INTRODUCTION

FACECLIN is a combination of Clindamycin and Nicotinamide which belongs to a group of medicines called Lincomycin antibiotics and Vitamin B3 complex, respectively.  FACECLIN is used to treat mild to moderate acne which is a skin condition that occurs when hair follicles become plugged with oil and dead skin cells which may occur due to variety of causes such as genetics, fluctuating hormone levels, stress, high humidity or using oily or greasy personal care products which may affect people of all ages. It is characterized by symptoms such as open or closed plugged pores, small red & tender bumps, pimples, large, solid, or painful lumps under the skin, and painful & pus-filled lumps under the skin.

Clindamycin is a lincomycin antibiotic that reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes), a bacteria found in sebaceous glands and follicles. Nicotinamide is a vitamin of B3 complex that exerts anti-inflammatory effect in acne and interrupts sebum production.

Avoid applying FACECLIN, if you are allergic to Clindamycin or Nicotinamide, and or have a history of regional enteritis (inflamed gastrointestinal tract), ulcerative colitis (inflammatory bowel disease), antibiotic associated colitis (inflammation of large intestine), liver or renal impairment. Before applying FACECLIN, inform your doctor if you have eczema (skin inflammation), or asthma.

FACECLIN is not recommended for use during pregnancy and in breastfeeding women, which is also not recommended for use in children and adolescents (below 12 years). Consult your doctor before applying FACECLIN. The most common symptoms of using FACECLIN are skin inflammation, contact dermatitis (red, itchy rash), inflammation of hair follicles, itchy skin, dry skin, peeling of skin and skin redness. Consult your doctor if any of these symptoms worsen.

USES OF FACECLIN

• Treats mild to moderate acne

HOW FACECLIN WORKS

FACECLIN helps to treat acne, where clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes), a bacteria found in sebaceous glands and follicles, and nicotinamide exerts anti-inflammatory effect in acne and interrupts sebum production.

DIRECTIONS FOR USE

Apply FACECLIN as advised by your physician. It is for external use only. Before applying the medicine normally wash and dry the affected area and apply a thin layer of this medicine on the affected area. Treated areas on the face need not be covered with a plaster or bandage. Do not apply FACECLIN on your face beyond the recommended duration. Avoid applying FACECLIN around your eyes, including eyelids. Rinse it off with water if you accidentally get it in these areas. 

SIDE EFFECTS OF FACECLIN

HOW TO MANAGE SIDE EFFECTS

Dry Skin:

Try moisturizing your skin with an ointment, cream, or lotion 2 or 3 times a day, or as more often as needed.  Moisturizers help to keep the area moisture, so they work best on damp skin. After you bathe, pat your skin dry then apply your moisturizer. Consult your before using any moisturizer. Try to avoid using skin care products and soaps that contain alcohol, fragrances, dyes, or other chemicals.

Diarrhoea:

Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before using FACECLIN, inform your doctor if you are taking any of the following medicines:

• neuromuscular blocking agents (used adjunctively with anesthesia to produce paralysis) Ex. cisatracurium, vecuronium
• birth control pills (used to prevent pregnancy) Ex. conjugated estrogen

Overdosage:

If you or anyone else accidentally applies too much of FACECLIN, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are diarrhea, bloody diarrhea, and colitis including pseudomembranous colitis (swelling or inflammation of the large intestine that occurs after antibiotic use).

SYNOPSIS

MORE INFORMATION

• Keep FACECLIN out of reach of children
• Store below 25 °C

FAQs ABOUT FACECLIN

What special precautions should I follow while using FACECLIN?

Patients before using FACECLIN must inform their doctor about their pre-existing conditions such as kidney, liver, or digestive tract diseases. Patients should also inform if they are pregnant, breast-feeding, having any allergies, or ulcerative colitis. Contact your doctor immediately if you have any unusual symptoms.

Is FACECLIN safe to use in patients with liver problems?

FACECLIN is not recommended for use in patients having liver disease such as liver impairment. It should be used with caution in patients having other liver diseases. Consult your doctor before applying FACECLIN.

What is FACECLIN used for?

FACECLIN is indicated for the treatment of mild to moderate acne in patients above 12 years of age. Do not use it for any other condition other than that prescribed by your doctor.

How should I use FACECLIN?

Always apply FACECLIN, as directed by your physician. It is for external use only. On the affected area, apply a thin layer of this medicine. Treated areas on the face need not be covered with a plaster or bandage. Do not apply FACECLIN on your face beyond 5 days. Avoid applying FACECLIN around your eyes, including eyelids.

Is FACECLIN safe to use in pregnant and breastfeeding women?

FACECLIN is not recommended for use during pregnancy and in women planning for pregnancy, also it is not recommended for use in breastfeeding women. Consult your doctor before applying FACECLIN.

REFERENCES

1. KD. Tripathi. Macrolide, Lincosamide, Glycopeptide & Other Antibacterial Antibiotics; Urinary Antiseptics and Vitamins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 756 & 914.

2. Pooja Bains, Manpreet Kaur, Jasleen Kaur, Saurabh Sharma. Nicotinamide: Mechanism of action and indications in dermatology. Indian Journal of Dermatology, Venereology, and Leprology. 2018. [Accessed on 7th June 2022] https://ijdvl.com/nicotinamide-mechanism-of-action-and-indications-in-dermatology/

3. A R Shalita, J G Smith, L C Parish, M S Sofman, D K Chalker. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 1995. [Accessed on 7th June 2022] https://pubmed.ncbi.nlm.nih.gov/7657446/

4. Aeropak Ltd. Electronic medicines compendium (EMC). [Revised in January 2019] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.6765.pdf

5. Amgen Inc. U.S. Food & Drug Administration. [Revised in August 2011] [Accessed on 7th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/50782lbl.pdf

6. Wellona Pharma. Acnewell-N. Clindamycin Phosphate & Nicotinamide Gel. [Accessed on 7th June 2022] https://wellonapharma.com/product/finished/clindamycin-phosphate-and-nicotinamide-gel

7. Curatio. Clinmiskin Gel. [Accessed on 7th June 2022] https://curatiohealthcare.com/product/clinmiskin-gel/