Can I take Domstal 10mg with other medications?

Medication type	Can you take it with Domstal 10mg?	Possible interaction/precaution
Antacids (e.g., Pantoprazole, Omeprazole)	Yes	Take Domstal 30 mins before the antacid for best results
Antibiotics (e.g., Clarithromycin, Erythromycin)	No	May increase Domstal side effects like heart rhythm issues
Antifungals (e.g., Ketoconazole, Itraconazole)	No	Increases the risk of severe side effects
Painkillers (e.g., Paracetamol, Ibuprofen)	Yes	Generally safe, but avoid excessive NSAIDs to manage stomach irritation
Blood Pressure Medications (e.g., Amlodipine, Metoprolol)	Caution	May increase dizziness, monitor blood pressure
Diabetes Medications (e.g., Metformin, Insulin)	Yes	Safe, but watch for changes in blood sugar levels
Antidepressants (e.g., SSRIs, Tricyclics)	Caution	Some may interact, increasing the risk of heart issues. Consult a doctor
Blood Thinners (e.g., Warfarin, Aspirin)	Caution	May increase the risk of bleeding, consult a doctor
Hormonal Pills (e.g., Birth Control, HRT)	Yes	No known significant interactions
Seizure Medications (e.g., Carbamazepine, Phenytoin)	Caution	May reduce Domstal’s effectiveness. Consult your doctor.

Drug - Food interaction

Potential Food Interactions:

Food type	Can you take it?	Possible Interaction/Precaution
Spicy & oily foods	Avoid	May worsen nausea, acid reflux, and bloating
Caffeine (coffee, tea, energy drinks)	Limit	Can reduce Domstal’s effectiveness and cause restlessness
Citrus fruits (oranges, lemons, grapefruit)	Caution	May increase stomach acid, potentially irritating the stomach
Dairy products (milk, cheese, yogurt)	Yes (if tolerated)	Safe for most, but avoid if lactose intolerant as it may cause bloating
High-fiber foods (whole grains, beans, lentils)	Yes	Supports digestion but should be consumed in moderation to avoid bloating
Fermented foods (pickles)	Yes	Can support gut health, but excessive intake may increase acidity
Sugary & processed foods (candy, sodas, fast food)	Avoid	Can worsen bloating and slow digestion

Synopsis

Drug	:	Domperidone
Pharmacological Category	:	Dopamine antagonists
Therapeutic Indication	:	Nausea and Vomiting
Dosage Forms	:	Tablets, Capsules, Dispersible tablets, Rapitab, Suspension, Oral Suspension, Syrup, Oral Drops, Drops

More Information

Domstal 10mg vs other anti-nausea medications – which one works best?

Medication	Best for	How it works	Time to work	Common side effects	Prescription required?
Domstal 10mg (Domperidone)	Nausea, bloating, acid reflux, gastroparesis	Blocks dopamine receptors in the gut, speeds up stomach emptying	30-60 minutes	Dry mouth, dizziness, heart rhythm issues (rare)	Yes
Ondansetron	Chemotherapy-induced nausea, post-surgery nausea, pregnancy nausea	Blocks serotonin in the brain and gut	30 minutes	Constipation, headache, dizziness	Yes
Metoclopramide	Gastroparesis, migraine-related nausea, GERD	Increases stomach motility, blocks dopamine	30-60 minutes	Fatigue, restlessness, involuntary muscle movements (long-term use risk)	Yes
Meclizine	Motion sickness, vertigo-related nausea	Blocks histamine receptors in the brain	1-2 hours	Drowsiness, dry mouth	No (otc)
Promethazine	Severe nausea, motion sickness, post-surgery nausea	Blocks dopamine and histamine receptors	20-30 minutes	Drowsiness, dizziness, dry mouth	Yes
Ginger Supplements	Mild nausea, pregnancy nausea, motion sickness	Natural anti-inflammatory, aids digestion	30-60 minutes	Mild heartburn (rare)	No (otc)

What to do if you experience side effects? (Quick tips):

Side effect	What to do?
Dry mouth	Drink plenty of water, chew sugar-free gum, or suck on ice chips
Dizziness	Avoid sudden movements, stand up slowly, and stay hydrated
Headache	Rest in a quiet place, drink water, and take a mild pain reliever if needed
Bloating/Gas	Eat light meals, avoid carbonated drinks, and try herbal teas (e.g., peppermint, ginger)
Diarrhea	Stay hydrated, avoid greasy/spicy foods, and eat plain foods like bananas and rice
Fatigue	Get enough rest, reduce caffeine intake, and avoid heavy activities

Gastrointestinal Disorders:

Nausea & Vomiting: Domstal 10mg is commonly prescribed for nausea, vomiting, and gastric motility disorders.

Common causes of Nausea & Vomiting:

Indigestion & acid reflux (GERD)
Gastric infections (food poisoning, stomach flu)
Pregnancy (morning sickness)
Motion sickness & vertigo
Side effects of medications (antibiotics, painkillers, chemotherapy)

Treatment options:

Domstal 10mg: Works by blocking dopamine receptors in the gut, promoting faster stomach emptying, and managing nausea
Ondansetron: Used for severe nausea (e.g., chemotherapy, post-surgery)
Natural remedies: Ginger, peppermint tea, acupressure on the wrist (P6 point)

Gastric Motility Disorders: These conditions affect how food moves through the digestive tract, often causing bloating, nausea, and delayed gastric emptying.

Common conditions:

Gastroparesis (Delayed stomach emptying)
Functional Dyspepsia (Chronic indigestion)
IBS (Irritable Bowel Syndrome) with slow digestion

Role of Domstal 10mg in management

Speeds up stomach emptying, reducing bloating & nausea
Improves gut movement, managing food from sitting in the stomach too long
Enhances digestion, making it useful for acid reflux & bloating

FAQs About DOMSTAL 10MG TABLET

Q: What is Domstal 10mg used for?

A: Domstal 10mg is used to manage in post-operative vomiting, drug-induced nausea and vomiting, vomiting due to radiation and anticancer drugs and in acute vomiting due to a variety of causes such as fever, gastritis, pancreatitis, uremia and hepatitis.

Q: How long does Domstal 10mg stay in the system?

A: Domstal 10mg have half-life approximately 7-9 hours in healthy adults. Typically takes around 35-45 hours (5 half-lives) for the drug to be fully cleared from the system.

Q: Can I take Domstal 10mg for acid reflux?

A:Domstal is mainly used for nausea, but it may provide some relief for acid reflux symptoms. If acid reflux is due to slow stomach emptying (gastroparesis), Domstal can improve digestion by increasing stomach motility.

Q: When reflux is associated with nausea and bloating, does Domstal 10mg can provide relief?

A: Yes, Domstal 10mg can help when reflux is accompanied by nausea, bloating, and slow stomach emptying (gastroparesis).

Q: Is Domstal 10mg safe for long-term use?

A:Prolonged use of Domstal 10mg should be monitored by a doctor to manage potential side effects.

Q: Can Children take Domstal 10mg?

A:Consult a pediatrician before giving Domstal 10mg to children.

Q: How long can I take Domstal 10mg?

A: It is recommended that Domstal 10mg be taken for the shortest period and at the lowest dose. This is because Domstal can cause an irregular heartbeat when taken for a longer period or at a high dose.

Q: Can I take Domstal 10mg with antibiotics?

A: Use of Domstal with antibiotics like erythromycin, levofloxacin, and some antifungals is not recommended as this can cause interaction.

Q: Does Domstal increase milk secretion?

A: Yes, Domstal may increase milk secretion also known as galactorrhoea. This is an uncommon side effect of using Domstal 10mg. Talk to your doctor if you are experiencing this side effect while taking this medicine.

Q: Does Domstal cause Heart problems?

A: Domstal may be associated with an increased risk of heart problems (like an irregular heartbeat) and heart attacks. The risk also increases when Domstal is given together with other medicines.

Q: Does Domstal 10mg cause dry mouth?

A: Yes. Domstal can cause dry mouth. A dry mouth can be managed by chewing sugar-free gum or sucking on sugar-free hard candies to stimulate the flow of saliva. Sip water at regular intervals of time. Do not use mouthwashes that contain alcohol because they can be drying.

Q: What is the best time to take Domstal 10mg Tablet?

A: It is recommended to take Domstal 10mg before meals. If taken after meals, absorption of the medicine is somewhat delayed. Patients should try to take each dose of Domstal at a scheduled time to avoid missing a dose.

Q: Is Domstal 10mg safe during pregnancy?

A: Domstal 10mg is classified as Pregnancy Category C, there is limited human research, and it should only be used if the benefits outweigh potential risks. It crosses the placenta, but no significant birth defects have been reported in studies.

Q: Can I take Domstal 10mg with antacids?

A: Yes. But take Domstal 10mg before meals (at least 30 minutes before food) or take antacids after meals, if needed, but at least 1-2 hours apart from Domstal.

References

KD Tripathi. Antiemetics. Essentials of Medical Pharmacology. Eighth edition. 2019. Page - 414.
Rhew K, Han N, Oh JM. Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed Central. August 2019. [Accessed on March 28th 2025]
NIH National Library of Medicine, National Centre for Biotechnology Information. Pubchem. Domperidone. [Accessed on March 28th 2025]
Savio C Reddymasu, Irfan Soykan, Richard W McCallum. Domperidone: review of pharmacology and clinical applications in gastroenterology. NIH National Library of Medicine, National Centre for Biotechnology Information. Pubmed.gov. September 2007. [Accessed on March 28th 2025]
S.C. Zentiva S.A. Electronic Medicines Compendium (emc). [Revised in April 2021] [Accessed on March 28th 2025]
Torrent Pharmaceuticals Ltd. Domstal DT (Domperidone). [Revised in February 2022]. [Accessed on March 28th 2025]
Torrent Pharmaceuticals Ltd. Domstal (Domperidone). [Revised in April 2022]. [Accessed on March 28th 2025]
Torrent Pharmaceuticals Ltd. Domstal OD (Domperidone). [Accessed on March 28th 2025]
Janssen-Cilag (New Zealand) Ltd. Medsafe. [Revised in November 2020]. [Accessed on March 28th 2025]
Morepen Laboratories Ltd. DOM DT 20mg, DOM DT 5mg [Accessed on March 28th 2025]

Author Details

Written By Dr. Janet.C - Pharm.D

Reviewed For Accuracy By Dr. Vrushabhakumar Jitendra Shah. - MBBS

Last updated on 29 Mar 2025 | 09:46 AM(IST)

Quick Links

Introduction About DOMSTAL 10MG TABLET

Uses Of DOMSTAL 10MG TABLET

Benefits of DOMSTAL 10MG TABLET

1. Relieves nausea and vomiting:

2. Improves digestion by enhancing stomach movement:

3. May help with bloating and discomfort:

How DOMSTAL 10MG TABLET Works

1. How quickly does Domstal 10mg work?

2. How effective is Domstal 10mg for nausea and vomiting?

How to use DOMSTAL 10MG TABLET

Domstal 10mg dosage instructions:

How to take Domstal 10mg Tablet:

Can Domstal 10mg be taken on an empty stomach?

How to take Domstal 10mg Tablet for best results?

What if I forgot to take DOMSTAL 10MG TABLET

Overdose

Symptoms of Domstal 10mg Overdose:

What to do in case of an overdose?

Side Effects Of DOMSTAL 10MG TABLET

Common:

When to consult a doctor?

How To Manage Side Effects

Dizziness Or Drowsiness

Dry Mouth

Stomach Pain

Warning & Precautions

Pregnancy

Breastfeeding

Driving and Using Machines

Kidney

Liver

Allergy

Heart Disease

Use In Pediatrics

Use In Geriatrics

Who should not take [GBNKEYWORD

Diet and Lifestyle Advice

Natural Remedies vs Domstal 10mg - what works faster?

Foods to eat when taking Domstal 10mg:

Foods to avoid when taking Domstal 10mg:

Lifestyle changes for better digestion:

Natural ways to reduce nausea - Do they work?

Drug - Drug interaction

Medications to Avoid: Can I take Domstal 10mg with other medications?

Drug - Food interaction

Potential Food Interactions:

Synopsis

More Information

Domstal 10mg vs other anti-nausea medications – which one works best?

What to do if you experience side effects? (Quick tips):

Gastrointestinal Disorders:

Common causes of Nausea & Vomiting:

Treatment options:

Common conditions:

Role of Domstal 10mg in management

FAQs About DOMSTAL 10MG TABLET

Q: What is Domstal 10mg used for?

Q: How long does Domstal 10mg stay in the system?

Q: Can I take Domstal 10mg for acid reflux?

Q: When reflux is associated with nausea and bloating, does Domstal 10mg can provide relief?

Q: Is Domstal 10mg safe for long-term use?

Q: Can Children take Domstal 10mg?

Q: How long can I take Domstal 10mg?

Q: Can I take Domstal 10mg with antibiotics?

Q: Does Domstal increase milk secretion?

Q: Does Domstal cause Heart problems?

Q: Does Domstal 10mg cause dry mouth?

Q: What is the best time to take Domstal 10mg Tablet?

Q: Is Domstal 10mg safe during pregnancy?

Q: Can I take Domstal 10mg with antacids?

References

Author Details

Gastro Intestinal Motility Disorders Medicines

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