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INTRODUCTION
DAXID 100MG TABLET contains Sertraline which belongs to the group of medicines called Selective Serotonin re-uptake Inhibitors. It is used to treat depression, panic disorder, social anxiety disorder, post-traumatic stress disorder and obsessive-compulsive disorder. It is also used to prevent recurrent depression in adults and treat obsessive compulsive disorder in children and adolescents aged 6-17 years old.
Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. It is also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems.
Anxiety disorder is known as mental health disorder with feelings of anxiety or fear. You may also experience physical signs of anxiety, such as a pounding heart and sweating. Obsessive compulsive disorder and panic disorders are illnesses linked to anxiety with symptoms like being constantly troubled by persistent ideas (obsessions) that make you carry out repetitive rituals (compulsions).
DAXID 100MG TABLET is not recommended for use in patients with angle closure glaucoma (eye disorder) and liver disease (such as mild, moderate or severe liver impairment).
Before taking DAXID 100MG TABLET, inform your doctor if you have suicidal thoughts, epilepsy or a history of seizures, schizophrenia, heart disease (such as prolonged QT interval, fast heart rhythm) and kidney disease (such as mild, moderate or severe renal impairment).
DAXID 100MG TABLET is not recommended for use in pregnant and breastfeeding women. It should be used with caution in children and adolescents (below 18 years of age). Your doctor will give the right dose depends on your child’s age, body weight and disease condition.
The most common side effects of taking DAXID 100MG TABLET are dizziness, sleepiness, headache, diarrhea, dry mouth, shaking and abnormal taste. Consult your doctor if any of the above side effects worsen.
USES OF DAXID 100MG TABLET
It is used to treat:
- depression and prevents recurrence of depression
- panic disorder
- social anxiety disorder
- post-traumatic stress disorder
- obsessive-compulsive disorder
HOW DAXID 100MG TABLET WORKS
DAXID 100MG TABLET works by increasing the levels of serotonin (a chemical messenger in the brain) that improves mood and physical symptoms of depression thus providing relief from symptoms of post-traumatic stress, obsessive-compulsive and panic disorder in affected individuals.
DIRECTIONS FOR USE
Take DAXID 100MG TABLET as advised by your physician. Do not crush or chew the medicine. Swallow the medicine with a glass of water. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF DAXID 100MG TABLET
COMMON
- insomnia
- dizziness
- tremor, shaking
- indigestion
- excess sweating
- sleepiness
- headache
- diarrhoea
- nausea
- dry mouth
- weakness
- cold chest
- sore throat
- runny nose
- decreased or increased appetite
- anxiety, depression, agitation
- decreased sexual interest
- nervousness
- nightmares
- teeth grinding
- muscular movement problems (such as moving a lot, spasms, tense muscles, difficulty walking and stiffness and involuntary movements of muscles)
- numbness and tingling
- lack of attention
- abnormal taste
- visual disturbances
- ringing in ears
- palpitations
- hot flush
- yawning
- constipation
- abdominal pain
- back, joint and muscle pain
- menstrual irregularities
- erectile dysfunction
- malaise
- chest pain
- fever
UNCOMMON
- gastroenteritis
- ear infection or pain
- hypothyroidism
- edema
- low thyroid hormones
- suicidal thoughts or behavior
- psychotic disorder
- thinking abnormal, lack of caring
- hallucination
- paranoia (feeling of being persecuted)
- amnesia
- migraine
- convulsion
- dizziness while standing up
- abnormal coordination
- speech disorder
- enlarged pupils
- fast heartbeat, heart problem
- bleeding problems (stomach bleeding)
- high blood pressure
- flushing, blood in urine
- shortness of breath
- nosebleed
- swallowing or breathing difficulty
- wheezing
- tarry stools
- tooth or tongue disorder
- inflammation of the oesophagus
- tongue problem
- hemorrhoids
- increased saliva
- difficulty
- eye swelling
- hair loss
- purple spots on skin
- skin problem with blisters, face oedema, cold sweat, dry skin
- osteoarthritis
- muscle twitching or cramps
- unable to urinate (problem urinating)
- urinary incontinence
- excessive vaginal bleeding
- vaginal hemorrhage
- swelling in legs
- chills
- difficulty walking
- thirst
- increase in liver enzyme levels
RARE
- signs of diverticulitis (inflammation or infection in one/more small pouches of digestive tract) such as pain, fever, abdominal tenderness, constipation
- swollen lymph glands
- decrease in clotting cells
- decrease in white blood cells
- severe allergic reaction
- endocrine problems
- high cholesterol
- diabetes
- increase or decrease in blood sugar
- drug dependence
- sudden severe headache (sign of reversible cerebral vasoconstriction syndrome)
- sensory disturbance
- glaucoma, double vision
- light hurts eye, blood in the eye
- light-headedness
- progressive scarring of lung tissue (Interstitial Lung Disease)
- closing up of throat
- difficulty talking
- breathing slow
- mouth ulceration
- pancreatitis
- problems with liver function
- serious liver function problems
- skin oedema
- hair texture abnormal
- skin odour abnormal
- hair rash
- breakdown of muscle tissue
- bone disorder
- breast discharge
- dry vaginal area
- genital discharge
- red painful penis and foreskin
- breast enlargement
- hernia
- drug tolerance decreased
- problems with clotting
- relaxation of blood vessels procedure
Stop taking DAXID 100MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of hyponatremia (low sodium level) such as nausea, vomiting, headache and confusion
- itchy skin rash, breathing problems, wheezing, swollen eyelids, face or lips (signs of allergic reaction)
- signs of stevens Johnson syndrome /toxic epidermal necrolysis (rare life-threatening skin reaction) such as severe skin rash that causes blisters on mouth and tongue
- signs of serotonin syndrome (condition marked by high secretion of serotonin) such as agitation, confusion, high temperature and blood pressure, diarrhea, excessive sweating and rapid heartbeat
- yellow skin and eyes which may mean liver damage
- ideas of harming or killing yourself (suicidal thoughts)
- feelings of restlessness and are not able to sit or stand still
- seizures
- manic episodes
HOW TO MANAGE SIDE EFFECTS
Dizziness:
If you feel dizzy, keep your eyes closed sit or lie down. Do not drive or operate machinery. Consult your doctor if the above symptoms did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if the symptom did not improve.
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.
Fatigue:
Get enough sleep and exercise on regular basis. Take part in relaxing activities and drink enough fluids to stay hydrated.
Stomach Pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
Nausea & Vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oily rich or spicy foods. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
DAXID 100MG TABLET should be used with caution during pregnancy only if it is clearly necessary. Consult your doctor before taking DAXID 100MG TABLET.
BREASTFEEDING
DAXID 100MG TABLET should be used with caution in breast-feeding women. Consult your doctor before taking DAXID 100MG TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines as DAXID 100MG TABLET can influence your ability to drive or operate machines. Consult your doctor before taking DAXID 100MG TABLET.
ALCOHOL
Avoid consumption of alcohol while taking DAXID 100MG TABLET. Consult your doctor before taking DAXID 100MG TABLET.
KIDNEY
DAXID 100MG TABLET should be used with caution in patients with kidney problems such as mild, moderate or severe renal impairment. Consult your doctor before taking the medicine.
LIVER
DAXID 100MG TABLET is not recommended for use in patients with mild, moderate or severe hepatic impairment. It should be used with caution in patients with other liver diseases. Consult your doctor before taking DAXID 100MG TABLET.
ALLERGY
Do not take DAXID 100MG TABLET if you are allergic to Sertraline or to any of the other ingredients of this medicine.
HEART DISEASE
DAXID 100MG TABLET should be used with caution in patients with heart disease, prolonged QT interval and Torsade de Pointes (fast heart rhythm), family history of QT prolongation (heart rhythm disorder), low heart rate. Consult your doctor before taking DAXID 100MG TABLET.
OTHERS
DAXID 100MG TABLET is not recommended for use if you:
- have angle closure glaucoma
Before taking DAXID 100MG TABLET, inform your doctor if you:
- suffer from sexual dysfunction
- have suicidal thoughts
- have epilepsy
- have suffered from schizophrenia or manic-depressive illness (bipolar disorder)
- have serotonin syndrome such as agitation or restlessness, sleeplessness, confusion
- have signs of low sodium level in your blood
- have diabetes
- have a history of bleeding disorders
- are undergoing electroconvulsive therapy (a type of medical treatment used in patients with severe major depression or bipolar disorder)
- have signs of low potassium levels
- have signs of low magnesium levels
Use in pediatrics:
DAXID 100MG TABLET should be used with caution in children and adolescents with obsessive compulsive disorder. Your doctor will give the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking the medicine.
Use in geriatrics:
DAXID 100MG TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DAXID 100MG TABLET, inform your doctor if you are taking:
- verapamil, diltiazem, flecainide, propafenone (used to treat high blood pressure, chest pain or regulate the rate and rhythm of the heart)
- monoamine oxidase inhibitors used to treat depression (Ex. selegiline, moclobemide, linezolid)
- pimozide (used to treat mental disorders such as psychosis)
- acetylsalicyclic acid, ibuprofen (used to treat pain, fever and inflammation)
- warfarin (used in treatment of blood clotting disorders)
- amphetamines (used to treat attention deficit hyperactivity disorder, narcolepsy and obesity)
- St. john’s wort (herbal medicine used for depression)
- tryptophan (used to help the body make its own protein)
- tramadol (used to treat severe pain)
- fentanyl, suxamethonium and mivacurium (anaesthesia)
- sumatriptan (used to treat migraines)
- diazepam (sedatives)
- phenytoin, phenobarbital, carbamazepine (used to treat epilepsy)
- tolbutamide (used to treat diabetes)
- lansoprazole, pantoprazole, rabeprazole, cimetidine, omeprazole (used to treat stomach acid, ulcers and heartburn)
- lithium (used to treat mania and depression)
- amitriptyline, nefazodone, fluoxetine, fluvoxamine nortriptyline (used to treat depression)
- perphenazine, olanzapine and levomepromazine (used to treat schizophrenia and other mental disorders)
- rifampicin, telithromycin, erythromycin, clarithromycin (used to treat bacterial infections)
- ketoconazole, posaconazole, voriconazole, fluconazole, itraconazole (used to treat fungal infections)
- medicines used to treat HIV (Ex. ritonavir, telaprevir)
- aprepitant (used to prevent nausea and vomiting after an operation or chemotherapy)
- antipsychotics (used to treat psychological disorders) Ex. amitriptyline
- antibiotics (used to treat bacterial infections) Ex. azithromycin, cefixime
- metamizole (used to treat pain and fever)
B. Drug-Food interaction:
Avoid drinking grapefruit juice while taking DAXID 100MG TABLET as it may increase the level of medicine in the body.
Over dosage:
If you or anyone else accidentally takes too much of DAXID 100MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are drowsiness, nausea, vomiting, rapid heart rate, shaking, agitation, dizziness, unconsciousness, seizures, high/low blood pressure, agitation, confusion or sleeplessness.
SYNOPSIS
| Drug | : | Sertraline |
| Pharmacological Category | : | Selective serotonin re-uptake inhibitor |
| Therapeutic Indication | : | Depression and prevents recurrence of depression, Panic disorder, social anxiety disorder, Post-traumatic stress disorder, Obsessive Compulsive Disorder (OCD) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep DAXID 100MG TABLET out of reach of children
- Store at room temperature
FAQs ABOUT DAXID 100MG TABLET
I have a history of seizures, can I take DAXID 100MG TABLET?
Seizures can make disease condition abnormal. So, before taking DAXID 100MG TABLET, inform your doctor if you have history of seizures or if you are using any medicines for seizures.
Can I drive after taking DAXID 100MG TABLET?
Do not drive or operate any heavy machines as DAXID 100MG TABLET can influence your ability to drive or operate any machines. Consult your doctor before taking DAXID 100MG TABLET.
How much dose of DAXID 100MG TABLET can I take in a day?
Take DAXID 100MG TABLET as advised by your physician. Do not crush or chew the medicine. Swallow the medicine with a glass of water. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Will I feel dizzy after taking DAXID 100MG TABLET?
Yes, you may feel dizzy after taking DAXID 100MG TABLET because dizziness is the most common side effect that occurs associated with the use of the medicine. If you feel dizzy, keep your eyes closed sit or lie down. Do not drive or operate machinery. Consult your doctor if the symptom did not improve.
What are the side effects of DAXID 100MG TABLET?
The most common side effects of taking DAXID 100MG TABLET are insomnia, dizziness, tremor, indigestion, excess sweating, sleepiness and headache. Consult your doctor if any of the symptom worsens.
REFERENCES
1. K.D.Tripathi, Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013 Page 461.
2. Andrea Cipriani,Teresa La Ferla,Toshi A Furukawa, Alessandra Signoretti, Atsuo Nakagawa, Rachel Churchill, Hugh McGuire and Corrado Barbui. Sertraline versus other antidepressive agents for depression. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in April 2010] [Accessed on 30th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163971/
3. Almatica Pharma LLC. Food and Drug Administration (FDA) [Revised in October 2021] [Accessed on 30th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/215133s000lbl.pdf
4. ZENTIVA k. s. Electronic Medicines Compendium (EMC) [Revised in March 2021] [Accessed on 30th May 2022] https://www.medicines.org.uk/emc/files/pil.11992.pdf
5. Haupt Pharma Latina S.r.l. Electronic Medicines Compendium (EMC) [Revised in February 2021] [Accessed on 30th May 2022] https://www.medicines.org.uk/emc/files/pil.2835.pdf
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 26 Oct 2022 | 01:44 PM(IST)
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