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Deriphyllin OD 300mg Tablet 15'S
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INTRODUCTION
DERIPHYLLIN OD 300MG TABLETcontains a combination of Etofylline and Theophylline which belongs to the group of medicines called Bronchodilators. It is used in the treatment of asthma (in which airways narrow and swell and may produce extra mucus, coughing and shortness of breath), chronic bronchitis (inflammation of the lining of bronchial tubes, which carry air to and from lungs causing cough and thick mucus), and chronic obstructive pulmonary disorder.
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production, and wheezing.
Before taking DERIPHYLLIN OD 300MG TABLET, inform your doctor if you have porphyria, liver, heart, or thyroid problems; worsening of chest symptoms; a stomach ulcer; cystic fibrosis; a high fever; a viral infection; fits; difficulty passing urine (in men); are a smoker; are diabetic; or are going to have an operation. Avoid consuming alcohol during this treatment.
Inform your doctor if you are pregnant or breastfeeding before taking DERIPHYLLIN OD 300MG TABLET. DERIPHYLLIN OD 300MG TABLET is not recommended for children under the age of six. The most common side effects of taking DERIPHYLLIN OD 300MG TABLET are nausea, vomiting, headache, restlessness, and dizziness. Consult your doctor if your symptoms do not improve.
USES OF DERIPHYLLIN OD 300MG TABLET
To treat:
- Asthma
- Chronic Bronchitis
- Chronic Obstructive Pulmonary Disease (COPD)
HOW DERIPHYLLIN OD 300MG TABLET WORKS
DERIPHYLLIN OD 300MG TABLET works by relaxing the smooth muscles in the airway, in which etofylline works by dilating and relaxing the airway muscles, and theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels, reducing the airway's responsiveness to allergens and thereby reducing inflammation.
DIRECTIONS FOR USE
Take DERIPHYLLIN OD 300MG TABLET as advised by your physician. Swallow the medicine with water. Do not crush or chew the medicine. Your doctor will determine the right dose and duration depending upon your age, body weight, and disease condition.
SIDE EFFECTS OF DERIPHYLLIN OD 300MG TABLET
COMMON
- nausea and vomiting
- headache
- abdominal pain
- diarrhea
- heartburn or gastrointestinal disorders
- difficulty in sleeping, agitation, anxiety or tremors
- fast, slow or irregular heartbeat
- dizziness
- difficulty in passing urine (especially in men)
- increased uric acid levels in the blood, which could cause painful, swollen joints
- seizures, fits or convulsions
- rash or itchy skin
RARE
Stop taking DERIPHYLLIN OD 300MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- sudden wheeziness, difficulties in breathing, swelling of the eyelids, face or lips, rash or itching especially those covering your whole body
HOW TO MANAGE SIDE EFFECTS
Diarrhea
Drink lots of or fruit juice to keep yourself hydrated. If the symptom does not show improvement, consult your doctor.
Headache
Avoid bright lights, drink more water, and take rest. If the symptom does not show improvement, consult your doctor.
Nausea And Vomiting
Stick to simple meals. Avoid eating rich or spicy food. If the symptom does not show improvement, consult your doctor.
Stomach Pain
Try to rest and relax and have smaller and frequent meals. Keep a heat pad on stomach. If the symptom does not show improvement, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredDERIPHYLLIN OD 300MG TABLET is not recommended for use in pregnant women or women planning to be pregnant uncles clearly necessary. Consult your doctor before taking DERIPHYLLIN OD 300MG TABLET.
BREASTFEEDING
Monitoring requiredDERIPHYLLIN OD 300MG TABLET is excreted in breastmilk so it will be given to you only if the benefits overweight the risk causing to the child. Consult your doctor before taking it.
DRIVING AND USING MACHINES
SafeDERIPHYLLIN OD 300MG TABLET has no or negligible effect on your ability to drive or use machines.
ALCOHOL
Consult your doctorDo not consume alcohol while taking DERIPHYLLIN OD 300MG TABLET as it can alter the way this medicine works.
KIDNEY
Use with CautionDERIPHYLLIN OD 300MG TABLET should be used with caution if you are male and have difficulty in passing urine (can be due to an enlarged prostate gland). Consult your doctor before taking it.
LIVER
Use with CautionDERIPHYLLIN OD 300MG TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take DERIPHYLLIN OD 300MG TABLET if you are allergic to Etofylline or Theophylline or any other ingredients of this medicine.
LUNGS
Use with CautionDERIPHYLLIN OD 300MG TABLET should be used with caution in patients with worsening of chest symptoms like breathlessness or cough. Consult your doctor before taking it.
HEART DISEASE
Use with CautionDERIPHYLLIN OD 300MG TABLET should be used with caution in patients with an irregular heartbeat, high blood pressure or any other heart problems. Consult your doctor before taking it.
USE IN PEDIATRICS
ContraindicatedDERIPHYLLIN OD 300MG TABLET is not recommended for use in children below 6 years of age. Consult your doctor before taking it.
USE IN GERIATRICS
Consult your doctorDose will be adjusted by your doctor depending on your age, body weight and disease condition. Consult your doctor before taking DERIPHYLLIN OD 300MG TABLET.
OTHERS
DERIPHYLLIN OD 300MG TABLET is not recommended for use if you:
- have porphyria (rare disease of the blood pigments)
Before taking DERIPHYLLIN OD 300MG TABLET, inform your doctor if you:
- have an over or under-active thyroid gland
- have a stomach ulcer
- have diabetes
- have cystic fibrosis
- suffer from seizures, fits or convulsions
- are unwell with fever
- have a viral infection
- are a smoker or addicted to alcohol
- are going to have an operation
INTERACTIONS
A. Drug - Drug interactions:
Before taking DERIPHYLLIN OD 300MG TABLET, inform your doctor if you are taking any of the following medicine:
- certain other medicines to treat asthma or breathing conditions that contain theophylline, aminophylline, salbutamol, terbutaline, or salmeterol, steroids (Ex. prednisolone, hydrocortisone)
- diuretics (to increase urine production)
- oral contraceptives
- St John’s Wort, fluvoxamine or lithium (for depression)
- aminoglutethimide, methotrexate or lomustine (to treat cancer)
- carbamazepine or phenytoin (for seizures, fits or convulsions)
- medicines known as barbiturates to help in sleeping
- adenosine, diltiazem, isoprenaline, mexiletine, propafenone, propranolol, verapamil or beta blockers, regadenoson or dipyridamol (for high blood pressure and other heart problems)
- pentoxifylline (for diseased blood vessels)
- benzodiazepines (to treat anxiety)
- aciclovir to treat Herpes viruses
- sulphinpyrazone or allopurinol (for gout)
- carbimazole (for problems of thyroid gland)
- cimetidine or nizatidine (to treat stomach ulcers, indigestion or heartburn)
- antibiotics (Ex. ciprofloxacin, clarithromycin, erythromycin, enoxacin)
- fluconazole (treat fungal infections)
- rifampicin or isoniazid (treat tuberculosis)
- ritonavir to treat HIV
- interferons (treat conditions such as herpes, cancer, leukaemia or hepatitis)
- thiabendazole to treat worms like threadworms
- doxapram to stimulate breathing
- disulfiram (treats alcoholism)
- cough medicine containing ephedrine.
- certain anesthetics such as halothane and ketamine
- you have recently had, or are going to have a flu injection
B. Drug - Food interaction:
- avoid caffeinated drinks during this treatment.
Overdosage:
If you or anyone else accidentally take too much of DERIPHYLLIN OD 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are stomach pains, feel or be sick (possibly vomiting blood), fast or irregular heartbeat, low blood pressure, restlessness, or unusual muscle stiffness, have a fit or even go into a coma.
SYNOPSIS
| Drug | : | Etofylline, Theophylline |
| Pharmacological Category | : | Bronchodilators |
| Therapeutic Indication | : | Asthma, Chronic bronchitis, COPD |
| Dosage Forms | : | Tablet, Injection |
MORE INFORMATION
- Keep DERIPHYLLIN OD 300MG TABLET out of reach from children
- Do not store above 25°C
FAQs ABOUT DERIPHYLLIN OD 300MG TABLET
Q: What is DERIPHYLLIN OD 300MG TABLET used for?
A: DERIPHYLLIN OD 300MG TABLET is used in the treatment of asthma, chronic bronchitis, and chronic obstructive pulmonary disorder. Consult your doctor for more information.
Q: Can DERIPHYLLIN OD 300MG TABLET be used by pregnant women?
A: DERIPHYLLIN OD 300MG TABLET should not be used in pregnant women or women planning to become pregnant unless absolutely necessary.Consult your doctor before taking it.
Q: Can DERIPHYLLIN OD 300MG TABLET be used in patients with heart problems?
A: DERIPHYLLIN OD 300MG TABLET should be used with caution in patients with an irregular heartbeat, high blood pressure, or any other heart problems. Consult your doctor before taking it.
Q: What if I accidentally take more of DERIPHYLLIN OD 300MG TABLET?
A: If you or anyone else accidentally takes too much DERIPHYLLIN OD 300MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are stomach pains, feeling or being sick (possibly vomiting blood), a fast or irregular heartbeat, low blood pressure, and restlessness.
Q: How does DERIPHYLLIN OD 300MG TABLET work?
A: DERIPHYLLIN OD 300MG TABLET works by relaxing the smooth muscles in the airway, in which etofylline works by dilating and relaxing the airway muscles, and theophylline relaxes the smooth muscles located in the bronchial airways and pulmonary blood vessels, reducing the airway's responsiveness to allergens and thereby reducing inflammation.
REFERENCES
1. KD Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Eighth Edition. 2019. Page –243-247.
2. Peter J. Barnes. Theophylline. [Accessed on 8th August 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033977/
3. J Zuidema, J Verhoeven, F W Merkus. Pharmacokinetics of etofylline after intravenous and oral administration to humans. [Accessed on 8th August 2021] https://pubmed.ncbi.nlm.nih.gov/7263108/
4. Napp Pharmaceuticals Limited. Electronic Medicines Compendium (EMC). [Revised in January 2019] [Accessed on 8th August 2021] https://www.medicines.org.uk/emc/files/pil.1021.pdf, https://www.medicines.org.uk/emc/product/1021/smpc
5. Pubchem. Etofylline. [Revised on August 2022] [Accessed on 8th August 2021] https://pubchem.ncbi.nlm.nih.gov/compound/etofylline
6. NIH. Etofylline. [Accessed on 8th August 2021] https://drugs.ncats.io/drug/L164909TBI
7. Etofylline, Theophylline. Mayoclinic. [Revised in April 2020] [Accessed on 8th August 2021] https://www.mayoclinic.org/diseases-conditions/copd/symptoms-causes/syc-20353679
USEFUL DIAGNOSTIC TESTS
- Lung function test
- Chest X-ray
- CT scan
AUTHOR DETAILS
Written By Dr. Dhivakaran R, BDS
Last updated on 13 Feb 2023 | 01:29 PM(IST)
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