INTRODUCTION

DUMAN 0.5MG contains Dutasteride which belongs to a group of medicines called 5-alpha reductase inhibitors. It is used to treat the symptoms of benign prostatic hyperplasia (BPH) in men with an enlarged prostate to improve symptoms, reduces the risk of acute urinary retention and the need for BPH-related surgery. Benign prostate hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland in men.

Symptoms of Benign prostate hyperplasia (BPH) may include difficulty in urination, urinary frequency and an inability to complete bladder emptying. It can also cause slower and less flow of the urine. If left untreated, there is a risk of acute urinary retention (urine flow will be completely blocked) which requires immediate medical treatment.

DUMAN 0.5MG prevents excessive Dihydrotestosterone (DHT) production in the prostate gland, delays the progression of an enlarged prostate and improves symptoms of BPH. It lowers Dihydrotestosterone (DHT) production in the body, leads to shrinkage of enlarged prostate in men. This medicine is intended for use only for men. It is not recommended for women, children and adolescents. The common side effects are low sexual drive, impotence and decreases sperm count. Before taking this medicine tell your doctor if you are taking any other medications.

USES OF DUMAN 0.5MG

• Treat the symptoms of benign prostatic hyperplasia in men

HOW DUMAN 0.5MG WORKS

DUMAN 0.5MG blocks 5-alpha reductase enzyme and prevents excessive Dihydrotestosterone (DHT) production in the prostate gland, delays the progression of an enlarged prostate and improves symptoms of benign prostatic hyperplasia (BPH). It lowers Dihydrotestosterone (DHT) production in the body, leads to shrinkage of enlarged prostate in men.

DIRECTIONS FOR USE

Take DUMAN 0.5MG according to the dose and frequency as advised by your doctor. Swallow the medicine whole, do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF DUMAN 0.5MG

HOW TO MANAGE SIDE EFFECTS

Skin rash:

Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If does not get better, speak to a doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

• verapamil, diltiazem (used to treat blood pressure)
• ritonavir, indinavir (used to treat HIV)
• itraconazole, ketoconazole (used to treat fungal infections)
• nefazodone (used to treat depression)
• alpha-blockers (used to treat enlarged prostate or high blood pressure)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT DUMAN 0.5MG

Is DUMAN 0.5MG effective?

Yes, it is effective if used in the correct dose and duration directed by your doctor.

What is BPH?

Benign prostatic hyperplasia (BPH) also known as prostate gland enlargement is a common condition in men. An enlarged prostate gland causes uncomfortable urinary symptoms.

Is DUMAN 0.5MG safe for a long time?

It is safe if used in the dose and duration directed by your doctor.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs: Androgens and Drugs for Erectile Dysfunction. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page - 303.

2. Chrousos GP. The Gonadal Hormones & Inhibitors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India; 2009. Page - 723.

3. Garrett D. Pohlman, Emily A. Pohlman and E. David Crawford. Dutasteride: A Review of its Use in the Management of Prostate Disorders: Clinical Medicine Insights: Therapeutics, April 28, 2011; [Accessed Nov 6 2020] https://journals.sagepub.com/doi/pdf/10.4137/CMT.S1956

4. GlaxoSmithKline Pharmaceuticals, Electronic Medicines Compendium (EMC); [Revised March 2020] [Accessed Nov 6 2020] https://www.medicines.org.uk/emc/files/pil.6758.pdf

5. Glaxo SmithKlin, 2001; U.S. Food & Drug Administration; [Revised Oct 2007] [Accessed Nov 6 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021319s014lbl.pdf

6. Accord Healthcare Limited, Electronic Medicines Compendium (EMC); [Revised Oct 2019] [Accessed Nov 6 2020] https://www.medicines.org.uk/emc/files/pil.8917.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count