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INTRODUCTION

CYPOTOL SYRUP is a combination of Cyproheptadine and Tricholine Citrate, which belong to the groups of medicines called antihistamines and bile acid-binding agents, respectively. It is used to treat loss of appetite, weight loss and anorexia nervosa (an eating disorder). It is also used to treat weight gain in anti-tubercular and antiretroviral regimens.

In children, it is used for gaining weight, having an inadequate dietary intake or loss of appetite or suffering from anaemia, liver disease or digestive disorders. It is also used to treat allergic rhinitis and conjunctivitis, migraine, asthma and hepatic disorders. Appetite loss is a state in which an individual has no desire to eat food, which leads to a deficiency of essential and non-essential nutrients that are required for the proper metabolism and growth of the body.

CYPOTOL SYRUP is not recommended for use in patients who have or had angle-closure glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction or pyloroduodenal obstruction. Alcohol should be avoided during CYPOTOL SYRUP treatment because it may increase the CYPOTOL SYRUP's action.

Before taking this medicine, tell your physician if you have a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, liver problems, kidney problems or hypertension. CYPOTOL SYRUP is not recommended for use by pregnant or breastfeeding women. It should be recommended for use in children and adolescents (below 18 years of age).

The most common side effects of taking this medicine are drowsiness, dizziness, insomnia, blurred vision, loss of coordination, skin rash, gastrointestinal upset, nausea or vomiting. Contact your physician if the symptoms worsen.

USES OF CYPOTOL SYRUP

CYPOTOL SYRUP is used to treat the following:

  • Loss of appetite
  • weight loss
  • Anorexia nervosa
  • As an adjunct to anti-tubercular and antiretroviral regimens to gain weight
  • In children to gain weight due to inadequate dietary intake or loss of appetite and also in children suffering from anemia, liver or digestive disorder
  • Allergic rhinitis and conjunctivitis
  • Migraine
  • Asthma
  • Hepatic disorders

HOW CYPOTOL SYRUP WORKS

CYPOTOL SYRUP contain Cyproheptadine and Tricholine Citrate, where Cyproheptadine prevents weight loss by reducing the effect of serotonin (a chemical messenger) in the hypothalamus that helps in regulating appetite and Tricholine Citrate is a bile acid-binding agent that works by removing the bile acids from the body, which results in the liver using cholesterol, leading to more production of bile acids, which causes a decreased cholesterol level in the body, resulting in weight gain.

DIRECTIONS FOR USE

Take CYPOTOL SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF CYPOTOL SYRUP

COMMON

  • drowsiness
  • dizziness
  • sleeplessness
  • blurred vision
  • loss of coordination
  • skin rash
  • signs of gastrointestinal upset such as body chills, burning sensation, cramps, discomfort and diarrhea
  • nausea
  • vomiting
  • constipation
  • dry mouth

RARE

Stop taking CYPOTOL SYRUP and contact your physician immediately if you experience any of the following side effects:

  • experience any other side effects or persistent problem

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit your consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.

Nausea or vomiting:

Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating rich or spicy foods.

Constipation:

Try to eat high-fiber foods such as vegetables, cereals and fresh fruit and drink plenty of water. Engage in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor about receiving alternate treatments for constipation.

Dry mouth:

Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and try to use mouthwash. Consult and inform your doctor if the symptom worsens.

WARNING & PRECAUTIONS

PREGNANCY

CYPOTOL SYRUP is not recommended for use in pregnant women. Consult your physician for advice.

BREASTFEEDING

CYPOTOL SYRUP is not recommended for use in breastfeeding women. Consult your physician for advice.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness or drowsiness after taking CYPOTOL SYRUP.

ALCOHOL

Avoid consumption of alcohol while taking CYPOTOL SYRUP since it may increase the risk of stomach problems.

KIDNEY

CYPOTOL SYRUP should be used with caution if you have any kidney disease such as renal failure. Consult your physician for advice.

LIVER

CYPOTOL SYRUP should be used with caution in patients with liver problems such as liver impairment. If you have any liver problems. Consult your physician for advice.

ALLERGY

Talk to your physician if you are allergic to Cyproheptadine, Tricholine citrate or any of the other ingredients in this medicine.

LUNGS

CYPOTOL SYRUP should be used with caution in patients with a history of bronchial asthma. Consult your doctor before taking CYPOTOL SYRUP.

HEART DISEASE

CYPOTOL SYRUP should be used with caution in patients with cardiovascular disease. Consult your physician for advice.

OTHERS

CYPOTOL SYRUP is not recommended for use if you:

  • have or had angle-closure glaucoma (an eye disorder)
  • have stenosing peptic ulcer
  • have symptomatic prostatic hypertrophy (enlarged prostate gland)
  • have bladder neck obstruction
  • have signs of pyloroduodenal obstruction (gastric outlet obstruction) such as vomiting
  • have high blood pressure

Before taking CYPOTOL SYRUP, inform your doctor if you:

  • have increased intraocular pressure (pressure in the eye)
  • have signs of hyperthyroidism (overactive thyroid) such as unintentional weight loss, rapid heartbeat, irregular heartbeat
  • have high blood pressure

Use in Pediatrics:

CYPOTOL SYRUP is recommended for use in children and adolescents (below 18 years of age). Consult your physician before taking it.

Use in Geriatrics:

CYPOTOL SYRUP is generally not recommended for use in elderly patients unless it is indicated necessary for use. Consult your physician before taking.

INTERACTIONS

A. Drug-Drug interactions:

Before taking CYPOTOL SYRUP, inform your doctor, if you are taking any of the following medicine:

  • medicine used to treat depression (Ex. monoamine oxidase inhibitors (MAO))
  • other antidepressants such as hypnotics (Ex. quazepam), sedatives (Ex. barbiturates), tranquilizers (Ex. diazepam)
  • antianxiety agents (medicines used to treat anxiety) such as alprazolam and chlordiazepoxide

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your physician immediately. The symptoms of overdosage are hallucinations, depression and fits.

SYNOPSIS

Drug :   Cyproheptadine, Tricholine Citrate
Pharmacological Category :   Antihistamine, Bile acid-binding agent
Therapeutic Indication :  

Loss of appetite, weight loss, anorexia nervosa, adjunct to anti-tubercular and antiretroviral regimens for weight gain, allergic rhinitis and conjunctivitis, migraine, asthma and hepatic disorders, in children suffering from anemia, liver or digestive disorder

Dosage Forms :   Drops, Syrup, Liquid

MORE INFORMATION

  • Keep out of reach from children
  • Store at a room temperature

FAQs ABOUT CYPOTOL SYRUP

Is it safe to consume alcohol along with CYPOTOL SYRUP?

Avoid consuming alcohol while taking CYPOTOL SYRUP as it has additive effects and may increase the risk of stomach problems. Consult your physician before taking it.

Does CYPOTOL SYRUP cause dry mouth?

The most common side effect of CYPOTOL SYRUP is dry mouth. When dry mouth occurs, try to manage it by drinking plenty of cold water, sipping on cold unsweetened drinks and using lip balm if lips are dry. Brush your teeth twice a day and try to use mouthwash. If the symptoms do not improve or get worse, consult your doctor immediately.

Can I use CYPOTOL SYRUP with children?

CYPOTOL SYRUP can be given to children and adolescents (below 18 years of age) if prescribed by the physician. The dose may vary depending on the child’s age, body weight and disease condition.

Can I take CYPOTOL SYRUP along with antidepressants?

No, CYPOTOL SYRUP should not be taken along with antidepressants, especially monoamine oxidase inhibitors (MAOI), as it may prolong and increase the effects of CYPOTOL SYRUP. Consult your physician before taking CYPOTOL SYRUP with other medicines to avoid unpleasant side effects.

Can I drive after taking CYPOTOL SYRUP?

Avoid driving and do not operate any machine after taking CYPOTOL SYRUP because CYPOTOL SYRUP may cause drowsiness and dizziness. Patients should be warned about engaging in activities requiring mental alertness and motor coordination. So, please consult your physician before taking CYPOTOL SYRUP.

REFERENCES

1. KD Tripathi. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine. Essentials of medical pharmacology. 7th edition. 2013. Page – 174.

2. Randal A. Skidgel. Histamine, Bradykinin and Their Antagonists. Goodman & Gilman’s The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 711-726.

3. Mayuresh Dilip Kiran, Shaheen Naseem Sheikh, Lalit Jeevan Pawaskar. Safety and Efficacy of a Combination of Cyproheptadine and Tricholine Citrate: Phase IV Study. Annals of International Medical and Dental Research. December 2017. [Accessed on 17th June 2022] https://www.readcube.com/articles/10.21276%2Faimdr.2018.4.2.pe1

4. Khadijehsadat Najib, MD, Mozhgan Moghtaderi, MD, Zohreh Karamizadeh, MD and Ebrahim Fallahzadeh, MD.  Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial. Iranian Journal of Pediatrics. December 2014. [Accessed on 17th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442838/

5. Centaur Pharmaceutical Pvt. Ltd. Oraxin syrup and drop. [Revised on January 2021] [Accessed on 17th June 2022] https://www.centaurpharma.com/downloads/2021/pediatrics/nutritional-and-vitamins/Oraxin%20syrup%20and%20drop.pdf

6. Alaina Pharma. Cyproheptadine and Tricholine citrate syrup. [Accessed on 17th June 2022] http://alainapharma.com/Cyproheptadine%20and%20Tricholine%20Citrate%20Syrup.html

USEFUL DIAGNOSTIC TESTS

  • Upper gastrointestinal (GI) endoscopy and biopsy
  • Complete Blood Count Test

PRODUCT DETAILS

    Country Of Origin
    India
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