COGMENTIN 10 Tablet 15's

Alzheimer Rx required

Best Price* ₹ 255.10 MRP ₹ 318.88
(Inclusive of all taxes) *15 Tablet(s) in a Strip * Mkt: Alteus Biogenics Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

COGMENTIN 10 is a combination of Donepezil and Memantine which belongs to the group of medicines called Acetylcholinesterase inhibitors and NMDA receptor antagonists respectively. It is used to treat moderate to severe dementia caused due to Alzheimer’s disease (Alzheimer’s type dementia) in patients previously treated with donepezil alone. Alzheimer’s type dementia is a type of brain disease where the dementia (disorder of thoughts, memory, and behaviour) happens due to degeneration of brain cells that carry memories.

Donepezil is an acetylcholinesterase inhibitor. It acts by restoring the levels of a brain chemical called acetylcholine that carries messages within the nerve cells. Memantine is a NMDA receptor antagonist. It acts by suppressing the overactivation of certain brain chemicals (glutamate) that damages the nerve cells. Together, they help in reducing the symptoms of Alzheimer’s type dementia.

Before taking COGMENTIN 10 inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have any stomach problems (ulcer or bleeding in the gut), breathing problems (asthma), bladder problems, epilepsy or are severely dehydrated due to excessive sweating, vomiting or diarrhea.

Consult your doctor before taking COGMENTIN 10 if you are pregnant or breastfeeding. COGMENTIN 10 may cause nausea and vomiting during the initial days of therapy. These side effects are unusually temporary and disappears as your body gets used to COGMENTIN 10. However, consult your doctor if they worsen. Other most common side effects of taking COGMENTIN 10 are headache, dizziness, and loss of appetite.

USES OF COGMENTIN 10

  • Treats moderate to severe Alzheimer’s type dementia

HOW COGMENTIN 10 WORKS

COGMENTIN 10 effectively controls the symptoms of dementia and Alzheimer’s disease by regulating the levels of certain chemical messengers (acetylcholine and glutamate) in the brain. Acetylcholine is a brain chemical which plays an important role in the functions of memory and cognition. Glutamate is another brain chemical that controls brain’s overall excitation. Overactivation of glutamate may cause damage to nerve cells. Alzheimer’s disease is usually characterized by decreased acetylcholine levels and increased glutamate levels in the brain.

COGMENTIN 10 contains two medicines, namely donepezil and memantine. Donepezil acts by restoring the levels of acetylcholine in the brain by blocking the actions of an enzyme called acetylcholinesterase which usually breaks down acetylcholine. Memantine acts by suppressing the overactivation of glutamate in the brain that causes nerve damage. Together, they restore the balance between chemical messengers in the brain, regulates proper transmission of nerve signals and reduces the symptoms of Alzheimer’s type dementia.

DIRECTIONS FOR USE

Take COGMENTIN 10 as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. COGMENTIN 10 can be taken with or without food. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF COGMENTIN 10

COMMON

  • diarrhea
  • bruising (bleeding under the skin)
  • headache, dizziness
  • nausea, vomiting
  • loss of appetite
  • increased weight
  • loss of bladder control
  • back pain
  • drowsiness

RARE

Stop taking COGMENTIN 10 and consult your doctor immediately if you experience any of the following side effects:

  • muscle problems
  • fast or slow or irregular heartbeat
  • difficulty in passing urine
  • fits (seizures)
  • worsening of lung problems in people with asthma or other lung disease
  • stomach or intestinal bleeding (causing black/bloody stools, vomit that contains blood or looks like coffee grounds, stomach pain)
  • mental or mood changes such as depression or aggression
  • severe dizziness or fainting
  • signs of allergic reaction (such as skin rash, itching or swelling of the face/tongue/throat, severe dizziness, trouble breathing)

HOW TO MANAGE SIDE EFFECTS

Nausea and Vomiting:

Take COGMENTIN 10 with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.

Diarrhea:

Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

Headache:

Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

WARNING & PRECAUTIONS

PREGNANCY

There is no proper information regarding the use of COGMENTIN 10 in pregnant women. Therefore, consult your doctor before taking COGMENTIN 10 if you are pregnant, think you may be pregnant or planning to have a baby.

BREASTFEEDING

There is no proper information regarding the use of COGMENTIN 10 in breastfeeding women. Therefore, consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness or drowsiness after taking COGMENTIN 10.

ALCOHOL

Avoid consumption of alcohol while taking COGMENTIN 10.

KIDNEY

COGMENTIN 10 should be used with caution in patients with kidney diseases. Therefore, consult your doctor before taking it.

LIVER

COGMENTIN 10 should be used with caution in patients with liver diseases. Therefore, consult your doctor before taking it.

ALLERGY

Do not take COGMENTIN 10 if you are allergic to Donepezil or Memantine.

LUNGS

COGMENTIN 10 should be used with caution in patients with lung problems (such as asthma or chronic obstructive pulmonary disease). Therefore, consult your doctor before taking it.

HEART DISEASE

COGMENTIN 10 should be used with caution in patients with heart problems. Therefore, consult your doctor before taking it.

OTHERS

Before taking COGMENTIN 10, inform your doctor if you:

  • have epilepsy
  • have stomach problems (such as ulcers or bleeding in the gut)
  • have bladder problems or difficulty in urination due to enlarged prostate
  • need to undergo any surgical, dental, or other medical procedures
  • have severe urinary tract infections
  • recently made any changes to your diet (such as changed from a high-protein diet to a vegetarian diet)
  • have severe dizziness or fainting
  • have low levels of potassium or magnesium in the blood
  • are severely dehydrated (due to excessive sweating, diarrhoea, or vomiting)

Use in pediatrics:

There is no proper information regarding the use of COGMENTIN 10 in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

Use in geriatrics:

COGMENTIN 10 should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it. Proper dose adjustment and careful monitoring are required in such patients.

INTERACTIONS

A. Drug-Drug Interaction:

Before taking COGMENTIN 10 inform your doctor if you are taking any of the following:

  • carbonic anhydrase inhibitors (used to reduce edema) such as acetazolamide, methazolamide
  • sodium bicarbonate (used to treat metabolic acidosis)
  • non-steroidal anti-inflammatory drugs (used for pain relief) Ex. aspirin, ibuprofen, naproxen
  • diuretics or water pills (used to treat edema and hypertension) Ex. furosemide, chlorothiazide
  • marijuana (a psychostimulant drug that causes addiction)
  • anesthesia (used before surgeries to cause numbness) Ex. lignocaine, bupivacaine, isoflurane, sevoflurane

Overdosage:

If you or anyone else took COGMENTIN 10 excessively, contact your doctor immediately or go to a nearby hospital straight away. Symptoms of overdosage might include passing out or trouble breathing, severe nausea or vomiting, excessive sweating, very slow heartbeat, slow or shallow breathing, seizures, restlessness, hallucinations, and loss of consciousness.

SYNOPSIS

Drug :  

Donepezil, Memantine

Pharmacological Category :   Acetylcholinesterase inhibitors, NMDA receptor antagonists
Therapeutic Indication :  

Alzheimer’s type dementia

Dosage Forms :   Tablet

MORE INFORMATION

  • Keep COGMENTIN 10 out of reach of children
  • Store COGMENTIN 10 at room temperature

FAQs ABOUT COGMENTIN 10

How and when should I take COGMENTIN 10?

COGMENTIN 10 is taken preferably after meals either in the morning or at night before going to bed. However, your doctor will decide the time of administration and number of doses to be taken per day based on your age, body weight and disease condition. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

What if I forget to take a dose of COGMENTIN 10?

If you forget to take a dose of COGMENTIN 10, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of COGMENTIN 10 to compensate a missed dose, as it could lead to toxicity.

What precautions do I need to follow while taking COGMENTIN 10?

Before taking COGMENTIN 10, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have bleeding in the stomach, asthma, or fits. Consult your doctor before taking COGMENTIN 10 if you are pregnant or think you may be pregnant or breastfeeding.

Can the use of COGMENTIN 10 cause headache?

Yes. COGMENTIN 10 may cause headache in some individuals. This side effect is unusually temporary and disappears as your body gets used to COGMENTIN 10. However, consult your doctor if they become uncontrollable to manage.

Can I stop taking COGMENTIN 10 once my symptoms subside?

Do not stop taking COGMENTIN 10 without consulting your doctor, as it may make your symptoms to reappear. If you feel that your symptoms subside after taking COGMENTIN 10, consult your doctor for advice. Your doctor will access your health condition and gradually reduce the dose of COGMENTIN 10 before complete cessation.

 Can COGMENTIN 10 cause vomiting?

Yes. COGMENTIN 10 may cause vomiting in some individuals. This side effect is unusually temporary and disappears as your body gets used to COGMENTIN 10. Meanwhile, get adequate rest. Drink plenty of fluids to keep yourself hydrated. Avoid eating oil rich spicy foods. Stick to simple meals. However, consult your doctor if they become uncontrollable to manage.

What does COGMENTIN 10 do?

COGMENTIN 10 effectively controls the symptoms of dementia and Alzheimer’s disease by regulating the levels of certain chemical messengers (acetylcholine and glutamate) in the brain. It restores the balance between chemical messengers in the brain, regulates proper transmission of nerve signals and reduces the symptoms of Alzheimer’s type dementia.

Is it safe to take COGMENTIN 10?

Yes. COGMENTIN 10 is generally safe when taken at the doses prescribed by the physician. However, it may cause few minor side effects like nausea, vomiting, diarrhea, weak muscle, headache, dizziness. These side effects are unusually temporary and disappears as your body gets used to COGMENTIN 10. However, consult your doctor if they become uncontrollable to manage.

Does COGMENTIN 10 improve cognition?

Yes. COGMENTIN 10 improves cognition in people suffering from mental illness like dementia. It controls the symptoms of dementia by increasing the levels of a chemical messenger (acetylcholine) in the brain which plays an important role in the functions of memory and cognition. As a result, it improves memory and reduce the unpleasant symptoms of dementia.

Can I take paracetamol along with COGMENTIN 10?

Avoid concomitant use of NSAIDS like paracetamol or ibuprofen while taking COGMENTIN 10, because it may increase the risk of bleeding. Consult your doctor for an alternative pain relief medicine.

Can COGMENTIN 10 be used in elderly patients?

Yes. COGMENTIN 10 should be used with caution in elderly patients (aged 65 years and above). Therefore, consult your doctor before taking it. Proper dose adjustment and careful monitoring are required in such patients.

Can COGMENTIN 10 cause diarrhea?

Yes. COGMENTIN 10 may cause diarrhea in some individuals. If you experience diarrhea, hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.

REFERENCES

1. KD. Tripathi. CNS Stimulants and Cognition Enhancers. Essentials of medical pharmacology. Seventh edition. 2013. Page – 490.

2. Rob Jones 1, Bart Sheehan, Patrick Phillips, Ed Juszczak, Jessica Adams, Ashley Baldwin, Clive Ballard, Sube Banerjee, Bob Barber, Peter Bentham, Richard Brown, Alistair Burns, Tom Dening, David Findlay, Richard Gray, Mary Griffin, Clive Holmes, Alan Hughes, Robin Jacoby, Tony Johnson, Roy Jones, Martin Knapp, James Lindesay, Ian McKeith, Rupert McShane, Ajay Macharouthu, John O'Brien, Caroline Onions, Peter Passmore, James Raftery, Craig Ritchie, Rob Howard, DOMINO-AD team. DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. July 2009. [Accessed on 30th Mar 2022] https://pubmed.ncbi.nlm.nih.gov/19630974/

3. Amneal Pharmaceuticals. [Revised on Oct 2016] [Accessed on 30th Mar 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2335950c-be3b-4248-ad04-e9763aee47d2

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    25 g
    Ingredient
    DONEPEZIL 5 mg+MEMANTINE 10 mg
    Hsn Code
    30049099
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COGMENTIN 10 Tablet 15's

COGMENTIN 10 Tablet 15's Mkt: Alteus Biogenics Pvt Ltd

M.R.P.: Rs.318.88
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