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INTRODUCTION

CLOBENATE GM CREAM is a combination of Clobetasol, Miconazole and Neomycin which belongs to the group of medicines called Corticosteroids, Antifungals and Antibiotics. It is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection.

CLOBENATE GM CREAM is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, viral infections (ex. herpes simplex, chickenpox) and perforated eardrum. Contact your doctor before applying.

CLOBENATE GM CREAM should be used with caution in patients with liver or kidney disease.  Contact your doctor before applying.

CLOBENATE GM CREAM is generally not recommended for use in pregnancy unless considered clearly necessary. CLOBENATE GM CREAM should be used with caution in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying.

CLOBENATE GM CREAM is not recommended for use in children under 2 years of age and should be used with caution in children above 2 years of age. Contact your doctor before applying.

Dosage adjustment is not required for CLOBENATE GM CREAM in the geriatric population. However, greater sensitivity of some older individuals cannot be ruled out. Contact your doctor before applying.

The most common side effects of this medicine are skin rash, itching, redness, burning sensation and contact dermatitis. Contact your physician if any of the symptoms worsen.

USES OF CLOBENATE GM CREAM

  • Treats resistant dermatoses (skin infections) with secondary bacterial or fungal infection

HOW CLOBENATE GM CREAM WORKS

CLOBENATE GM CREAM helps to treat infection, where Clobetasol have anti-inflammatory, antipruritic, and vasoconstrictive properties, which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy. Miconazole is an antifungal which stops the growth of fungi while Neomycin is an antibiotic which stops the growth of bacteria in the skin.

DIRECTIONS FOR USE

Apply CLOBENATE GM CREAM as directed by your physician. It is for external use only. Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with eyes, face, groin or in the skin folds.

SIDE EFFECTS OF CLOBENATE GM CREAM

COMMON

  • skin rash, itching, redness
  • burning sensation
  • contact dermatitis

RARE

Stop applying CLOBENATE GM CREAM and contact your physician immediately if you experience any of the following side effects:

  • severe allergic reactions such as anaphylaxis or angioedema (skin rash, swelling of the face, lips, tongue, or throat causing breathing difficulty)

HOW TO MANAGE SIDE EFFECTS

Itchy skin:

Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if itching worsens.

WARNING & PRECAUTIONS

PREGNANCY

CLOBENATE GM CREAM is generally not recommended for use in pregnancy unless considered clearly necessary. Contact your doctor before applying.

BREASTFEEDING

CLOBENATE GM CREAM should be used with caution in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying.

KIDNEY

CLOBENATE GM CREAM should be used with caution in patients with kidney disease. Contact your doctor before applying.

LIVER

CLOBENATE GM CREAM should be used with caution in patients with liver disease. Contact your doctor before applying.

ALLERGY

CLOBENATE GM CREAM is not recommended for use in patients allergic to clobetasol, miconazole, neomycin, or to other ingredients of this medicine.

OTHERS

CLOBENATE GM CREAM is not recommended for use if you have:

  • rosacea
  • acne vulgaris
  • perioral dermatitis
  • perianal and genital pruritus
  • viral infections (ex. herpes simplex, chickenpox)
  • perforated eardrum

Use in pediatrics:

CLOBENATE GM CREAM is not recommended for use in children under 2 years of age and should be used with caution in children above 2 years of age. Contact your doctor before applying.

Use in geriatrics:

Dosage adjustment is not required for CLOBENATE GM CREAM in the geriatric population. However, greater sensitivity of some older individuals cannot be ruled out. Contact your doctor before applying.

INTERACTIONS

A. Drug-Drug interactions:

Tell your doctor if you are taking,

  • ritonavir (medicines used for HIV infections)
  • itraconazole (medicines used for fungal infections)
  • aminoglycosides like amikacin, gentamicin (medicines used for bacterial infections)
  • neuromuscular blocking agents like atracurium, pancuronium (medicines used in anaesthesia)
  • warfarin (medicines used to treat or prevent blood clots)

Overdosage:

If you or anyone else accidentally use too much of CLOBENATE GM CREAM, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage are skin irritation, Hypothalamic-pituitary adrenal (HPA) axis suppression, cushingoid features (Ex. moon face, central obesity), ear damage and kidney damage may occur.

SYNOPSIS

Drug :   Clobetasol, Miconazole, Neomycin
Pharmacological Category :   Corticosteroids, Antifungals, Antibiotics
Therapeutic Indication :   Skin infections
Dosage Forms :   Cream, Lotion, Ointment

MORE INFORMATION

  • Keep out of reach of children
  • Store CLOBENATE GM CREAM below 25°C

FAQs ABOUT CLOBENATE GM CREAM

Q: What are the possible side effects of applying CLOBENATE GM CREAM?

A: The most common side effects of this medicine are skin rash, urticaria, itching, redness, burning sensation and contact dermatitis. Contact your physician if any of the symptoms worsen.

Q: Can I use CLOBENATE GM CREAM in children?

A: CLOBENATE GM CREAM is not recommended for use in children under 2 years of age and should be used with caution in children above 2 years of age. Contact your doctor before applying.

Q: For what conditions CLOBENATE GM CREAM is used?

A: CLOBENATE GM CREAM is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection.

Q: Does CLOBENATE GM CREAM cause itching on the skin?

A: Yes, CLOBENATE GM CREAM may cause skin itching at the site of application as a temporary side effect. However, if the itching persists or worsens, consult your doctor for advice.

Q: Can I stop using CLOBENATE GM CREAM when my symptoms are relieved?

A: No, do not stop using CLOBENATE GM CREAM and complete the full course of treatment, even if you feel better. Your symptoms may improve before the infection is completely cured.

Q: Who should not use CLOBENATE GM CREAM?

A: CLOBENATE GM CREAM is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, viral infections (ex. herpes simplex, chickenpox), perforated eardrum. Contact your doctor before applying.

REFERENCES

1. K.D. Tripathi. Drugs acting on the skin and mucous membrane, Antifungal Drugs & Aminoglycoside Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 895, 792, 750.

2. Bethesda (MD). Clobetasol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/5311051

3. Bethesda (MD). Miconazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/4189

4. Bethesda (MD). Neomycin. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Neomycin

5. Blue Cross labs. Clobetasol, Miconazole and Neomycin. [Revised on May 2020] [Accessed on 24th June 2022] https://www.bluecrosslabs.com/img/sections/SONADERM-NM-CREAM.pdf

PRODUCT DETAILS

    Country Of Origin
    India
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