Combitaz 250/31.25mg Injection 10ml

Introduction About COMBITAZ 250/31.25MG INJECTION

COMBITAZ 250/31.25MG INJECTION is a combination of Ceftazidime and Tazobactam which belongs to the group of medicines called Antibiotics. It is indicated in the management of various infections such as joint and bone infections, gynaecological infections, infections in patients suffering from Febrile Neutropenia, meningitis, lung infections (Ex. pneumonia, pseudomonal lung infection in Cystic Fibrosis), bacterial infections of the skin, lower respiratory tract infections, urinary tract infections, intra-abdominal infections, septicaemia, ear infections, vibrio infections, and perioperative prophylaxis.

Prior to the management with COMBITAZ 250/31.25MG INJECTION, your doctor might ask you to take certain diagnostic tests. COMBITAZ 250/31.25MG INJECTION is not recommended for use in patients with liver disease, seizures, or infection due to a specific bacteria (C. difficile). In pregnant and breastfeeding women, COMBITAZ 250/31.25MG INJECTION should be used with caution.

The most common side effects of receiving COMBITAZ 250/31.25MG INJECTION are injection site inflammation, rashes, fever, diarrhoea, nausea, headache, dizziness, constipation, indigestion, and pain. Inform your doctor if any of these worsen or don’t improve.

Uses Of COMBITAZ 250/31.25MG INJECTION

Manages,

• joint and bone infections
• gynaecological infections
• infections in patients suffering from febrile neutropenia
• meningitis
• lung infections (Ex. pneumonia, pseudomonal lung infection in Cystic Fibrosis)
• bacterial infections of the skin
• lower respiratory tract infections
• urinary tract infections
• intra-abdominal infections
• septicaemia
• ear infections
• vibrio infections
• perioperative prophylaxis

How COMBITAZ 250/31.25MG INJECTION Works

COMBITAZ 250/31.25MG INJECTION aids in the management of a variety of infections. Ceftazidime is a cephalosporin antibiotic that inhibits penicillin-binding proteins, which are essential for bacterial survival. This leads to the destruction of the bacterial cell wall and, hence, the bacteria. Tazobactam is a beta-lactamase inhibitor, which interacts with an enzyme called beta-lactamase and protects the efficiency of ceftazidime against bacteria.

How to use COMBITAZ 250/31.25MG INJECTION

COMBITAZ 250/31.25MG INJECTION will be given to you only by a doctor or a nurse into a vein or a muscle as an intravenous or intramuscular infusion. Your doctor will decide the correct dose and duration of COMBITAZ 250/31.25MG INJECTION for you depending upon your age, body weight and disease condition.

Side Effects Of COMBITAZ 250/31.25MG INJECTION

How To Manage Side Effects

Constipation

Eat plenty of fiber rich foods such as vegetables, fresh fruits, and cereals and drink plenty of water while taking COMBITAZ 250/31.25MG INJECTION. Exercise more regularly. If the symptom doesn’t improve, contact your doctor.

Diarrhea

Drink a lot of fluids, such as water, squash, or fruit juice to keep yourself hydrated. Do not consume any medicine by yourself with COMBITAZ 250/31.25MG INJECTION without consulting your doctor. If the symptom doesn’t improve, contact your doctor.

Headache

Try to take a rest. Apply a pain-relieving balm on your forehead. If the symptom doesn’t improve, contact your doctor.

Nausea And Vomiting

While receiving COMBITAZ 250/31.25MG INJECTION, stick to simple meals. Avoid eating rich or spicy food. If the symptom doesn’t improve, contact your doctor.

Warning & Precautions

Pregnancy

Use with Caution

COMBITAZ 250/31.25MG INJECTION should be used with caution in pregnant women. Consult your doctor before receiving COMBITAZ 250/31.25MG INJECTION.

Breastfeeding

Use with Caution

COMBITAZ 250/31.25MG INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving COMBITAZ 250/31.25MG INJECTION.

Liver

Use with Caution

COMBITAZ 250/31.25MG INJECTION should be used with caution in patients having liver disease. Consult your doctor before receiving it.

Allergy

Contraindicated

Tell your doctor before receiving COMBITAZ 250/31.25MG INJECTION if you are allergic to Ceftazidime and Tazobactam.

Use In Pediatrics

Consult your doctor

Your doctor will decide the correct dose and duration of the management with COMBITAZ 250/31.25MG INJECTION for your child depending upon your child’s age, diseases condition and body weight. Consult your doctor for advice.

Use In Geriatrics

Consult your doctor

Your doctor will decide the correct dose and duration of the management with COMBITAZ 250/31.25MG INJECTION for you depending upon your age, diseases condition and body weight. Consult your doctor for advice.

Interactions

A. Drug–Drug Interactions:

Before receiving COMBITAZ 250/31.25MG INJECTION, inform your doctor if you are taking any of the following medicine:

• other cephalosporins such as cefadroxil, cefepime, ceftriaxone and other penicillins such as amoxicillin, nafcillin, and ampicillin (used to manage various infections)

Overdosage:

COMBITAZ 250/31.25MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

Synopsis

More Information

• Keep COMBITAZ 250/31.25MG INJECTION out of reach from children
• Store at room temperature

FAQs About COMBITAZ 250/31.25MG INJECTION

Q: What is COMBITAZ 250/31.25MG INJECTION and why is it prescribed?

A: COMBITAZ 250/31.25MG INJECTION is a combination of Ceftazidime and Tazobactam, which belongs to the group of medicines called antibiotics. It is used to manage a variety of infections, including joint and bone infections, gynaecological infections, infections in patients with febrile neutropenia, meningitis, lung infections (such as pneumonia and pseudomonal lung infection in Cystic Fibrosis), bacterial skin infections, lower respiratory tract infections, urinary tract infections, intra-abdominal infections, septicaemia, ear infections, vibrio infections, and perioperative prophylaxis.

Q: How is COMBITAZ 250/31.25MG INJECTION administered?

A: COMBITAZ 250/31.25MG INJECTION will be given to you only by a doctor or a nurse into a vein or a muscle as an intravenous or intramuscular infusion. Your doctor will determine the correct dose and duration of COMBITAZ 250/31.25MG INJECTION for you depending on your age, body weight, and disease condition.

Q: Can COMBITAZ 250/31.25MG INJECTION be administered to pregnant and breastfeeding women?

A: In pregnant and breastfeeding women, COMBITAZ 250/31.25MG INJECTION should be used with caution. Consult your doctor before receiving COMBITAZ 250/31.25MG INJECTION.

Q: Can COMBITAZ 250/31.25MG INJECTION cause diarrhoea?

A: Diarrhoea is a common side effect of COMBITAZ 250/31.25MG INJECTION. Drink a lot of fluids, such as water, squash, or fruit juice, to keep yourself hydrated. Do not take any medicine containing COMBITAZ 250/31.25MG INJECTION without first consulting your doctor. If the symptom doesn’t improve, contact your doctor.

Q: Is COMBITAZ 250/31.25MG INJECTION an antibiotic?

A: Yes. COMBITAZ 250/31.25MG INJECTION is a combination of Ceftazidime and Tazobactam, which are antibiotics. They work by destroying the bacterial cell and managing further growth, effectively managing infections. 

References

1. KD. Tripathi. Antimicrobial Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 725, 728.

2. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Ceftazidime. [Accessed on 15th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Ceftazidime

3. NIH National Library of Medicine, National center for biotechnology information. Pubchem. Tazobactam. [Accessed on 15th July 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Tazobactam

4. Bionova Lifesciences. Ceftadis-TB. [Accessed on 15th July 2022] https://www.bionova.co.in/ceftadis-tb-injection.html

5. Mits Healthcare Mietrex – TM. [Accessed on 15th July 2022] https://www.mitshealthcare.in/product/ceftriaxone-tazobactam-injection-manufacturers-suppliers-2

6. MIMS. Cazotaz. [Accessed on 15th July 2022] https://www.mims.com/india/drug/info/cazotaz

Useful Diagnostic Tests

• Complete Blood Count
• Urine Analysis
• Xray

Author Details

Written By Dr. Dhivakaran R - BDS

Reviewed For Accuracy By Dr. Salem Gill - MBBS

Last updated on 21 Feb 2023 | 06:32 PM(IST)