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Gabanyl NT 400/10mg Tablet 10'S
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INTRODUCTION
GABANYL NT 400/10MG TABLET is a combination of Gabapentin and Nortriptyline which belongs to the group of medicines called Anticonvulsant and Antidepressants respectively. GABANYL NT 400/10MG TABLET is used to treat neuropathic pain in adults.
Neuropathic pain is caused due to damage to the sensory nerves usually due to chronic progressive nerve disease, infection, or injury. The pain could be occasional or continuous, which is thought of as a prickling, stabbing, tingling, or burning sensation.
Avoid consumption of alcohol while taking GABANYL NT 400/10MG TABLET as it may lead to more dizziness. If you have self-harming thoughts, contact your physician or go to the hospital straight away.
GABANYL NT 400/10MG TABLET is not recommended to use if you had a recent heart attack or heartbeat disorder, heart block, or coronary artery disease. Consult your doctor before taking.
GABANYL NT 400/10MG TABLET should not be used among women who are pregnant or breastfeeding mothers. GABANYL NT 400/10MG TABLET is not recommended for use in children and adolescents (below 18 years of age).
It should be used with caution in elderly patients (above 65 years of age). The most common side effects of GABANYL NT 400/10MG TABLET are viral infection, feeling drowsy, dizziness, lack of coordination, feeling tired, constipation, nausea, headache, tremor, and fever. Consult your doctor for advice if your symptoms get worsen over time.
USES OF GABANYL NT 400/10MG TABLET
- Used to treat neuropathic pain (in adults)
HOW GABANYL NT 400/10MG TABLET WORKS
GABANYL NT 400/10MG TABLET is a combination of Gabapentin and Nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels, which in turn helps in relieving nerve pain. Nortriptyline works by increasing the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of signals of pain in the brain. Together Gabapentin and Nortriptyline relieve neuropathic pain (pain from damaged nerves).
DIRECTIONS FOR USE
Take GABANYL NT 400/10MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
SIDE EFFECTS OF GABANYL NT 400/10MG TABLET
COMMON
- dry mouth
- excessive sweating
- constipation
- nausea
- headache
- tremor
- blocked nose
- accommodation disorder of the eyes
- irregular or heavy heartbeat
- weight gain
- aggression
- strange body movements
- flushing
- weakness, fatigue
- dizziness
- confusion
- problem in the heart called ‘prolonged QT interval
- changes in taste
- blurred vision
- decreases in libido and erectile dysfunction
- agitation
- tingling in arms and legs
- problems urinating (increased or decreased)
- feeling thirsty
- low sodium concentration in the blood
- viral infection
- high blood pressure, dilation of blood vessels
- difficulty breathing, sore throat, cough, bronchitis, dry nose
- vomiting (being sick), problems with teeth, inflamed gums, diarrhea, stomach pain, indigestion, or throat, flatulence
- facial swelling, bruises, rash, itch, acne
- pain in the joints, muscles, and back, and twitching
- swelling in the legs and arms, difficulty in walking, feeling unwell, weakness, pain, flu-like symptoms
- decrease in the number of white blood cells, increase in weight
- accidental injury, abrasion, fracture
UNCOMMON
- swelling that may involve the limbs, face, and trunk
- abnormal blood test results (problems with the liver)
- mental impairment
- increase in blood glucose levels
- difficulty swallowing
- changes in sleep patterns (including nightmares)
- increased production or outflow of breast milk without breastfeeding
RARE
- respiratory depression (trouble breathing, shallow breaths)
- confusional states (delirium)
- hallucinations
- hair loss
- enlargement of male breast tissue
Stop taking GABANYL NT 400/10MG TABLET and contact your physician immediately if you experience any of the following side effects:
- muscle pain and/or weakness or tenderness
- signs such as persistent stomach pain, feeling sick, and being sick (acute pancreatitis) (inflamed pancreas)
- swelling of the lips, tongue, and face, skin rash and redness, and/or hair loss, hives, fever, swollen glands that do not go away
- yellowing of the skin or of the whites of the eyes, unusual bruising or bleeding, severe fatigue or weakness, and unexpected muscle pain
- breathing problems
HOW TO MANAGE SIDE EFFECTS
Nausea or Vomiting:
Try to take GABANYL NT 400/10MG TABLET with, or just after, a meal or snack and stick to simple meals, and do not eat oil-rich or spicy food. Consult your physician if your symptom does not improve.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. Consult your physician if your symptom does not improve.
Constipation:
Eat more foods that are fiber-rich such as fresh fruits, vegetables, and cereals, and drink plenty of water. Exercise more regularly.
Diarrhoea:
Drink more fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own for diarrhea without consulting your physician.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have lesser and more frequent meals. Keep a heating pad on your stomach. Consult your physician if your symptom does not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Contact your doctor if your headache did not improve.
Dizziness:
Lie down until dizziness goes away and then move slowly and carefully. Take more rest and drink more fluids. Consult your physician if your symptom worsens.
WARNING & PRECAUTIONS
PREGNANCY
GABANYL NT 400/10MG TABLET is not recommended to use in pregnant women unless considered clearly necessary. Consult your doctor before taking the medicine.
BREASTFEEDING
GABANYL NT 400/10MG TABLET is contraindicated for breastfeeding women. Consult your doctor before taking GABANYL NT 400/10MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines or do anything that needs alertness or clear vision after taking GABANYL NT 400/10MG TABLET.
ALCOHOL
Avoid consumption of alcohol while taking GABANYL NT 400/10MG TABLET as it may lead to more dizziness. Consult your doctor before taking GABANYL NT 400/10MG TABLET.
KIDNEY
GABANYL NT 400/10MG TABLET should be taken with caution in patients with kidney problems including haemodialysis. Consult your doctor before taking.
LIVER
GABANYL NT 400/10MG TABLET is not recommended for patients with severe liver diseases. Consult your doctor before taking.
ALLERGY
Do not take GABANYL NT 400/10MG TABLET if you are allergic to Gabapentin, Nortriptyline or any other tricyclic antidepressants (Ex. amitriptyline) or to any other ingredients of this medicine.
HEART DISEASE
GABANYL NT 400/10MG TABLET is not recommended for patients who had recent myocardial infarction, any degree of heart block or other cardiac arrhythmias. It should be used with patients with mild to moderate heart disease. Consult your doctor before taking.
OTHERS
GABANYL NT 400/10MG TABLET is not recommended if you:
- suffer from mania (abnormally raised mood)
Before taking GABANYL NT 400/10MG TABLET, inform your doctor if you have:
- nervous system disorders
- respiratory disorders
- suicidal thoughts or aggressive behaviour
- schizophrenia, bipolar disorder
- thyroid conditions
- a history of epilepsy
- high pressure in the eyes (glaucoma)
- an enlarged prostate
- diabetes
- difficulty in passing urine
- paralytic ileus (blocked intestine) and pylorus stenosis (narrowing of the gastric outlet)
- excessive fever (hyperpyrexia)
- undergo electroconvulsive therapy
Use in pediatrics:
GABANYL NT 400/10MG TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking.
Use in geriatrics:
GABANYL NT 400/10MG TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking GABANYL NT 400/10MG TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking GABANYL NT 400/10MG TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used as monoamine oxidase inhibitors (Ex. phenelzine, moclobemide, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline (used to treat Parkinson's disease)
- medicines used to treat opioid dependence (Ex. buprenorphine)
- medicines used in cough or cold medicine, and in some anesthetics (Ex. adrenaline, isoprenaline, ephedrine, noradrenaline, phenylephrine, and phenylpropanolamine)
- medicine used to treat high blood pressure (Ex. diltiazem and verapamil) (Ex. guanethidine, bethanidine, debrisoquine, clonidine reserpine, and methyldopa)
- medicines used to treat Parkinson’s disease and gastrointestinal disorders (Ex. atropine, hyoscyamine)
- medicine used to treat schizophrenia (Ex. thioridazine)
- medicine used as a painkiller (Ex. tramadol)
- medicines to treat fungal infections (Ex. fluconazole, terbinafine, ketoconazole, and itraconazole)
- medicine used as sedatives (Ex. barbiturates)
- medicine used as antidepressants (Ex. fluoxetine, paroxetine, fluvoxamine), and bupropion)
- medicines used to treat certain heart conditions (Ex. beta-blockers and antiarrhythmics)
- medicine used to treat stomach ulcers (Ex. cimetidine)
- medicine used to treat ADHD (Ex. methylphenidate)
- oral contraceptives
- medicine used to treat infections (Ex. rifampicin)
- medicine used to treat epilepsy (Ex. phenytoin and carbamazepine)
- an herbal remedy used for depression (Ex. St. John’s Wort)
- medicine used for thyroid problems
- medicines used to treat heart rhythm (Ex. amiodarone, cisapride, dofetilide, pimozide, procainamide, quinidine, sotalol)
Overdosage:
If you or anyone else accidentally takes too much of GABANYL NT 400/10MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose may include blurred vision, fast or irregular heartbeats, difficulties passing water, dry mouth and tongue, intestinal blockage, fits, fever, agitation, confusion, hallucinations, uncontrolled movements, low blood pressure, weak pulse, pallor, difficulty breathing, blue discoloration of the skin, decreased heart rate.
SYNOPSIS
| Drug | : | Gabapentin, Nortriptyline |
| Pharmacological Category | : | Anticonvulsants and Antidepressants |
| Therapeutic Indication | : | Neuropathic pain |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep GABANYL NT 400/10MG TABLET out of reach to children
- Store at a temperature, not more than 30°C
FAQs ABOUT GABANYL NT 400/10MG TABLET
What for GABANYL NT 400/10MG TABLET is used?
GABANYL NT 400/10MG TABLET is used to treat neuropathic pain. Neuropathic pain is caused due to damage to the sensory nerves usually due to chronic progressive nerve disease, infection, or injury. Consult your doctor before taking it.
Is GABANYL NT 400/10MG TABLET safe to use in pregnancy?
GABANYL NT 400/10MG TABLET is generally not recommended to use in pregnant women unless considered clearly necessary. Consult your doctor before taking GABANYL NT 400/10MG TABLET.
Can GABANYL NT 400/10MG TABLET be used in patients with heart problems?
GABANYL NT 400/10MG TABLET should not be used in patients with heart problems like a recent heart attack or heartbeat disorder, heart block, or coronary artery disease. Consult your doctor before taking GABANYL NT 400/10MG TABLET.
Can I drink alcohol along with GABANYL NT 400/10MG TABLET?
Avoid consumption of alcohol while taking GABANYL NT 400/10MG TABLET as it may lead to more dizziness. Consult your doctor before taking GABANYL NT 400/10MG TABLET.
Is GABANYL NT 400/10MG TABLET can be used in children?
GABANYL NT 400/10MG TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking.
REFERENCES
1. Misty D. Smith, Cameron S. Metcalf, and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 303-326.
2. James M. O’Donnell, Robert R. Bies, and Richard C. Shelton. Drug Therapy of Depression and Anxiety Disorders. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 267-277.
3. KD. Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 411- 424.
4. KD. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drug. Essentials of medical pharmacology. Seventh edition. 2013. Page – 454- 468.
5. Ian Gilron 1, Joan M Bailey, Dongsheng Tu, Ronald R Holden, Alan C Jackson, Robyn L Houlden. Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. The Lancets. September 2009 [Accessed on 28th June 2022] https://pubmed.ncbi.nlm.nih.gov/19796802/
6. Gabapentin and Nortriptyline. www.leogenic.com. [Accessed on 28th June 2022] https://www.leogenic.com/gabdew-nt-gabapentin-and-nortriptyline-tablet
7. Gabapentin and Nortriptyline. www.larenon.com. [Accessed on 28th June 2022] https://www.larenon.com/wp-content/uploads/2016/06/LAregab-NT.pd
8. Gabapentin and Nortriptyline. www.leleon.in. [Accessed on 28th June 2022] https://www.leleon.in/Gabapentin.html
9. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed 28th June 2022] https://www.medicines.org.uk/emc/files/pil.7410.pdf
10. Mylan Ltd. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed 28th June 2022] https://www.medicines.org.uk/emc/files/pil.11267.pdf
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 29 Oct 2022 | 07:46 PM(IST)
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