INTRODUCTION

DULOXEE 30MG contain duloxetine which belongs to a group of medicine called serotonin-norepinephrine reuptake inhibitors (SNRIs). It is used in adults to treat depression, generalized anxiety disorder and diabetic neuropathic pain. It works by increasing the levels of chemical messengers such as serotonin and noradrenaline, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest which affects how you feel, think and behave and can lead to a variety of emotional and physical problems. Generalized anxiety disorder is a long-term condition that causes you to feel anxious most days and often struggle to remember the last time they felt relaxed. Diabetic neuropathy is a type of nerve damage characterized by tingling, burning, sharp, shooting, and lancinating or even as electric shock sensations that can occur if you have diabetes. High blood sugar (glucose) can injure nerves throughout your body.

Always take DULOXEE 30MG exactly as your doctor has told you. This medicine must be taken with or without food. It is not recommended for use in children and adolescents under 18 years. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Do not drive or operate any machine while taking this medicine as it may cause sleepiness or dizziness. Pregnant and breastfeeding women should consult their doctor before taking this medicine. The most common side effects are nausea, headache, dry mouth, trouble sleeping.

USES OF DULOXEE 30MG

• Treat depression, generalized anxiety disorder and diabetic neuropathic pain

HOW DULOXEE 30MG WORKS

DULOXEE 30MG works by increasing the levels of chemical messengers such as serotonin and noradrenaline, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.

DIRECTIONS FOR USE

Always take DULOXEE 30MG exactly as your doctor has told you. This medicine must be taken with or without food. Try to take his medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.

SIDE EFFECTS OF DULOXEE 30MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Nausea and vomiting:

Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.

Dry mouth:

Chew sugar-free gum or suck sugar-free hard candies. Control caffeine intake. Do not use mouthwashes. Sip water regularly.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Constipation: 

Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.

Stomach pain:

Keep try to rest and relax. Eat and drink slowly and smaller and frequent meals. Applying a heat pad or covered hot water bottle on your stomach. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor if you are taking,

• medicines used to treat depression
• antibiotic such as linezolid (used to treat infection)
• medicines such as triptans, tramadol, tryptophan
• SSRIs such as paroxetine and fluoxetine
• SNRIs such as venlafaxine
• St John’s Wort (hypericum perforatum)
• medicines with oral anticoagulants or antiplatelet agents (used to prevent blood clot)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT DULOXEE 30MG

Is DULOXEE 30MG highly addictive?

No, it is not habit-forming (addictive).

If I start feeling better, can I stop taking DULOXEE 30MG?

No, you should not stop taking this medicine suddenly and without consulting your doctor. Your doctor will monitor your response to the medicine every few months.

Can I take DULOXEE 30MG during liver disease?

No, it is not recommended in patients with active liver diseases. Before taking, discuss the risks and benefits with your doctor.

REFERENCES

1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page – 1279-1283.

2. Sanjay Gupta 1, Nikhil Nihalani, Prakash Masand. Duloxetine: review of its pharmacology, and therapeutic use in depression and other psychiatric disorders. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Apr- Jun 2007. [Accessed 28 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/17612852/

3. Ahsan Y Khan and Matthew Macaluso. Duloxetine for the treatment of generalized anxiety disorder: a review. US National Library of Medicines, National Institutes of Health. 8 Apr 2009. [Accessed 28 Nov 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695226/

4. Pharmathen International SA; Electronic Medicines Compendium (EMC); [Revised on Oct 2016] [Accessed 28 Nov 2020] https://www.medicines.org.uk/emc/files/pil.8650.pdf

USEFUL DIAGNOSTIC TESTS

• Glycosylated Hemoglobin