INTRODUCTION

CODOX L CAPSULE is a combination of Doxycycline and Lactic Acid Bacillus, which belong to the groups of medicines called antibiotics and probiotics, respectively. It is used in adults prone to intra-abdominal bacterial infection and to treat antibiotic-associated diarrhoea.

Before taking CODOX L CAPSULE, inform your doctor about your pre-existing conditions, allergies or if you are taking any other medicines. CODOX L CAPSULE is not recommended for use in pregnant women, breastfeeding women or children (younger than 8 years), so consult your doctor before taking it.

The most common side effects of taking CODOX L CAPSULE are loss of appetite, nausea, vomiting, diarrhoea, rash, light sensitivity, hives and haemolytic anaemia. Consult your doctor if any of your symptoms get worse.

USES OF CODOX L CAPSULE

• Treats intra-abdominal bacterial infection
• Treats antibiotic-associated diarrhea

HOW CODOX L CAPSULE WORKS

CODOX L CAPSULE improves gastrointestinal symptoms where doxycycline gets accumulated inside the bacteria, gets attached to the 30S subunit of the bacterial ribosome and inhibits bacterial protein synthesis; lactobacillus restores the natural microbial flora within the digestive tract and helps in the breakdown of food, resulting in the production of lactic acid, hydrogen peroxide and other by-products.

DIRECTIONS FOR USE

Take CODOX L CAPSULE as advised by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will determine your correct dose and duration based on your age, body weight and disease condition.

SIDE EFFECTS OF CODOX L CAPSULE

HOW TO MANAGE SIDE EFFECTS

Loss of appetite:

Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. Consult your doctor if your symptom does not improve or persist.

Nausea:

Take CODOX L CAPSULE with or just after, meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your symptom does not improve or persist.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don't have to eat or avoid any specific foods. Do not take any medicine for vomiting without your doctor's consultation. Consult your doctor if your symptom does not improve or persist.

Diarrhoea:

Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Check with your doctor before taking any medicine for diarrhoea. Consult your doctor if your symptom does not improve or persist.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking CODOX L CAPSULE, inform your doctor if you are taking any of the following medicines:

• medicines used to treat blot clots (Ex. dabigatran, rivaroxaban)
• medicines used to reduce acidity (Ex. aluminum, calcium, magnesium, bismuth subsalicylate)
• iron-containing medicines
• medicines used to prevent pregnancy (Ex. norethindrone, ethinyl estradiol)
• medicines used to treat fits (Ex. phenobarbital, carbamazepine, phenytoin)

Overdosage:

If you or anyone else accidentally take too much of CODOX L CAPSULE, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep CODOX L CAPSULE out of reach from children
• Store below 30°C

FAQs ABOUT CODOX L CAPSULE

Can CODOX L CAPSULE be given to children?

CODOX L CAPSULE is not recommended for use in children (under 8 years of age) as it may cause permanent discoloration of teeth. Your doctor will decide on the correct dose or select a suitable alternative treatment for your child.

What if I forget to take a dose of CODOX L CAPSULE?

If you forget to take a dose of CODOX L CAPSULE, take it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not take the medicine twice to make up for the missed dose.

Can CODOX L CAPSULE be stopped?

Continue taking CODOX L CAPSULE until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or new symptoms. Contact your doctor in such a case.

How should CODOX L CAPSULE be taken? Can it be crushed?

No. Do not break, crush or chew CODOX L CAPSULE. Take it as advised by your physician. Swallow it with a glass of water. Your doctor will determine your correct dose and duration based on your age, body weight and disease condition.

What is CODOX L CAPSULE used for?

CODOX L CAPSULE is used in adults prone to intra-abdominal bacterial infection and antibiotic-associated diarrhoea.

Can CODOX L CAPSULE cause vomiting?

Vomiting is a common side effect of CODOX L CAPSULE. In such cases, get adequate rest and drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don't have to eat or avoid any specific foods. Do not take any medicine for vomiting without your doctor's consultation. If vomiting does not get better, contact your doctor.

What should I tell my doctor before taking CODOX L CAPSULE?

Patients taking CODOX L CAPSULE must inform their doctor about their pre-existing conditions or allergies. Patients should also tell their doctor if they are pregnant or breastfeeding. Consult your doctor if you experience anything different.

Can CODOX L CAPSULE be taken during pregnancy?

CODOX L CAPSULE is not recommended for use in pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking it. Inform your doctor immediately if you become pregnant during this treatment.

Can I take other medicines with CODOX L CAPSULE?

Before taking CODOX L CAPSULE, inform your doctor if you have taken or might take any other medicine, including prescription, over-the-counter or herbal medicine, as these might cause serious side effects by interacting with each other.

REFERENCES

1. Sean C Sweetman. Antibacterials. Martindale The Complete Drug Reference. 36th edition. Page- 267.

2. Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. April 2018. [Accessed on 11th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917019/

3. Micro Labs Ltd. Doxycycline + Lactobacillus. [Accessed on 11th August 2022] http://www.microlabsltd.com/elibrary/node/2315