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DOXOLL PLUS 400 Tablet 10's
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INTRODUCTION
DOXOLL PLUS 400 TABLET is a combination of Ambroxol and Doxophylline, which belongs to the group of medicines called Mucolytics and Bronchodilators. It is used to treat asthma (the airways get narrow, swell and produce extra mucus, which leads to breathing difficulties, chest pain, a severe dry cough and a fast heartbeat) and chronic obstructive pulmonary disorder (a lung disorder in which the flow of air to the lungs is blocked, leading to shortness of breath, a dry cough with phlegm, wheezing, fatigue and weight loss).
Limit the consumption of beverages and foods containing caffeine while taking DOXOLL PLUS 400 TABLET as it may increase the risk of side effects. DOXOLL PLUS 400 TABLET is not recommended for use in patients with acute myocardial infarction and hypotension. If you are pregnant or breastfeeding, consult your doctor for advice before taking DOXOLL PLUS 400 TABLET.
DOXOLL PLUS 400 TABLET is not recommended for use by children under 6 years of age. The most common side effects of taking DOXOLL PLUS 400 TABLET may include taste changes, nausea and numbness in the throat and mouth. Contact your doctor if any of your symptoms get worse or persist.
USES OF DOXOLL PLUS 400 TABLET
- Treat asthma and chronic obstructive pulmonary disorder (COPD)
HOW DOXOLL PLUS 400 TABLET WORKS
DOXOLL PLUS 400 TABLET is a combination of Ambroxol that stimulates the production of a substance that lowers surface tension, which keeps the air sacs in the lungs from collapsing after exhalation. Doxophylline inhibits certain enzymes in the body called phosphodiesterase, which increases the substances that lead to muscle relaxation, leading to dilation of the constricted airway tract. It also acts as an anti-inflammatory agent to reduce inflammation. This combined action makes breathing easier.
DIRECTIONS FOR USE
Take DOXOLL PLUS 400 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration will be decided by your doctor for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF DOXOLL PLUS 400 TABLET
COMMON
- changes in taste sensation
- numbness in the throat
- nausea and numbness in the mouth
UNCOMMON
- vomiting
- diarrhoea
- indigestion
- stomach pain
- dry mouth
RARE
- increased blood sugar
- protein in the urine
- skin rash and itchiness
Stop taking DOXOLL PLUS 400 TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic symptoms (skin itchiness, rashes, difficulty in breathing or eye swelling)
- skin rash including lesions on the mucous membranes of the mouth, throat, nose, eyes and reproductive organs
- severe nausea, vomiting, stomach pain, headache, irritability, insomnia, increased heart rate, skipped heartbeat and fast breathing
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating fiber-rich or spicy foods. If the symptom does not improve, contact your doctor.
Taste changes:
Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Rinse your mouth after each meal and clean your tongue once daily. Do not consume any medicine on your own without consulting your doctor.
WARNING & PRECAUTIONS
PREGNANCY
DOXOLL PLUS 400 TABLET is generally not recommended for use in pregnant women as the medicine can cross the placental barrier. Consult your doctor for advice before taking it.
BREASTFEEDING
DOXOLL PLUS 400 TABLET is generally not recommended for use in breastfeeding women as it may pass through the breastfed milk. Consult your doctor before taking the medicine.
DRIVING AND USING MACHINES
DOXOLL PLUS 400 TABLET does not affect the patient’s alertness and therefore does not interfere with the ability to drive and use machines.
KIDNEY
DOXOLL PLUS 400 TABLET should be taken with caution in patients with impaired kidney function. Consult your doctor before taking the medicine.
LIVER
DOXOLL PLUS 400 TABLET should be taken with caution in patients with severe liver disease. Consult your doctor before taking the medicine.
ALLERGY
Do not take DOXOLL PLUS 400 TABLET if you are allergic to Ambroxol, Bromhexine, Doxophylline or other Xanthine derivatives.
LUNGS
DOXOLL PLUS 400 TABLET should be taken with caution in patients with existing lung conditions such as chronic obstructive lung disorder, severe uncontrolled asthma, pneumonia or bronchial motor activity disorder along with excessive mucous secretion (risk of a mucous plug).
HEART DISEASE
DOXOLL PLUS 400 TABLET is not recommended for use in patients with acute myocardial infarction and hypotension. It should be taken with caution in patients with heart disease, hypertension, pulmonary heart disease, congestive heart failure and severe hypoxemia.
OTHERS
Before taking DOXOLL PLUS 400 TABLET, inform your doctor if you:
- have hyperthyroidism
- have peptic ulcer or predilection for the development of peptic ulcers
- have concomitant infections
- have a low immune system due to other health conditions (e.g., HIV)
Use in Pediatrics:
DOXOLL PLUS 400 TABLET is generally not recommended for use in children (under 6 years of age). Consult your doctor before taking it.
Use in Geriatrics:
DOXOLL PLUS 400 TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DOXOLL PLUS 400 TABLET, inform your doctor if you are taking any of the following medicine:
- medicines used as antibiotics (ex. erythromycin, TAO (troleandomycin), lincomycin, clindamycin)
- allopurinol (used to treat gout)
- cimetidine (used to treat ulcers and indigestion)
- propranolol (used to treat hypertension)
- influenza vaccine (protect against flu infection)
- phenytoin (used in epilepsy treatment)
- medicines used in cancer treatment (ex. melphalan, busulfan, methotrexate)
B. Drug-food interaction:
Avoid consuming beverages and food containing caffeine while taking DOXOLL PLUS 400 TABLET as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your physician immediately. The symptoms of overdosage include severe cardiac arrhythmias and tonic-clonic seizures may occur.
SYNOPSIS
| Drug | : | Ambroxol, Doxophylline |
| Pharmacological Category | : | Aromatic amines, Methylxanthines |
| Therapeutic Indication | : | Asthma, Chronic obstructive pulmonary disorder (COPD) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep DOXOLL PLUS 400 TABLET out of reach from children
- Store at room temperature
FAQs ABOUT DOXOLL PLUS 400 TABLET
How to use DOXOLL PLUS 400 TABLET?
Take DOXOLL PLUS 400 TABLET as advised by your physician. Swallow the medicine with enough water. Do not crush or chew the medicine. The correct dose and duration will be determined for you by your doctor, depending on your age, body weight and disease condition.
What are the common side effects of DOXOLL PLUS 400 TABLET?
The most common side effects of this medicine include nausea or vomiting, diarrhoea, indigestion, epigastric pain, headache, irritability, insomnia, heartburn or bloating, abdominal pain, dry mouth or dry throat. Consult your physician for advice if the symptoms wo
Does DOXOLL PLUS 400 TABLET have any dietary restrictions?
It is recommended to avoid or limit the consumption of beverages and foods containing caffeine. Avoid smoking as well while taking DOXOLL PLUS 400 TABLET because it can alter the effects of the drug.
What happens if I forget to take DOXOLL PLUS 400 TABLET?
If you miss a dose of DOXOLL PLUS 400 TABLET, take it as soon as possible. However, if it is nearly time for your next dose, skip the missed dose and go back to your regularly scheduled dose. Do not double the dose.
Is DOXOLL PLUS 400 TABLET safe for use in patients with liver, heart or kidney disease?
It is essential to inform your doctor before taking DOXOLL PLUS 400 TABLET if you have any heart problems, kidney problems, lung problems, liver problems, pneumonia or other lung infections, a low immune system due to other health conditions (ex. HIV), lung conditions such as COPD (chronic obstructive pulmonary disorder) or severe uncontrolled asthma, severe hypoxemia, hyperthyroidism or a peptic ulcer.
REFERENCES
1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. 7th edition. 2013. Page – 218-219, 227.
2. Ahmad Kantar, Ludger Klimek, Dorotheea Cazan, Annette Sperl, Ulrike Sent and Margarida Mesquita. An overview of efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with special regard to children. Journal of Multidisciplinary Respiratory Medicine. March 2020. [Accessed on 15th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137760/
3. Paola Rogliani, Luigino Calzetta, Josuel Ora, Mario Cazzola & Maria Gabriella Matera. Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis. Journal of Multidisciplinary Respiratory Medicine. August 2019. [Accessed on 15th June 2022] https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0189-0
4. Mario Cazzola, Maria Gabriella Matera. The effect of doxofylline in asthma and COPD. Journal of Respiratory Medicine. April 2020. [Accessed on 15th June 2022] https://www.resmedjournal.com/article/S0954-6111(20)30044-5/fulltext
5. Vibcare Pharma Pvt. Ltd. vibcare.co.in. [Accessed on 15th June 2022] https://vibcare.co.in/doxofylline-ambroxol/#!/SIDEEFFECTS
6. Pharmaceutical Society of Singapore. hsa.gov. (Revised in April 2017) [Accessed on 15th June 2022] https://www.hsa.gov.sg/docs/default-source/announcements/prescription-only-medicines-(pom)/ambroxol-pil-26-04-2017.pdf
7. ABC FARMACEUTICI. www.abcfarmaceutici.it. [Revised on March 2011] [Accessed on 15th June 2022] https://www.abcfarmaceutici.it/uploads/news/40_file3_en.pdf
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 09 Dec 2022 | 12:19 PM(IST)
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