INTRODUCTION

ESTRABET 1MG TABLET contains Estradiol which belongs to the group of medicines called Estrogens. ESTRABET 1MG TABLET is used in postmenopausal women (with at least 6 months since their last natural period) to provide relief from symptoms that occurs after menopause. It is also used to prevent osteoporosis (condition marked by weak and fragile bones) which occurs after menopause in few women.

ESTRABET 1MG TABLET is not recommended for use in patients allergic to Estradiol. It is also not recommended for use in patients who have/had/suspected of breast/endometrial cancer or thrombosis (blood clot in vein). The medicine is also not indicated for use in patients who suffer from unusual vaginal bleeding, untreated endometrial hyperplasia (excessive thickening of the womb lining), lung disease (such as pulmonary embolism), heart disease (such as heart attack/heart block), and/or liver disease (such as benign liver tumour).

Before taking ESTRABET 1MG TABLET, inform your doctor if you have fibroids (non-cancerous growths inside womb), endometriosis (growth of womb lining outside womb)/endometrial hyperplasia (excessive growth of the womb lining), and/or suffer from epilepsy, otosclerosis (disease that affects eardrum and hearing), kidney problems, and/or lung problems (such as asthma).

ESTRABET 1MG TABLET is not recommended for use in pregnant and breast-feeding women since it is intended to be used only in postmenopausal women. The medicine is also not recommended for use in children and adolescents since it is indicated for use only in postmenopausal women. It is advised to be used with caution in elderly women (aged 60 years and above) after consulting the doctor since the medicine may increase the risk of heart disease in elderly patients.

The common side effects of taking ESTRABET 1MG TABLET are headache, nausea, cramps in legs, abdominal/pelvic pain, unscheduled bleeding/spotting, asthenia (feeling of weakness), and/or rash/itching. Consult your doctor if any of these symptoms worsens.

USES OF ESTRABET 1MG TABLET

• Provides relief from symptoms that occur after menopause in postmenopausal women
• Prevents osteoporosis in post-menopausal women

HOW ESTRABET 1MG TABLET WORKS

ESTRABET 1MG TABLET contains precursor of ovarian hormones (responsible for menstruation and reproduction in women) which replaces natural Estradiol hormone in the body that helps in maintaining adequate level of circulating hormones thus providing relief from vasomotor symptoms (such as hot flashes) in post-menopausal women.

DIRECTIONS FOR USE

Take ESTRABET 1MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ESTRABET 1MG TABLET

HOW TO MANAGE SIDE EFFECTS

Headache:

If ESTRABET 1MG TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking ESTRABET 1MG TABLET. If it lasts more than a week or becomes severe, then consult and inform your doctor.

Nausea/vomiting:

Take ESTRABET 1MG TABLET with/just after a meal. Stick to simple meals. Avoid eating oil rich/spicy foods, sugary snacks and drinks. Avoid drinking too much liquid along with your meals, and drink slowly in between meals. Consult your doctor if the condition worsens.

Rashes:

Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.

Itchy Skin:

Try to pat or tap your skin instead of scratching it. Hold a damp towel to cool your skin. Wear loose clothing and avoid tight clothes, or clothes made from wool or synthetic fabrics. Avoid using perfumed soaps, deodorants or moisturizers and use a skin softener regularly.

Indigestion:

Try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea, or alcohol and lose weight if you are obese.  Try to avoid smoking and don’t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.

Tiredness:

Make sure you take rest and drink plenty of fluids. Avoid or limit the consumption of alcohol. Try to take ESTRABET 1MG TABLET at a time when you can sit down (or lie down) when the symptoms are at their worst. Avoid driving or using tools or machinery until you feel well.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions:

Before taking ESTRABET 1MG TABLET, inform your doctor if you are taking any of the following medicine:

• medicines used to prevent blood clotting (Ex. warfarin)
• medicines used to treat epilepsy (Ex. phenobarbital, phenytoin, carbamazepine)
• medicines used to treat tuberculosis (Ex. rifampicin, rifabutin)
• anti-retroviral medicines used to treat HIV (Ex. nevirapine, efavirenz, ritonavir, nelfinavir)
• St John’s Wort (herbal medicine used to treat depression)
• medicines used to treat Hepatitis C Virus (Ex. boceprevir, telaprevir)
• tacrolimus, cyclosporin (medicines used to prevent rejection of organ transplants)
• fentanyl (used to reduce pain)
• theophylline (used for asthma and other breathing problems)

Overdosage:

If you or anyone else accidentally takes too much of ESTRABET 1MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, sleepiness, dizziness, and/or withdrawal bleeding.

SYNOPSIS

MORE INFORMATION

• Keep ESTRABET 1MG TABLET out of reach of children
• Store ESTRABET 1MG TABLET at room temperature

FAQs ABOUT ESTRABET 1MG TABLET

Q. What is ESTRABET 1MG TABLET used for?

A. ESTRABET 1MG TABLET is used in postmenopausal women (with at least 6 months since their last natural period) to provide relief from symptoms that occurs after menopause. It is also used to prevent osteoporosis (condition marked by weak and fragile bones) which occurs after menopause in few women.

Q. What are the common side effects of taking ESTRABET 1MG TABLET?

A. The most common side effects of taking ESTRABET 1MG TABLET are headache, nausea, cramps in legs, abdominal/pelvic pain, unscheduled bleeding/spotting, asthenia (feeling of weakness), and/or rash/itching. Consult your doctor if any of these symptoms worsens.

Q. How ESTRABET 1MG TABLET is taken?

A. Take ESTRABET 1MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Q. What happens if ESTRABET 1MG TABLET is taken more than its required dosage?

A. If you or anyone else accidentally takes too much of ESTRABET 1MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea, vomiting, sleepiness, dizziness, and/or withdrawal bleeding.

Q. How ESTRABET 1MG TABLET works?

A. ESTRABET 1MG TABLET contains precursor of ovarian hormones (responsible for menstruation and reproduction in women) which replaces natural Estradiol hormone in the body that helps in maintaining adequate level of circulating hormones thus providing relief from vasomotor symptoms (such as hot flashes) in post-menopausal women.

REFERENCES

1. K.D. Tripathi. Estrogens, Progestins and Contraceptives. Essentials of Medical Pharmacology. seventh edition. 2013. Page – 306.

2. Nosek, M., Kennedy, H.P. and Gudmundsdottir, M. Distress during the menopause transition: a rich contextual analysis of midlife women’s narratives. Sage Open. 2012. [Accessed on 6th July 2022] https://journals.sagepub.com/doi/pdf/10.1177/2158244012455178#:~:text=The%20women%20reported%20a%20range,%3B%20see%20also%20Table%201)

3. Estradiol. NIH National Library of Medicine. National center for biotechnology information. PubChem. July 2022. [Accessed on 6th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Estradiol

4. Cipla Ltd. Estova Tablet. [Revised in February 2021] [Accessed on 6th July 2022] https://www.ciplamed.com/content/estova-tablets

5. TTK Healthcare Limited. Primiwal Tablet. [Revised in February 2021] [Accessed on 6th July 2022] https://ttkhealthcare.com/ethical-products/

6. Abbott Biologicals BV. Electronic Medicines Compendium (EMC) [Revised in March 2022] [Accessed on 6th July 2022] https://www.medicines.org.uk/emc/files/pil.1174.pdf

USEFUL DIAGNOSTIC TESTS

• Liver Function Test (LFT)