INTRODUCTION

ERYTOP GEL contains Clindamycin, which belongs to the group of medicines called Antibiotics. It is used in the treatment of acne vulgaris. Acne vulgaris is a common skin condition that occurs when hair follicles get blocked with oil and dead skin cells. Symptoms include whiteheads, blackheads, small red, tender bumps, pimples, and pus-filled lumps on the skin.

Before applying ERYTOP GEL, inform your doctor if you have or ever had diarrhea, bloody diarrhea and pseudomembranous colitis. ERYTOP GEL is not recommended for use if you have a history of regional enteritis (inflammation of the small intestine), ulcerative colitis (inflammation of the large intestine) or antibiotic-associated colitis.

ERYTOP GEL should be used with caution during pregnancy or by breastfeeding women only if clearly needed. The safety and effectiveness of ERYTOP GEL in children under the age of 12 has not been established. The most common side effects of applying ERYTOP GEL are burning, itching, and redness of the skin. Consult your doctor if symptoms worsen.

USES OF ERYTOP GEL

• Treats acne vulgaris

HOW ERYTOP GEL WORKS

ERYTOP GEL acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis), which in turn prevents protein synthesis and kills the infection-causing bacteria.

DIRECTIONS FOR USE

Apply ERYTOP GEL as advised by your physician. It is for external use only. Wash your hands before use. Wash and dry the whole area, apply a thin film once daily to the skin where acne lesions appear and use enough to cover the entire affected area. In case of contact with the eyes, mouth or nostrils, rinse it off immediately and thoroughly with water. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.

SIDE EFFECTS OF ERYTOP GEL

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before applying ERYTOP GEL, inform your doctor if you are taking any of the following medicine:

• neuromuscular blocking agents (Ex. rocuronium, vecuronium)
• other anti-acne, topical agents

Overdosage:

If you or anyone else accidentally applied too much of ERYTOP GEL, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep ERYTOP GEL out of reach from children
• Store at room temperature

FAQs ABOUT ERYTOP GEL

What is ERYTOP GEL used for?

ERYTOP GEL is used in the treatment of acne vulgaris. Acne vulgaris is a common skin condition that occurs when hair follicles get blocked with oil and dead skin cells. Symptoms include whiteheads, blackheads, small red, tender bumps, pimples, and pus-filled lumps on the skin.

How to use ERYTOP GEL?

Apply ERYTOP GEL as advised by your physician. It is for external use only. Wash your hands before use. Wash and dry the whole area, apply a thin film once daily to the skin where acne lesions appear and use enough to cover the entire affected area. In case of contact with the eyes, mouth or nostrils, rinse it off immediately with plenty of water.

How does ERYTOP GEL work?

ERYTOP GEL acts against the bacteria by binding to the 50S subunit of the bacterial ribosome (site of protein synthesis), which in turn prevents protein synthesis and kills the infection-causing bacteria.

Can ERYTOP GEL be used in pregnancy?

The safety and effectiveness of ERYTOP GEL in pregnant women or women planning to have a baby have not been established yet. It will be given to you by the doctor only if clearly needed. Consult your doctor before applying ERYTOP GEL.

Can ERYTOP GEL be used in breastfeeding women?

ERYTOP GEL should be used with caution in breastfeeding women as it is not known if the medicine is excreted in human milk. Your doctor will decide whether to discontinue nursing or the medicine, considering the benefits to the mother and baby. If it is applied to the chest, care should be taken to avoid accidental ingestion by the infant. Consult your doctor before applying ERYTOP GEL.

REFERENCES

1. KD Tripathi. Macrolide, Lincosamide, Glycopeptide and Other Anti bacteria IN Antibiotics. Urinary Antiseptics. Essentials of Medical Pharmacology. Eighth Edition. 2019. Page –805-806.

2. Patrick B, Murphy, Karlyle G. Bistas, Jacqueline K.Le. Clindamycin. National Library of medicine, National center for biotechnology information. [Revised in July 2021] [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK519574/

3. Manuel Polanco Morales, Anna Paola Thome Carvallo, Karla Adriana Bautista Espinosa,and Edgar Enrique Meza Murillo. A young man with myelosuppression caused by clindamycin: a case report. National Library of medicine, National center for biotechnology information. Pubmed Central 2014. [Accessed on 11th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917410/

4. DPT Laboratories, Ltd.U.S. Food & Drug Administration. (Clindamycin topical gel). [Revised in November 2000] [Accessed on 11th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/50782lbl.pdf

5. Perrigo Yeruham. Daily med. (Clindamycin phosphate lotion). [Revised in December 2021] [Accessed on 11th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a10dda0c-28fa-4678-8cea-a6ce2fce4b52

6. Pharmaceutical Society of Singapore. Clindamycin gel/solution/lotion 1%. [Revised in March 2016] [Accessed on 11th May 2022] https://www.pss.org.sg/sites/default/files/public-resource/clindamycin_pil_31-3-2016.pdf

7. Taro Pharmaceutical Industries Ltd. Dailymed. (Clindamycin topical solution). [Revised in April 2021] [Accessed on 11th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=5b8a6767-2d46-401c-9f85-d427dda9eff7

8. Torque Pharma. Ticin Gel. (Clindamycin gel 1%). [Accessed on 11th May 2022] https://www.torquepharma.com/ticin-gel/